Can a single injection calm infants waking from anesthesia?

NCT ID NCT05091242

Recruiting now Symptom relief Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether a single dose of clonidine, given during surgery, can reduce emergence agitation—crying, thrashing, and confusion—when infants wake from anesthesia. The study includes infants aged 3 to 12 months undergoing general anesthesia with sevoflurane. Half receive clonidine, half receive a placebo, and researchers monitor agitation, pain, and side effects during recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clonidine injection (3 mcg/kg) given once during surgery
What this could lead to: If effective, a single dose of clonidine could become a standard way to prevent distressing post-anesthesia agitation in infants, improving recovery comfort.
What could go wrong: This is a mid-stage trial, and clonidine may not reduce agitation in all infants. Possible side effects include low blood pressure or slow heart rate, and results may not apply to all surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for EMERGENCE DELIRIUM are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

delirium Emergence Delirium Pain, Postoperative Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMERGENCE DELIRIUM

Contacts and locations

Locations

Copenhagen University Hospital, Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Perth Children's Hospital, Department of Anaesthesia and Pain Medicine
RECRUITING

Perth, Nedlands, WA 6009, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.