Can a stool transplant calm an inflamed pouch?

NCT ID NCT03545386

Completed Disease control Sponsor: McMaster University Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study tests whether giving healthy donor stool through an enema once a week for six weeks can help people with active pouchitis—a condition where the surgically created intestinal pouch becomes inflamed. Half the participants receive the real transplant, while the other half get a placebo enema. The goal is to see if the treatment can reduce symptoms and inflammation enough to achieve remission.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fecal microbiota transplantation (donor stool given as an enema)
What this could lead to: If it works, this could offer a new, non-drug way to calm pouchitis and help people avoid long-term antibiotics or surgery.
What could go wrong: This is a small, early-stage trial, so results may not hold up in larger groups. The enema procedure may be uncomfortable, and there is a small risk of infection from donor stool.

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Conditions

The condition(s) this trial relates to.

pouchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POUCHITIS

Contacts and locations

Locations

McMaster University

Hamilton, Ontario, L8S4K1, Canada

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