Amgen

This early-stage study is testing a new drug called maridebart cafraglutide to see if it can help the body use insulin better and improve how the pancreas produces insulin in people with type 2 diabetes. The trial will enroll 70 adults who are already taking metformin. Participan…

This study aims to see if adding the cholesterol-lowering drug Repatha to standard heart care helps prevent major cardiovascular events like heart attacks and strokes better than standard care alone. It will follow 7,000 Chinese adults who already have heart disease in a real-wor…

This study is comparing two different drug combinations for people with advanced non-small cell lung cancer that has a specific genetic change (KRAS G12C) and low levels of a protein called PD-L1. About 750 participants will be randomly assigned to receive either a new targeted d…

This study is testing whether adding a new drug called tarlatamab to standard chemotherapy and immunotherapy helps people with advanced small-cell lung cancer live longer. Researchers will compare two treatment combinations in 330 participants who haven't received prior treatment…

This study is testing a new, under-the-skin injection of a drug called blinatumomab in children under 12 years old with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has come back or hasn't responded to other treatments. The main goals are to see …

This early-stage study is testing the safety and best dose of a new drug called anvumetostat when given with other cancer therapies. It is for adults with advanced cancers of the digestive system (like pancreatic, stomach, or bile duct cancers) that have a specific genetic change…

This study is testing an experimental injection called AMG 732 for people with moderate-to-severe thyroid eye disease, which causes painful, bulging eyes. The research has two parts: first checking safety in healthy volunteers, then testing if the treatment reduces eye bulging an…

This early-stage study is testing whether tarlatamab, given as an injection under the skin, is safe and tolerable for people with extensive stage small cell lung cancer that has worsened after initial treatment. The study will enroll about 220 adults to monitor side effects and s…

This study is testing whether a new injectable drug called maridebart cafraglutide can reduce breathing pauses during sleep for adults with obstructive sleep apnea who are overweight or obese and do not use CPAP therapy. About 250 participants will receive either the drug or a pl…

This study is testing whether an investigational drug called maridebart cafraglutide, combined with a reduced-calorie diet and exercise, is better than a placebo at reducing liver fat and body weight. It will involve about 180 adults who are overweight or have obesity and have hi…

This study is testing a drug called etelcalcetide in children and infants with advanced kidney disease who are on dialysis. The drug aims to control a common and serious hormone problem that causes bone disease and growth problems. Researchers want to see if it is safe and effect…

This is the first study in humans to test the safety of a new experimental drug called AMG 691 for asthma. Researchers will give single and multiple doses to 124 healthy adults and adults with mild-to-moderate asthma to see how their bodies handle the drug and check for side effe…

This study is testing a drug called avacopan in children aged 6 to 18 who have a rare autoimmune condition called ANCA-associated vasculitis. The main goal is to see if adding avacopan to standard treatments helps children achieve and maintain disease remission over one year. Res…

This study aims to see if a new drug called ABP 234 works similarly in the body to the established cancer drug Keytruda. It will involve 154 adults with early-stage non-squamous lung cancer who have already had surgery and chemotherapy. The main goal is to compare how both drugs …

This study is testing whether a new treatment approach works better than standard chemotherapy for older adults with a fast-growing blood cancer called acute lymphoblastic leukemia (ALL). The new approach combines a targeted immunotherapy drug (blinatumomab) with lower-intensity …

This is the first study in people testing an experimental drug called AMG 509 for advanced prostate cancer that has spread and stopped responding to standard hormone therapies. The main goals are to find a safe dose, see how the body processes the drug, and check for early signs …

This study aims to check the long-term safety of an experimental drug called dazodalibep for people with Sjögren's syndrome, an autoimmune disease. It is open only to 844 people who have already finished a previous 48-week study with this drug. The main goal is to monitor for any…

This early-stage study is testing the safety and effectiveness of combining two or three experimental drugs for people with extensive stage small cell lung cancer. It will enroll about 200 adults whose cancer has progressed after standard treatment or who are newly diagnosed. The…

This study is testing if a new drug called ABP 692 works the same way as the established MS treatment Ocrevus. It will involve 444 people with relapsing-remitting MS to see if the drugs have similar levels in the body and are equally effective at reducing new brain lesions seen o…

This study aims to understand the safety and side effects of the drug sotorasib when used in real-world medical settings in China. It will follow about 115 Chinese adults with a specific type of advanced lung cancer who have already tried at least one other treatment. The main go…

This early-stage study is testing a new oral drug called AMG 436, both alone and combined with other cancer therapies. It aims to find safe doses and see how the body processes the drug in adults with advanced solid tumors that have specific genetic features (MSI-H or dMMR). The …

This study is testing a medication called inebilizumab in children aged 2 to 18 who have a rare autoimmune disease that attacks the nerves in the eyes and spinal cord. Researchers want to understand how the drug behaves in children's bodies, how safe it is, and if it helps contro…

This study is testing two different drugs for people with severe autoimmune diseases that haven't responded well to other treatments. It's looking at inebilizumab for lupus with kidney problems and blinatumomab for lupus and rheumatoid arthritis. The main goals are to see if thes…

This study is testing whether a new drug called maridebart cafraglutide can help control obstructive sleep apnea and reduce weight in adults who are overweight or obese and already use a CPAP machine. It will compare the drug to a placebo over one year to see if it reduces breath…

This large study is testing whether a new injectable medication, maridebart cafraglutide, can help prevent serious heart problems in people who already have heart disease and are overweight or obese. It will compare the drug to a placebo (inactive shot) in over 12,000 participant…

This study aims to understand the long-term safety and effectiveness of avacopan, a medication for ANCA-associated vasculitis—a serious autoimmune condition that causes blood vessel inflammation. The trial will follow 300 adults with this condition for up to 5 years to monitor si…

This early-stage study is testing a new oral drug called AMG 410, alone or with other treatments, for people with advanced solid tumors that have KRAS gene changes. The main goals are to find the safest and most effective dose and to see how the body processes the drug. Researche…

This early-stage study is testing a new drug called xaluritamig in children, teens, and adults with Ewing sarcoma that has returned or hasn't responded to standard chemotherapy. The main goals are to find a safe dose and understand how the body processes the drug. Researchers wil…

This study is testing a drug called etelcalcetide in children and teens with advanced kidney disease who are on dialysis. The goal is to see if it safely and effectively lowers high levels of a harmful hormone that can damage bones and the heart. Researchers will monitor 24 parti…

This study aims to see if a new drug called xaluritamig helps men with advanced prostate cancer live longer than current standard treatments. It will enroll about 675 men whose cancer has spread and stopped responding to prior hormone therapy and one round of chemotherapy. Partic…

This study follows children who have already been taking apremilast for Behçet's disease mouth ulcers or juvenile psoriatic arthritis to check its long-term safety over three more years. It involves about 48 children aged 2-17 who completed a previous one-year study. Researchers …

This study is testing a drug called inebilizumab in children aged 2 to 18 who have generalized myasthenia gravis (gMG), a rare autoimmune disease that causes severe muscle weakness. The main goals are to understand how children's bodies process the drug and to check if it is safe…

This study is testing whether adding an experimental drug called xaluritamig to standard hormone therapy helps men with advanced prostate cancer live longer. It will compare this combination against current standard treatments in 750 men whose cancer has spread and stopped respon…

This study allows people with advanced solid tumors and a specific KRAS gene mutation to continue taking an experimental drug combination if they are already benefiting from it in a previous Amgen trial. The main goal is to check the long-term safety and side effects of continuin…

This early-stage study is testing a new drug called xaluritamig in men with intermediate or high-risk prostate cancer that hasn't spread. The main goal is to see if it's safe to give the drug before planned surgery to remove the prostate. Researchers will check if the treatment c…

This study is testing a new drug, AMG 193, alone and in combination with other cancer therapies for adults with advanced lung or chest tumors that have a specific genetic change called MTAP-deletion. The main goals are to find the safest and most effective dose and to see how wel…

This study is testing whether the drug apremilast can help control symptoms of juvenile psoriatic arthritis in children and teenagers aged 5 to 18. About 60 participants will be randomly assigned to receive either the real drug or a placebo for 16 weeks to see if it reduces joint…

This study is testing a new combination of targeted drugs for people newly diagnosed with advanced colorectal cancer that has spread and has a specific genetic change (KRAS G12C mutation). It will compare the new combination (sotorasib, panitumumab, and FOLFIRI chemotherapy) agai…

This study is testing how well the approved drug Prolia works to improve bone density in people whose bones have weakened from taking steroid medications like prednisone. It will enroll 100 adults in China who are currently on steroid treatment and have low bone mass. Researchers…

This study aims to see if a new drug called romosozumab works better than standard medications at preventing broken bones in children and teens with osteogenesis imperfecta (brittle bone disease). About 106 participants, aged 5 to 18, will receive either the new drug or standard …

This early-stage study is testing the safety and best dose of a two-drug combination (tarlatamab and AB248) for people with extensive stage small cell lung cancer that has worsened after at least one prior treatment. The main goal is to see how well the body handles the drugs tog…

This study is testing whether giving a gout medication called pegloticase as a simple injection under the skin works as well as giving it through an IV drip. Both methods are given along with another medication called methotrexate. The goal is to see which method better controls …

This is an early-stage study to check if a new drug called AMG 513 is safe for people with obesity. It will involve about 80 adults and will test different doses to see how the body handles the drug. The main goal is to identify any side effects and understand how the drug behave…

This early-stage study is testing the safety and side effects of a new drug called xaluritamig when given alongside standard hormone-blocking treatments. It is for men whose prostate cancer has spread and is still responding to hormone therapy. The main goal is to see if the comb…

This study is testing whether a drug called tarlatamab can help people with a specific type of lung cancer stay in remission longer after their initial treatment. It will involve about 400 adults whose cancer has not gotten worse after standard chemotherapy and radiation. The mai…

This study is testing an experimental drug called AMG 193 for people with advanced non-small cell lung cancer that has a specific genetic change called MTAP-deletion and has stopped responding to prior treatments. The main goals are to see if the drug is safe, if it shrinks tumor…

This large, late-stage study is testing whether a new injectable drug, maridebart cafraglutide, can help people who have a specific type of heart failure and are also obese. The main goal is to see if the drug, added to standard care, can reduce the risk of dying from heart probl…

This study is testing a new, more convenient under-the-skin injection version of a drug called blinatumomab. It aims to see if this method is safe and effective for treating adults and adolescents (12+) whose B-cell acute lymphoblastic leukemia has come back or hasn't responded t…

This study is testing different dosing schedules of an experimental drug called tarlatamab for people with advanced small cell lung cancer that has worsened after initial chemotherapy. The main goal is to see how well the drug shrinks tumors and controls the cancer. About 240 par…

This large study is testing whether a drug called olpasiran can prevent first major heart problems in people who have high levels of a specific blood fat called lipoprotein(a). It will involve 11,000 adults aged 50+ who have high risk factors for heart disease but have not yet ha…

This study is testing if the drug apremilast can reduce the number and pain of mouth ulcers in children and teenagers with Behçet's disease. For 12 weeks, 60 participants aged 2 to 18 will receive either the study drug or a placebo (inactive pill) to see which is more effective. …

This study aims to understand the safety of the migraine medication Aimovig (erenumab) during pregnancy. It will follow pregnant women with migraines who are either taking Aimovig or not, to compare rates of major birth defects and other pregnancy outcomes in their babies. The go…

This early-stage study aims to understand how two different versions of the cholesterol-lowering drug evolocumab are absorbed and processed by the body. It will involve 400 healthy adults who will receive a single dose. The main goal is to compare how much of each drug version ge…

This study aims to understand the safety of the NMOSD medication UPLIZNA during pregnancy. It will follow about 60 women who received the drug while pregnant or just before conception. Researchers will collect information over 10 years to monitor birth outcomes and infant health,…

This early-stage study aims to understand how the body absorbs two different versions of an experimental drug called AMG 133, which is being developed for weight management. It will involve about 340 adults who are living with overweight or obesity. The main goal is to compare ho…