CARCINOMA

This program offers taletrectinib to adults with advanced or spreading ROS1-positive non-small cell lung cancer who cannot use approved treatments or join ongoing studies. Participants must have a ROS1 gene fusion and adequate organ function. The goal is to provide potential bene…

This early-phase study tests a personalized cell therapy for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, modified to recognize and attack a protein called B…

This study tests a new drug called savolitinib against a standard treatment (sunitinib) for people with a rare, advanced kidney cancer called MET-driven papillary renal cell carcinoma. The goal is to see if savolitinib works better at slowing cancer growth and has fewer side effe…

This study tests whether adding savolitinib to osimertinib can help people with a specific type of advanced lung cancer (EGFR-mutated, MET-positive) whose cancer has worsened on osimertinib alone. About 345 adults will be randomly assigned to receive either the drug combination o…

This early-stage study tests a personalized cell therapy for children and young adults (ages 1–30) with solid tumors that have come back or not responded to treatment. The therapy uses the patient's own immune cells, modified to recognize and attack tumors that carry a protein ca…

This early-phase study tests a new way to deliver chemotherapy directly into the abdomen after surgery for cancer that has spread to the lining of the belly. It includes 21 adults with appendix or colon cancer. The goal is to find the safest dose and see if the treatment helps co…

This study is testing whether adding a second drug called savolitinib to an existing drug (osimertinib) can help control advanced non-small cell lung cancer that has started growing again after initial treatment. It will involve about 367 adults whose cancer has specific genetic …

This study looks at whether a urine test called BladMetrix can safely detect bladder cancer coming back after surgery. About 500 adults with non-invasive bladder cancer will provide extra urine samples during their regular check-ups over two years. The goal is to see if the test …

This study tests a computer program that helps doctors analyze images from colonoscopies. The software automatically finds growths in the colon and gives a probability of whether they are adenomas (precancerous) or non-adenomas (benign). The goal is to see if the tool improves ho…

This study compares two treatments for early-stage throat cancer: robotic surgery or radiation therapy. It looks at which one leads to better quality of life, especially swallowing. About 138 people took part. The goal is to help patients and doctors choose the best option.

This study looks at whether a pre-surgical toolkit (OPTI-Surg) can improve recovery in older adults with cancer who are having major surgery. The toolkit provides recommendations before surgery to help patients regain physical function faster. About 325 participants will be follo…

This study collects blood and urine samples from 1,000 adults who are receiving radiation therapy for cancer. Researchers want to learn how radiation affects genes in white blood cells, damages red blood cells, and changes hormone levels. Samples are taken before, during, and aft…