Pseudomonas infection

This early-stage trial tests MP101, a mix of two viruses that attack bacteria (phages), in 18 adults with Pseudomonas aeruginosa pneumonia. Participants receive a single dose of MP101 or a placebo alongside standard antibiotics. The main goal is to check safety and how the body h…

This first-in-human trial tests an experimental drug called CTX-187 for safety and tolerability. It starts with healthy volunteers to assess single and multiple doses, then moves to patients with bronchiectasis who have a chronic Pseudomonas infection. The goal is to see if the d…

This study tests whether a microbiome therapy—a capsule of healthy gut bacteria—can reduce drug-resistant bacteria living in the gut of hospitalized patients. About 40 adults who carry these superbugs will receive either the therapy or a placebo. The goal is to see if the treatme…

This study looks at 600 adults with infections caused by a hard-to-treat bacteria called Pseudomonas aeruginosa. Researchers will compare newer and older antibiotics to see which works best to cure the infection. The goal is to find the most effective treatment for these dangerou…

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part,…

This study looks at stool samples from 100 critically ill patients to understand how a common bacteria, Pseudomonas aeruginosa, becomes dangerous in the gut. Researchers will test if the gut environment makes the bacteria more harmful. No treatment is given; the goal is to learn …

This study follows 150 adults with bronchiectasis for two years to understand how bacteria in the airways and gut influence disease progression. Researchers will also examine how macrolide antibiotics (like azithromycin) work to improve symptoms. Participants provide sputum, stoo…

This study aims to develop new antibody treatments for Pseudomonas aeruginosa, a bacteria that can be resistant to many antibiotics. Researchers will collect blood from 30 patients who have had this infection to isolate and produce antibodies that can fight the bacteria. The goal…

This study looks at whether adults with cystic fibrosis can collect sputum samples at home and mail them in for infection testing, compared to standard clinic collection. With 150 participants, researchers will compare how well home samples detect bacteria like Pseudomonas aerugi…