New asthma drug candidate enters first human safety tests

NCT ID NCT06637371

Ongoing Symptom relief Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing an experimental drug called AMG 691 in 21 healthy volunteers and people with mild-to-moderate asthma. The main goal is to see if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as an injection under the skin. This study does not aim to treat asthma but to gather essential safety data before larger trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AMG 691 (an experimental drug given as an injection under the skin)
What this could lead to: If this early study shows the drug is safe, it could lead to larger trials testing whether AMG 691 helps control asthma symptoms.
What could go wrong: This is a very small, early-phase trial focused on safety, not on whether the drug works for asthma. Many drugs that appear safe in Phase 1 fail in later stages.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

Locations

Algemeen Ziekenhuis Sint Maarten-Emmaus vzw

Mechelen, 2800, Belgium
Allergy Asthma and Clinical Research Center

Oklahoma City, Oklahoma, 73120, United States
Brigham and Womens Hospital

Boston, Massachusetts, 02115, United States
Chelsea and Westminster Hospital

London, SW10 9NH, United Kingdom
Chesapeake Clinical Research Inc

White Marsh, Maryland, 21162, United States
ClinCept, LLC

Columbus, Georgia, 31904, United States
Clinical Medical and Analytical eXellence CMAX

Adelaide, South Australia, 5000, Australia
Destiny Research Center

Palmetto Bay, Florida, 33157, United States
Endeavor Clinical Trials

San Antonio, Texas, 78240, United States
Mayflower Clinical

South Dartmouth, Massachusetts, 02747, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Monroe Biomedical Research

Monroe, North Carolina, 28112, United States
Monroe Biomedical Research

North Charleston, South Carolina, 29406, United States
North Carolina Clinical Research

Raleigh, North Carolina, 27607, United States
Orange County Research Center

Lake Forest, California, 92630, United States
Prism Research LLC dba Nucleus Network

Saint Paul, Minnesota, 55114, United States
The Medicines Evaluation Unit

Manchester, M23 9QZ, United Kingdom
Translational Clinical Research LLC

Aventura, Florida, 33180, United States
University of North Carolina Clinical and Translational Research Center

Chapel Hill, North Carolina, 27599, United States
VPD Heart and Lung Research Institute

Cambridge, CB2 0AY, United Kingdom
Winchester District Memorial Hospital

Winchester, Ontario, K0C 2K0, Canada

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