Could direct heart pacing beat standard therapy for heart failure?

NCT ID NCT07492979

Recruiting now Disease control Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 4 times

Summary

This study compares a newer pacing method (HIS or left bundle branch pacing) to the standard biventricular pacing in 1100 heart failure patients across Nordic countries. The goal is to see if the new approach reduces death or unplanned heart failure hospitalizations. Participants must have severe heart failure and a specific heart block pattern.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Conduction system pacing (HIS bundle or left bundle branch pacing) procedure
What this could lead to: If successful, this could offer a more effective pacing method for heart failure patients, potentially reducing deaths and hospital stays.
What could go wrong: This is a large trial but has not yet started recruiting. The new pacing technique may not prove superior and carries procedural risks like bleeding or lead complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARDIAC RESYNCHRONISATION THERAPY (CRT) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

conduction system disorder heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC RESYNCHRONISATION THERAPY (CRT) CONDUCTION SYSTEM PACING HEART FAILURE

Contacts and locations

Locations

Dept of Cardiology, Meilahti Hospital, Helsinki
NOT_YET_RECRUITING

Helsinki, 00290, Finland
Dept. of Cardiology, Aarhus University Hospital, Aarhus
NOT_YET_RECRUITING

Aarhus, 8200, Denmark
Haukeland Universitetssykehus
NOT_YET_RECRUITING

Bergen, 5009, Norway
Rigshospitalet, Copenhagen University Hospital
RECRUITING

Copenhagen, 2100, Denmark
Sahlgrenska University Hospital
NOT_YET_RECRUITING

Gothenburg, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.