Mcmaster University

This study is testing a new COVID-19 vaccine that you breathe in as a mist, aiming to trigger a stronger immune defense right in the lungs. It will involve 350 healthy adults who have already had three doses of an mRNA COVID vaccine. Researchers will compare the new inhaled vacci…

This study is testing whether a single, lower dose of a steroid medicine is just as safe and effective as the standard two-dose treatment for pregnant people at risk of delivering their baby too early. The medicine helps speed up the baby's lung development before birth. Research…

This study is a pilot to see if a larger trial is possible. It aims to find out if surgery or physical therapy is better at preventing the shoulder from dislocating again after a first-time injury. It will enroll 100 young patients (ages 14-40) and follow them for two years to co…

This study is testing whether adding a medication called semaglutide to a standard lifestyle program helps teens with obesity lose weight more effectively. Researchers want to see if the medication helps the body burn calories more efficiently during and after weight loss. The st…

This early-stage study is testing the safety of a new intravenous treatment called DNase I for patients with sepsis in intensive care. The treatment aims to break down harmful webs released by the immune system that can clog blood vessels and damage organs. Researchers will enrol…

This study is creating a registry to compare the safety and effectiveness of different blood-thinning medication combinations for people with antiphospholipid syndrome (APS) who have recently had an artery clot. It will follow 150 adult patients for two years, tracking whether th…

This study compares two surgical methods for repairing damaged hip cartilage in adults aged 18-55. Forty patients will be randomly assigned to receive either the standard microfracture procedure or a newer technique called AMIC. Researchers will track participants for two years t…

This small pilot study is testing whether a new support program can help young adults with bipolar disorder stay healthier after leaving the hospital. The program combines group education, one-on-one peer support, and guidance for community doctors. Researchers want to see if thi…

This study is testing a new exercise program for people recovering from stroke. It compares high-speed 'power training' to standard strength training to see which better improves walking, balance, and strength. Sixty participants, at least six months after their stroke, will be r…

This study is testing a web app called IAMABLE, designed to help people with chronic conditions like arthritis, heart disease, or neurological issues manage their daily lives. Fifty adults aged 45-75 will use the app for four months to see if it improves their physical function, …

This study is testing whether adding a specialized physiotherapist, called a navigator, to a cancer care team is practical and helpful. The navigator would check in regularly with patients during their cancer treatments to spot side effects early, help manage issues like fatigue,…

This study is testing if analyzing a patient's phlegm (sputum) helps doctors choose more effective treatments to reduce chronic cough in people with interstitial lung disease (ILD). About 120 adults with ILD and a daily cough will be randomly assigned to either receive treatment …

This study aims to understand how hormonal birth control affects the body's ability to manage blood sugar. Researchers will compare young, healthy women who use birth control pills, hormonal IUDs, or no hormonal contraception. Participants will drink a sugary beverage and have th…

This study is testing a new way to help more people, especially women and those with language difficulties after stroke, join stroke recovery research. It compares a simplified video and leaflet approach to traditional paperwork to see which helps people decide about joining a tr…

This study aims to understand why some people with asthma don't get better with standard inhaler medicines. Researchers will use special MRI and CT scans to look at the shape of participants' airways. They want to see if blocked or narrow airways stop inhaled medicine from reachi…

This study is testing an online training program designed to help doctors, nurses, and other healthcare providers have better conversations with patients who have serious illnesses. The program teaches communication skills through online modules and virtual workshops. Researchers…

This small pilot study aims to see if a common food preservative (potassium sorbate) influences how much food people eat in a 24-hour period. Researchers will recruit 20 adults with obesity to test if it's feasible to measure food intake after a single dose of the additive versus…

This Canadian study aims to understand how mucus buildup affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and other tests to measure mucus in 240 adults and 50 children over two years. The goal is to find better ways to identify and treat mucus p…