Rigshospitalet, Denmark

This study tests whether injections of stem cells from donated fat tissue can improve the quality of old burn scars. 39 adults with hypertrophic scars (at least 2 years old) will receive stem cells in one scar area and a placebo in another. The main goal is to see if patients rep…

This study tests whether replacing a narrowed heart valve right away (within 12 hours) helps people with severe aortic stenosis who are in cardiogenic shock, compared to the usual approach of stabilizing them in the ICU first. Thirty participants will be randomly assigned to one …

This study tests whether opening blood vessels (vasodilation) or removing fluid (diuretics) is better for treating sudden fluid buildup in the lungs from heart failure. About 1,100 adults with severe shortness of breath and low oxygen levels will receive one of three treatments i…

This study tests a special balloon procedure called ischemic postconditioning in 1800 people having a heart attack. After opening the blocked artery, doctors briefly inflate and deflate a balloon four times to see if it reduces heart damage. The goal is to lower the chance of hea…

This study tests whether a program of resistance training and nutritional counseling, started before a stem cell transplant, can improve quality of life for blood cancer patients. 110 adults scheduled for a transplant will be randomly assigned to either the prehabilitation progra…

This trial is testing two improvements to standard radiation therapy for men with high-risk prostate cancer. First, it adds a higher radiation dose (a boost) directly to the visible tumor inside the prostate, aiming to reduce the chance of cancer spreading. Second, it compares gi…

This study tests whether an automated insulin delivery system (CamAPS FX) can help women with type 1 diabetes maintain better blood sugar control before and during pregnancy, compared to their usual insulin routine. The trial will enroll 305 women aged 18-45 who are either planni…

This study tests whether oral semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside standard care. The goal is to see if it works as well …

This study looks at whether people with severe nasal polyps who have been symptom-free for at least a year on biologic drugs like Dupixent or Nucala can safely stop taking them. 66 participants will either stop their medication or continue as usual, and researchers will track if …

This study tests whether replacing an infected heart device immediately after removal is as safe and effective as waiting for a later procedure. About 176 adults with device infections will be randomly assigned to either immediate or delayed reimplantation. The main goal is to se…

This study looks at whether people with chronic nasal polyps who are stable on biologic drugs like dupilumab or mepolizumab can safely extend the time between doses from every 4 weeks to every 6 or 8 weeks. The goal is to see if symptom control can be maintained with fewer inject…

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

This study explores whether a 3D ultrasound scan of removed skin cancer tissue can accurately measure how deep the tumor goes. Researchers will compare ultrasound images to standard lab analysis. If it works, this technique might help surgeons know immediately if they got all the…

This study tests whether adding anemia treatment (iron, vitamins, and a hormone that boosts red blood cells) to standard care helps people with a serious heart valve infection feel better and walk farther. About 74 adults with both the infection and anemia will be enrolled. The g…

This study looks at whether a structured 18-week exercise program can improve health-related quality of life in people with metastatic colorectal cancer who are starting their first round of chemotherapy. About 150 adults will be randomly assigned to either the exercise group or …

This study tests whether a virtual reality (VR) program can help adults with long-term non-cancer pain keep their pain from getting worse. 44 participants will either use a VR-based pain self-management program or receive usual care. The goal is to see if VR can reduce pain inten…

This study tests a new way to give radiation for head and neck cancer. Instead of a fixed plan, the radiation is adjusted daily to match changes in the patient's body. The goal is to lower side effects like trouble swallowing and dry mouth. About 40 adults with throat or voice-bo…

This study looks at whether a personalized strength exercise program can improve muscle function and reduce weakness attacks in adults with hypokalemic or hyperkalemic periodic paralysis. Over 24 weeks, 36 participants will be tested at the start, at 12 weeks, and after 12 weeks …

This study tests whether telepresence robots can help children aged 5-17 with cancer attend school remotely when they can't be there in person. The robots let kids see, hear, and talk in class from their hospital or home. Researchers will track school attendance, social well-bein…

This study tests whether a personalized bike exercise program can reduce symptoms in adults with post-concussion syndrome (PCS), a condition where concussion symptoms last for weeks or longer. Seventy participants will either receive the exercise program plus usual care, or usual…

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing after lung surgery (VATS lobectomy or segmentectomy) in patients who score high on a pain-expectation scale. 80 adults will be randomly assigned to receive either a high dose (1 mg/kg)…

This study tests whether injecting a botulinum toxin (similar to Botox) around nerves in the lower legs can safely reduce pain from diabetic neuropathy. About 80 adults with diabetes and chronic foot pain will receive either the active drug or a placebo injection every 12 weeks f…

This study looks at how showing AI predictions to doctors affects their confidence and accuracy in predicting preterm birth. About 125 obstetricians will review ultrasound images and make decisions, first without and then with AI help. The goal is to see which way of presenting A…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study looks at whether an artificial intelligence (AI) model can predict preterm birth from cervical ultrasound images, and if the way the images are taken affects its accuracy. Researchers will collect images from 2000 pregnant women during their routine second-trimester sc…

This study aims to find early signs that a patient is developing serious complications, like cytokine release syndrome, after immunotherapy for blood cancer. Researchers will track vital signs and immune responses in 100 adults receiving CAR-T or bispecific antibody therapy. The …

This study looks at two conditions that can cause sudden vision loss: giant cell arteritis (GCA), a blood vessel inflammation that needs urgent treatment, and NAION, a similar condition that does not benefit from that treatment. Researchers will use special PET/MRI scans and eye …

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study looks back at the last 10 years in Denmark to understand how many people use breathing machines at home through a tube in their windpipe. Researchers will track which diseases lead to this need and how many patients survive one year after starting. The goal is to spot …

This study looks at what happens to appetite when physically active men aged 40-55 suddenly become inactive for two weeks. Forty healthy, normal-weight men who bike or exercise regularly will either keep their routine or cut steps to under 1,500 per day. Researchers will measure …

This study investigates why up to 20% of people continue to have moderate-to-severe pain after hip or knee replacement surgery, even after normal healing time. Researchers will assess 100 patients using questionnaires to classify the type of pain they experience. The goal is to b…

This study aims to better understand how blood flow and sugar use in the brain are altered in Alzheimer's disease, especially in people who also have type 2 diabetes. Researchers will use advanced PET scans to measure these changes in 60 participants across three groups: people w…

This study looks at how well patients understand the information they get before major abdominal cancer surgery and whether that affects regret afterward. Researchers will survey 90 adults before surgery, then one month and three months after. The goal is to improve how doctors c…

This study is for men over 65 who have chest pain but no blocked heart arteries. It checks if a hidden condition called cardiac amyloidosis might be the cause. Participants will have blood tests, heart scans, and other exams. The goal is to find out how common this hidden disease…

This study uses advanced full-body PET scans to see how natural gut hormones (GIP and GLP-1) affect how the body takes up sugar and blood flow. It includes healthy adults and people with type 2 diabetes. The goal is to better understand how these hormones work after eating, which…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.

This study is a large European registry that will observe up to 500 patients with lymphatic disorders related to congenital heart disease. Researchers will collect data on current diagnostic imaging and treatments like lymphatic embolization to see which approaches improve sympto…

This study tests a wearable chest patch that continuously measures heart rate, breathing, oxygen levels, blood pressure, and temperature in patients recovering from major spinal surgery. Researchers want to see if nurses and patients find the device easy and useful compared to st…

This study tests a special rehabilitation program designed to help people who survived a sudden cardiac arrest return to work. The program includes tailored support and is compared to usual care alone. About 214 survivors will take part, and researchers will track their work stat…

This study in Kyrgyzstan is testing whether using a rapid C-reactive protein (CRP) blood test and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections like coughs and sore throats. About 1050 adults will be randomly assign…

This study looks at the tiny blood vessels inside thyroid nodules using a special ultrasound technique. Researchers hope this will help doctors better tell which nodules are harmless and which might need surgery. The study involves 50 adults, including patients with thyroid nodul…

This study follows 1,000 children who have surgery for a brain tumor in the back part of the brain. Up to 1 in 4 of these children develop a condition called Cerebellar Mutism Syndrome, where they lose the ability to speak. Researchers want to understand why this happens and how …

This study aims to see if an online screening tool can help find mental health problems in children aged 5-17 who were born with heart defects. Researchers will ask parents and children to complete questionnaires and check if they meet criteria for psychiatric diagnoses. The goal…

This study looks at why many people with Waldenström's macroglobulinemia, a rare blood cancer, develop nerve damage that can cause pain, numbness, and trouble moving. Researchers will examine 90 patients to find out how common this nerve damage is and what causes it. The goal is …