Could a high dose of steroids ease pain after lung surgery?

NCT ID NCT07213375

Recruiting now Symptom relief Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing after lung surgery (VATS lobectomy or segmentectomy) in patients who score high on a pain-expectation scale. 80 adults will be randomly assigned to receive either a high dose (1 mg/kg) or a low dose (8 mg) of dexamethasone during surgery. The main goal is to measure pain levels the morning after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexamethasone (a steroid drug)
What this could lead to: If it works, this could provide a better way to manage pain after lung surgery, reducing the need for strong painkillers.
What could go wrong: This is a small, early-phase trial (Phase 2/3) with only 80 participants. The high dose may not work better than the low dose, and steroids have side effects like high blood sugar or infection risk.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGETIC GLUCOCORTICOID LUNG CANCER (NSCLC) VIDEO ASSISTED THORACIC SURGERY (VATS)

Contacts and locations

Locations

Department for Cardiothoracic Surgery, Rigshospitalet
RECRUITING

Copenhagen, Copenhagen, 2100, Denmark

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