Amgen

This early-stage study tested an experimental drug called AMG 133, given as injections under the skin, in 120 adults who are overweight or have obesity. The main goal was to understand how the drug moves through and stays in the body after multiple doses. Researchers also closely…

This study tested whether a drug called romiplostim could help patients with gastrointestinal, pancreatic, or colorectal cancer stay on their planned chemotherapy schedule. Chemotherapy can cause dangerously low platelet counts (thrombocytopenia), which often forces doctors to de…

This study tested if a new eye injection called ABP 938 works as well and is as safe as the established drug Eylea for treating wet age-related macular degeneration (AMD), a leading cause of vision loss. About 576 participants with this condition received injections of either the…

This study tested the safety and side effects of a bone-building medication called romosozumab (EVENITY®) in 100 postmenopausal women in India who have osteoporosis and a high risk of breaking a bone. The main goal was to see how well the women tolerated the drug and to monitor f…

This international study tested whether shorter or longer treatment courses with the drug teprotumumab are safe and effective for adults with Thyroid Eye Disease. Researchers compared three different treatment durations in 313 participants to see how well they controlled eye symp…

This study tested whether adding an investigational drug called rocatinlimab to standard eczema creams works better than using the creams alone. It involved 746 adults with moderate-to-severe atopic dermatitis (eczema) whose skin didn't respond well enough to strong prescription …

This study tested whether a gout medication called pegloticase could be safely given as a shorter infusion. About 180 adults with severe, uncontrolled gout received the medication every two weeks, with infusion times tested at 60, 45, and 30 minutes. All participants also took me…

This large, completed study tested whether a cholesterol-lowering drug called evolocumab could prevent major heart problems like heart attacks and strokes in adults at high risk who had not yet experienced one. Over 12,000 participants with high cholesterol and other risk factors…

This early-stage study tested the safety and side effects of an experimental drug called AMG 133 (maridebart cafraglutide) in adults with obesity. The main goal was to see how the body processes the drug and what side effects occur when given as single or multiple doses. Research…

This study looked back at medical records to see how well the drug teprotumumab worked for people with Thyroid Eye Disease (TED) in China. Researchers checked if the treatment reduced eye bulging (proptosis) and improved other symptoms for 5 patients who received it. The goal was…

This was the first study in humans to test a new cancer drug called AMG 305. It aimed to find a safe dose and see how the body processes the drug in 37 adults with advanced solid tumors who had run out of standard treatment options. The main goal was to check for side effects and…

This early-stage study tested how an experimental drug called AMG 133 affects how quickly the stomach empties in people with overweight or obesity. Researchers gave 57 participants either the drug or a placebo and measured its effects using a common painkiller (acetaminophen) as …

This study tested whether an experimental drug called AMG 133 could help people lose weight and keep it off for a year. Nearly 600 adults with obesity, some of whom also had type 2 diabetes, received either the drug or a placebo injection. Researchers measured how much weight par…

This early-stage study tested the safety of an experimental drug called AMG 786 in healthy adults and people with obesity. Researchers gave single and multiple doses to 65 participants to check for side effects and see how the body processes the drug. The main goal was to determi…

This study tested sotorasib as the first treatment for people with advanced non-small cell lung cancer who have a specific KRAS G12C mutation. The trial involved 42 participants who had not received prior treatment for their metastatic cancer. Researchers measured how well tumors…

This study tested whether a new drug called rocatinlimab can help adults with moderate-to-severe eczema when other creams haven't worked well enough. 769 participants were randomly assigned to receive either the drug or a placebo injection for 24 weeks. Researchers measured how m…

This early-stage study tested a new oral drug called AMG 510 (sotorasib) in 12 patients of Chinese descent with advanced cancers that had a specific genetic change called KRAS G12C. The main goals were to check the drug's safety, how the body processes it, and see if it showed an…

This study tested a combination of three drugs—carfilzomib, pomalidomide, and dexamethasone—for adults with multiple myeloma whose cancer had returned once or twice after previous treatments. The main goal was to see how well this combination worked to control the disease and how…

This early-stage study tested a single dose of an experimental weight management drug called AMG 133 (Maridebart Cafraglutide) in 20 Chinese adults with overweight or obesity. The main goal was to see how the drug moves through the body and to check for any immediate side effects…

This study offered children aged 6-17 with moderate to severe plaque psoriasis the option to continue taking the drug apremilast for up to four years after completing a previous trial. The main goal was to monitor the long-term safety of the medication in growing children, tracki…

This study tested a new drug called bemarituzumab in adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety and see if it could shrink tumors. Researchers enrolled 260 people with various cancers, inclu…

This early-stage study tested the safety and initial effectiveness of an experimental drug called Tarlatamab (AMG 757) in men with advanced neuroendocrine prostate cancer. The trial involved 41 participants and aimed to find the safest and most effective dose for future studies. …

This was an early-stage safety study for a new cancer drug called AMG 256. It involved 34 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose for future testing and to understand how the body processes the …

This was the first human study of an experimental drug called AMG 890 (now called olpasiran) designed to lower lipoprotein(a), a substance in blood linked to heart disease risk. Researchers tested single doses in about 80 adults with elevated lipoprotein(a) levels to check safety…

This study tested an injectable medication called rocatinlimab for teenagers with moderate-to-severe eczema (atopic dermatitis). Over 500 participants received either the drug or a placebo for 52 weeks to see how well it cleared skin and reduced itching. The main goal was to see …

This study aimed to understand the safety and effectiveness of the drug Otezla when used by real patients in everyday doctor's offices. It followed over 1,000 people with psoriasis or psoriatic arthritis who were starting Otezla for the first time. The goal was to collect informa…

This study tested a new injectable medication called rocatinlimab in teenagers with moderate-to-severe eczema (atopic dermatitis). The main goal was to check how safe and well-tolerated the treatment was over one year. It involved 187 adolescents whose eczema was not well-control…

This study tested whether a monthly injection called erenumab could help adults with very frequent chronic migraines who also overuse headache medications. The goal was to see if the treatment could reduce both the number of headache days and the need for daily painkillers. About…

This study followed over 500 adults with active psoriatic arthritis for about two years to see how well the drug apremilast (Otezla®) worked in everyday medical practice. Researchers tracked changes in joint pain, swelling, skin symptoms, and overall quality of life. The goal was…

This study tested whether a monthly injection called erenumab could safely reduce the number of migraine days in children and teenagers with chronic migraine. It involved 284 participants aged 6 to 18 who had frequent migraines. The goal was to see if the treatment was better tha…

This early-stage study tested the safety and best dose of a two-drug combination (tarlatamab plus AMG 404) for adults with small cell lung cancer that had worsened after standard chemotherapy. The main goal was to see how well patients tolerated the drugs and to check for any ser…

This small, early-stage study tested the safety and side effects of an intravenous drug called blinatumomab in six Japanese adults with a specific type of newly diagnosed blood cancer (B-ALL). The goal was to see how the drug is processed by the body and to check for any serious …

This study tested if a gout medication called KRYSTEXXA, given as an infusion every 4 weeks along with a weekly pill (methotrexate), could effectively lower uric acid in people with severe, hard-to-treat gout. It involved 50 adults whose gout did not improve with standard treatme…

This study tested whether a pill called apremilast could help control moderate-to-severe plaque psoriasis in Chinese adults. Over 200 participants were randomly assigned to receive either the real drug or a placebo pill for 16 weeks. Researchers measured how much the drug improve…

This study tested whether daxdilimab, given as an injection under the skin, could reduce disease activity in adults with dermatomyositis or anti-synthetase inflammatory myositis—two rare autoimmune conditions that cause muscle weakness and skin rashes. The 12 participants were ra…

This early-stage study tested how a common anti-nausea medicine (ondansetron) affects the way the body processes a new weight management drug called AMG 133. It involved 59 adults who were overweight or had obesity. The main goal was to check if taking the two drugs together chan…

This study checked if a new eczema medication called rocatinlimab affects how well vaccines work. Researchers compared 221 adults with moderate-to-severe eczema who received either the drug or a placebo. They measured participants' immune responses to tetanus and meningococcal va…

This study tested if a new drug, ABP 206, behaves in the body similarly to an approved drug called nivolumab (OPDIVO®). It involved 256 adults with advanced melanoma that had been surgically removed, aiming to see if the new drug could be just as effective and safe at preventing …

This early study tested how a single dose of an experimental drug called olpasiran behaves in people with different levels of kidney function. It involved 33 adults, some with healthy kidneys and others with mild to severe kidney problems, including some on dialysis. The main goa…

This study examined how a single dose of the weight loss drug AMG 133 is processed in people with different levels of liver impairment compared to those with normal liver function. It involved 36 adults to measure drug levels in the blood and check for safety issues. The goal was…

This early-stage study aimed to understand how a single dose of the experimental drug olpasiran is processed by the body in people with different levels of liver damage. It compared 25 participants with mild, moderate, or severe liver impairment to participants with normal liver …

This early-stage study tested how a single dose of an experimental weight-loss drug, AMG 133, is processed by the body in people with normal kidney function and in people with various levels of kidney impairment. The main goal was to see if the drug behaves differently in people …

This early-stage study tested a single dose of an experimental drug called rocatinlimab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and to check for any immediate side effects. This information helps researchers understand the drug's…

This early-stage study aimed to understand how a single dose of the drug teprotumumab moves through the body and how safe it is. It involved 20 healthy Chinese volunteers who received either the drug or a placebo. The main goal was to gather basic safety and drug-level data, not …

This study monitored melanoma patients who received the treatment IMLYGIC in real-world settings. Researchers followed 187 patients for up to five years to understand the risk of herpes infections from the treatment and whether those infections could spread to close contacts or h…

This study aimed to understand how common high levels of a specific blood fat called lipoprotein(a) are in people who already have heart disease. Researchers measured or collected existing blood test results from nearly 40,000 participants with a history of heart attacks, strokes…

This small, early-stage study aimed to understand how a new drug for moderate-to-severe eczema (rocatinlimab) might change how the body processes other common medications. It involved 21 adults with eczema to measure drug levels in the blood when taken alone and together. The mai…

This study aimed to see if a new auto-injector pen delivers a drug for atopic dermatitis (eczema) as effectively as the standard vial and syringe method. It involved 231 healthy adults who received a single dose. Researchers measured the drug levels in the blood and monitored for…

This study aimed to see if a single dose of the experimental drug olpasiran (AMG 890) causes any changes to the electrical activity of the heart in healthy people. It involved 32 healthy adult volunteers who received the drug, a placebo, and a control medication in a specific ord…

This study aimed to see if a potential eczema medication, rocatinlimab, is absorbed the same way by the body when given from a traditional glass vial versus a newer, ready-to-use prefilled syringe. It involved 240 healthy adults who received a single injection. The main goal was …

This small, early study aimed to understand how a single dose of the drug avacopan is processed by the body in two groups: people with healthy kidneys and people with end-stage kidney disease who need dialysis. The main goal was to measure the drug levels in the blood and see how…