A 5-hour test may replace days of waiting for the right antibiotic in blood infections

NCT ID NCT06174649

Completed Diagnosis Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether a rapid diagnostic test called Reveal can improve outcomes for hospitalized patients with gram-negative bloodstream infections. The test measures bacterial growth by detecting gases they release, giving results in about 5 hours instead of the usual 2-3 days. Patients are randomly assigned to receive either standard testing or the rapid test plus standard care, and researchers track survival, complications, and recovery up to 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a rapid diagnostic test called Reveal that measures bacterial growth by detecting volatile metabolites
What this could lead to: If successful, this rapid test could help doctors choose the right antibiotic hours sooner, potentially reducing complications and deaths from bloodstream infections.
What could go wrong: The test may not work as well in all settings or for all bacteria, and faster results do not guarantee better outcomes. The trial is still testing this question.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease with sepsis gram-negative bacterial infections Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOODSTREAM INFECTION GRAM-NEGATIVE BACTEREMIA

Contacts and locations

Locations

Attikon University General Hospital

Chaïdári, Attica, 12462, Greece
Complexo Hospitalario Universitario A Coruña (CHUAC) Sergas

A Coruña, 15006, Spain
Kasturba Medical College, Mangalore

Attāvara, Mangalore, 575001, India
Meir Medical Center

Kfar Saba, 4428162, Israel
Rambam Health Care Campus

Haifa, 3109601, Israel
Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel
Tzaneio General Hospital

Piraeus, 18536, Greece

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