Can quitting cannabis rewire the Brain's threat and reward responses?

This study investigates how three weeks of cannabis abstinence influences brain responses to threat, reward, and cannabis cues in women with cannabis use disorder. Participants are randomly assigned to either continue using cannabis as usual or abstain for three weeks, with lab visits and phone surveys tracking changes. Using brain activity measures, the study aims to see if abstinence alters how the brain processes emotional and rewarding stimuli, and whether these changes differ between those who successfully abstain and those who relapse.