Could a simple antibiotic combo save lives after heart valve surgery?

NCT ID NCT07442357

Not yet recruiting Disease control Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will test whether giving an extra antibiotic during a heart valve replacement procedure (TAVI) can lower the chance of bloodstream infection or death within 6 months. About 2,000 patients in Denmark will take part. Half will get the standard antibiotic, and half will get the standard plus an extra one targeting a specific bacteria.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Beta-lactam antibiotic (e.g., ampicillin) plus cephalosporin
What this could lead to: If it works, this could point toward a better way to prevent serious infections after heart valve replacement, potentially saving lives.
What could go wrong: This trial hasn't started yet, and it's testing a small change in routine care. The benefit may be small or not exist, and adding antibiotics carries risks like allergic reactions or antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis bacterial infectious disease with sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE STENOSIS

Contacts and locations

Locations

Copenhagen University Hospital, Rigshospitalet

Copenhagen, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.