Mcmaster University

This study tests a new COVID-19 vaccine that you breathe in as a mist, aiming to boost immunity in the lungs and blood. About 350 healthy adults who have already had three mRNA COVID shots will get either the experimental vaccine or a placebo. Researchers will check safety and im…

This pilot study tests a structured program to help young adults (ages 18-35) recently diagnosed with bipolar disorder transition from hospital to community care. The program includes group education, one-on-one peer support, and guidance for community healthcare providers. The g…

This study is a registry that will track 150 adults with antiphospholipid syndrome who have had an artery clot in the past year. Researchers will compare four different blood-thinning treatment plans to see which works best to prevent new clots and has the fewest bleeding risks. …

This early-stage study tests a drug called DNase I given through a vein to 36 ICU patients with sepsis. The main goal is to check if the drug is safe and feasible to give in this setting. Researchers will also track how patients' organ function changes over time.

This study looks at whether giving pregnant people at risk of preterm birth a single, lower dose of steroids works as well as the usual two-dose treatment. The goal is to reduce serious health problems in premature babies, like breathing issues or brain bleeding. About 3,250 part…

This study looks at how the body adapts to weight loss in teens with obesity. It compares a lifestyle program alone to the same program plus a medication called semaglutide. The goal is to see which approach works better for long-term weight management. About 74 teens aged 12-17 …

This study compares a new cartilage repair technique called AMIC to the standard microfracture procedure for people with hip cartilage damage. Forty adults aged 18-55 with hip pain lasting at least 6 months will be randomly assigned to one of the two surgeries. The goal is to see…

This study aims to find out whether surgery or non-surgical physical therapy is better for preventing repeat dislocations after a first-time shoulder dislocation. It will enroll 100 young adults and athletes who recently dislocated their shoulder. Researchers will compare the rat…

This study tests a 10-week power training program for people who had a stroke at least 6 months ago. The goal is to see if fast, explosive exercises can improve walking, strength, and balance better than standard slow strength training. Sixty participants will be randomly assigne…

This study tests whether analyzing a patient's phlegm can help doctors choose better treatments for chronic cough in interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either standard care or care guided by…

This study looks at whether a virtual therapy program led by parents can help teens with anorexia nervosa get faster care. About 90 families will try Guided Self-Help Family-Based Therapy (GSH FBT) online. The goal is to see if this approach reduces eating disorder symptoms and s…

This study tests a virtual health coaching program for adults with type 2 diabetes and mental health challenges. Participants receive weekly coaching calls, support from a care team, and online tools. The goal is to see if this approach improves quality of life compared to usual …

This study tests whether a physiotherapist navigator can help cancer patients manage side effects like fatigue and strength loss. 26 adults recently diagnosed with cancer will either receive usual care or extra support from a physiotherapist navigator for 12-18 weeks. The navigat…

This study looks at how different types of hormonal birth control (pills, IUDs, or none) affect the way young healthy women process sugar. Researchers will give participants a sugary drink and take blood samples over two hours to measure glucose and insulin levels. The goal is to…

This study tests a training program called ABCs that teaches healthcare providers how to have better conversations with patients facing serious illnesses. The program includes online lessons and virtual workshops. Researchers want to see if this training helps clinicians feel mor…

This study aims to understand how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and other tests to measure mucus in 240 adults and 50 children with these conditions, plus 100 healthy volunteers. The goal is to find…

This study looks at better ways to invite people with stroke into research, especially women and those with language problems after stroke. Researchers will compare a new recruitment method to the usual one across several hospitals. The goal is to make sure study results reflect …

This study looks at why some people with asthma don't get better with standard inhaled medications. Researchers will use MRI and CT scans to see if blocked or narrowed airways prevent the medicine from reaching the right spots in the lungs. The goal is to understand if these stru…

This pilot study explores whether a common food additive (potassium sorbate) affects how much people eat. Twenty adults with obesity will receive either the additive or a placebo, and their food intake over 24 hours will be measured. The goal is to see if this type of study is fe…

This study is testing a web-based app called IAMABLE that provides rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological problems. Researchers will give 50 adults aged 45 to 75 either the app or general health information for …