New hope for rare kidney cancer: targeted drug savolitinib faces off against standard therapy

NCT ID NCT03091192

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This phase 3 study compares a new drug, savolitinib, to the standard drug sunitinib in 60 people with a specific type of advanced kidney cancer called MET-driven papillary renal cell carcinoma. The goal is to see if savolitinib is better at stopping the cancer from growing and to check its side effects. Participants take one of the two pills by mouth daily.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: savolitinib
What this could lead to: If it works, this could provide a more effective treatment option for people with a specific type of kidney cancer that has spread.
What could go wrong: This is a phase 3 trial, but it's small (60 people) and results may not apply to all patients. Savolitinib may not prove better than sunitinib and could have unexpected side effects.

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Conditions

The condition(s) this trial relates to.

benign urinary system neoplasm carcinoma kidney cancer kidney disorder kidney neoplasm Neoplasms by Site papillary renal cell carcinoma renal cell adenocarcinoma renal cell carcinoma urinary system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA CARCINOMA, RENAL CELL ENZYME INHIBITORS KIDNEY DISEASES KIDNEY NEOPLASMS NEOPLASMS BY SITE PROTEIN KINASE INHIBITORS UROLOGIC NEOPLASMS

Contacts and locations

Locations

Research Site

La Jolla, California, 92093, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60637, United States
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Iowa City, Iowa, 52242, United States
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Boston, Massachusetts, 02215, United States
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Kansas City, Missouri, 64132, United States
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New York, New York, 10021, United States
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Nashville, Tennessee, 37203, United States
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Barretos, 14784-400, Brazil
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Curitiba, 81520-060, Brazil
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Passo Fundo, 99010-080, Brazil
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Pelotas, 096015-280, Brazil
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Porto Alegre, 90050-170, Brazil
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Porto Alegre, 90610-000, Brazil
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Porto Alegre, 91350-200, Brazil
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Rio de Janeiro, 22793-080, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01323-903, Brazil
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Bordeaux, 33000, France
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Vandœuvre-lès-Nancy, 54519, France
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Villejuif, 94805, France
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Arezzo, 52100, Italy
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Meldola, 47014, Italy
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Milan, 20133, Italy
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Modena, 41100, Italy
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Orbassano, 10043, Italy
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Pavia, 27100, Italy
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Roma, 00152, Italy
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Krasnoyarsk, 660133, Russia
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Moscow, 105077, Russia
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Moscow, 115478, Russia
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Moscow, 115522, Russia
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Moscow, RU-121356, Russia
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Murmansk, 183047, Russia
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Nizhny Novgorod, 603109, Russia
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Obninsk, 249036, Russia
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Omsk, 644013, Russia
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Saint Petersburg, 194017, Russia
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Saint Petersburg, 195271, Russia
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Saint Petersburg, 196603, Russia
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Volgograd, 400138, Russia
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Daejeon, 35015, South Korea
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Goyang-si, 10408, South Korea
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Hwasun-gun, 58128, South Korea
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Incheon, 21565, South Korea
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Seoul, 03080, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 120-752, South Korea
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Dnipro, 49005, Ukraine
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Dnipro, 49102, Ukraine
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Ivano-Frankivsk, 76018, Ukraine
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Kharkiv Region, 61070, Ukraine
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Kyiv, 03022, Ukraine
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Kyiv, 03115, Ukraine
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Odesa, 65055, Ukraine
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Sumy, 40022, Ukraine

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