ASTHMA

This study tests two ways to prevent asthma attacks in people with persistent asthma: using inhaled steroids as a rescue treatment (called R-ICS) or taking the antibiotic azithromycin regularly. Researchers want to see which approach works best, alone or together, to reduce the n…

This study tests whether a combination inhaler (budesonide/albuterol) taken only when needed can reduce severe asthma attacks in teenagers compared to a standard albuterol inhaler. About 440 teens aged 12 to 18 with asthma and a history of at least one severe attack in the past y…

This study tests a drug called benralizumab in 200 children aged 6 to 17 with severe eosinophilic asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce asthma attacks and improve daily symptoms. Participants will receive injections an…

This study tests a new inhaler (PT027) against a standard one (PT007) for Chinese adults with asthma. About 790 people who have had at least one severe asthma attack in the past year will use the inhaler as needed. The goal is to see if PT027 can delay or reduce severe asthma att…

This study looks at whether dupilumab, an asthma medication, can improve how well the lungs clear mucus in people with moderate to severe asthma. About 30 adults will receive either dupilumab or a placebo for 12 weeks. The main goal is to measure mucus clearance using a special i…

This study tests whether metformin, a common diabetes drug, can improve asthma control in overweight or obese adults whose asthma is not well-managed with standard inhalers. About 100 participants will take metformin or a placebo for 24 weeks, with remote check-ins and in-person …

This study looks at whether a smart inhaler system (SiA®) can help adults with poorly controlled asthma use their inhaler correctly and take their medication as prescribed. About 60 participants will use the smart device and app for one year while continuing their usual asthma tr…

This study looks at how well Airsupra works compared to albuterol for preventing severe asthma attacks in real-world settings. About 4,000 people with asthma who use rescue inhalers will be included. Researchers will track asthma attacks, medication use, and patient characteristi…

This study tests a new inhaler that combines two medicines (fluticasone and albuterol) to see if it can prevent severe asthma attacks better than albuterol alone. About 2,700 adults with asthma who have had at least one severe attack in the past year will take part. The study las…

This study looks at whether placing a temporary balloon in the stomach, along with diet and exercise, can improve asthma control in obese adults whose asthma is not well managed by standard inhalers. About 84 participants will be randomly assigned to receive either the balloon pl…

This study monitors the safety and effectiveness of the Enerzair inhaler in 600 adults with asthma over 24 weeks. Participants use the inhaler as prescribed by their doctor in everyday life. The goal is to track side effects and see how well the medicine controls asthma symptoms.

This study tests a new drug called brenipatide in adults with moderate-to-severe asthma that is not well controlled by current treatments. About 531 participants will receive either brenipatide or a placebo for 52 weeks to see if it reduces asthma attacks and improves breathing. …

This study tests a new medicine called tozorakimab for adults whose asthma is not well controlled even with medium-to-high dose inhaled steroids. About 540 participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if tozorakimab can …

This study is testing whether adding an extra medication called glycopyrronium to standard asthma treatment can improve lung function in children aged 4 to under 12. About 69 children with asthma will receive two different doses of the drug and a placebo in a random order to see …

This study looks at whether giving a medication called Airsupra to adults with acute asthma right in the emergency department can lower the chance of another asthma attack needing urgent care within 3 months. About 1,860 people aged 18 to 55 who are being sent home from the ER wi…

This study tests whether extra support from an asthma navigator after a child's hospital stay can reduce asthma-related readmissions. About 340 children aged 4-12 and their caregivers will be randomly assigned to standard care or standard care plus navigator support. The study fo…

This study tests a new drug called 610 in 480 Chinese adults with severe eosinophilic asthma. The goal is to see if it reduces the number of serious asthma attacks over one year compared to a placebo. Participants must have had asthma for at least a year and be using regular inha…

This study tests a new drug called SHR-1905 for people with severe asthma that is not controlled by current treatments. The goal is to see if it can reduce asthma attacks and improve breathing. About 408 adults will receive either the drug or a placebo, and researchers will track…

This study tests whether a new digital inhaler (Whizz spacer) helps children aged 5 to 16 with asthma use their medication correctly and consistently. Researchers will compare it to a standard spacer and also look for biological markers and environmental factors that affect asthm…

This study is testing how well a triple inhaler therapy (BDP/FF/G) works in real life for people with asthma. It involves 200 adults whose asthma is not well controlled despite current treatments. The main goal is to see if symptom scores improve after 6 months of using the inhal…

This study tests a drug called depemokimab in 150 adults with asthma caused by a specific type of inflammation (eosinophilic). The goal is to see if the drug reduces mucus plugs and airway thickening in the lungs over 26 to 52 weeks. Participants will receive the drug and undergo…

This study compares a new version of an asthma inhaler that uses a more environmentally friendly propellant to the current inhaler. Researchers want to make sure both versions work equally well for people with mild to moderate asthma. About 780 adults will participate in this pha…

This study tests a mobile health program to help African American young adults (ages 18-30) better control their asthma. Participants use a smartphone app, video calls with an asthma nurse, text reminders, and activity tracking. The goal is to improve asthma symptoms and quality …

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps (with or without asthma). About 110 people will be followed for up to a year to see if their nasal polyps shrink and congestion improves. The drug is already approved, and this resea…

This study tests whether a newer extrafine inhaler (Trimbow) works better than a standard one (Trelegy) for people with moderate to severe asthma that is not well controlled. Researchers will use special MRI scans to see how well the medicine reaches the lungs and measure breathi…

This study is testing whether a special education program called 'Asthma School' can help adults with asthma have fewer flare-ups, emergency room visits, and hospital stays over a year. The program teaches patients how to better manage their condition and follow their treatment p…

This study tests an experimental pill called ENV-294 in 50 adults with moderate-to-severe asthma who already use inhalers. Participants take the pill or a placebo once daily for 12 weeks. Researchers will check if the drug is safe and helps control asthma symptoms and lung functi…

This study looks at whether connecting youth (ages 12-25) with community programs rooted in Native Hawaiian culture can improve their mental and physical health. Participants will take part in activities that strengthen their connection to the land and culture, and complete surve…

This study tests an investigational drug called tezepelumab in children aged 5 to 12 with severe asthma that is not well controlled by current treatments. The goal is to see if it can reduce serious asthma attacks and improve lung function. About 231 children will receive either …

This study is testing a smartphone app called ASTHMAXcel Voice that helps people with asthma track their symptoms and voice changes. About 200 English-speaking adults with persistent asthma who own a smartphone will either use the app or receive usual care. The goal is to see if …

This study tests a program called BREATHE that helps Black adults with uncontrolled asthma work together with their doctors to make better treatment decisions. The goal is to improve asthma control and quality of life. About 400 participants will take part at community health cen…

This study tests a new injectable drug called lunsekimig for adults with asthma that is not well-controlled but who are not yet eligible for current biologic treatments. The goal is to see if it can reduce asthma attacks and improve breathing over about a year. Around 1,147 parti…

This study tests a new inhaler that combines two common asthma medicines (fluticasone and albuterol) to see if it works better than each medicine alone or a placebo. About 724 people aged 12 and older with asthma will use the inhaler four times daily for four weeks. The goal is t…

This study tests an experimental medicine called PF-07275315 for adults with moderate-to-severe asthma that is not well controlled. Participants will receive either the study drug or a placebo as injections over 12 weeks. The goal is to see if the drug improves lung function and …

This study tests whether escitalopram, a common antidepressant, can reduce the number of severe asthma attacks in adults with moderate to severe asthma who have had at least three attacks in the past year. About 105 participants will receive either escitalopram or a placebo, and …

This study looks at 250 adults with asthma that is not well controlled by their current medium-dose inhaler. Researchers want to see if adding a drug called dupilumab to the usual inhaler works better than simply increasing the inhaler dose. The goal is to reduce severe asthma at…

This study tests an injectable medicine called dupilumab in children aged 2 to under 6 years whose asthma or wheezing is not well controlled with standard inhalers. The goal is to see if it can reduce severe asthma attacks and improve breathing safety over a year. About 90 childr…

This study tests whether a three-drug inhaler (FF/UMEC/VI) works better than a two-drug inhaler (FF/VI) for teens aged 12-17 whose asthma is not well controlled with their current medication. About 292 participants will use one of the two inhalers daily for 24 weeks. The main goa…

This study tests whether semaglutide, a drug already approved for diabetes and weight loss, can improve asthma control in adults with obesity who still have symptoms despite using inhaled steroids. About 100 participants will receive either semaglutide or a placebo for up to 24 w…

This study compares a new combination inhaler (QMF149) to a standard asthma inhaler (budesonide) in 200 children aged 6 to 12 with asthma. Each child will try both treatments for 12 weeks to see which one improves lung function and symptom control more. The goal is to find a more…

This study looks at the long-term safety and effectiveness of a drug called lunsekimig for adults with asthma. Participants who finished a previous study can join this one and receive the drug for up to 96 weeks. The goal is to see if the drug continues to help control asthma and…

This study tests whether a single inhaler that both relieves symptoms and prevents asthma attacks works better than the standard approach of using separate inhalers. About 1,000 children and teens aged 6-18 with asthma will be followed for one year. The goal is to see if the comb…

This study will test if a smartphone app called AWARE can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing breathing sounds. Researchers will enroll 800 people aged 8-70, including healthy volunteers, to compare the app's results wit…

This study looks at whether measuring inflammation in the breath and blood can help prioritize who gets asthma tests first. About 1,500 people aged 6 and older with suspected asthma will take a simple breath test and a blood test before their regular lung function tests. The goal…

This study looks at whether two simple, non-invasive tests—a breath test (FeNO) and a blood test (eosinophils)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires complex hospital-based tests. The goal is to see if these simpler te…

This study is testing a small, wearable device called AeviceMD that listens to lung sounds to detect wheezing. Researchers want to see if the device can find wheezes as accurately as a doctor using a stethoscope. The study will include 160 people aged 3 and older who are having a…

This study looks at whether two easy breathing tests—oscillometry and FeNO—can help family doctors accurately diagnose asthma and COPD without needing complex spirometry. About 600 adults with symptoms like wheezing or shortness of breath will take these tests at their primary ca…

This study tests a device called fenoTRACK that measures a gas in your breath (FeNO) to check airway inflammation. It involves 160 adults and children with asthma, some with uncontrolled symptoms and some with controlled asthma. The goal is to see if the device can accurately tra…

This study is testing whether giving pregnant women higher doses of vitamin D than currently recommended can prevent asthma and persistent wheezing in their children during the first three years of life. Researchers will enroll 2,000 pregnant women in Denmark and follow their chi…

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The researchers are recruiting 2,000 pregnant women in Denmark who have low blood levels of omega-3 fatty acids. Participants will t…

This study compares two types of exercise—energy conservation techniques and circuit training—to see which better helps people with asthma manage shortness of breath, improve physical function, and boost quality of life. Researchers will track 32 adults with mild-to-moderate asth…

This study is testing a serious video game designed to help teenagers aged 12 to 16 build emotional skills and improve their quality of life. It includes 600 teens, some healthy and some living with chronic conditions like type 1 diabetes, asthma, food allergies, or allergic rhin…

This study tests whether giving intravenous magnesium early to children aged 2 to 17 with severe asthma in the emergency room helps them breathe better. About 192 children who still have moderate-to-severe breathing trouble after standard treatment will receive either magnesium o…

This study tests whether weekly phone calls with education, relaxation techniques, and motivational coaching can help adults with asthma who are anxious about using their steroid inhalers. 216 participants will be split into two groups: one gets the extra phone support, the other…

This study tests two doses of an inhaled drug called glycopyrronium in 42 children aged 6 to 12 with moderate to severe asthma. The goal is to see how well it opens up the airways and to check its safety. Results will help decide the right dose for a future combination asthma tre…

This study tests a new inhaled drug called LQ036 in about 216 people aged 12 to 75 whose asthma is not well controlled despite using standard inhalers. The goal is to see if LQ036 improves lung function and reduces asthma attacks over 24 weeks. Participants will inhale the drug o…

This study tests whether a new way of talking about asthma care can improve quality of life for teenagers. About 98 teens aged 12-18 with asthma will be randomly assigned to either a standard clinic visit or one where their confidence in managing asthma is assessed and addressed.…

This study looks at whether adding physical exercise to a restricted diet can improve lung function and weight in women who have both polycystic ovary syndrome (PCOS) and asthma. About 40 obese women with these conditions will take part. The goal is to see if this combination hel…

This early-stage study tests whether a new drug called AMG 691 is safe for people. It includes healthy volunteers and people with mild-to-moderate asthma. Researchers will give single or multiple doses and watch for side effects. The goal is to see if the drug is safe enough for …

This study tests a device that coaches people with COPD or asthma on how to use their inhalers properly. About 140 adults will be randomly assigned to learn with the device or get standard brief training. The goal is to see if the device improves inhaler technique and reduces eme…

This study tests an inhaled medicine called ARO-RAGE in 36 adults with mild asthma. The goal is to see if it can improve small airway function after breathing in an allergen. Participants will receive either the drug or a placebo and have their lung function measured over time.

This study looks at whether combining neck exercises with special breathing techniques can improve lung function and chest movement in adults with asthma who also have poor posture. 22 people will take part in a 4-week program. The goal is to find a simple, drug-free way to help …

This study looks at whether a new propellant (HFA-152a) in salbutamol inhalers works as well as the current one (HFA-134a) for people with mild asthma. About 84 adults aged 18 to 65 will take single doses of the inhaler and have their lung function measured. The goal is to make s…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study tests whether an online therapy program can help children aged 8-17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. About 30 children and their parent…

This early-stage study tests a new drug called IBI3002 in adults with asthma. The main goal is to check if multiple doses are safe and tolerable. About 12 to 27 participants will receive either the drug or a placebo by injection. The study lasts about 24 weeks total, including sc…

This study tests whether alternate nostril breathing exercises or using an incentive spirometer (a device that helps you take deep breaths) works better for improving lung function in people with mild to moderate asthma. Researchers will measure how much air you can exhale and yo…

This study looks at whether using a CPAP machine at night can improve asthma control in adults with severe, hard-to-control asthma and obstructive sleep apnea. Researchers will measure asthma symptoms and lung function in 138 participants over time. The goal is to see if treating…

This study looks at why some people with asthma don't get better with standard inhalers. Researchers will use MRI and CT scans to see if blocked or narrow airways stop the medicine from reaching the lungs. They will test if oral medications work better for these patients. The goa…

This study looks at how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and breathing tests to compare mucus patterns in 240 adults and 50 children with these conditions, plus 100 healthy volunteers. The goal is to f…

This study looks at how common asthma and COPD are among workers in an industrial zone in Thailand. About 310 workers aged 18 and older will answer a questionnaire and take a breathing test. The goal is to find out how many have these lung conditions.

This study aims to find specific substances (metabolites) in the blood and urine of children aged 12-17 with asthma that could signal an asthma flare-up. Researchers will analyze samples from 100 children who are already receiving standard asthma care. The goal is to better under…

This study follows 1,000 people with atopic dermatitis (eczema) and related allergies to see how and why symptoms sometimes go away. Researchers will collect medical and lifestyle data to find patterns and possible biomarkers. The goal is to better understand the disease and deve…

This study tracks 500 adults with moderate-to-severe asthma in Hong Kong over two years to see how well their symptoms are controlled and how often they have flare-ups. Researchers will also monitor patients using newer biologic drugs to gather real-world data. The goal is to hel…

This study follows 400 nonsmoking adults aged 18 to 60 with moderate to severe asthma for up to 5 years. Researchers collect blood, urine, stool, dust, saliva, and lung samples to see how bacteria and other environmental factors affect asthma symptoms and flare-ups. Participants …

This study compares airway cells from 24 adults with and without asthma to learn why mucus builds up. Participants will have a bronchoscopy to collect cell samples. No treatment is given; the goal is to better understand asthma at the cellular level.

This study follows 500 adults in Taiwan with severe asthma who are taking biologic medications. Researchers want to see how well these drugs control asthma in everyday life, what happens when patients switch biologics, and which factors predict the best treatment. The goal is to …

This study is a registry that collects detailed health information from 500 adults with severe asthma. The goal is to track how patients respond to treatments and better understand the disease. This data will help researchers develop improved care and therapies for severe asthma.

This study looks at the bacteria and viruses living in the airways of 140 adults with asthma. Researchers want to see if different germ patterns are linked to different asthma types and how severe the disease is. The goal is to find new ways to prevent or treat asthma by targetin…

This study aims to understand what triggers airway inflammation in people with allergic asthma. Researchers will expose participants to allergens like cat dander or dust mites and then measure how inflammatory cells respond. The goal is to identify key factors that recruit these …

This study tests whether computer alerts in the electronic health record can help doctors avoid prescribing antibiotics when they aren't needed for children with lower respiratory tract infections like pneumonia, bronchiolitis, or asthma flare-ups. Most of these infections are ca…

This study looks at whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants. The goal is to see if home ho…

This observational study looks at how many adults with mild-to-moderate asthma in Thailand achieve remission and what factors might help. About 289 participants will fill out a symptom questionnaire, take a breathing test, and have a blood test. The goal is to better understand r…

This study looks at whether tongue images and pulse wave data can help doctors diagnose and track asthma in children aged 5 to 18. Researchers will collect these non-invasive measurements during routine check-ups and compare them with standard lung function tests. The goal is to …

This study looks at how fungi in the environment, like mold, affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect sputum and dust samples from 125 adults aged 18-80 to measure fungal exposure and track disease cha…

This study uses a special gas called hyperpolarized xenon in an MRI to take detailed pictures of lung function. It includes healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to develop a better way to measure lung health …

This study looks at how genes are linked to different types and severities of asthma in Chinese people. Researchers will collect genetic data from 2,000 asthma patients to find common gene variations. The goal is to better understand asthma and improve future treatments.

This study uses special lung imaging to measure how inhaled steroids and fast-acting rescue inhalers change airflow and blood flow in the lungs of adults with asthma. Researchers will compare images taken before and after medication to understand regional lung function. The goal …

This study looks at 60 adults aged 35-75 with either allergic or eosinophilic asthma to see if their symptoms, breathing problems, and frailty levels differ. Researchers will measure lung function, breathlessness, fatigue, and quality of life. The goal is to help doctors design b…

This study tests two new types of lung MRI (using special gases) to see if they can better show lung problems in people with cystic fibrosis or asthma. About 30 people aged 8 and older, including healthy volunteers, will have scans to compare lung structure and function. The goal…

This study is collecting detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. The goal is to identify different disease subtypes and shared features, which could lead to more personaliz…

This study examines lung tissue from 120 adults (ages 18-70) with and without asthma to measure levels of two proteins, ezrin and Pip5k1α, in airway smooth muscle. The goal is to understand how these proteins change in asthma, which could lead to new treatment approaches. Partici…

This study is observing 355 adults with asthma in China to learn about their symptoms, treatments, and biological markers. The goal is to identify different types of asthma to help develop more personalized treatment strategies in the future. Participants will undergo lung functi…

This study looks at the bacteria living in the airways of infants under 2 years old with severe asthma. Researchers want to understand how these bacteria differ from normal and how they relate to the immune system. The goal is to find new ways to treat severe asthma in babies. Th…

This study is testing a wearable device called C-mo System that can automatically detect and analyze coughs. About 300 people aged 2 and older who cough frequently due to conditions like asthma or COPD will wear the device for 24 hours. The goal is to see how accurately the devic…

This study gathers up to 10 years of health information from 3,500 asthma patients who previously took part in the Salford Lung Study. Researchers will review electronic medical records and ask patients to fill out a one-time questionnaire. The goal is to learn more about asthma …

This study tracks 30 adults with asthma who have frequent attacks. Sensors placed inside and outside their homes measure pollutants like fine particles and chemicals. The goal is to see if changes in pollution levels are linked to asthma attacks, which could help people better ma…

This study aims to describe the characteristics, treatment burden, and quality of life of 2,500 people with asthma across different severity levels. It includes a one-time assessment and a follow-up to track changes over time. No new treatments are tested; the goal is to gather r…

This study looks at how two different inhalers deliver asthma medicine into the bodies of children aged 4 to 12. The goal is to compare the amount of drug absorbed and check for safety. About 12 children with stable asthma will take part. The results will help doctors understand …

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers want to see if a specific group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy,…

This study looks at how a person's genes and their environment (like pollution, diet, and lifestyle) work together to cause common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires and genetic data from 25,000 adults to build a…

This study looks back at medical records of 360 adults in Hong Kong with severe asthma who received biologic therapy. Researchers want to understand which biologics are used, how well they control asthma, and if they reduce flare-ups. The goal is to see how these treatments work …

This study looks at whether a simple breathing test called impulse oscillometry (IOS) can better track asthma control than standard tests. Fifty adults with asthma who are changing their maintenance medication will take lung function tests and questionnaires at the start and agai…

This study follows 6,000 children in Switzerland who have breathing issues like wheezing, coughing, or trouble breathing during exercise. Researchers collect information from doctor visits and family questionnaires to learn more about these problems and how to diagnose and treat …

This study looks at how airway inflammation from asthma might change brain activity and relate to feelings of depression or anxiety. Over three visits, 100 adults (with and without asthma) will answer questionnaires, do computer tasks, give blood and sputum samples, and have brai…

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will analyze DNA from up to 3,500 people, including healthy volunteers, to find genetic differences linked to lung problems. A small optional part of the s…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will complete an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their primary care doctor or usual ca…

This study aims to see if a Turkish version of the Brompton Breathing Pattern Assessment Tool (BPAT) is a valid and reliable way to measure breathing patterns in people with asthma. Researchers will enroll 100 Turkish-speaking adults with severe asthma and compare the tool's resu…

This study looks at how the body processes high doses of the steroid prednisolone in people with inflammatory diseases like thyroid eye disease, asthma, and vasculitis. Researchers will measure drug levels in the blood over time to compare short-term and long-term use. The goal i…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. Participants will do walking and sitting tests to measure br…