Bacterial infectious disease with sepsis

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study will test whether giving an extra antibiotic during a heart valve replacement procedure (TAVI) can lower the chance of bloodstream infection or death within 6 months. About 2,000 patients in Denmark will take part. Half will get the standard antibiotic, and half will g…

This study tests a new antibiotic combination (BV100 plus other drugs) against hard-to-treat infections like pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii. About 120 adults in the hospital will receive either the new combo or the best…

This study tests whether giving a daily antibiotic (pivmecillinam) to kidney transplant patients at high risk of bloodstream infections can reduce those infections. 150 participants will receive either the antibiotic or a placebo for 5 months after transplant. The goal is to see …

This study tests whether adding N-acetylcysteine (NAC) to standard care helps newborns with sepsis. Sepsis causes dangerous inflammation and cell damage. NAC may reduce this damage by boosting the body's defenses. The trial will enroll 50 near-term and term infants to see if NAC …

This study tests whether adjusting beta-lactam antibiotics based on blood levels helps critically ill sepsis patients recover faster. 198 adults in the ICU will be randomly assigned to either standard dosing or dosing guided by regular blood tests. The goal is to see if personali…

This study compares standard beta-lactam antibiotics alone versus beta-lactam plus levofloxacin in adults with streptococcal bacteremia (bacteria in the blood). 165 participants will be randomly assigned to receive either the combination or monotherapy. The goal is to see if addi…

This study will test a new biomarker called t6A to see if it can help doctors diagnose bacterial infections in newborn babies early. Researchers will measure t6A levels in 210 infants who need blood tests for suspected infection. The goal is to find a more accurate way to detect …

This study explores whether routine blood tests—like CBC and lactate levels—can help doctors diagnose sepsis in newborns more quickly than waiting 2-3 days for a blood culture. Researchers will enroll 80 infants in the NICU with signs of infection and compare these rapid test res…

This study tests whether a taurolidine lock solution, placed inside central catheters, can prevent bloodstream infections in newborns. About 576 infants with central lines will receive either the taurolidine lock or a saline lock every 48 hours. The goal is to see if this approac…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for any problems. The goal is to see if a shorter …

This study will examine heart function in 80 newborns with sepsis using a special ultrasound (tissue Doppler echocardiography) and blood tests for cardiac troponin and other sepsis markers. The goal is to see if these tests can predict heart problems early. The study includes bot…

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This study will look at how using a risk calculator changes the way doctors manage suspected early-onset sepsis in newborns. Researchers will compare data from before and after the calculator was introduced at one hospital, involving about 6,300 infants. The goal is to see if the…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes travels to the heart and causes a serious infection called infective endocarditis. Researchers will analyze the gut bacteria of 90 adults with this bloodstream infection to see if an imbalance in the…

This study tests a new rapid diagnostic system that can tell doctors which antibiotic will work against a blood infection in 4-6 hours, instead of the usual 18-24 hours. Researchers want to see if this faster information helps ICU doctors change to a better antibiotic sooner. The…

This observational study will compare blood cultures taken from arterial lines versus standard vein punctures in 1,500 ICU patients. The goal is to see if the arterial method reduces contamination and improves detection of bloodstream infections. Researchers will also check if mo…