Could a simple pill replace IV drips for serious blood infections?

NCT ID NCT06080698

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part, and their recovery and any complications will be tracked for 30 days.

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Conditions

The condition(s) this trial relates to.

escherichia coli infection gram-negative bacterial infections Pseudomonas infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAM-NEGATIVE BACTEREMIA

Contacts and locations

Locations

Carilion Clinic
RECRUITING

Roanoke, Virginia, 24011, United States
Denver Health Hospital Authority
RECRUITING

Denver, Colorado, 80204, United States
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Houston Methodist
RECRUITING

Houston, Texas, 77030, United States
Johns Hopkins University Hospital Systems
RECRUITING

Baltimore, Maryland, 21287, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Rutgers-RWJ University Hospital
RECRUITING

New Brunswick, New Jersey, 08901, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21202, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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