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CBD oil may curb chronic pain after knee surgery

NCT ID NCT03825965

Prevention Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

About 25% of people who have knee replacement surgery develop persistent pain that can last for months. This trial tests whether taking a CBD-dominant oil before and after surgery can reduce that risk. Researchers will randomly assign about 40 adults to receive either CBD oil or a placebo, and follow them for six months. The main goal is to see if a larger study is feasible, but they will also track pain levels and opioid use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CBD-dominant oil (cannabidiol with a small amount of THC)
What this could lead to
If this pilot succeeds, it could lead to a larger trial testing whether CBD oil can prevent long-term pain after knee replacement, offering an alternative to opioids.
What could go wrong
This is a small pilot focused on feasibility, not proof of pain relief. CBD may cause side effects like drowsiness or liver issues, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

39 people

The number who actually took part.

Started

May 2023

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing TKA aged 18 or older * Cognitive ability and English-language skills required to complete outcome measures * Provision of informed consent * Successful completion of the run-in period Exclusion Criteria: * Severe cardio-respiratory disease (For operationalizing: ASA 4/NYHA 4) * Substance use disorder based on DSM-V criteria * Allergy or intolerance to cannabis, cannabis derivatives, or other ingredients of the study drug * Patients who are pregnant, planning to be pregnant, or breastfeeding * Revision TKA * Bilateral TKA * Presenting for their pre-surgical consultation less than 4 weeks before surgery * Patients with a chronic pain condition affecting the knee (other than osteoarthritis) (e.g.: patients with knee pain due to fibromyalgia or chronic pain syndrome will be excluded) * Unwilling or unable to follow the study protocol

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Conditions

The condition(s) this trial relates to.

cannabis dependence osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario, L8N 4A6, Canada

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1W8, Canada

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