Ozone therapy put to the test: could it harm your eyes?

NCT ID NCT07718100

Completed Knowledge-focused Sponsor: Yuzuncu Yil University Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matched controls, measuring corneal cell health and oxidative stress markers over six months. The goal is to determine if this increasingly popular treatment is safe for the eyes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: systemic ozone therapy (major autohemotherapy)
What this could lead to: If safe, it may support wider use of ozone therapy for pain and inflammation without worrying about eye damage.
What could go wrong: This is a small, early safety study, not a test of effectiveness. It may find no harm, but results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

chronic pain syndrome Corneal Endothelial Cell Loss fibromyalgia osteoarthritis, knee peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORNEAL ENDOTHELIAL CELL LOSS OZONE THERAPY

Contacts and locations

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Locations

Yuzuncu Yil University

Van, 65080, Turkey (Türkiye)

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