Amgen

This study tested whether a gout medication (pegloticase) given every 4 weeks works as well as the standard every-2-week schedule, when both are paired with weekly methotrexate. The goal was to lower uric acid levels in people with severe, hard-to-treat gout. About 262 adults wit…

This study tests a drug called sotorasib in people with advanced solid tumors that have a specific genetic change (KRAS G12C). The trial has two phases: first to find the safest dose, then to see how well it shrinks tumors. About 713 adults with various cancers, including lung ca…

This Phase 3 trial tested the drug blinatumomab in 111 children with high-risk relapsed B-precursor acute lymphoblastic leukemia (ALL). Blinatumomab is an immunotherapy that helps the body's immune cells attack cancer cells. The study compared blinatumomab to standard chemotherap…

This phase 3 study tested a drug called rocatinlimab in 726 adults with moderate-to-severe atopic dermatitis (eczema) that wasn't well controlled by creams. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goals were to see if the…

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This completed Phase 1 trial tested how the experimental drug maridebart cafraglutide (AMG 133) is absorbed when given as two different injections. 348 adults with overweight or obesity received a single dose. The main goal was to measure drug levels in the blood, not weight loss…

This phase 3 trial tested whether adding a targeted drug called bemarituzumab to standard chemotherapy helps people with advanced stomach or gastroesophageal junction cancer that has a specific protein (FGFR2b). The study enrolled 547 adults whose cancer could not be removed by s…

This study tested an experimental drug called daxdilimab in 12 adults with dermatomyositis or anti-synthetase myositis that wasn't well controlled by standard treatments. The goal was to see if the drug could reduce disease activity and skin symptoms, and help lower steroid use o…

This study tested a gout medication called pegloticase (KRYSTEXXA) given every 4 weeks along with weekly methotrexate pills in 54 adults with severe gout that didn't respond to standard treatments. The goal was to see if this combination could lower uric acid levels and keep them…

This early-phase study tested the safety of the drug blinatumomab (Blincyto®) in 6 Japanese adults newly diagnosed with a type of leukemia called B-ALL. The main goal was to see what side effects occurred. Researchers also looked at how the drug moves through the body and whether…

This study looked at how safe and tolerable the drug Kyprolis is for Indian patients whose multiple myeloma has come back or stopped responding to treatment. A total of 101 adults took part, and researchers tracked side effects and how long the drug kept the cancer from getting w…

This early-phase trial tested the drug sotorasib (AMG 510) in 12 Chinese patients with advanced solid tumors that have a specific KRAS G12C mutation. The main goals were to check safety, how the drug moves through the body, and whether it shrinks tumors. All participants took the…

This phase 3 trial tested whether combining sotorasib (a pill) and panitumumab (an infusion) can slow tumor growth better than standard chemotherapy in 160 adults with metastatic colorectal cancer that has a specific KRAS G12C mutation. Participants were randomly assigned to rece…

This study tested a new two-drug combination (anvumetostat and IDE397) in 53 adults with advanced solid tumors that lack a gene called MTAP. The goal was to find a safe dose and see if the drugs shrink tumors, especially in lung cancer. Participants had cancers that had stopped r…

This completed study looked at how safe sotorasib is for Chinese patients with a certain type of advanced lung cancer (KRAS G12C-mutated NSCLC). 102 patients who had already tried other treatments took sotorasib pills daily. Researchers tracked side effects and how long patients …

This phase 2 trial tested olpasiran, an injectable drug, in 281 adults with high lipoprotein(a) – a genetic risk factor for heart disease. Participants received either olpasiran or a placebo. The main goal was to see how much the drug lowered Lp(a) levels after 36 weeks. Results …

This phase 3 trial tested whether ABP 206, a biosimilar to the cancer drug nivolumab (Opdivo), works similarly in people with advanced melanoma that has been surgically removed. 256 participants received either ABP 206 or Opdivo every 4 weeks for a year. The goal was to see if th…

This study tested whether teenagers and adults with moderate-to-severe eczema (atopic dermatitis) could successfully give themselves injections of the drug rocatinlimab at home using special devices. The main goal was to see how many full doses were self-administered correctly up…

This early-stage trial tested a new drug called AMG 133 (Maridebart cafraglutide) in 57 adults with overweight or obesity. The goal was to see how the drug affects stomach emptying, using acetaminophen as a marker. Participants received either the drug or a placebo, and researche…

This early-phase study tested a new drug called AMG 305 in 37 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety and find the best dose for future studies. Participants received the drug and were mo…

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who were receiving chemotherapy. The goal was to see if romiplostim could prevent low platelet counts (thrombocytopenia) that often force doctors to delay or reduce c…

This early-stage study tested a single dose of an investigational drug called AMG 890 in 79 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. The main goal was to check safety and how the drug moves through the body. Researchers measured side eff…

This phase 2 study tested three different doses of a new injectable drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults who were overweight or obese, some with type 2 diabetes. The main goal was to see how much weight participants lost over 52 weeks. The…

This study looked at how safe and tolerable different lengths of treatment with teprotumumab are for adults with thyroid eye disease (TED). About 313 participants received the drug for varying durations to see if shorter treatment works as well and reduces side effects. The goal …

This study tested a drug called rocatinlimab in 532 teenagers with moderate-to-severe eczema that didn't improve with standard creams. The goal was to see if the drug could clear skin and reduce itching over 24 to 52 weeks. Participants received either the drug or a placebo, and …

This early-phase study tested a single injection of a new drug called AMG 133 (Maridebart Cafraglutide) in 20 overweight or obese Chinese adults. The main goal was to see how the drug moves through the body and to check for any safety issues. This is a first step to see if the dr…

This study tested the drug apremilast (Otezla) in 203 Chinese adults with moderate to severe plaque psoriasis. Participants took either apremilast or a placebo pill twice daily for 16 weeks. The main goal was to see if more people on apremilast achieved at least a 75% improvement…

This study looked at the long-term safety and effects of the drug apremilast in 160 children aged 6 to 17 with moderate to severe plaque psoriasis. Participants who had already completed one year of treatment could continue taking the drug for up to 208 weeks (about 4 years). The…

This study tested a drug called rocatinlimab in 187 teenagers aged 12 to 17 with moderate-to-severe eczema that didn't respond well to standard creams. The goal was to see if the drug is safe and tolerable over 52 weeks. Participants received regular injections, and researchers t…

This early-stage trial tested a new drug called maridebart cafraglutide (AMG 133) in 110 adults with obesity. The main goal was to see if the drug is safe and tolerable when given as a single dose or multiple doses. Researchers also measured how the drug moves through the body. T…

This study tested a new medicine called rocatinlimab, given as an injection, for adults with moderate-to-severe eczema that wasn't well controlled with standard creams. About 746 participants received either the study drug or a placebo, along with topical treatments. The goal was…

This study tested a new medication called rocatinlimab for adults with moderate-to-severe eczema (atopic dermatitis). About 769 people took part to see if the drug can clear skin and reduce itching better than a placebo. The goal is to provide a new treatment option for those who…

This study tested the safety of romosozumab (Evenity) in 100 postmenopausal women in India who have osteoporosis and a high risk of bone fractures. Researchers tracked side effects, serious events, and changes in lab tests and vital signs. They also measured bone density changes …

This early-stage trial tested the safety of a new drug called AMG 786 in 65 healthy adults and people with obesity. Participants received either the drug or a placebo tablet, and researchers monitored for side effects and how the drug moves through the body. The goal was to see i…

This study tested a daily oral drug called sotorasib in 42 adults with advanced (stage IV) non-small cell lung cancer that has a specific KRAS G12C mutation and has not been treated before. The goal was to see how well the drug shrinks tumors and how safe it is. Participants rece…

This study tested whether giving the gout drug pegloticase over a shorter time is safe and works well for people with uncontrolled gout. About 191 adults with hard-to-treat gout received methotrexate before and during pegloticase infusions for up to 24 weeks. The main goal was to…

This completed Phase 1 trial tested an experimental drug called AMG 133 in 120 adults with overweight or obesity. Participants received multiple doses of the drug or a placebo to see how the body processes it and to check for safety issues. The study did not aim to measure weight…

This early-phase study tested a new drug called AMG 256 in 34 adults with advanced solid tumors that could not be cured by standard treatments. The main goals were to check the drug's safety and find the best dose for future studies. Researchers monitored side effects and how the…

This early-phase study tested a combination of two drugs, tarlatamab and AMG 404, in 23 adults with small cell lung cancer that had worsened after standard chemotherapy. The main goal was to check safety and find the right dose for future studies. Participants had to be in fairly…

This completed phase 4 trial tested erenumab (Aimovig) in 620 adults with chronic migraine who also overused headache medication. Participants received injections of erenumab or a placebo every 4 weeks. The study measured whether erenumab could reduce medication overuse and heada…

This early-stage trial tested a drug called Tarlatamab in 41 men with a rare and aggressive form of prostate cancer called neuroendocrine prostate cancer. The main goal was to check the drug's safety and find the best dose. The drug works by helping the body's immune cells recogn…

This phase 3 trial tested whether a new drug called ABP 938 works as well as the standard treatment Eylea for wet age-related macular degeneration (AMD), a leading cause of vision loss. 576 adults aged 50 and older with wet AMD received injections of either ABP 938 or Eylea every…

This completed study observed over 1,000 people with psoriasis who were prescribed OTEZLA (apremilast) for the first time. Researchers tracked side effects, symptom improvement, and quality of life over several years. The goal was to see how well the drug works in real-world sett…

This completed study looked at how well teprotumumab (TEPEZZA) works in real-world use for 5 Chinese patients with thyroid eye disease. The main goal was to see how many patients had a reduction in eye bulging (proptosis) after their last IV infusion. The study also collected bas…

This phase 2 study tested a combination of three drugs—carfilzomib, pomalidomide, and dexamethasone—in 54 adults whose multiple myeloma had come back after one or two prior treatments. The goal was to see how many patients responded to the therapy. The study is complete, and resu…

This study followed 526 adults with active psoriatic arthritis who were already prescribed apremilast (Otezla) by their doctors. Researchers observed them for up to 100 weeks to see how well the drug controlled their symptoms in everyday practice. The goal was to gather long-term…

This study tested the drug erenumab in 512 adults who have frequent migraines (7 to 14 headache days per month) and had already tried at least one other preventive treatment that didn't work. The main goal was to see if erenumab could reduce the number of hours they spent with mo…

This study tested whether the drug erenumab can help prevent migraines in children (ages 6 to 12) and teenagers (ages 12 to 18) who have chronic migraines. About 284 participants received either the drug or a placebo. The main goal was to see if the drug reduced the number of mig…

This study tested whether a more concentrated version of ABP 501 (a biosimilar to the drug adalimumab) works the same in the body as the standard version. 372 healthy adults received a single injection of either the high-concentration or low-concentration form. Researchers measur…

This completed Phase 1 study looked at how the drug avacopan is processed in 13 people with normal kidney function and those with end-stage renal disease requiring hemodialysis. Researchers measured drug levels in the blood and dialysis fluid after a single dose. The goal was to …

This study looked at how the body processes a single dose of the drug AMG 133 in people with different levels of liver impairment compared to those with healthy livers. Thirty-six adults took part, and researchers measured drug levels in the blood and checked for side effects. Th…

This completed Phase 1 study tested a single dose of teprotumumab (Tepezza) in 20 healthy Chinese adults. The goal was to see how the drug moves through the body and check for side effects. Participants received either the drug or a placebo by IV, and researchers measured drug le…

This study looked at how a single dose of the drug AMG 133 is processed by the body in people with normal kidney function compared to those with various levels of kidney problems. A total of 44 adults aged 18 to 75 who are overweight or obese took part. The goal was to understand…

This study followed 187 melanoma patients treated with IMLYGIC, a modified herpes virus that attacks cancer cells. Researchers tracked whether the virus spread to patients' close contacts or healthcare providers, and monitored long-term safety for up to 5 years. The goal was to u…

This study tested how well the body absorbs rocatinlimab, a drug for atopic dermatitis (eczema), when given through an autoinjector pen compared to a traditional vial and syringe. It involved 231 healthy adults aged 18-60. The goal was to see if the autoinjector delivers the drug…

This early-phase study tested a single dose of the experimental drug rocatinlimab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and whether it is safe. This is a first step toward possibly using the drug to treat atopic dermatitis (ecz…

This study tested whether taking an anti-nausea drug (ondansetron) along with AMG 133 changes how the body processes AMG 133. Fifty-nine adults with overweight or obesity participated. The goal was to measure drug levels and check for side effects, not to treat the condition.

This study tested how the body absorbs rocatinlimab, a potential eczema treatment, when given through a vial versus a prefilled syringe. 240 healthy adults received a single dose to compare the two methods. The goal was to see if the syringe works as well as the vial, not to trea…

This early-phase study looked at how rocatinlimab, an experimental drug for eczema, affects the way the body processes several common medications (caffeine, metoprolol, midazolam, warfarin, omeprazole). 21 adults with moderate to severe eczema took these drugs with and without ro…

This early-phase study looked at how a single dose of the drug olpasiran moves through the body in people with normal kidneys and those with various levels of kidney impairment. Thirty-three adults received one shot under the skin. The main goal was to measure drug levels in the …

This study looked at whether rocatinlimab, a drug for moderate-to-severe eczema, changes how well vaccines work. About 221 adults with eczema received either the drug or a placebo, then got tetanus and meningococcal vaccines. The goal was to see if the drug lowers the body's abil…

This study looked at nearly 40,000 people with a history of heart disease caused by clogged arteries. The goal was to measure their levels of lipoprotein(a), a fatty substance that can increase heart risk. Researchers wanted to see how these levels vary by age, sex, race, and reg…

This study checked whether a single dose of olpasiran (AMG 890) affects the heart's electrical activity in 32 healthy adults aged 18 to 60. Participants received olpasiran, a placebo, and a positive control in random order. The main goal was to measure changes in the QT interval,…

This study looked at how the drug olpasiran is processed by the body in people with mild, moderate, or severe liver problems compared to those with healthy livers. A total of 25 adults took a single dose of the drug. The goal was to understand safety and how the liver affects dru…