Could a diabetes injection curb cannabis cravings? small trial aims to find out
NCT ID NCT07671248
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 3 times
Summary
This 12-week study tests whether a weekly injection of tirzepatide, a drug used for diabetes, combined with motivational therapy can help adults with moderate to severe cannabis use disorder. Fifteen participants will receive escalating doses of tirzepatide along with counseling. The main goals are to see if the treatment is safe and tolerable, and whether it reduces cannabis use. This is a very early proof-of-concept trial, so results are not yet known.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tirzepatide (a diabetes drug that may reduce cravings) combined with motivational therapy
- What this could lead to
- If it works, this could point toward a new treatment option for cannabis use disorder by reducing cravings and withdrawal.
- What could go wrong
- This is a very small early proof-of-concept study with only 15 people, so results may not apply broadly. The drug may cause side effects like nausea or vomiting, and it's not yet known if it actually reduces cannabis use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
MacAnxiety Research Centre
Hamilton, Ontario, L8S 1B8, Canada
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