Could a quicker infusion tame tough gout?

NCT ID NCT04511702

Completed Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving the gout drug pegloticase over a shorter time is safe and works well for people with uncontrolled gout. About 191 adults with hard-to-treat gout received methotrexate before and during pegloticase infusions for up to 24 weeks. The main goal was to see how many had infusion reactions, and a key measure was whether uric acid levels stayed low.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pegloticase with methotrexate
What this could lead to: If successful, this could make pegloticase infusions faster and more convenient for people with uncontrolled gout.
What could go wrong: This is a completed Phase 4 study, but results may not apply to all patients. Shorter infusions might still cause infusion reactions or anaphylaxis.

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Conditions

The condition(s) this trial relates to.

gout

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC UNCONTROLLED GOUT GOUT UNCONTROLLED GOUT

Contacts and locations

Locations

Abigail Rebecca Neiman, MD, PA

Houston, Texas, 77024, United States
Altoona Center for Clinical Research

Duncansville, Pennsylvania, 16635, United States
Amicis Research Center

Northridge, California, 91324, United States
Arizona Arthritis & Rheumatology Research

Gilbert, Arizona, 85297, United States
Arizona Arthritis & Rheumatology Research

Phoenix, Arizona, 85037, United States
Arthritis & Rheumatology Research

Mesa, Arizona, 85210, United States
Arthritis Northwest

Spokane, Washington, 99204, United States
Bradenton Research Center

Bradenton, Florida, 34205, United States
Cape Fear Arthritis Care

Leland, North Carolina, 28451, United States
Chattanooga Research & Medicine PLLC (CHARM)

Chattanooga, Tennessee, 37404, United States
ClinPro Research Solutions

Tampa, Florida, 33609, United States
D&H National Research Centers

Miami, Florida, 33155, United States
D&H Tamarac Research Centers

Tamarac, Florida, 33321, United States
Denver Arthritis Clinic

Denver, Colorado, 80230, United States
ForCare Clinical Research

Tampa, Florida, 33613, United States
GCP Clinical Research

Tampa, Florida, 33064, United States
IRIS Research and Development, LLC

Plantation, Florida, 33324, United States
LIFE Clinical Trials

Margate, Florida, 33063, United States
Long Island Arthritis & Osteoporosis Care

Babylon, New York, 11702, United States
MD Medical Research

Oxon Hill, Maryland, 20745, United States
MedPharmics, LLC

Metairie, Louisiana, 70006, United States
Medvin Clinical Research

Covina, California, 91722, United States
Medvin Clinical Research

Thousand Oaks, California, 91360, United States
Medvin Clinical Research

Tujunga, California, 91042, United States
Napa Research Center

Pompano Beach, Florida, 33064, United States
Orthopedic Physicians Alaska

Anchorage, Alaska, 99508, United States
PMG Research of Hickory, LLC

Hickory, North Carolina, 28602, United States
PMG Research of Salisbury, LLC

Salisbury, North Carolina, 28144, United States
Pioneer Research Solutions Inc - Houston

Houston, Texas, 77099, United States
Prohealth Research Center

Doral, Florida, 33166, United States
Providence Saint John's Health Center

Santa Monica, California, 90404, United States
Research Carolina Elite

Denver, North Carolina, 28037, United States
Santa Fe Rheumatology

Santa Fe, New Mexico, 87505, United States
Shelby Clinical Research, LLC

Shelby, North Carolina, 28150, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Colorado Division of Rheumatology

Aurora, Colorado, 80045, United States
Velocity Clinical Research Cincinnati

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research, Salt Lake City

West Jordan, Utah, 84088, United States
Western Washington Medical Group

Bothell, Washington, 98021, United States

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