New shot shows promise for tough eczema in major trial

NCT ID NCT05651711

Completed Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tested a drug called rocatinlimab in 726 adults with moderate-to-severe atopic dermatitis (eczema) that wasn't well controlled by creams. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goals were to see if the drug could clear or nearly clear the skin and reduce eczema severity by at least 75%.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Rocatinlimab (a drug given as a shot under the skin)

What this could lead to

If it works, this could offer a new treatment option for people with moderate-to-severe eczema that isn't controlled by creams.

What could go wrong

This is a phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is not a cure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

atopic eczema Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS

Contacts and locations

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Locations

About Allergy

Johannesburg, Gauteng, 2057, South Africa
Ace Clinical Trials

New York, New York, 10022, United States
Advanced Dermatology of the Midlands

Omaha, Nebraska, 68144, United States
Advanced Medical Research PC

Sandy Springs, Georgia, 30328, United States
Ajou University Hospital

Suwon-si, Gyeonggi-do, 16499, South Korea
Alina Clinical Trials, LLC

Dallas, Texas, 75225, United States
Amicare Spolka z ograniczona odpowiedzialnoscia Spolka Komandytowa Amicare Centrum Medyczne

Lodz, 91-495, Poland
Andante Research

San Antonio, Texas, 78229, United States
AppleTreeClinics Network Spzoo

Lodz, 90-349, Poland
Asan Medical Center

Seoul, 05505, South Korea
Asthma and Allergy Physicians of Rhode Island Clinical Research Institute

Warwick, Rhode Island, 02886, United States
Bakircay Universitesi Cigli Egitim ve Arastirma Hastanesi

Izmir, 35620, Turkey (Türkiye)
Beacon Dermatology

Calgary, Alberta, T3E 0B2, Canada
Bellaire Dermatology Associates

Bellaire, Texas, 77401, United States
Bernstein Clinical Research Center LLC

Cincinnati, Ohio, 45236, United States
Bezmialem Vakif Universitesi Hastanesi

Istanbul, 34093, Turkey (Türkiye)
Box Hill Hospital

Box Hill, Victoria, 3128, Australia
Burke Pharmaceutical Research

Hot Springs, Arkansas, 71913, United States
CCR Czech as

Pardubice, 530 02, Czechia
CCR Prague sro

Prague, 130 00, Czechia
CETI - Centro de Estudo em Terapias Inovadoras

Curitiba, Paraná, 80030-110, Brazil
CRST Helsinki

Helsinki, 00180, Finland
CRST Turku

Helsinki, 00180, Finland
California Dermatology and Clinical Research Institute

Encinitas, California, 92024, United States
Center for Dermatology Clinical Research Inc

Fremont, California, 94538, United States
Center for Dermatology and Plastic Surgery

Scottsdale, Arizona, 85260, United States
Centermed krakow sp zoo

Krakow, 31-530, Poland
Centre de Recherche Dermatologique du Quebec Metropolitain

Québec, Quebec, G1V 4X7, Canada
Centro Hospitalar Universitario do Porto, EPE - Hospital de Santo Antonio

Porto, 4099-001, Portugal
Centro Hospitalar de Sao Joao EPE - Hospital de Sao Joao

Porto, 4200-319, Portugal
Centro Hospitalar e Universitario de Coimbra, EPE

Coimbra, 3000-075, Portugal
Centro Multidisciplinar de Estudos Clinicos - CEMEC

São Bernardo do Campo, São Paulo, 09715-090, Brazil
Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna

Lodz, 90-338, Poland
Chosun University Hospital

Gwangju, 61453, South Korea
Chung-Ang University Hospital

Seoul, 06973, South Korea
Clarity Dermatology

Castle Rock, Colorado, 80109, United States
ClinicMed Daniluk Nowak Spolka komandytowa

Bialystok, 15-879, Poland
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Clinical Best Solutions Sp zoo Spolka Komandytowa

Lublin, 20-078, Poland
Clinical Research Center Spzoo Medic-R Spolka Komandytowa

Poznan, 61-731, Poland
Clinical Research Centre

Tartu, 50106, Estonia
Clinical Research Services Berlin GmbH

Berlin, 13672, Germany
Clinical Science Institute

Santa Monica, California, 90404, United States
Clinical Trials Institute of Northwest Arkansas

Fayetteville, Arkansas, 72703, United States
Clinique Andre Renard

Herstal, 4040, Belgium
Clinique Dermatologique de Sherbrooke

Sherbrooke, Quebec, J1G 1X9, Canada
Clínica de Enfermedades Crónicas y de Procedimientos Especiales

Morelia, Michoacán, 58249, Mexico
Corning Center For Clinical Research

Horseheads, New York, 14845, United States
Crystal Run Healthcare

Monroe, New York, 10950, United States
Cura Clinical Research

Palmdale, California, 93551, United States
DS Research

Louisville, Kentucky, 40241, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03766, United States
Dermamedest sro

Prague, 120 00, Czechia
Dermapolis Medical Dermatology Center dr n med Edyta Gebska

Chorzów, 41-500, Poland
Dermatologicka ambulance MUDr Petr Trestik

Svitavy, 568 02, Czechia
Dermatologie Maldegem

Maldegem, 9990, Belgium
Dermatologikum Hamburg

Hamburg, 20354, Germany
Dermatology Clinical Research Center of San Antonio

San Antonio, Texas, 78229, United States
Dermatology and Ophthalmology Kume Clinic

Sakai-shi, Osaka, 593-8324, Japan
Dermatology and Skin Cancer Center of Overland Park

Overland Park, Kansas, 66223, United States
Direct Helpers Research Center

Hialeah, Florida, 33012, United States
Doctor Chih-Ho Hong Medical Incorporated

Surrey, British Columbia, V3R 6A7, Canada
Driven Research LLC

Coral Gables, Florida, 33134, United States
Duke South Durham

Durham, North Carolina, 27713, United States
Eastern Virginia Medical School

Norfolk, Virginia, 23507, United States
Epic Clinical Research Incorporated

Lewisville, Texas, 75057, United States
Erciyes Universitesi Tip Fakultesi Hastanesi

Kayseri, 38030, Turkey (Türkiye)
Evimed sp zoo centrum medyczne evimed

Warsaw, 02-625, Poland
Ewha Womans University Seoul Hospital

Seoul, 07804, South Korea
FMCScience LLC

Lampasas, Texas, 76550, United States
Fachklinik Bad Bentheim

Bad Bentheim, 48455, Germany
Fakultni nemocnice Plzen

Pilsen, 305 99, Czechia
Forest Hills Dermatology Group

Kew Gardens, New York, 11415, United States
Foxhall Research Center

Washington D.C., District of Columbia, 20016, United States
Gaziantep Universitesi Tip Fakultesi Hastanesi

Gaziantep, 27310, Turkey (Türkiye)
Gentofte Hospital

Hellerup, 2900, Denmark
Glick Skin Institute

Margate, Florida, 33063, United States
Guys Hospital

London, SE1 9RT, United Kingdom
Hacettepe Universitesi Tip Fakultesi Hastanesi

Ankara, 06230, Turkey (Türkiye)
Hallym University Kangnam Sacred Heart Hospital

Seoul, 07441, South Korea
Hamamatsu University Hospital

Hamamatsu, Shizuoka, 431-3192, Japan
Hautarztpraxis Mortazawi

Remscheid, 42897, Germany
Hautzentrum Friedrichshain - Dermatologie

Berlin, 10247, Germany
Helios Klinikum Wuppertal

Wuppertal, 42283, Germany
Hiway Medical Centre

Durban, 3630, South Africa
Hopital Erasme

Brussels, 1070, Belgium
Hospital Arnau de Vilanova de Valencia

Valencia, Valencia, 46015, Spain
Hospital Cuf Descobertas

Lisbon, 1998-018, Portugal
Hospital Garcia de Orta, EPE

Almada, 2801-951, Portugal
Hospital General Universitario de Alicante

Alicante, Valencia, 03010, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, 28222, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena

Seville, Andalusia, 41009, Spain
Hospital de Manises

Manises, Valencia, 46940, Spain
ISPEM - Instituto São José dos Campos em Pesquisas Médicas

São José dos Campos, São Paulo, 12243-280, Brazil
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Inha University Hospital

Incheon, 22332, South Korea
Innovation Medical Research Center Inc

Palmetto Bay, Florida, 33157, United States
International University of Health and Welfare Narita Hospital

Narita-shi, Chiba, 286-8520, Japan
James Del Rosso Dermatology Research

Las Vegas, Nevada, 89117, United States
Karolinska Universitetssjukhuset Solna

Stockholm, 171 76, Sweden
Kentucky Advanced Medical Research LLC

Murray, Kentucky, 42071, United States
Kingsway Clinical Research

Etobicoke, Ontario, M8X 1Y9, Canada
KliFOs Klinische Forschung Osnabrueck

Osnabrück, 49074, Germany
Klinikum der Medizinischen Fakultaet der Martin-Luther-Universitaet Halle-Wittenberg

Halle, 06120, Germany
Kobe University Hospital

Kobe, Hyōgo, 650-0017, Japan
Kocaeli Universitesi Tip Fakultesi Hastanesi

Kocaeli, 41380, Turkey (Türkiye)
Konkuk University Medical Center

Seoul, 05030, South Korea
Korea University Anam Hospital

Seoul, 02841, South Korea
Korea University Ansan Hospital

Ansansi, Gyeonggido, 15355, South Korea
Kozni ambulance Fialova sro

Prague, 106 00, Czechia
Kozni ambulance Kutna Hora sro

Kutná Hora, 284 01, Czechia
Kyung Hee University Hospital at Gangdong

Seoul, 05278, South Korea
Kyungpook National University Hospital

Daegu, 41944, South Korea
Lakeside Healthcare

Corby, NN17 2UR, United Kingdom
Lynderm Research Inc

Markham, Ontario, L3P 1X3, Canada
MedCare Pharma - Houston

Houston, Texas, 77037, United States
MetroBoston Clinical Partners

Brighton, Massachusetts, 02135, United States
Miami Dade Medical Research Institute, LLC

Miami, Florida, 33176, United States
Mita Dermatology Clinic

Minato-ku, Tokyo, 108-0014, Japan
Miyata Dermatology Clinic

Matsudo-shi, Chiba, 271-0092, Japan
Montefiore Medical Center

The Bronx, New York, 10467, United States
MultiCare Institute for Research and Innovation

Spokane, Washington, 99202, United States
Nagasaki University Hospital

Nagasaki, Nagasaki, 852-8501, Japan
National Hospital Organization Sagamihara National Hospital

Sagamihara-shi, Kanagawa, 252-0392, Japan
National Medical Center

Seoul, 04564, South Korea
Nemocnice Novy Jicin as

Nový Jičín, 741 01, Czechia
North Estonia Medical Centre

Tallinn, 13419, Estonia
Odense University Hospital

Odense, 5000, Denmark
OptiSkin Medical

New York, New York, 10128, United States
Options Research Group LLC

West Lafayette, Indiana, 47906, United States
Oregon Medical Research Center

Portland, Oregon, 97223, United States
Osaka Habikino Medical Center

Habikino-shi, Osaka, 583-8588, Japan
Oulun Yliopistollinen sairaala (OYS)

Oulu, 90029, Finland
Phylasis Clínicas Research S. De R. L. De C. V.

Cuautitlán Izcalli, 54750, Mexico
Praglandia sro

Prague, 150 00, Czechia
Premier Specialists

Kogarah, New South Wales, 2217, Australia
Pusan National University Hospital

Busan, 49241, South Korea
Renaissance Research and Medical Group

Cape Coral, Florida, 33991, United States
Research Solutions of Arizona, PC

Litchfield Park, Arizona, 85340, United States
Research Toronto

Toronto, Ontario, M4W 2N4, Canada
Revival Research Institute LLC

Troy, Michigan, 48084, United States
Ryexo Clinical Research

Centurion, Gauteng, 0157, South Africa
SKiN Centre for Dermatology

Peterborough, Ontario, K9J 5K2, Canada
Saint Jude Clinical Research

Doral, Florida, 33172, United States
Sakarya Egitim ve Arastirma Hastanesi

Sakarya, 54050, Turkey (Türkiye)
Scientia Investigacion Clinica Sc

Chihuahua City, 31203, Mexico
Seibo International Catholic Hospital

Shinjuku-ku, Tokyo, 161-8521, Japan
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Shirasaki Dermatology Clinic

Takaoka-shi, Toyama, 933-0871, Japan
Showa University Hospital

Shinagawa-ku, Tokyo, 142-8666, Japan
Showa University Northern Yokohama Hospital

Yokohama, Kanagawa, 224-8503, Japan
Sienna Dermatology Research

Missouri City, Texas, 77459, United States
Sinclair Dermatology

East Melbourne, Victoria, 3002, Australia
Skin Cancer and Dermatology Institute

Reno, Nevada, 89509, United States
Skin Health Institute

Carlton, Victoria, 3053, Australia
Sneeze, Wheeze, and Itch Associates, LLC

Normal, Illinois, 61761, United States
Somerset Skin Centre

Troy, Michigan, 48084, United States
Soon Chun Hyang University Bucheon Hospital

Bucheon-si, Gyeonggi-do, 14584, South Korea
Southampton General Hospital

Southampton, SO16 6YD, United Kingdom
Spitalul Clinic Colentina

Bucharest, 020125, Romania
St George Dermatology and Skin Cancer Centre

Darlinghurst, New South Wales, 2010, Australia
St Marianna University Hospital

Kawasaki-shi, Kanagawa, 216-8511, Japan
Sugamo Kobayashi Derma Clinic

Toshima-ku, Tokyo, 170-0002, Japan
Terveystalo Tampere

Tampere, 33100, Finland
Texas Dermatology and Laser Specialists

San Antonio, Texas, 78218, United States
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The Catholic Univ of Korea Seoul St Marys Hospital

Seoul, 06591, South Korea
The Catholic University of Korea Incheon St Marys Hospital

Incheon, 21431, South Korea
The Centre for Clinical Trials Inc

Oakville, Ontario, L6J 7W5, Canada
The Centre for Dermatology

Richmond Hill, Ontario, L4B 1A5, Canada
The Ohio State University Dermatology East

Gahanna, Ohio, 43230, United States
The Royal Melbourne Hospital

Parkville, Victoria, 3050, Australia
The South Bend Clinic LLP

South Bend, Indiana, 46617, United States
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
US Dermatology Partners Cedar Park

Cedar Park, Texas, 78613, United States
Universitaetsklinikum Muenster

Münster, 48149, Germany
Universitaetsklinikum Schleswig-Holstein

Kiel, 24105, Germany
University of California at San Francisco, Dermatology Clinic at Mount Zion

San Francisco, California, 94115, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of South Florida Health Morsani Center for Advanced Healthcare

Tampa, Florida, 33612, United States
University of Utah MidValley Dermatology

Murray, Utah, 84107, United States
Uniwersyteckie Centrum Kliniczne

Gdansk, 80-214, Poland
Velocity Clinical Research

Leipzig, 04103, Germany
Velocity Clinical Research - Denver

Denver, Colorado, 80209, United States
Velocity Clinical Research - Grants Pass

Grants Pass, Oregon, 97527, United States
Velocity Clinical Research - North Hollywood

North Hollywood, California, 91606, United States
Velocity Clinical Research - San Diego

La Mesa, California, 91942, United States
Velocity Clinical Research Chula Vista

Chula Vista, California, 91911, United States
Weiss Medical

Riverdale, New Jersey, 07457, United States
Wendy Sadoff MD Dermatology PC

Farmington Hills, Michigan, 48334, United States
West Coast Research LLC

Dublin, California, 94568, United States
XLR8 Medical Research, Incorporated

Windsor, Ontario, N8T 1E6, Canada
Zenos Clinical Research, LLC

Dallas, Texas, 75230, United States