Can a Pre-Surgery skin coating stop wound infections?

NCT ID NCT00940979

Terminated Prevention Sponsor: Rijnstate Hospital Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether applying a microbial sealant called Integuseal to the skin before leg bypass surgery can reduce postoperative wound infections. About 450 people scheduled for lower-limb arterial bypass procedures will be randomly assigned to receive the sealant or standard care. The study tracks infection rates, complications, and costs to see if this simple step offers a protective benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Integuseal, a microbial sealant applied to the skin before surgery
What this could lead to: If effective, this simple pre-surgery step could lower infection rates after leg bypass operations, reducing complications and healthcare costs.
What could go wrong: The trial is early and results may not show a clear benefit. Infections depend on many factors, so the sealant might not make a significant difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arterial Occlusive Diseases peripheral arterial disease Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTERIAL OBSTRUCTIVE DISEASES

Contacts and locations

Locations

Ziekenhuis Nij Smellinghe

Drachten, Netherlands
Ziekenhuis Rijnstate

Arnhem, 6800 TA, Netherlands
Ziekenhuis Slingland

Doetinchem, Netherlands

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