Could a new drug finally silence chronic cough?
NCT ID NCT04765722
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether mepolizumab, a drug already used for asthma, can reduce coughing in people with chronic cough and eosinophilic airway disease. 46 adults received either the drug or a placebo over 12 weeks. The main goal was to see if cough frequency decreased, measured by a special monitor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mepolizumab (Nucala)
What this could lead to
If successful, this could point toward a new treatment option for chronic cough in people with certain airway conditions.
What could go wrong
This is a small, early proof-of-concept study with only 46 participants, so results may not apply to everyone. The drug may not significantly reduce cough frequency.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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McMaster University
Hamilton, Ontario, L8S 4L8, Canada