CARCINOMA

This study tests a new oral drug (NRC-2694-A) taken with chemotherapy (paclitaxel) in people with advanced head and neck cancer that has returned or spread and no longer responds to immunotherapy. About 21 adults will participate to see if the combination shrinks tumors. The goal…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study is for adults with liver cancer that still has active tumors or has come back after a previous treatment called TARE. Researchers want to see if a precise type of radiation called carbon ion radiotherapy can safely shrink or control these remaining tumors. About 48 par…

This early-stage trial tests a treatment where a child's own immune cells are collected, modified to better attack cancer, and given back as a one-time infusion. It is for children and young adults up to age 21 with solid tumors that have come back or not responded to standard th…

This study tests whether adding a precise type of radiation (carbon ion radiotherapy) to standard immunotherapy drugs (atezolizumab and bevacizumab) can better control advanced liver cancer. About 52 adults with liver cancer that cannot be surgically removed will receive this com…

This study looks at how well the drug vorolanib works for people with advanced kidney cancer that has spread or cannot be removed by surgery. It is for patients who need a second treatment after the first one stopped working. Researchers will track how long patients live without …

This study tests whether a blood test that detects tumor DNA can help doctors choose the right amount of chemotherapy and radiation after surgery for HPV-related throat cancer. The goal is to give each patient just enough treatment to prevent the cancer from coming back, while re…

This early-stage study tests a new PET imaging agent, 18F-Clofarabine, to measure an enzyme (DCK) activity in metastatic cancers. The goal is to see if this scan can predict whether drugs like gemcitabine will be taken up by cancer cells. About 4 adults with metastatic cancer wil…

This study is testing whether a simple blood test that looks for tumor DNA can detect if kidney cancer has come back after surgery, possibly earlier than standard imaging scans. Researchers will follow 450 people with newly diagnosed kidney cancer who are having surgery. The goal…

This study collects tumor samples and medical information from 1,500 people with pancreatic cancer. The goal is to build a large biobank that researchers can use to better understand the disease and develop new treatments. Participants do not receive any experimental therapy; the…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study aims to validate a French version of the Nasal Reconstruction FACE-Q questionnaire, which measures appearance, quality of life, and side effects after nasal reconstruction or prosthetic rehabilitation for nasal skin cancer. About 346 adult patients who had surgery 4 mo…

This study is a large registry that will follow about 2,000 people in Germany with advanced ovarian or endometrial cancer. Researchers will collect information on the treatments patients actually receive, how their disease progresses, and their quality of life. The goal is to bet…