Mcmaster University

This study looked at 30 adults with severe asthma whose symptoms didn't improve with usual treatments. Researchers tested whether dupilumab, a drug that blocks certain inflammatory signals, could reduce signs of the immune system attacking the airways. The goal was to see if this…

This study tested whether using a low-chloride IV fluid instead of normal saline could lower the risk of death or kidney damage in people with septic shock. Over 1,100 adults who needed fluid resuscitation for severe infection and low blood pressure took part. The goal was to see…

This study tested the drug tezepelumab in 27 adults with moderate-to-severe asthma that was not well controlled by current treatments. The goal was to see if the drug could improve how air moves through the lungs and reduce airway inflammation and mucus plugs. Participants receiv…

This study tested a program to help seniors aged 70 and older who take 5 or more medications reduce their pill burden. The program involved a pharmacist review and a doctor visit, focusing on safely stopping or lowering doses. The goal was to see if this approach could improve he…

This study tested whether mepolizumab, a drug that targets specific white blood cells called eosinophils, could help control COPD in patients who have high levels of these cells in their airways. The goal was to see if reducing these cells could decrease severe symptom flare-ups …

This study looked at whether giving melatonin, a natural sleep hormone, can prevent delirium (sudden confusion) in older adults after major surgery. Delirium is common in elderly patients and can lead to longer hospital stays and other problems. The study was a small pilot with 8…

This study looked at whether cognitive behavioral therapy (CBT) can help people who had surgery for a broken bone feel less pain over the next year. Over 1,000 adults took part, some getting CBT and others usual care. The goal was to see if CBT lowers the chance of developing lon…

This study tested whether Equine Assisted Learning (working with horses) can reduce trauma symptoms in public safety personnel like firefighters, police, and paramedics. 40 participants from Saskatchewan took part in the program. Researchers measured changes in PTSD, depression, …

This study tested a smartphone app called Back2Play to help youth recover from concussion. The app provides step-by-step guidance for returning to school and physical activity. Researchers measured whether the app reduced re-injury and symptoms in 181 participants. The goal was t…

This study tested whether mepolizumab, a drug that reduces certain immune cells (eosinophils), can lessen chronic cough in people with asthma or eosinophilic bronchitis. 46 adults with a cough lasting over 8 weeks and high eosinophil levels participated. The main goal was to see …

This study tested a modified cognitive training program called Trauma-Informed Goal Management Training (TI-GMT) in 33 adults with PTSD. The program aims to improve thinking skills like attention and goal management, and reduce PTSD symptoms. Participants attended 9 weekly online…

This study tested whether a new training program helps healthcare and social service providers better recognize and respond to intimate partner violence and child maltreatment in veteran families. Forty providers took part, either in a facilitator-led workshop or self-guided onli…

This study tested whether coaching sessions are a practical way to help young people with rheumatic diseases (like juvenile arthritis) move from pediatric to adult rheumatology care. Researchers enrolled 26 patients and measured how many agreed to join, attended sessions, and com…

This study looked at whether gluten or whole wheat (which contains gluten plus other proteins) causes stomach and bowel symptoms in people with Irritable Bowel Syndrome (IBS). 29 adults who already felt better on a gluten-free diet were given special bars containing either purifi…

This study looked at how many women with chronic pain at a pain clinic might have iron deficiency. Researchers asked 81 women questions about heavy periods and other risk factors. The goal was to find out how often iron deficiency happens in this group and whether treating it hel…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their ability to move and do daily tasks changed over time. Researchers measured mobility, thinking skills, and frailty at several points after discharge. The goal is to understand the long road t…

This study looked at how heavy drinkers' brains respond when thinking about buying alcohol after seeing pictures of drinks versus non-alcoholic beverages. 72 non-treatment-seeking heavy drinkers had their brains scanned while making hypothetical drink purchase decisions. The goal…

This study examined how the COVID-19 pandemic affected primary care for people with chronic conditions like diabetes, heart failure, and depression in Canada. Researchers analyzed health records from nearly 920,000 adults to see changes in doctor visits, tests, and treatments. Th…

This study looked at how the COVID-19 pandemic affected children, youth, and families dealing with eating disorders in Canada. Researchers tested virtual parent-led peer support groups to see if they could help reduce stress and improve support for parents. About 120 parents, you…

This study tested whether a transition coach could help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult healthcare. 27 teens took part in a coaching program to build self-management skills. The main goal was to see if …

This study looked at why certain foods cause symptoms in people with irritable bowel syndrome (IBS). Researchers focused on how gut bacteria produce histamine when digesting specific carbohydrates (FODMAPs). Thirty adults with IBS followed a low-FODMAP diet and took special drink…

This study tested whether a new educational program (called VEGA) helps medical residents better recognize and respond to child maltreatment. 84 residents from Canadian universities took part, either in a self-guided online course or a live virtual workshop. The goal was to see i…

This study tested whether matching specific exercises to people with chronic low back pain leads to better results. Researchers used a simple questionnaire to group participants and assigned them to either motor control exercises or graded activity. The goal was to see if persona…

This study looked at how different doses of a ketone supplement affect blood flow to the brain and thinking skills in 20 healthy young adults. Participants drank either a high or low dose of the supplement, and researchers measured brain blood flow and memory. The goal was to lea…