Amgen

This large study is testing whether a new drug called olpasiran can reduce the risk of heart attacks, heart-related deaths, and emergency heart procedures in people who already have heart disease and high levels of a specific blood fat called lipoprotein(a). About 7,300 participa…

This study is testing a new drug called tarlatamab, given alongside standard chemotherapy and an immunotherapy drug, for people newly diagnosed with extensive stage small cell lung cancer. The main goal is to see if this combination is safe and tolerable for patients. Researchers…

This study is testing whether a new biosimilar drug called ABP 234 works as well as the established cancer drug Keytruda (pembrolizumab) for people with advanced non-squamous lung cancer. The trial will enroll 315 adults who haven't had previous treatment for their advanced cance…

This study compares a new targeted drug called AMG 510 against standard chemotherapy (docetaxel) for people with advanced lung cancer that has a specific KRAS mutation and has stopped responding to previous treatments. The trial aims to see if AMG 510 can better control cancer gr…

This study is testing the drug XGEVA (denosumab) in Chinese adults and adolescents with a rare bone tumor called giant cell tumor of bone (GCTB). The main goal is to see if the drug can shrink tumors and help patients avoid major surgeries like limb amputation. Researchers will a…

This study is for people with extensive-stage small-cell lung cancer who have already completed their first round of chemotherapy and immunotherapy (durvalumab) without their cancer getting worse. It aims to see if adding a new drug called tarlatamab to their ongoing durvalumab t…

This study is testing a new drug called bemarituzumab, given in combination with other cancer therapies, for people with previously untreated advanced stomach or gastroesophageal junction cancer. The main goals are to see if the combinations are safe and if they can shrink tumors…

This study is testing whether a drug called inebilizumab can help control myasthenia gravis, a disease that causes severe muscle weakness. About 238 adults with moderate to severe symptoms are comparing the drug to a placebo to see if it improves their ability to perform daily ac…

This study is testing how well the medication Prolia works to improve bone density in Chinese men with osteoporosis. About 100 men aged 30-90 with low bone density will receive Prolia injections and be monitored for 12 months. Researchers will measure changes in bone density and …

This study is for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C and has worsened after at least one prior treatment. It aims to see if a new combination of two targeted drugs (sotorasib and panitumumab) works better and is safer than t…

This study is testing if a medicine for severe, hard-to-treat gout can be given safely and effectively every four weeks instead of every two weeks. It involves about 260 adults whose gout is not controlled by standard pills. The main goal is to see if the less frequent schedule w…

This large Phase 3 trial is testing whether a new injectable drug called maridebart cafraglutide helps adults with type 2 diabetes who are overweight or obese lose weight and better control their blood sugar. Over 1,100 participants will receive either the drug or a placebo for 7…

This study is testing whether a new drug called tarlatamab helps people with small cell lung cancer live longer and feel better after their cancer has returned following initial chemotherapy. It compares tarlatamab directly against the current standard treatments. The main goal i…

This early-stage study is testing the safety and initial effectiveness of an experimental drug called xaluritamig. It involves about 50 men whose prostate cancer has started to return (shown by rising PSA levels) but hasn't spread to other body parts. The main goal is to see if t…

This study is testing an investigational drug called tarlatamab for Chinese adults with advanced small cell lung cancer that has continued to grow after at least two prior treatments. The main goal is to see if the drug can shrink tumors and control the cancer. Researchers will a…

This study is testing a new drug called sotorasib for people with advanced solid tumors that have a specific genetic change called KRAS p.G12C. The main goals are to find a safe dose and see how well the body handles the drug. Researchers also want to learn if the drug can help s…

This large, late-stage study is testing whether a new injectable medicine called maridebart cafraglutide helps adults with obesity or overweight lose more weight than a placebo over 72 weeks. It will also check if the drug improves health measures like blood pressure, cholesterol…

This is an early-stage safety study testing a new drug called tarlatamab in people with advanced small cell lung cancer that has returned or stopped responding to standard chemotherapy. The main goals are to find a safe dose, check for side effects, and see how the drug behaves i…

This study is testing a drug called blinatumomab in Chinese children whose B-cell acute lymphoblastic leukemia (B-ALL) has come back or hasn't responded to other treatments. The main goal is to see if the drug can put the cancer into remission. Researchers will also closely monit…

This study is testing whether adding a new targeted drug called bemarituzumab to standard chemotherapy helps people with advanced stomach or gastroesophageal cancer live longer. It is for adults with a specific biomarker (FGFR2b) in their tumor who have not yet received treatment…

This study is testing whether a new injectable medicine called maridebart cafraglutide helps adults in Japan lose weight and improve their health better than a placebo (dummy treatment). It involves 279 adults with obesity and related health conditions like high blood pressure or…

This study is testing whether a drug called romiplostim can help cancer patients avoid delays or reductions in their chemotherapy. It focuses on patients with lung, breast, or ovarian cancer who develop low platelet counts from chemo, a common side effect. The goal is to see if t…

This study is testing whether an investigational drug called HZN-1116 can safely reduce disease activity and ease symptoms in people with Sjögren's syndrome, an autoimmune disorder. About 209 participants will receive either the drug or a placebo via injection for 48 weeks. The g…

This early-stage study is testing a new combination of two oral drugs, AMG 193 and IDE397, for adults with advanced solid tumors that have a specific genetic feature called MTAP-null. The main goals are to find the safest and most effective dose and to see if the treatment can sh…

This study is testing whether an injectable medication called rocatinlimab can help reduce the frequency of serious asthma attacks in adults whose asthma is not fully controlled by their current inhalers and medications. About 317 participants will receive either the study drug o…

This study is testing whether the medication apremilast can safely and effectively reduce skin symptoms in Japanese children and teenagers (ages 6-17) who have moderate to severe plaque psoriasis. It involves 17 participants and will measure how much their skin clears up and how …

This early-stage trial is testing the safety and effectiveness of a drug called sotorasib, both by itself and combined with other cancer therapies. It is for adults with advanced solid tumors that have a specific genetic change known as the KRAS p.G12C mutation. The main goal is …

This early-stage study aims to check if an experimental drug called maridebart cafraglutide affects heart rhythm in people with overweight or obesity. It will involve 81 healthy adults to see if the drug is safe for the heart before larger studies can test if it helps with weight…

This study is testing a new injectable drug called maridebart cafraglutide for adults with type 2 diabetes. Over 400 participants will receive different doses or a placebo for 24 weeks to see how well it controls blood sugar and affects body weight. The main goal is to find the m…

This study is testing whether an investigational drug called rocatinlimab can reduce severe itching and improve skin lesions in adults with prurigo nodularis, a chronic skin condition. Participants will receive either the drug or a placebo for 52 weeks to see which is more effect…

This study is testing if giving a cholesterol-lowering drug called evolocumab very early after a heart attack, along with standard care, is better than standard care alone at preventing future serious heart problems. It involves over 6,000 adults who were hospitalized for a heart…

This is the first study in people testing a new drug called AMG 355, both by itself and combined with an existing immunotherapy (pembrolizumab). It aims to find safe doses and see if the treatment helps adults with advanced solid tumors that have stopped responding to standard tr…

This study is checking the long-term safety and effectiveness of an investigational drug called rocatinlimab for people with moderate-to-severe eczema (atopic dermatitis). It involves over 2,600 adults and adolescents who previously took the drug in earlier studies. The main goal…

This Phase 3 trial is testing whether an injectable medication called teprotumumab can reduce eye bulging and other symptoms in people with active, moderate-to-severe Thyroid Eye Disease. The study involves 89 participants who receive either the drug or a placebo injection to com…

This study is testing whether a drug called inebilizumab can prevent disease flares in people with IgG4-Related Disease (IgG4-RD), a condition where the immune system attacks the body's own tissues in multiple organs. About 135 adults with active IgG4-RD who are at high risk of f…

This study is testing whether a monthly injection called erenumab can safely reduce the number of migraine days for children and teenagers. It involves about 457 participants, aged 6 to 17, who have episodic migraines. The main goal is to see if the treatment leads to fewer migra…

This study is testing a new oral drug, AMG 193, for people with advanced solid tumors that have lost a specific gene called MTAP. The main goals are to find a safe dose, see how the body processes the drug, and check if it helps shrink tumors, both by itself and when given with a…

This study is testing if a new drug called ABP 206 works as well as the standard treatment (nivolumab) for people with advanced melanoma that cannot be removed by surgery. It involves 633 adults who have not yet received any treatment for their advanced cancer. The goal is to see…

This study is checking the safety of the oral medication apremilast in children and teenagers with mild to moderate plaque psoriasis. It involves 51 participants aged 6 to 17 who have not been well-controlled with topical creams. The main goal is to monitor for side effects and s…

This study is testing a new drug called tarlatamab for people with advanced small cell lung cancer that has come back or stopped responding to at least two prior treatments. The main goals are to see if the drug shrinks tumors and to understand its safety and side effects. The st…

This study follows people with NMOSD, a rare autoimmune disorder, who are taking or stopping the drug inebilizumab. Researchers want to understand how long-term treatment affects the immune system and how quickly it recovers after stopping the medication. They will monitor 32 par…

This is a very early, first-in-human study to check the safety and side effects of an experimental treatment called AMG 119 in adults with small cell lung cancer that has come back or stopped responding to standard chemotherapy. AMG 119 is a type of CAR T-cell therapy, where a pa…

This study is testing whether people with moderate-to-severe eczema can successfully give themselves injections of an investigational medication called rocatinlimab at home. It involves 151 participants aged 12 and older who have not responded well to standard topical treatments.…

This study is testing whether adding a new targeted drug called bemarituzumab to standard chemotherapy and immunotherapy helps people with advanced stomach or gastroesophageal cancer live longer. It's for adults with a specific tumor marker (FGFR2b) who haven't had treatment for …

This large, late-stage study is testing whether an investigational drug called dazodalibep can reduce the widespread disease activity in people with moderate-to-severe Sjögren's syndrome. It involves 651 participants who will receive either the drug or a placebo to see if it safe…

This study is testing whether an investigational drug called dazodalibep can reduce the main symptoms of Sjögren's syndrome, such as severe dryness, pain, and fatigue. It will involve about 434 adults who have been diagnosed with Sjögren's and are experiencing a high level of the…

This early-stage study aims to understand how the body absorbs and processes an experimental drug called maridebart cafraglutide (AMG 133) for weight management. Researchers will compare two different injection forms of the drug in 348 adults living with overweight or obesity. Th…