Mcmaster University

This study aims to determine whether early surgery or rehabilitation works better for preventing repeat shoulder dislocations in teenagers experiencing their first dislocation. Researchers will follow 30 adolescents aged 12-18 for one year, comparing arthroscopic stabilization su…

This pilot study aims to determine if a larger trial is feasible to compare two standard treatments for mild degenerative cervical myelopathy—a condition where spinal cord compression in the neck causes symptoms like numbness, weakness, and balance problems. Researchers will recr…

This study is testing a virtual support program for adults who have both type 2 diabetes and mental health challenges like anxiety or depression. It compares a new program of weekly health coaching calls and online tools with standard medical care. The goal is to see if this extr…

This small pilot study is testing if the antibiotic vancomycin, taken by mouth, can safely improve symptoms of active ulcerative colitis in adults who also have a liver disease called primary sclerosing cholangitis. Fourteen participants will take either the antibiotic or a place…

This study aims to find the best way to prevent a kneecap from dislocating again after a first-time injury. Young patients (ages 16-25) will be randomly assigned to either have a ligament-repair surgery or to follow a rest and physical therapy program. Researchers will track them…

This is a small pilot study to see if it's possible to run a larger trial testing whether adding chiropractic care to standard medical treatment can help adults with long-term back pain use fewer opioid pain medications. The study will involve 24 adults from four Canadian communi…

This study is testing a family coaching program called the Family Check-Up to see if it can prevent emotional and behavior problems in young children. It will enroll 300 families in Ontario who are at risk for these issues, often due to parental stress or other family challenges.…

This study is testing if a combination of two common blood-thinning medications (rivaroxaban and aspirin) can better prevent heart attacks and blood clots in patients who have had hip fracture surgery and show signs of heart injury. It will involve 100 patients aged 45 and older.…

This study is testing if adding a low-dose ketamine infusion to standard sedation helps adult patients in the intensive care unit (ICU) who are on breathing machines. Researchers want to see if ketamine can reduce delirium, lower the need for other strong pain and sedative drugs,…

This study is testing whether a 10-week virtual exercise program with peer support can help older adults with cancer become more physically active and improve their well-being. Researchers will compare three groups: one gets a peer buddy plus a coach, one gets just a peer buddy, …

This study is testing whether listening to music before and during wound dressing changes can help reduce pain and improve healing for older adults with pressure injuries (bed sores). Researchers will compare care with and without music in 11 long-term care homes, using standard …

This study aims to find the best way to reduce coughing and improve life for adults with a persistent, unexplained cough that hasn't improved with standard treatments. It will directly compare two common medications (low-dose morphine and pregabalin) and a virtual coaching progra…

This study will test whether a mobile app called PeerOnCall can improve mental health and work performance for Canadian firefighters. Researchers will enroll 2000 firefighters to compare two ways of introducing the app, which provides private peer support and wellness resources. …

This small pilot study is testing whether a structured exercise and education program helps people with melanoma recover better from surgery. The program includes sessions with a physiotherapist before and after the operation to build strength and manage symptoms. Researchers wil…

This study is testing whether a cream called Multiprofen-CC can reduce pain for adults with hand osteoarthritis. Forty-two participants will use the active cream and a placebo cream for two weeks each, in a random order, to see which works better. Researchers will measure changes…

This research study aims to understand if eating more salt worsens gut inflammation and symptoms in people with Crohn's disease. It will follow 300 participants for two years, closely tracking their diet, especially salt intake, and measuring markers of gut health. The goal is to…

This is a small pilot study to see if it's practical to test an educational brochure for adults who survived sepsis in the ICU. Researchers want to know if they can successfully recruit 30 participants and deliver the brochure as planned. The study will compare usual discharge ca…

This early-stage study aims to understand if the hormone progesterone changes how women's muscles build protein after strength training. Researchers will compare a progesterone pill to a placebo in 20 healthy premenopausal women. Participants will do leg exercises, receive an inf…