ASTHMA

This study is testing whether a special clinic for follow-up care after an asthma flare-up helps adults manage their asthma better and reduces future severe attacks. Researchers will compare 230 adults who either attend this clinic for in-person check-ups or receive standard phon…

This study aimed to find the best next step for adults with asthma that remains uncontrolled despite using standard medium-dose inhalers. Researchers planned to compare two approaches: increasing the steroid dose in the current inhaler versus adding a third medication to create '…

This study is testing whether switching from a standard rescue inhaler to a combination inhaler reduces asthma flare-ups. It involves 1,500 adults with asthma who have recently had a severe flare-up. Researchers will compare how often participants need emergency care or oral ster…

This study is observing 155 adults with severe, uncontrolled asthma in Greece who are newly prescribed the biologic drug tezepelumab. The goal is to see how well the drug controls asthma symptoms and improves quality of life over two years in a real-world clinic setting, outside …

This study is testing a new system of visual guides, called pathways, to help doctors and nurses in community hospitals follow the best-known treatment steps for children hospitalized with common breathing illnesses like asthma, pneumonia, or bronchiolitis. It involves nearly 4,0…

This study is testing a virtual coaching tool called 'Coach McLungs' to help children and teens with asthma and their doctors make better treatment decisions together. The goal is to see if using this tool in regular doctor's offices can help improve asthma control and reduce tri…

This study aims to see if personalized education helps children and teenagers with asthma use their inhalers more effectively. Researchers will use a 'Smart Spacer' device to monitor how often and how well participants use their inhalers at home. About 100 children aged 6-18 will…

This study aimed to see if safely removing thick mucus plugs from the airways of people with asthma could help them breathe better. Researchers planned to test this by performing a bronchoscopy procedure and measuring lung function before and after. The trial was withdrawn before…

This study is testing whether the drug benralizumab can reduce inflammation and improve the physical structure of the lungs in people with a severe type of asthma. It involves 75 adults whose asthma is not well-controlled despite using standard high-dose inhalers. Researchers wil…

This study is testing an investigational antibody drug for adults with a specific type of severe asthma. The goal is to see if adding this drug to standard care can help people breathe better and have fewer serious asthma attacks over a year. About 225 participants will receive e…

This study aims to see if a three-drug combination inhaler works better than the standard two-drug inhaler for adults whose asthma is not well controlled. It will involve about 1,366 participants and will measure improvements in lung function and asthma symptoms over one year. Th…

This study is testing a new long-lasting injection called GSK5784283 for adults whose asthma remains poorly controlled despite using standard daily inhaler medications. The drug works by blocking a specific protein in the body (TSLP) thought to drive asthma inflammation. Research…

This study aims to see if an asthma inhaler using a new, more environmentally friendly propellant (HFO) works just as well as the same medicine using the current propellant (HFA). It involves 422 adults with asthma who will try both versions in a carefully controlled 12-week tria…

This study is testing whether an injectable medication called rocatinlimab can help reduce the frequency of serious asthma attacks in adults whose asthma is not fully controlled by their current inhalers and medications. About 317 participants will receive either the study drug o…

This study aimed to see if adding a nebulized steroid (budesonide) to the usual oral steroid treatment could better prevent children's asthma from flaring up again after an emergency room visit. It planned to enroll children aged 2-8 who were treated for an asthma attack and sent…

This study investigates whether using air purifiers at home helps overweight children with asthma more than it helps lean children with asthma. Researchers from Johns Hopkins University enrolled 198 children with persistent asthma, giving half real air purifiers and half fake one…

This study is testing a web-based program called CAMP Air, designed to help urban teenagers, primarily Black and Hispanic youth, better manage their uncontrolled asthma. The research involves 374 teens and aims to see if the online program improves asthma control, reduces urgent …

This is an early-stage study to check the safety and side effects of a new drug called APG777 in adults with mild-to-moderate asthma. About 31 participants will be randomly assigned to receive either the drug or a placebo (inactive substance) for a year. The main goal is to see h…

This study tests whether a 24-week lifestyle program helps Black women with asthma manage their condition better through increased physical activity. Participants receive either group exercise sessions with text support or asthma education alone. Researchers will track asthma con…

This study is testing if adding a medication called dupilumab to standard asthma treatment can help prevent severe asthma attacks in children and teenagers living in urban areas. About 240 participants, aged 6 to 17, who have frequent asthma flare-ups will receive either the new …

This study is testing the long-term safety and effectiveness of an injectable drug called amlitelimab for adults with moderate-to-severe asthma. It follows 335 people who were already in a previous amlitelimab study, tracking them for up to 3 years to see if the drug continues to…

This study aims to see if people with a specific gene variant (IL-4RαR576) respond better to the asthma drug dupilumab. About 150 participants, ages 12 and older with moderate-to-severe asthma, will receive either the drug or a placebo for 48 weeks. The main goal is to see if the…

This is the first study in humans to test the safety and side effects of a new drug called GB-0895. It involves 156 adults with mild to moderate asthma or COPD. Researchers will give different doses to see how the body handles the drug and monitor for any problems.

This study follows asthma patients who are starting treatment with Dupixent in real-world medical settings. Researchers will track 376 patients for up to 3 years to understand how well the medication works, what side effects occur, and how patients use the treatment alongside oth…

This small, early-stage study is exploring whether taking a daily probiotic supplement for 12 weeks can help improve asthma control and reduce insulin resistance in obese adults who have both conditions. Researchers will measure changes in gut and airway bacteria, body weight, in…

This study is testing a different way to use asthma inhalers for people who have trouble remembering to take their daily preventive medication. Instead of requiring daily use, the new approach lets patients use a combination inhaler only when they have symptoms, while researchers…

This study is testing a shorter questionnaire and comparing two types of breathing tests to help doctors better identify small airway dysfunction in people with COPD and asthma. The goal is to create a more practical tool for everyday doctor visits that can lead to more personali…

This study is testing whether giving a medication called omalizumab to 2-3 year old children at high risk for asthma can prevent them from developing the condition. About 200 children will receive either the real medication or a placebo for two years, followed by two years of obs…

This study is testing whether transferring vaginal bacteria to babies born by C-section can help prevent allergies and asthma. Researchers are comparing C-section babies who receive this transfer with those who don't, and with babies born vaginally. The goal is to see if this ear…

This study aimed to learn more about mucus plugs in people with asthma. Researchers planned to use a guided camera (bronchoscopy) to take small samples from the lungs of people with asthma, both with and without mucus plugs, and from healthy volunteers. By comparing these samples…

This study aims to understand how many people in Hong Kong with asthma or COPD actually have both conditions overlapping. Researchers will observe 1,600 patients with these lung diseases, tracking their health, treatments, and outcomes over three years. The goal is to gather real…

This study aims to understand how daily patterns of air pollution interact with the body's natural 24-hour clock to affect asthma symptoms. Researchers are measuring air quality and collecting samples from 20 adults with severe asthma over 48 hours to look for biological connecti…

This study aims to observe and describe how Chinese patients with asthma use biologic medications in real-world settings. It will follow about 200 patients for one year to see how consistently they take their prescribed biologics and what their health outcomes are. The study does…

This is an early safety study testing a new antibody drug called SM17. It involves 30 healthy Chinese adults to check for side effects and see how the body processes the drug when given as an injection under the skin or into a vein. The main goal is to gather basic safety informa…

This study aimed to understand how a COVID-19 infection affects people with asthma over time. Researchers planned to compare two groups of asthma patients—one group that had COVID-19 and one that did not—for one year. They would check lung function and asthma control to see if th…

This study is testing a new digital platform designed to improve how patient information is shared when someone is transferred between different hospitals. The goal is to make sure doctors at the receiving hospital have all the necessary details to provide safe, continuous care. …

This study aims to better understand the different types of asthma by observing over 1,000 people who already have it. Researchers are not testing a new treatment; instead, they are collecting real-world information on how patients with different asthma profiles respond to their …

This study aims to create a detailed database of adult asthma patients to help recruit participants for future research. Researchers will collect medical histories, lung function tests, and sputum samples to better understand the different types and severities of asthma. The goal…

This study aimed to develop a computer program that could predict how long patients would need to stay in home hospital care. Researchers used existing patient records to train the program, then tested it on different patient groups. The goal was to help hospitals better plan car…

This study aimed to understand how an asthma drug called terbutaline works when given through an IV versus an injection under the skin. Researchers wanted to measure how the drug moves through the body and find the best IV dose to improve breathing in adults with asthma. The stud…

This study aims to understand why young children with asthma experience different types of wheezing attacks. Researchers will observe 150 children under 5 during a severe asthma attack and again 8 weeks later, measuring immune system markers in their blood and mucus. The goal is …

This study is observing 718 asthma patients age 12 and older who are starting treatment with DUPIXENT® in real-world settings. Researchers will track who gets the treatment, how it's used, and how well it controls asthma and related conditions over three years. The goal is to gat…