Could carbon dioxide replace contrast dye to save kidneys?

NCT ID NCT06656988

Recruiting now Disease control Sponsor: University of Leipzig Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using carbon dioxide gas instead of standard iodinated contrast dye during leg artery procedures can prevent serious kidney problems. About 1,960 people with peripheral artery disease who are at higher risk for kidney injury will be randomly assigned to receive either CO2 or standard dye. The main goal is to see if the CO2 approach reduces major adverse kidney events within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: carbon dioxide (CO2)
What this could lead to: If successful, this approach could offer a safer way to perform leg artery procedures, reducing the risk of kidney injury for patients with vulnerable kidneys.
What could go wrong: This is a large Phase 3 trial, but CO2 imaging may not provide the same clarity as standard dye, potentially affecting procedure outcomes. The benefit may also vary by patient.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

kidney disorder peripheral arterial disease peripheral vascular disease acute kidney injury prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY DISEASES PERIPHERAL VASCULAR DISEASES

Contacts and locations

Locations

DIAKO Krankenhaus gGmbH Flensburg
NOT_YET_RECRUITING

Flensburg, 24939, Germany
GRN - Klinik Weinheim
RECRUITING

Weinheim, Germany
Klinikum Chemnitz gGmbH
NOT_YET_RECRUITING

Chemnitz, 09116, Germany
Klinikum rechts der Isar der Technischen Universität München
RECRUITING

München, Germany
Kreiskrankenhaus Alsfeld
RECRUITING

Alsfeld, Germany
MVZ CCB Frankfurt und Main-Taunus GbR
RECRUITING

Frankfurt a.M., Germany
Tirol Kliniken Innsbruck
RECRUITING

Innsbruck, Austria
Universitäts-Herzzentrum Freiburg-Bad Krozingen
RECRUITING

Bad Krozingen, Germany
Universitätsklinik für Innere Medizin II
RECRUITING

Vienna, Austria
Universitätsklinikum Bonn
NOT_YET_RECRUITING

Bonn, 53127, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Germany

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