LUNG CANCER (NSCLC)

This study tests a new medicine called PF-08634404, given alone or with chemotherapy, for adults with early or locally advanced non-small cell lung cancer. The trial has three parts: before surgery, after surgery if cancer remains, or after chemoradiation. Researchers will check …

This early-stage trial tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancer that has stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a powerful cancer-killing agent directly to tumor cells…

This early-phase trial is testing a new oral drug called RMC-5127, alone or combined with other drugs, in adults with advanced solid tumors that have a specific KRAS G12V mutation. The study includes people with lung, colorectal, and pancreatic cancers who have already tried stan…

This study tests whether adding the immunotherapy drug tislelizumab after surgery can help prevent lung cancer from coming back in people with high-risk stage I non-small cell lung cancer. About 108 adults whose tumors are 2–4 cm and have certain high-risk features will receive e…

This early study tests whether injecting two cancer drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe for people with a specific type of lung cancer that has spread to the lining of the brain. The trial will enroll 19 adults whose cancer has worsened despi…

This study tests whether adding a local treatment (like radiation or ablation) to the standard drug osimertinib can better control advanced EGFR-mutated lung cancer. About 64 adults with stable disease after 3-6 months on osimertinib and up to 3 remaining active spots will be ran…

This early-phase study tests a new drug called SH009 in people with advanced solid tumors (like liver, lung, breast, or stomach cancer) that have not responded to standard treatments. The main goals are to see if the drug shrinks tumors and to check its safety. About 150 adults w…

This study is for people with a type of advanced lung cancer that cannot be removed by surgery. It tests a new approach that combines chemotherapy, radiation, and two types of immunotherapy to see if it can control the cancer longer. The trial involves 56 participants and aims to…

This Phase 1 trial is testing TJ101, an experimental antibody-drug conjugate that delivers chemotherapy directly to cancer cells. It is for adults with advanced or metastatic solid tumors (lung, prostate, esophageal, and others) who have run out of standard options. The study aim…

This study tests a therapy using a patient's own tumor-infiltrating lymphocytes (TILs) to treat advanced non-small cell lung cancer. Doctors collect immune cells from a tumor, grow them in a lab, and infuse them back after mild chemotherapy. The goal is to see if this slows cance…

This study tests an inhaled treatment called KB707, a modified herpes virus designed to trigger the immune system against lung tumors. It is for adults with advanced solid tumors that have spread to the lungs and who have run out of standard options. The trial will test KB707 alo…

This study tests an experimental drug called JBI-802, either alone or with the immunotherapy pembrolizumab, in 30 adults with advanced lung cancer that has a specific genetic change (STK11 mutation). The main goals are to check safety and see if the treatment can shrink tumors or…

This Phase 2 trial is testing whether lab-grown immune cells (dendritic and natural killer cells) are safe for people with advanced non-small cell lung cancer. Ten participants will receive injections of their own cultured cells. The main goal is to check for side effects, not ye…

This study is testing a new AI-powered blood test that looks at platelets and immune cells to find early signs of eight different cancers, including lung, breast, and pancreatic cancer. Researchers will collect blood samples from 6,000 adults aged 40 and older, both with and with…

This study tests whether using a mobile app that gives visual feedback can help lung cancer patients do breathing exercises more effectively after having part of a lung removed. Forty patients will try both standard breathing training and app-guided training on the same day. Rese…

This study tests whether regular phone support from a trained lay health worker can improve quality of life for veterans with lung cancer. 194 veterans will either receive usual care or weekly calls for 6 months. The goal is to see if this extra support helps with healthcare plan…

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing after lung surgery (VATS lobectomy or segmentectomy) in patients who score high on a pain-expectation scale. 80 adults will be randomly assigned to receive either a high dose (1 mg/kg)…

This study tests whether combining 4D MRI and 4D CT scans can better track lung tumors and nearby organs as a person breathes during radiation therapy. Researchers will compare this new method to the current standard. The goal is to see if it improves targeting of the tumor while…

This study tests a short, 10-15 minute health assessment called the Practical Geriatric Assessment (PGA) for adults aged 65 and older with early-stage non-small cell lung cancer who are about to receive radiation therapy. The goal is to see if using this quick checkup leads to mo…

This study tests whether advanced MRI scans can identify different immune types of non-small cell lung cancer (NSCLC) without needing a tissue biopsy. Researchers will scan 50 adults with early-stage lung cancer and compare MRI results to standard lab tests. If successful, this a…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study looks at whether measuring DNA methylation markers in the blood can predict if lung cancer will come back after a minimally invasive treatment called Co-ablation. Researchers will follow 30 patients with early-stage non-small cell lung cancer who cannot have surgery. B…

This study looks at whether a blood test that checks for specific DNA changes (methylation) can find leftover cancer cells after lung cancer surgery. About 30 people with non-small cell lung cancer will give blood samples before and after surgery for up to two years. The goal is …