ASTHMA

This study looks at a new way to use asthma inhalers for people who often forget or choose not to take their daily maintenance medication. Instead of using a daily controller inhaler, participants will use a combination inhaler only when they have symptoms. The goal is to see if …

This study follows 155 people with severe asthma who are starting a new medicine called tezepelumab. Researchers want to see how well it controls asthma symptoms and improves quality of life over two years in real-world clinics across Greece. The goal is to understand if this tre…

This study tests a virtual program called Coach McLungs that helps children with asthma and their doctors make treatment decisions together. About 19 kids aged 5 to 17 with persistent asthma will use the tool during primary care visits. Researchers will track emergency visits and…

This study looks at whether people aged 12 and older with a specific gene change (IL-4RαR576) get more relief from the asthma drug dupilumab. Over 48 weeks, researchers track how many severe asthma attacks occur compared to a placebo. The goal is to see if genetic testing can hel…

This study looks at the long-term safety and effectiveness of a drug called amlitelimab for adults with moderate-to-severe asthma. Participants had already completed a previous amlitelimab study and will continue receiving the drug for up to 144 weeks. The goal is to see if the d…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma symptoms, lower insulin resistance, and reduce inflammation in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and lung function. The …

This study looks at whether a structured follow-up at an asthma flare-up clinic can improve outcomes for adults after an asthma attack. About 230 participants will either attend in-person clinic visits or receive phone follow-up. Researchers will compare rates of severe asthma at…

This study tests a new medicine, solrikitug, for adults with asthma who still have symptoms despite using standard inhalers. About 145 people will receive either the drug or a placebo to see if it safely lowers certain blood cells linked to asthma inflammation. The goal is to bet…

This study tests a new antibody drug (called 610) for adults with severe asthma that is not well controlled by standard inhalers. About 225 participants will receive either the drug or a placebo to see if it improves lung function and reduces asthma attacks over 52 weeks. The dru…

This study tests whether dupilumab, an add-on treatment, can slow the loss of lung function in adults with moderate to severe asthma that is not well controlled by standard inhalers. About 1,339 participants will receive either dupilumab or a placebo for 3 years, while continuing…

This study is testing a wearable device called AeviceMD that lets doctors listen to a child's lungs remotely. It includes 20 children aged 3 to 18 with poorly controlled asthma. The goal is to see if using this monitor at home helps families manage asthma better and reduces the n…

This study aimed to compare two treatment options for adults with a specific type of asthma (T2-high) that was not well controlled with medium-dose inhalers. The goal was to see which approach helped more people achieve better control and fewer severe attacks over a year. However…

This study tests a smart spacer device that tracks how children and young people (ages 6-18) use their asthma inhalers. The goal is to see if giving personalized feedback based on the device's data improves inhaler use and asthma control compared to standard care. The study invol…

This study looks at whether benralizumab can help repair lung structure and improve breathing in people with severe asthma caused by high levels of certain white blood cells (eosinophils). About 75 adults aged 18-70 with persistent symptoms despite standard inhaler therapy will r…

This study tests a new long-lasting medicine called GSK5784283 for adults aged 18 to 75 whose asthma is not well controlled despite regular treatments. The medicine blocks a protein called TSLP that can cause airway inflammation. The trial has two parts: Part A finds the best dos…

This study tests whether a triple-combination inhaler (FF/UMEC/VI) works better than the usual two-medication inhalers (ICS/LABA) for adults whose asthma is not well controlled. About 1,366 participants will be followed for up to 52 weeks to measure lung function and symptom cont…

This study tests whether the drug dupilumab can help prevent asthma attacks in children and teenagers aged 6 to 17 who live in urban areas and have frequent asthma problems. About 240 participants will receive either dupilumab or a placebo for one year, and researchers will count…

This study tests an experimental drug called rocatinlimab in 317 adults with moderate-to-severe asthma. The goal is to see if it can reduce the number of asthma attacks. Participants continue their usual asthma medications while receiving the drug or a placebo.

This study looks at whether changing the rescue inhaler from albuterol alone to albuterol plus budesonide can lower the number of severe asthma attacks. About 1,500 adults with asthma who have had at least one severe attack in the past year will switch to the new inhaler. Researc…

This study checks if a new version of a common asthma inhaler works just as well as the current one. About 422 adults with asthma will use both inhalers and a placebo to compare lung function. The goal is to make sure the new propellant is safe and effective.

This study tests a web-based program called CAMP Air designed to help urban teens, especially Black and Hispanic youth, better control their asthma. The program teaches teens how to prevent asthma symptoms and manage their condition. Researchers will measure if it reduces urgent …

This study tests if a drug called omalizumab can stop asthma from developing in young children at high risk. Researchers are giving the drug to 200 children aged 2-3 for two years, then watching them for another two years to see if they develop asthma. The goal is to find a way t…

This study explores whether exposing C-section babies to their mother's vaginal bacteria shortly after birth can lower their risk of developing allergies and asthma. Researchers are enrolling 114 infants with a family history of allergic diseases. The goal is to see if this simpl…

This study looks at whether giving pregnant mothers extra vitamin D can stop their children from developing asthma symptoms like wheezing. About 600 mothers from a Danish asthma study take either a high dose (2400 IU) of vitamin D3 or a placebo daily from week 24 of pregnancy unt…

This study tests a 24-week physical activity program designed specifically for Black women with asthma. The goal is to see if the program improves asthma control and quality of life compared to standard asthma education. About 224 women will take part, and researchers will also c…

This early-stage study tests a new drug called GB-0895 in adults with mild to moderate asthma or COPD. The main goal is to check if the drug is safe and how the body handles it. About 156 participants will receive either the drug or a placebo. This research is a first step to see…

This study looks at whether mepolizumab, a drug already used to reduce asthma attacks, can also help people with severe asthma become more physically active. About 62 adults with severe eosinophilic asthma will have their daily steps and exercise tolerance measured before and aft…

This study aimed to see if giving children with asthma a nebulized steroid (budesonide) after an emergency room visit, on top of standard oral steroids, could reduce the chance of another attack within a month. It planned to enroll children aged 2 to 8 who had an asthma flare-up …

This study looks at whether using HEPA air purifiers at home can improve asthma symptoms in children aged 8 to 17. Researchers want to see if overweight children benefit more than lean children. About 200 kids from Baltimore with persistent asthma will take part. Half will get re…

This study tests a self-management program called SaMBA-WTC for World Trade Center responders who have asthma. About 56 adults with uncontrolled asthma will either join the program or receive standard attention. The goal is to see if the program helps improve asthma control, medi…

This study tested a digital platform that attaches to asthma inhalers to give real-time feedback on technique and medication reminders. About 26 people with uncontrolled asthma used the sensor and a mobile app for 3 months. The goal was to see if the platform improves inhaler ski…

This early-stage study tests a new drug called APG777 in 31 adults with mild-to-moderate asthma. The main goal is to check if the drug is safe and how the body handles it. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug…

This study was designed to see if osteopathic manipulative treatment (OMT) — a hands-on technique to improve chest movement — could reduce lung inflammation and improve breathing in adults with asthma. Researchers planned to measure lung function and inflammation in about 100 par…

This study looks at how air pollution and the body's internal clock (circadian rhythm) interact in people with asthma. Researchers will measure tiny molecules called microRNAs in sputum samples from 20 adults with and without asthma, collected at different times over 48 hours. Th…

This study is a registry that tracks about 718 asthma patients who are starting the medication DUPIXENT® as part of their normal care. Researchers want to learn who these patients are, how they use the drug, and how well it works and is tolerated over time. No experimental treatm…

This study follows 180 infants from birth to age 2 to see how bacteria in their upper airways change over time. Researchers want to find out if certain bacteria cause inflammation and lower lung function, which could lead to asthma. The babies are enrolled in their first week of …

This study observes 100 people with severe asthma who are taking biologic drugs. Researchers measure how the body's immune system reacts to the drug and whether that affects how well the treatment works. The goal is to better understand drug effectiveness and safety over time.

This study was designed to test if safely removing mucus plugs from the airways of people with asthma can improve lung function. Researchers planned to use a bronchoscopy procedure to clear the plugs and then measure breathing changes after one week and six months. The study was …

This study watches how Chinese asthma patients use biologic medicines and how well they work. About 202 people will be followed for a year while getting their usual care. The goal is to learn about treatment patterns, not to test a new drug.

This study looked at using a computer program (machine learning) to predict how long patients would stay in a home hospital. Researchers used information from past patients, like their health conditions and background, to train the computer model. The goal was to see if the model…

This study looks at over 1,000 adults with asthma to better understand different types of the disease. Researchers will use real-world information and genetic data to describe asthma based on treatment response and underlying biology. No new treatments are being tested; the goal …

This study watches 315 people with severe asthma who are starting a drug called tezepelumab in Italy. It aims to learn about their health history and how well the drug controls asthma attacks over two years. No new treatment is given—just observation of real-world results.

This study aims to gather detailed information about adults with asthma, including their medical history and lung function. The goal is to create a database that helps researchers better understand asthma and design future studies. Participants will not receive any treatment, but…

This study planned to use a computer program (machine learning) and a simple heart test (single-lead ECG) to predict potassium levels in the blood of hospitalized patients. Researchers would have analyzed data from a previous study at Brigham and Women's Hospital. However, the st…

This study works to create a better questionnaire to find small airway dysfunction in people with COPD. Researchers will also compare two breathing tests—spirometry and oscillometry—to see which is more accurate. About 108 adults with COPD, asthma, or both will take part. The goa…

This study looks at 1,600 adults in Hong Kong who have been diagnosed with asthma or COPD to find out how many actually have both conditions (called Asthma-COPD Overlap). Researchers will track their health for 3 years to see how they do and whether their treatments match current…

This study uses advanced MRI scans with special gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 patients over several years to track lung changes. The goal is to better understand why some people have severe breathing proble…

This study was designed to find the best way to give the asthma drug terbutaline sulfate, comparing injection under the skin versus into a vein. Researchers planned to enroll adults with asthma to measure how the drug moves in the body and how well it improves breathing. However,…

This study was designed to see if COVID-19 makes asthma worse or changes how well patients can control their asthma. Researchers planned to follow two groups of asthma patients—those who had a serious COVID-19 infection and those who did not—for one year. They would measure lung …

This study examines inflammation in preschool children (ages 1 to 5) hospitalized for a severe asthma attack. Researchers compare different wheezing patterns to see if the type of inflammation varies. The goal is to better understand these patterns and how they affect the child's…

This study aimed to understand why some people with asthma develop mucus plugs in their airways. Researchers planned to use a thin, camera-guided tube to collect samples from the lungs of 60 adults—some with asthma and mucus plugs, some with asthma but no plugs, and healthy volun…

This study tests a new digital tool that helps hospitals share patient information more reliably when a person is transferred from one hospital to another. The goal is to reduce medical mistakes and improve safety. About 1,000 adults being transferred to a major hospital will tak…

This study follows 376 asthma patients aged 12 and older who are starting Dupixent in real-world clinics. Researchers will collect information on patients' medical history, how they use the drug, and how well it controls their asthma. The goal is to understand typical patient pro…