Could a Two-Drug rescue inhaler cut asthma attacks?

NCT ID NCT06422689

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 4 times

Summary

This study tests whether switching from a standard rescue inhaler (albuterol alone) to one that also contains an anti-inflammatory steroid (budesonide) can reduce severe asthma attacks. About 1,500 adults with asthma who have had at least one severe attack in the past year will use the combination inhaler as needed. Researchers will compare how often attacks occur before and after the switch.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Albuterol and budesonide inhalation aerosol
What this could lead to: If it works, this could offer a better rescue inhaler for asthma that reduces severe attacks and the need for oral steroids.
What could go wrong: This is an early-phase, single-arm study without a placebo group, so results may not prove the combination is better than standard care. Side effects from budesonide are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

Locations

Research Site

North Hollywood, California, 91602, United States
Research Site

Walnut Creek, California, 94598, United States
Research Site

Louisville, Kentucky, 40217, United States
Research Site

Boston, Massachusetts, 02111, United States
Research Site

Ann Arbor, Michigan, 48109, United States
Research Site

Flint, Michigan, 48532, United States
Research Site

Minneapolis, Minnesota, 55425, United States
Research Site

Asheville, North Carolina, 28803, United States
Research Site

Greenville, North Carolina, 27834, United States
Research Site

DuBois, Pennsylvania, 15801, United States
Research Site

Austin, Texas, 78738, United States

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