Bacterial infectious disease with sepsis

This study tests whether adding the antibiotic linezolid to standard treatment improves outcomes for people with Staphylococcus aureus bloodstream infections. About 606 hospitalized adults will receive either linezolid or a placebo for five days. The goal is to see if the combina…

This study tests a new IV antibiotic (aztreonam-avibactam) in hospitalized children aged 9 months to 18 years with serious gram-negative bacterial infections. About 48 participants will receive either the new drug or the best available standard treatment. The goal is to see how t…

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The stu…

This study tests whether penicillin works better than the usual antibiotic cloxacillin for people with a Staph blood infection that is sensitive to penicillin. About 420 adults will be randomly assigned to one of the two treatments. The main goal is to see who survives 90 days wi…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study looks at whether switching to the blood thinner dabigatran can improve outcomes for people with a serious staph bloodstream infection who are already taking other blood thinners. Researchers will compare those who switch to dabigatran with those who stay on their curre…

This study tests three different antibiotic combinations to treat a dangerous, drug-resistant bacteria called CRAB that causes infections in intensive care patients. Researchers will compare colistin combined with either fosfomycin, ampicillin/sulbactam, or eravacycline in 108 su…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study looks at whether using a combination of antibiotics is more effective than a single drug for treating Enterococcus faecalis bloodstream infections. Researchers will also analyze the gut bacteria of 510 adult patients to see how it affects treatment success. The goal is…

This study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…

This study is testing whether a combination of two steroids (hydrocortisone and fludrocortisone) can reduce death or long-term organ failure in adults with sepsis in the ICU. About 1,800 participants will receive either the steroid combo or a placebo, and researchers will track t…

This study tests whether a combination of clinical guidelines, feedback, and education can reduce the overuse of vancomycin in children with suspected sepsis in intensive care units. Over 52,000 patients and many clinicians across five hospitals will take part. The goal is to low…

This study tests a new, non-invasive tool called the POP-Score to predict infection in newborns within the first 6 hours of life. The score combines light-based measurements of muscle oxygen with routine vital signs like heart rate and blood pressure. Researchers will enroll 93 n…

This study is testing whether a tiny camera in a pill (colon capsule endoscopy) can find colorectal cancer or precancerous growths in people who have had a bloodstream infection with certain gut bacteria. About 100 adults will swallow the camera 4-8 weeks after leaving the hospit…

This trial tests whether adding a quick blood test for presepsin can safely reduce unnecessary antibiotic use in very preterm infants. Currently, over 85% of these babies get antibiotics right after birth, but only 1 in 70 actually has an infection. The study will enroll 900 infa…

This study is testing whether a set of blood markers can accurately rule out late-onset sepsis in newborns in intensive care. Researchers will enroll 358 babies with signs of infection and compare the markers against a panel of experts. If the markers work well, doctors could avo…

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This study tests whether increasing kangaroo care (skin-to-skin contact) in neonatal intensive care units can reduce severe infections and antibiotic-resistant bacteria in very premature infants (born before 32 weeks). Over 3,000 babies across multiple hospitals will be involved.…

This study compares two common hand rubs—chlorhexidine and alcohol—used by medical staff before touching premature babies in the NICU. The goal is to see which one better prevents healthcare-associated infections. One hundred premature infants will be monitored with blood culture…

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for any problems. The goal is to see if a shorter …

This trial tests whether button-sized wireless sensors can accurately measure heart rate, oxygen levels, and skin temperature in extremely preterm infants in the NICU. The sensors aim to replace bulky wired monitors that can stress fragile babies. Ten stable preterm infants will …

This study tests whether it is possible to set up a system to monitor antibiotic resistance at a general referral hospital in semirural Kinshasa, Democratic Republic of Congo. Researchers will enroll about 210 patients with suspected bloodstream infections to collect blood sample…

This study tests whether adding electrochemical sensors to standard blood culture bottles can identify bacteria early, while the sample is still growing. Researchers will collect extra blood samples from 200 patients with suspected bloodstream infections and spike them with known…

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

This study looks back at medical records of 60 critically ill adults in an intensive care unit who received a blood-cleaning treatment called hemoadsorption. The goal is to see if the therapy helps lower the need for drugs that raise blood pressure, improves lab results, and affe…

This study tests whether a rapid lab test can help doctors choose the right antibiotic sooner for patients with bloodstream infections. About 400 adults with positive blood cultures will be randomly assigned to either the rapid test or standard testing. The goal is to see if the …

This study looks at 790 adults with S. maltophilia infections, a hard-to-treat bacteria. Researchers will compare patients who got one antibiotic versus those who got a combination, to see which group has fewer deaths within 30 days. The goal is to find the best treatment approac…

This study is observing 200 hospitalized adults with carbapenem-resistant Acinetobacter baumannii (CRAB) infections—a type of superbug—who are treated with the antibiotic sulbactam-durlobactam. Researchers will compare their outcomes to patients receiving other treatments to see …

This study aims to figure out where bloodstream infections in children with central lines actually come from. By comparing the DNA of bacteria from the blood with bacteria from the gut, mouth, and skin, researchers hope to tell whether the infection started from the line itself o…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, and bone infections. Researchers will collect medical data and biological samples to describe the infections and their treatments. The goal is to better under…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This study looks at the sticky layer (biofilm) that can form on arterial catheters in intensive care patients. About 60 adults in the ICU will have their catheters examined after removal to see what types of bacteria or fungi are present and how the biofilm is structured. The goa…

This study compares two strong antibiotics, polymyxin B and colistin, in treating serious infections caused by bacteria that are resistant to many common drugs. Researchers will look at medical records of 480 adults with pneumonia or bloodstream infections to see which antibiotic…

This study tests a rapid PCR test that identifies bacteria and drug resistance in about an hour, compared to standard methods that take 1-3 days. 300 adults with bloodstream infections will be randomly assigned to get either the rapid test plus standard care or standard care alon…

This study looks at how to help hospital units reduce the use of vancomycin, an antibiotic, in preterm infants. Researchers will compare two approaches to implementing new guidelines across 13 NICUs. The goal is to see which method works better at safely lowering antibiotic use.

This study looks at whether people with a staph bloodstream infection and a low risk score (VIRSTA score less than 3) can safely avoid a routine heart ultrasound. About 700 participants will be randomly assigned to either get the ultrasound or not. The goal is to see if skipping …

This study will roll out three proven antibiotic stewardship strategies in Dutch hospitals to see if they reduce unnecessary antibiotic use in newborns with suspected early-onset sepsis. Researchers will compare data from before and after the strategies are put in place, involvin…

This study compares five different non-surgical treatments for advanced gum disease (periodontitis) to see how they affect inflammation throughout the body and the risk of bacteria entering the bloodstream. Researchers will measure blood markers like C-reactive protein and interl…

This study collects amniotic fluid from 275 pregnant women delivering at various stages, including extremely preterm. Researchers will analyze the fluid's microbes and chemicals, and link them to the baby's gut bacteria and health outcomes like necrotizing enterocolitis (NEC) and…