Mcmaster University

This study tested a program to help seniors taking five or more medications work with their doctor and pharmacist to safely reduce or stop some pills. The goal was to see if lowering medication burden improves health, quality of life, and reduces side effects. Seniors were random…

This study tested whether a drug called tezepelumab could improve lung structure and function in adults with moderate-to-severe asthma that remains uncontrolled despite standard treatments. Researchers used advanced MRI and CT scans to see if the drug reduced airway blockages and…

This study looked at whether the drug dupilumab could help control severe asthma by reducing autoimmune activity in the airways. It involved 30 patients with severe asthma who weren't getting enough relief from standard steroid treatments. Researchers measured markers of autoimmu…

This study tested whether using intravenous fluids with lower chloride levels is better than standard saline for people with septic shock—a life-threatening drop in blood pressure caused by severe infection. Over 1,100 critically ill patients received either standard high-chlorid…

This study tested whether a mobile app could help children and teens recover from concussions more safely and effectively. Researchers gave 181 participants either the app or standard care instructions to see which group had fewer repeat injuries and less severe symptoms. The app…

This study tested whether a drug called mepolizumab could help control a specific type of chronic obstructive pulmonary disease (COPD). It focused on COPD patients whose lungs have high levels of a specific inflammatory cell called an eosinophil, which is linked to severe symptom…

This study tested if a simple questionnaire could match people with chronic low back pain to the exercise type most likely to help them. Over 400 participants were randomly assigned to receive one of two common exercise programs. The goal was to validate a method for personalizin…

This study tested whether a coaching program is practical and acceptable for young adults with childhood-onset arthritis (like juvenile idiopathic arthritis or lupus) as they move from pediatric to adult rheumatology care. The program aimed to provide support and teach self-manag…

This study tested if melatonin, a natural sleep hormone, could prevent post-operative delirium—a sudden, severe confusion—in elderly patients after major surgery. It was a small pilot study with 88 participants to see if a larger trial was possible. The goal was to check if takin…

This study tested whether Equine Assisted Learning—a therapy where participants work with horses under guidance—could reduce trauma symptoms in public safety personnel like firefighters, police, and paramedics. Forty trauma-exposed first responders from Saskatchewan were assigned…

This study tested a new coaching program to help teenagers with juvenile arthritis or inflammatory bowel disease (IBD) move from pediatric to adult healthcare. 27 teens were randomly assigned to receive either the coaching sessions or standard care. The main goal was to see if th…

This study tested whether a type of talk therapy called cognitive behavioral therapy (CBT) could help reduce long-term pain after surgery for a broken arm or leg. Over 1,000 adults who had surgery for a fracture received either CBT or standard care. The goal was to see if changin…

This study tested a new, 9-week online group therapy program called Trauma-Informed Goal Management Training (TI-GMT). It was designed to help adults with PTSD improve their thinking skills, like focus and memory, and reduce their PTSD symptoms. Researchers wanted to see if the p…

This study tested whether mepolizumab, an existing medication, could reduce the number of coughs in adults suffering from a long-term, hard-to-treat cough linked to specific airway inflammation. It involved 46 adults with chronic cough and evidence of eosinophilic airway disease,…

This study tested whether a new educational program called VEGA is a practical and acceptable way to train medical residents. The goal was to see if the training improves doctors' ability to recognize and properly respond to child abuse and domestic violence. Researchers compared…

This study aimed to find out how many women visiting a pain clinic for conditions like fibromyalgia also had iron deficiency. Researchers surveyed 81 women about their symptoms and menstrual history to identify those at risk, then offered lab tests and iron treatment if needed. T…

This study used brain scans to understand how seeing pictures of alcohol affects the decisions and cravings of heavy drinkers. Researchers scanned the brains of 72 non-treatment-seeking adults while they made hypothetical choices about buying drinks after viewing alcohol or neutr…

This study looked at how two different doses of a ketone supplement drink affect blood flow to the brain and thinking skills in healthy young adults. Researchers measured brain blood flow, took blood samples, and tested memory after participants drank the supplement. The goal was…

This study followed 211 older adults who were hospitalized with COVID-19 to understand how they recover their mobility and daily function over time. Researchers tracked participants' physical abilities, breathing, and overall health after leaving the hospital. The goal was to gat…

This study tested two ways to train healthcare and social service providers to better recognize and respond to intimate partner violence and child maltreatment affecting veterans and their families. Researchers compared a self-guided online course with a live, instructor-led work…

This study looked back at the health records of nearly 1 million Canadian adults to understand how the COVID-19 pandemic affected their regular care for long-term conditions like diabetes, heart failure, and depression. Researchers compared the number of doctor visits, tests, and…