Mcmaster University

This study looks at two ways to treat a first-time kneecap dislocation in people aged 16 to 25. One group will rest and do physical therapy, while the other will have surgery to repair the ligament. The goal is to see which approach better prevents the kneecap from dislocating ag…

This study looks at whether early surgery or rehabilitation is better for teenagers (ages 12-18) who have dislocated their shoulder for the first time. The goal is to see which approach reduces the chance of future dislocations and improves pain and shoulder function. Thirty part…

This study tests whether a combination of two blood thinners (rivaroxaban and aspirin) can prevent heart attacks, strokes, and blood clots after hip fracture surgery in patients who had a heart injury. About 100 adults aged 45 and older will take either the combo for 90 days or s…

This study tests whether a special package of skin care and controlled exposure to food allergens can prevent food allergies in babies at risk. About 64 families will either follow this package or get regular care. Parents will keep a weekly diary and attend check-ups when the ba…

This study tests whether the antibiotic vancomycin can safely improve symptoms of ulcerative colitis in adults who also have a liver condition called primary sclerosing cholangitis. Fourteen participants will take vancomycin or a placebo for 4 weeks to see if it helps and is well…

This study tests a new rehabilitation program for people with melanoma, a serious skin cancer. The program includes exercises and support before and after surgery to help patients regain strength and confidence. The study will include 30 adults who are scheduled for surgery after…

This study tests whether a virtual exercise program with a peer buddy helps older adults (60+) who have had cancer become more active and feel better. Participants are split into three groups: one gets a peer plus guidance from exercise pros, one gets peer support only, and one g…

This pilot study will test whether adding chiropractic care to standard medical care can help adults with long-term back or neck pain reduce their use of prescription opioids. The study involves 24 patients from four community health centers in Canada. The main goal is to see if …

This study tests two common medications (low-dose morphine and pregabalin) and a virtual cough control therapy, alone or together, in 124 adults with chronic cough that hasn't improved with standard treatments. The goal is to see which approach best reduces coughing frequency and…

This study looks at whether listening to music before and during wound care can reduce pain and improve healing for older adults with bed sores. About 50 residents in long-term care homes will either get music or standard care. The goal is to see if music makes wound care more co…

This study tests whether short, guided mindfulness audio recordings can help people with broken arms or legs manage pain and anxiety before and after surgery. Fifty adults will be randomly assigned to listen to either a mindfulness exercise or an educational recording. The main g…

This study looks at whether adding a low-dose ketamine drip to standard sedation helps adults on breathing machines in the ICU. Ketamine treats both sedation and pain, possibly reducing delirium and the need for other drugs. About 54 patients across Canadian ICUs will be randomly…

This study tests a structured program called TransitionED to help youth aged 16+ with eating disorders move from pediatric to adult healthcare. The program includes planning guides, meetings with clinicians, and peer support. Researchers want to see if the program is practical an…

This study is a small 'pilot' trial to see if a larger study comparing two standard treatments for mild degenerative cervical myelopathy (a type of spinal cord compression in the neck) is possible. Researchers will enroll 56 adults with mild symptoms and randomly assign them to e…

This early-stage study looks at whether the hormone progesterone affects how muscles build protein after resistance exercise. Twenty healthy women aged 18-30 will take either progesterone or a placebo, then do leg exercises. Researchers will measure muscle changes through biopsie…

This study will test a parenting program called Family Check-Up+ for families with children aged 2 to 6 who have behavior problems. The program is tailored to each family's needs and aims to improve parent-child relationships and prevent child maltreatment. About 300 families in …

This study looks at how eating salt affects gut health in people with Crohn's disease. Researchers want to see if a high-salt diet increases gut inflammation and symptoms. 300 adults with Crohn's will track their salt intake and provide stool and tissue samples. The goal is to cr…

This study tests a new way to recruit women into stroke research. Women often have worse outcomes after a stroke but are left out of studies. The ORDER toolkit uses easy-to-understand materials made with patients. Researchers will compare this approach to usual recruitment and tr…

This study tests a mobile app called PeerOnCall that lets Canadian firefighters connect with each other for private support and wellness resources. About 2000 firefighters will use the app and complete surveys over one year. The goal is to see if extra features like reminders and…

This study tests whether giving a simple brochure to sepsis patients leaving the intensive care unit (ICU) is practical and helpful. Researchers will enroll 30 adults with sepsis to see if they can successfully deliver the brochure and answer questions. The goal is to learn if th…