KIDNEY DISEASES

This study tests a program called NAVIGATE-Kidney for people with advanced chronic kidney disease. The goal is to help them start kidney replacement therapy (dialysis or transplant) without needing a temporary catheter, which can lead to infections. About 448 adults will take par…

This study tests two tools to help Black patients with advanced kidney disease get timely care and possibly delay the need for dialysis. Researchers will use a computer alert system and health coaching to connect patients to specialists. The goal is to slow kidney decline, reduce…

This study looks at the long-term safety of a drug called zigakibart for adults with IgA nephropathy, a kidney disease. It is for people who have already finished a previous zigakibart study. Researchers will monitor side effects and check kidney function over time.

This pilot study gives free produce boxes to 20 Veterans with kidney disease who also struggle to get enough healthy food. Researchers will check if the boxes help lower blood pressure and improve kidney function. They will also interview participants to learn about their experie…

This study looks at how well the drug vorolanib works for people with advanced kidney cancer that has spread or cannot be removed by surgery. It is for patients who need a second treatment after the first one stopped working. Researchers will track how long patients live without …

This study aims to validate a test that analyzes proteins in amniotic fluid to predict how well a baby's kidneys will work after birth. Researchers will collect samples from 78 pregnant women whose fetuses have kidney and urinary tract abnormalities. The goal is to see if the tes…

This study tests two different approaches to prevent cytomegalovirus (CMV) disease in adults who have received a kidney from a CMV-positive donor but are themselves CMV-negative. One group will take daily antiviral medication for 200 days, while the other will have weekly blood t…

This study tests a new way to perform leg artery procedures that may protect the kidneys. Instead of using standard contrast dye, doctors will use carbon dioxide gas to see the arteries. The goal is to prevent serious kidney problems in the 90 days after the procedure. About 1,96…

This study looks at whether a 21-day spa program, including mineral water baths and exercise, can help people with chronic kidney and urinary tract problems. Researchers will check 150 adults (ages 40-70) before and after treatment using blood tests, urine tests, and quality-of-l…

This study aims to find kidney disease early in children by using simple urine tests and ultrasound scans. About 13,000 children from China will be screened and followed for 3-6 years. Those with abnormal results will get further care. The goal is to better understand and prevent…

This study is a Danish national registry that will follow 160 high-risk patients with resistant hypertension and blocked kidney arteries who undergo a procedure called percutaneous transluminal renal angioplasty (PTRA) to open the blockage. The main goal is to measure changes in …

This study aims to find genetic links to kidney disease by analyzing DNA from 50,000 adults across the US. You don't need to have kidney disease to join. Participation is online: fill out a 20-minute health survey and provide a saliva sample by mail. In return, you can get free g…

This study looks at kidney tissue from adults with diabetic kidney disease who are already having a kidney biopsy or surgery. Researchers want to understand how SGLT2 inhibitors, a common diabetes medicine, change the kidney's molecular makeup. Participants donate a tissue slide,…

This study looks at 500 older adults to find better ways to diagnose malnutrition, kidney disease, and dehydration. Researchers will compare new methods like body scans and blood tests to current standards. The goal is to make diagnosis more accurate for hospitalized and vulnerab…

This study looks at whether people who carry one copy of the cystic fibrosis gene (carriers) are more likely to have early signs of kidney or pancreas problems. Researchers will compare blood, urine, and stool samples from 1,250 carriers and non-carriers. The goal is to understan…

This study looks at how certain natural chemicals in the body, like angiotensin-(1-7), affect high blood pressure and damage to the heart and kidneys in children. Researchers will follow 125 children with newly diagnosed high blood pressure and healthy kids for two years, collect…

This study looks at how a gene called APOL1 affects kidney transplant success. People of African ancestry are more likely to have certain versions of this gene that can cause kidney disease. Researchers will test DNA from 5,000 kidney donors and recipients to learn how these gene…

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals. The goal is to understand how the drug works, not to cur…

This study is building a large collection of human biological samples and health data to help scientists understand diseases better. It will collect samples from up to 10,000 people, including both healthy individuals and those with conditions like cancer, heart disease, and diab…