Mcmaster University

This 12-week study tests whether a weekly injection of tirzepatide, a drug used for diabetes, combined with motivational therapy can help adults with moderate to severe cannabis use disorder. Fifteen participants will receive escalating doses of tirzepatide along with counseling.…

This pilot study will test whether early arthroscopic surgery or standard rehabilitation (immobilization followed by physical therapy) is better for teens aged 12-18 who have dislocated their shoulder for the first time. The goal is to see which approach reduces the chance of rep…

This pilot study tests whether the antibiotic vancomycin can safely treat active ulcerative colitis in adults who also have primary sclerosing cholangitis, a liver condition. Fourteen participants will take vancomycin or a placebo for 4 weeks, with an optional 4-week extension. T…

This pilot study tests whether a combination of two blood thinners (rivaroxaban and aspirin) can prevent heart attacks and blood clots in patients who had a hip fracture surgery and also suffered a heart injury. About 100 adults aged 45 and older will be randomly assigned to eith…

This pilot study tests whether early surgery to repair a torn ligament in the knee works better than rest and physical therapy for young people who have dislocated their kneecap for the first time. About 30 patients aged 10-25 will be randomly assigned to either surgery or rehab …

This study tests whether a special package of bathing, skincare, and allergen exposure advice can prevent food allergies in infants at risk. Researchers will compare the package to usual care in 64 newborns. Parents will follow recommendations like delaying the first bath and avo…

This study tests whether a short, supervised handgrip exercise program is practical and enjoyable for older adults (65+) with high blood pressure. Thirty participants will do handgrip exercises twice a week for 4 weeks. Researchers will check if the program is easy to stick with …

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether playing a person's favorite music before and during wound care can reduce pain and help pressure injuries (bed sores) heal faster. Researchers will compare wound care with music to standard care without music in 50 older adults living in long-term care ho…

This study tests whether a virtual exercise program with peer support helps older adults (60+) with cancer become more active and feel better. Participants are matched with a peer and receive guidance from exercise professionals or just peer support, compared to usual care. Over …

This pilot study tests whether a personalized exercise and education program, given before and after surgery, can help melanoma patients regain strength and function. Thirty adults with melanoma who are scheduled for surgery after chemotherapy will take part. The main goal is to …

This study looks at whether adding chiropractic care to regular medical care can help adults with long-term back or neck pain reduce their use of prescription opioids. Researchers will enroll 24 patients from four community health centers in Canada to see if a larger study is pos…

This study tests two common nerve-pain drugs (low-dose morphine and pregabalin) and a virtual cough-control therapy, alone or together, in 124 adults with chronic cough that hasn't improved with standard treatments. The goal is to see which approach best reduces coughing frequenc…

This study tests whether adding a low-dose ketamine infusion to usual care can improve sedation and pain control for adults on breathing machines in the ICU. About 54 patients across Canadian hospitals will be randomly assigned to receive either ketamine or a placebo, without kno…

This study looks at whether people with acid reflux or a hiatal hernia can safely skip a test called esophageal manometry before their surgery. The test, which involves a thin tube through the nose to measure throat muscles, can be uncomfortable and delay surgery. Researchers wil…

This study looks at how dopamine levels affect the ability to keep a steady beat in people with early-stage Parkinson's disease. 34 participants will do simple tapping tasks both on their usual levodopa medication and after skipping it for 12 hours. The goal is to understand whet…

This study tests a new way to recruit women into stroke research using easy-to-understand materials like brochures and videos. Researchers will compare this approach to usual recruitment methods with 1,600 participants. The goal is to make stroke studies more inclusive so treatme…

This study tests a structured program called TransitionED designed to help youth aged 16+ with eating disorders move from pediatric to adult healthcare. The program includes planning packages, guided meetings, and a personal profile to share with new providers. Researchers will c…

This pilot study tests whether giving sepsis survivors a simple educational brochure when they leave the intensive care unit (ICU) is feasible. Researchers will enroll 30 adults with sepsis and randomly assign them to receive either usual care or the brochure plus a chance to ask…

This study will test a stepped prevention program called Family Check-Up+ for families with young children at risk of behavior problems. Researchers will enroll 300 families in Ontario, Canada, and focus on how well the program reaches families and is delivered in routine setting…

This pilot study aims to see if a larger trial comparing two standard treatments for mild degenerative cervical myelopathy (spinal cord compression) is possible. 56 adults with mild symptoms will be randomly assigned to either decompressive surgery or a structured conservative ca…

This study tests a mobile app called PeerOnCall that lets Canadian firefighters connect with each other for private peer support and wellness resources. About 2,000 firefighters will use the app for one year, and researchers will compare two ways of introducing it to see which le…

This study looks at how eating salt affects gut health in people with Crohn's disease. Researchers will track salt intake and measure gut inflammation in 300 participants. The goal is to understand if a high-salt diet worsens symptoms and to improve dietary advice for managing th…