Rigshospitalet, Denmark

This study looks at whether people with severe nasal polyps who have been symptom-free for at least a year while taking biologics (Nucala or Dupixent) can safely stop the medication. Half will stop treatment and half will continue, with both groups monitored for symptom return. T…

This study tests whether a personalized exercise and nutrition program before a stem cell transplant can improve quality of life and recovery for adults with blood cancer. About 110 participants will be randomly assigned to the program or standard care. The goal is to reduce hosp…

This study tests if a technique called ischemic postconditioning, done during emergency artery-opening treatment, can reduce heart damage and lower the chance of heart failure or death. About 1,800 adults with a severe type of heart attack (STEMI) and completely blocked arteries …

This study tests whether giving a higher radiation dose directly to prostate tumors can reduce the chance of cancer spreading or returning. About 1,016 men with high-risk prostate cancer will be randomly assigned to receive either standard radiotherapy or standard radiotherapy pl…

This study compares an automated insulin delivery system (CamAPS FX) to usual insulin methods in 305 women with type 1 diabetes who are planning pregnancy or are in early pregnancy. The goal is to see if the automated system helps keep blood sugar in a healthy range and improves …

This study looks at whether people with chronic sinusitis and nasal polyps can safely take their biologic injections (like dupilumab or mepolizumab) less often without losing symptom control. About 135 adults who have been stable on these drugs for at least a year will have their…

This study compares two approaches for people with severe aortic stenosis who go into cardiogenic shock (the heart can't pump enough blood). One group gets a valve replacement within 12 hours of arriving at the hospital; the other gets standard care (stabilization in the ICU) and…

This study tests whether replacing an infected heart device (like a pacemaker) immediately after removing the old one is as safe and effective as waiting several days for a new device. About 176 adults with heart device infections will be randomly assigned to either immediate or …

This study tests whether a daily tablet (semaglutide) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the tablet or a placebo for 14 weeks, alongside their usual care. The goal is to see if the tablet …

This study tests whether a special 3D ultrasound scan of removed skin cancer tissue can accurately measure if the cancer was fully removed. About 30 adults with a common skin cancer will have their tumor scanned after surgery, and the results will be compared to standard lab test…

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual clinical exam (looking and feeling) versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if u…

This study compares three emergency treatments for fluid buildup in the lungs caused by acute heart failure: a standard diuretic (furosemide), a vasodilator (isosorbide dinitrate), or both together. About 1,100 adults with sudden breathing trouble and low oxygen will receive one …

This study tests whether a virtual reality (VR) program can help people with long-term pain keep their pain from getting worse. 44 adults with chronic non-cancer pain will either use a VR pain self-management program or continue with their usual care. The goal is to see if VR can…

This study tests whether a custom exercise program can help adults with post-concussion syndrome, where symptoms last for weeks or longer. About 70 participants will follow a tailored bike-riding plan to see if it reduces symptoms like headache and fatigue. The goal is to find a …

This study tests whether telepresence robots—which let children attend school remotely—along with school navigation support can help kids aged 5-17 with cancer attend school more often and feel better socially. About 128 children from three hospitals in Denmark will take part. Th…

This study tests whether injecting a form of Botox around nerves in the lower legs can safely reduce pain caused by diabetic neuropathy. About 80 adults with diabetes and long-term, moderate-to-severe nerve pain in both feet will receive either the Botox or a placebo every 12 wee…

This study tests a new way to give radiation for head and neck cancer that adjusts each day to changes in the patient's anatomy. The goal is to lower radiation to healthy organs and reduce side effects like trouble swallowing and dry mouth. About 40 adults with throat or voice bo…

This study tests whether a personalized strength exercise program can improve muscle function and reduce attacks in adults with hypokalemic or hyperkalemic periodic paralysis. Over 24 weeks, participants will be tested and fill out questionnaires at the start, at 12 weeks, and af…

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing the morning after lung surgery. It includes 80 adults with lung cancer who are expected to have higher pain levels. Participants receive either a high or low dose of the drug during su…

This study tests a special rehabilitation program designed to help people who survived a sudden cardiac arrest outside the hospital return to work. The program includes personalized support and is added to usual care. Researchers will compare how many participants are working 12 …

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers check the fluid from the drain for signs of infection. The goal is to see if changes in a substance called lactate can help doctors catch infections sooner. No new treatments are tes…

This study checks how common a hidden heart condition called cardiac amyloidosis is in men over 65 who have chest pain but no blocked arteries. Participants will have blood tests, heart scans, and other exams to find the condition. No treatment is given—the goal is to learn how o…

This study looks at why people with Waldenström's macroglobulinemia (a rare blood cancer) often develop nerve damage, causing pain, numbness, and trouble moving. Researchers will examine 90 adults with symptoms to find the exact cause and see if early treatment can prevent lastin…

This study looks at how showing AI predictions in different ways affects doctors' judgment when assessing preterm birth risk. 125 doctors will review cases with ultrasound images and make decisions before and after seeing AI results. The goal is to see which AI format helps docto…

This study aims to understand why up to 20% of people still have moderate-to-severe pain after hip or knee replacement surgery. Researchers will survey about 100 participants to classify their pain type (nerve-related, tissue-related, or mixed). The goal is to improve how doctors…

This study follows 1,000 children under 18 who have surgery for a brain tumor in the back part of the skull. Up to 1 in 4 of these children develop a condition called Cerebellar Mutism Syndrome, where they lose the ability to speak or move normally. Researchers want to understand…

This study looks at how blood flow and sugar use in the brain change in Alzheimer's disease, especially in people who also have type 2 diabetes. Researchers will use special PET scans to measure these changes in 60 older adults, including those with Alzheimer's, those with both A…

This study looks at how well patients understand the information they get before major abdominal cancer surgery and how their expectations match their actual recovery. Researchers will follow 90 adults having surgery for cancers of the pancreas, liver, esophagus, stomach, or bowe…

This study is collecting information from 500 patients across Europe who have lymphatic disorders, often linked to heart disease. Researchers want to see how well current diagnostic tests and treatments, like lymphatic embolization, work in real life. The goal is to find the best…

This study looks at how natural gut hormones (GIP and GLP-1) change the way the body uses sugar and moves blood through organs. Healthy volunteers and people with type 2 diabetes will get special PET scans after receiving these hormones or a placebo. The goal is to better underst…

This study aims to see if an online screening tool can help find mental health problems in children aged 5-17 who were born with heart defects. Researchers will test the screening in 4800 Danish kids and create a website to help families and doctors better understand and address …

This study uses a special ultrasound technique to look at the tiny blood vessels inside thyroid nodules. Researchers hope this will help doctors better tell which nodules are harmless and which might be cancer, so patients can avoid unnecessary surgery. The study involves 50 adul…

This study looks at what happens to appetite when physically active men aged 40-55 suddenly stop exercising for two weeks. Researchers want to see if inactivity changes how much they eat and what foods they prefer. Participants are randomly assigned to either keep their normal ro…

This study watches 100 blood cancer patients closely after they receive CAR T-cell or bispecific antibody therapy. Researchers track vital signs and immune markers to find early warning signs of cytokine release syndrome and other complications. The goal is to learn who needs ext…

This study looks back at the past 10 years to understand how many people in Denmark use a breathing machine at home through a tube in their windpipe. Researchers will track which diseases lead to this need, such as ALS or spinal cord injury, and how many patients survive one year…

This study looks at whether measuring CRP levels (a sign of inflammation) and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections. About 1050 adults in Kyrgyzstan will take part. The goal is to find the best CRP cutoff to…

This study looks at how much physical activity (like moving or exercising) is given to adults with serious brain injuries in intensive care units in Scandinavia. It will track 198 patients to see how activity levels relate to their safety and recovery. The goal is to understand c…

This study explores whether a small, wearable sensor can continuously track heart rate, breathing, oxygen levels, blood pressure, and temperature in adults recovering from major spinal surgery. Researchers want to see if nurses and patients find the device easy to use and helpful…