New lung cancer drug shows promise in early trial

NCT ID NCT07489066

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests a new medicine called PF-08634404, given alone or with chemotherapy, for adults with early or locally advanced non-small cell lung cancer. The trial has three parts: before surgery, after surgery if cancer remains, or after chemoradiation. Researchers will check safety and how well the drug shrinks or controls the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-08634404 (also known as SSGJ-707), a biologic drug given by infusion, sometimes with chemotherapy
What this could lead to: If successful, this could offer a new treatment option for non-small cell lung cancer, potentially shrinking tumors before surgery or controlling cancer after standard therapy.
What could go wrong: This is an early Phase 2 study with only 120 participants, so results may not apply to everyone. The drug may cause side effects or not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

carcinoma lung cancer lung disorder lung neoplasm non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA CARCINOMA, NON-SMALL-CELL LUNG (NSCLC) LUNG CANCER (NSCLC) LUNG DISEASE LUNG NEOPLASMS NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER, NON-SQUAMOUS NON-SMALL CELL LUNG CANCER, SQUAMOUS NON-SMALL-CELL LUNG

Contacts and locations

Locations

Cancer Partners of Nebraska
RECRUITING

Lincoln, Nebraska, 68516, United States
Clearview Cancer Institute
NOT_YET_RECRUITING

Huntsville, Alabama, 35805, United States
Clearview Cancer Institute (Crestwood)
NOT_YET_RECRUITING

Huntsville, Alabama, 35801, United States
Guangdong Provincial People's Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510180, China
Hope and Healing Clinical Research
RECRUITING

Hinsdale, Illinois, 60521, United States
Hope and Healing Clinical Research
RECRUITING

New Lenox, Illinois, 60451, United States
Hospital Oncologico Dr. Isaac Gonzalez Martinez
RECRUITING

Rio Piedras, 00935, Puerto Rico
Pan American Center for Oncology Trials, LLC - Bayamón Office
RECRUITING

Bayamón, 00959, Puerto Rico
Pan American Center for Oncology Trials, LLC - Ciudadela Office
RECRUITING

San Juan, 00909, Puerto Rico
Pan American Center for Oncology Trials, LLC - Manati Office
RECRUITING

Manati, 00674, Puerto Rico
Pan American Center for Oncology Trials, LLC - Ponce Office
RECRUITING

Ponce, 00730, Puerto Rico
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
University Cancer & Blood Center, LLC
NOT_YET_RECRUITING

Athens, Georgia, 30607, United States
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.