Amgen

This study tested a combination of three drugs (carfilzomib, pomalidomide, and dexamethasone) in 54 adults whose multiple myeloma had come back after previous treatment. The goal was to see how many patients responded to the treatment. While the results may help control the disea…

This study tested a daily pill called apremilast in 203 Chinese adults with moderate to severe plaque psoriasis. Participants took either the drug or a placebo for 16 weeks. The main goal was to see if the drug could reduce psoriasis severity by at least 75%. This is a disease co…

This early-stage study tested a new drug called AMG 786 in 65 healthy and obese adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects. The goal is to gather initial safety data, no…

This early-stage study tested the safety of blinatumomab in 6 Japanese adults newly diagnosed with a type of leukemia (B-ALL). The main goal was to see what side effects occurred. Participants received the drug through an IV after initial chemotherapy. Results help guide future r…

This study tested three doses of a new drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults with overweight or obesity, some of whom also had type 2 diabetes. The main goal was to see how much weight participants lost after 52 weeks. The drug aims to help…

This early-stage study tested a new drug called AMG 133 in 120 adults with overweight or obesity. Researchers gave multiple doses under the skin to see how the drug behaves in the body and whether it is safe. The goal was to gather information for future studies, not to treat or …

This study looked at whether giving the gout medication pegloticase over a shorter time is safe and works well for people with uncontrolled gout who are also taking methotrexate. About 191 adults took part. The main goal was to check for infusion reactions, and a key measure was …

This study tested whether teenagers and adults with moderate-to-severe eczema (atopic dermatitis) could successfully give themselves injections of the drug rocatinlimab at home. 151 participants used special injection devices over 16 weeks. The main goal was to see how many full …

This study tested a gout medication called pegloticase (KRYSTEXXA) given every 4 weeks along with weekly methotrexate in 50 adults with chronic gout that did not respond to standard treatments. The goal was to see if this combination could lower uric acid levels and be safe. Resu…

This study tested a new medication, ABP 938, against an existing drug called Eylea for people with wet age-related macular degeneration (AMD), a condition that causes vision loss. About 576 adults aged 50 and older with wet AMD received injections of either ABP 938 or Eylea into …

This study tested two experimental drugs, anvumetostat and IDE397, in 53 adults with advanced solid tumors that lack a gene called MTAP. The goal was to find a safe dose and see if the combination can shrink tumors, especially in a type of lung cancer. The trial is complete, and …

This early-stage study tested a daily pill called sotorasib (AMG 510) in 12 Chinese adults with advanced solid tumors that have a specific KRAS G12C mutation. The main goals were to check safety and how the drug moves through the body. Researchers also looked for early signs that…

This study tested if a new drug, ABP 206, works similarly to the approved drug OPDIVO for people with advanced melanoma that has been removed by surgery. The trial involved 256 adults and compared how the drugs move through the body, their safety, and their effectiveness. The goa…

This early-stage study tested a new medicine called AMG 890 in 79 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. The goal was to check the drug's safety and how the body processes it. Participants received a single dose of the drug or a placeb…

This study looked at how well the drug teprotumumab works for thyroid eye disease, a condition that can cause bulging eyes. It involved 5 people in China who received the drug. The main goal was to see if their eye bulging improved by at least 2 millimeters after treatment.

This early-stage study tested a single dose of the experimental drug AMG 133 in 20 Chinese adults who are overweight or have obesity. The main goal was to see how the drug behaves in the body and to check for any safety issues. This is a first step to see if the drug might help m…

This study tested a daily pill called sotorasib in 42 adults with advanced lung cancer that has a specific genetic change (KRAS G12C) and has not been treated yet. The goal was to see if the drug shrinks tumors and how safe it is. Participants received either a 960 mg or 240 mg d…

This study tested a drug called erenumab in 620 adults with chronic migraine who also overused headache medications. The goal was to see if erenumab could reduce the number of headache days and the need for painkillers. Participants received either erenumab or a placebo, and rese…

This study tested a new drug called olpasiran in 281 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. Participants received either the drug or a placebo as a shot. The main goal was to see if olpasiran could safely lower Lp(a) levels over severa…

This study tested whether evolocumab, a cholesterol-lowering drug, can reduce major heart problems like heart attacks and strokes in adults at high risk but who have never had one before. Over 12,000 participants aged 50-80 with high cholesterol took either evolocumab or a placeb…

This study tested a drug called rocatinlimab in 187 teenagers aged 12 to 17 with moderate-to-severe atopic dermatitis (eczema) that didn't improve with standard creams. The main goal was to check the drug's safety over 52 weeks. This is a disease-control treatment, not a cure, me…

This study looked at the safety of the drug Kyprolis (carfilzomib) in 101 Indian patients whose multiple myeloma had come back or stopped responding to treatment. Researchers tracked side effects and how long patients lived without their cancer getting worse. The goal was to conf…

This early-stage study tested a new drug called AMG 256 in 34 adults with advanced solid tumors that had not responded to standard treatments. The main goal was to check the drug's safety and find the best dose for future studies. The study is now complete, but it does not offer …

This study tested an investigational drug called daxdilimab in 12 adults with dermatomyositis or anti-synthetase myositis that was not well controlled by standard treatments. The goal was to see if daxdilimab could reduce disease activity and skin symptoms, and help lower steroid…

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who were getting chemotherapy. The goal was to see if it could prevent low platelet counts, which can force doctors to delay or reduce chemo doses. Results showed tha…

This study looked at how safe and effective OTEZLA is for people with psoriasis (skin plaques) or psoriatic arthritis when used in normal doctor visits. Over 1,000 adults who had not gotten enough relief from creams or other skin treatments took part. Researchers tracked side eff…

This study tested a new medicine called rocatinlimab, given as an injection, along with standard skin creams, in 746 adults with moderate-to-severe eczema. The goal was to see if the combination could clear the skin and reduce itching better than creams alone. Results showed that…

This study looked at the long-term safety and effects of the drug apremilast in children aged 6 to 17 with moderate to severe plaque psoriasis. Participants who completed a previous year-long study could continue taking apremilast for up to 208 weeks (about 4 years), followed by …

This study tested a drug called bemarituzumab in 260 people with solid tumors that have too much of a protein called FGFR2b. The main goals were to see if the drug is safe and if it can shrink tumors. Participants had already tried other treatments without success.

This study looked at how safe and tolerable different lengths of treatment with teprotumumab are for adults with Thyroid Eye Disease (TED), a condition that can cause bulging eyes and discomfort. About 313 participants received the drug for varying durations to see if shorter or …

This study tested whether a gout medication called pegloticase can be given every 4 weeks instead of every 2 weeks, while still controlling uric acid levels. About 262 adults with hard-to-treat gout took part. The goal was to see if the longer interval works just as well when com…

This study tested the safety of a drug called romosozumab (EVENITY) in 100 postmenopausal women in India who have osteoporosis and a high risk of breaking a bone. The main goal was to see what side effects occurred. The drug is already approved and aims to strengthen bones, but t…

This early-stage study tested a new drug called AMG 133 in 110 adults with obesity to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single dose or multiple doses. The main goal was to check for side effects and changes in…

This study tested a combination of two drugs (sotorasib and panitumumab) against standard treatments in 160 adults with advanced colorectal cancer that has a specific KRAS G12C mutation and has not responded to prior therapy. The goal was to see if the new combination could slow …

This early-stage study tested a new drug, Tarlatamab, in 41 men with a rare and aggressive form of prostate cancer called neuroendocrine prostate cancer. The main goal was to check the drug's safety and find the best dose. The drug works by helping the body's immune cells attack …

This study tested a new medication called rocatinlimab for adults with moderate-to-severe atopic dermatitis (eczema) that didn't improve with standard creams. About 769 participants received either the drug or a placebo for 24 weeks. The goal was to see if the drug could clear sk…

This study tested a new medication called rocatinlimab in 532 teenagers aged 12 to 17 with moderate-to-severe eczema that didn't improve with standard creams. The goal was to see if the drug could clear skin and reduce itching over 24 weeks. Participants received either the drug …

This early-stage study tested a combination of two drugs, tarlatamab and AMG 404, in 23 adults with small cell lung cancer that had returned after standard treatment. The main goal was to check safety and find the best dose for future studies. This is not a cure, but aims to cont…

This early-phase study tested a new drug called AMG 305 in 37 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety and find the best dose for future studies. Participants received the drug and were mo…

This study followed about 526 adults with active psoriatic arthritis who were already prescribed apremilast (Otezla) by their doctor. Researchers tracked how many patients saw at least a 1-point improvement on a 0-4 doctor-rated skin and joint scale after 6 months, and continued …

This study tested the drug erenumab in 512 adults with high-frequency episodic migraine (7 to 14 migraine days per month) who had already tried at least one other preventive treatment without success. The main goal was to see if erenumab could reduce the total hours of moderate-t…

This study tested whether the drug erenumab can help prevent migraines in children aged 6 to 17 with chronic migraine (15+ headache days per month). About 284 participants received either erenumab or a placebo. The main goal was to see if the drug reduced the number of monthly mi…

This study looked at how the drug olpasiran moves through the body in people with normal kidneys and those with kidney problems. 33 adults received one dose to measure drug levels and safety. The goal was to gather information, not to treat any condition.

This study looked at nearly 40,000 people with a history of heart disease to measure their levels of lipoprotein(a), a fatty substance in the blood that can increase heart risk. Researchers wanted to see how common high levels are and whether they differ by age, sex, or region. T…

This study tested a single dose of the drug teprotumumab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and if it is safe. Participants were closely monitored for side effects and drug levels in the blood.

This study tested a single dose of rocatinlimab in 20 healthy Chinese adults to see how the drug moves through the body and if it is safe. The goal was to gather information, not to treat any disease. Participants were monitored for side effects and drug levels in the blood.

This study looked at how the body processes a single dose of the drug AMG 133 in 36 adults with mild, moderate, or severe liver problems compared to those with healthy livers. The goal was to see if liver function changes drug levels and safety. Results will help doctors decide t…

This early-phase study looked at how rocatinlimab changes the way the body processes certain other medications in 21 adults with moderate to severe atopic dermatitis (eczema). Participants received a cocktail of common drugs before and after rocatinlimab to measure differences in…

This study looked at how the body processes rocatinlimab when given as a shot from a vial versus a prefilled syringe. It involved 240 healthy adults aged 18 to 65. The goal was to see if both methods work the same way, not to treat any disease.

This early-stage study tested the drug AMG 133 in 57 adults with overweight or obesity. The main goal was to see how the drug affects stomach emptying, measured by how the body processes acetaminophen. The study also checked for side effects and changes in appetite and food intak…

This study looked at whether rocatinlimab, a drug for moderate-to-severe eczema, changes how well vaccines work. 221 adults with eczema received either rocatinlimab or a placebo, then got tetanus and meningococcal vaccines. The goal was to see if the drug affects the body's abili…

This study looked at how the drug avacopan is processed in people with normal kidneys and those with end-stage kidney disease who need dialysis. A single dose was given to 13 adults, and researchers measured drug levels in the blood and dialysis fluid. The goal was to understand …

This study followed 187 adults with melanoma who were treated with IMLYGIC, a virus-based therapy. Researchers wanted to see if the virus spreads to patients' close contacts or healthcare providers, and to check for long-term side effects over 5 years. The goal was to better unde…

This study looked at whether a single dose of olpasiran changes heart rhythm in 32 healthy adults aged 18 to 60. Participants received the drug, a placebo, or another drug to compare effects. The goal was to gather safety data, not to treat any disease.

This study looked at how an anti-nausea drug (ondansetron) affects the levels of an experimental weight-loss medication (AMG 133) in the blood. It involved 59 adults who were overweight or obese. The goal was to gather information on drug interactions, not to treat or cure obesit…

This study tested how well the drug rocatinlimab enters the body when given by an autoinjector pen versus a traditional vial and syringe. 231 healthy adults aged 18 to 60 received a single dose. The goal was to compare drug levels and check for side effects, not to treat eczema.

This study looked at how a single dose of the experimental drug AMG 133 is processed in people with normal kidneys and those with various levels of kidney problems. 44 adults took part. The goal was to understand safety and how the drug moves through the body, not to treat obesit…

This study looked at the safety of the drug sotorasib in 102 Chinese adults with a specific type of advanced lung cancer (KRAS G12C-mutated NSCLC). Researchers tracked side effects like liver problems, lung inflammation, and kidney issues. The goal was to understand real-world ri…

This early-stage study aimed to understand how a single dose of an experimental drug called olpasiran is processed by the body in people with different levels of liver damage. It compared 25 participants with mild, moderate, or severe liver impairment to participants with normal …