BRONCHIECTASIS

This study tests a daily pill called BI 1291583 (Verducatib) in 1755 adults and teens with bronchiectasis, a lung condition causing frequent infections and coughing. Participants take either the drug or a placebo for up to 76 weeks. The main goal is to see if the drug reduces the…

This study tests a new drug called GSK3862995B in 446 adults with bronchiectasis, a long-term lung condition. The goal is to see if the drug can reduce the number of serious lung infections (exacerbations) compared to a placebo. Participants will receive either one of two doses o…

This pilot study is testing whether the antifungal drug itraconazole is feasible and safe for people with bronchiectasis who have mold growing in their airways. Thirty participants will take itraconazole twice daily for six weeks. The study will measure how many people complete t…

This study tests a device called BiWaze Clear that helps people with bronchiectasis clear mucus from their lungs using gentle vibrations and lung expansion. About 85 participants will use the device at home for 6 months. Researchers will track how many lung infections they get co…

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study tests whether inhaling a salty mist (3% hypertonic saline) can improve breathing symptoms in people with nontuberculous mycobacterial (NTM) lung disease who haven't yet started antibiotics. About 262 adults will either start the saltwater treatment right away for 6 mon…

This study compares two ways to help people with bronchiectasis breathe easier during a sudden worsening of their condition. Twenty patients in the ICU will receive either a high flow nasal cannula or non-invasive ventilation. Researchers will measure how long patients stay in th…

This early-stage trial tests the safety of an inhaled study drug called CHF6333. It involves 45 participants: first, healthy volunteers and people with bronchiectasis receive a single dose; then, people with bronchiectasis receive repeated doses. The goal is to check for side eff…

This study tests a special breathing exercise program for adults with bronchiectasis, a chronic lung disease that causes coughing and shortness of breath. The program combines breathing muscle training with core-strengthening exercises. Researchers will measure lung function, mus…

This study is testing whether using an oscillating PEP (OPEP) device—a handheld breathing tool that helps clear mucus—can improve quality of life for people with bronchiectasis. Researchers will give questionnaires to 60 children (ages 8+) and adults before and after they start u…

This study is testing a new interactive digital breathing game designed to help children with bronchiectasis clear mucus from their lungs at home. The game aims to replace the need for a physiotherapist by using a device connected to a phone or computer. The trial will involve 40…

This study follows 900 people with bronchiectasis—a condition where airways are damaged and prone to infection—to learn why they get sick repeatedly. Researchers will collect medical history, lung function tests, and blood, urine, and sputum samples from patients and their family…

This study reviews medical records of 500 Polynesian patients with bronchiectasis (widened airways) to understand why the condition is so common in French Polynesia. Researchers will look at age of onset, family history, infections, and CT scan patterns to see if a genetic cause …

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This observational study is developing a computer model to identify different types of bronchiectasis in adults. Researchers will collect health data from 750 participants over time to see if they can predict disease patterns. No treatments or interventions are given; participant…

This study is creating a new scoring system called BASE to measure how severe bronchiectasis is and predict the chance of a flare-up over the next year. Researchers will follow 750 adults with non-cystic fibrosis bronchiectasis for 12 months, collecting routine medical data. No n…

This study looks at 80 adults—40 with NTM lung disease (not on antibiotics) and 40 with bronchiectasis alone—to see if their health needs differ. Using questionnaires and simple physical tests, researchers will assess quality of life, nutrition, mood, and muscle strength. The goa…

This study looks at how having heart problems affects the severity of lung flare-ups and quality of life in people with bronchiectasis (a chronic lung condition). Researchers will compare 30 adults with bronchiectasis who also have heart conditions to those without heart issues. …

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an NTM infection. Researchers will collect sputum and airway samples from 1000 participants to compare the lung microbiome of those with and withou…

This study is gathering detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze clinical, biological, and lifestyle factors to identify distinct disease subtypes. …

This study follows 150 adults with bronchiectasis for two years to understand how bacteria in the airways and gut influence disease progression. Researchers will also examine how macrolide antibiotics (like azithromycin) work to improve symptoms. Participants provide sputum, stoo…

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18–80 and follow them for 6 months. The goal …

This study follows 1,850 bronchiectasis patients over three years, collecting sputum samples monthly to analyze how lung bacteria change over time. Researchers will sequence the DNA of bacteria like Pseudomonas aeruginosa to see how they evolve and become resistant to antibiotics…

This study looks at how nutrition impacts the progression of bronchiectasis, a chronic lung disease. Researchers will measure things like arm circumference, grip strength, and body mass index in 300 adults. They will track how often participants have flare-ups and how their lung …

This study surveys 384 adults in Türkiye who have completed a pulmonary rehabilitation program for lung conditions like COPD or asthma. Researchers want to learn how satisfied patients are and how the rehab team's structure affects their experience. No new treatment is being test…