Massive trial aims to outsmart superbugs in blood infections

NCT ID NCT06537609

Recruiting now Disease control Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares different antibiotic strategies for people hospitalized with Gram-negative bloodstream infections. The goal is to find which approach leads to better outcomes, like survival and fewer complications, while also reducing the risk of antibiotic resistance. About 2,500 participants will be enrolled across multiple hospitals.

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Conditions

The condition(s) this trial relates to.

gram-negative bacterial infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAM-NEGATIVE BACTEREMIA

Contacts and locations

Locations

CHU de Québec - Université Laval
RECRUITING

Laval, Quebec, Canada
Centre hospitalier affilié universitaire régional (CHAUR)
RECRUITING

Trois-Rivières, Quebec, G8Z 3R9, Canada
Dr. Everett Chalmers Regional Hospital
RECRUITING

Fredericton, New Brunswick, Canada
Eastern Regional Health Authority
RECRUITING

St. John's, Newfoundland and Labrador, Canada
Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, Australia
Foothills Hospital
RECRUITING

Calgary, Alberta, Canada
Grace Hospital
RECRUITING

Winnipeg, Manitoba, Canada
Health Sciences Centre
RECRUITING

Winnipeg, Manitoba, Canada
Humber River Health system
RECRUITING

North York, Ontario, Canada
Hôpital de la Cité de la Santé
RECRUITING

Laval, Quebec, Canada
John Hunter Hospital
RECRUITING

New Lambton, New South Wales, Australia
Michael Garron Hospital
RECRUITING

Toronto, Ontario, Canada
Middlemore Hospital
RECRUITING

Auckland, Auckland, 2025, New Zealand
Monash Medical Center
RECRUITING

Clayton, Victoria, Australia
Montreal General Hospital- McGill
RECRUITING

Montreal, Quebec, Canada
Mount Sinai Hospital
RECRUITING

Toronto, Ontario, Canada
Niagara Health System
RECRUITING

St. Catharines, Ontario, Canada
North York General Hospital
RECRUITING

North York, Ontario, Canada
Peter Lougheed Centre
RECRUITING

Calgary, Alberta, Canada
Redcliffe Hospital
RECRUITING

Redcliffe, Queensland, Australia
Rockyview General Hospital
RECRUITING

Calgary, Alberta, Canada
Royal Brisbane and Women's Hospital
RECRUITING

Herston, Queensland, 4006, Australia
Royal Victoria Hospital- McGill
RECRUITING

Montreal, Quebec, Canada
Sheba Medical Center
RECRUITING

Ramat Gan, Tel Aviv, Israel
South Health Campus
RECRUITING

Calgary, Alberta, Canada
St George Hospital
RECRUITING

Kogarah, New South Wales, 2217, Australia
St John of God
RECRUITING

Murdoch, Western Australia, Australia
St. Boniface Hospital
RECRUITING

Winnipeg, Manitoba, Canada
St. Joseph's Health Centre
RECRUITING

Toronto, Ontario, Canada
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N3M5, Canada
Sunshine Coast University Hospital
RECRUITING

Sunshine Coast, Queensland, Australia
Surrey Memorial Hospital
RECRUITING

Surrey, British Columbia, Canada
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, Canada
Trillium Health Partners - Mississauga Hospital
NOT_YET_RECRUITING

Mississauga, Ontario, Canada
Universidad de La Sabana
RECRUITING

Chía, Cundinamarca, Colombia
University Health Network
RECRUITING

Toronto, Ontario, Canada
University of Alberta
RECRUITING

Edmonton, Alberta, Canada
Université de Sherbrooke
RECRUITING

Sherbrooke, Quebec, Canada
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, Canada

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