Gout

This phase 3 trial tests whether a subcutaneous (under-the-skin) injection of pegloticase works as well as the standard intravenous (IV) infusion for people with uncontrolled gout. About 270 adults will receive either the shot or the IV, both with weekly methotrexate. The goal is…

This study tests whether a tart cherry citrate tablet can lower uric acid levels in people who have high uric acid but no gout symptoms. About 196 adults will take either the active tablet or a placebo twice daily for 24 weeks, along with lifestyle advice. The main goal is to see…

This study tests a new medicine called PRX-115, given through a vein, to see if it can lower uric acid levels in adults with gout who haven't improved with standard pills. About 150 participants will receive either PRX-115 (with or without methotrexate) or a placebo over 24 weeks…

This study tests a new drug called dotinurad in 90 adults with gout who cannot take common medications like allopurinol or have not responded to other treatments. The goal is to see if dotinurad can safely lower uric acid levels over 24 weeks. Participants are randomly assigned t…

This study looks at whether giving gout medication (febuxostat) right after an attack is better than waiting 6 weeks, which is the current standard. About 128 people with gout will be split into two groups to compare how many days they have gout symptoms. The goal is to see if ea…

This study tests a new medicine called dotinurad against the standard drug allopurinol for lowering uric acid in adults with gout. About 500 people who have had at least two gout flares in the past year will take either dotinurad or allopurinol for 24 weeks. The main goal is to s…

This study tests whether empagliflozin (Jardiance), a drug used for diabetes, can lower uric acid levels and reduce inflammation in people with gout. Sixty adults with gout and high uric acid will take either the drug or a placebo daily for 12 weeks. Researchers will measure chan…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests a new medicine called dotinurad against the standard drug allopurinol in 250 adults with tophaceous gout (gout with hard lumps under the skin). The main goal is to see if dotinurad lowers uric acid levels better after 24 weeks. Researchers will also check if toph…

This study looks at whether people with well-controlled gout (for at least 5 years) can safely reduce or stop their daily febuxostat. Fifty-nine adults will be split into three groups: one that lowers the dose, one that stops for 6 months then restarts a lower dose, and one that …

This early-stage study is testing whether a new investigational drug called ABP-671 can be safely taken together with the standard gout medication allopurinol. Twenty adults with gout who are already on a stable dose of allopurinol will take the drugs alone and together over thre…

This study compares two ways of managing gout: a supported self-management approach where patients monitor their own urate levels with a finger-prick test and adjust medication via a smartphone app, versus usual care where a doctor manages treatment. The goal is to see if the sel…

This study tests whether adding a new drug (SHR4640) to a standard gout medication (febuxostat) works better than just increasing the dose of febuxostat alone. About 340 adults with gout and high uric acid who are not well-controlled on 40 mg of febuxostat will take either the co…

This study is testing whether taking probiotics (with or without extra fiber) every day for 6 weeks can lower uric acid levels in people with hyperuricemia. Researchers will enroll 99 adults with high uric acid and compare the probiotic groups to a placebo. They also aim to figur…

This Phase 3 trial tests whether a new drug, tigulixostat, is better than the standard gout medication febuxostat at lowering uric acid levels in Chinese adults with gout. About 600 participants will take one of the two drugs for 24 weeks, then switch to tigulixostat for another …

This study tests a new program to help people with gout get the follow-up care they need after an emergency room visit for a flare-up. The goal is to improve both short-term treatment and long-term management of gout. The study will enroll 200 adults and also aims to increase par…

This early-stage study tests a new injectable drug called peguricase, given together with methotrexate, in 36 adults with gout that standard treatments cannot control. The main goals are to check safety, how the drug moves through the body, and whether it helps lower uric acid. P…

This study tests whether dotinurad is better than febuxostat at improving blood vessel stiffness in 360 adults with high uric acid and high blood pressure. Participants will take one of the two drugs for 24 weeks. The goal is to see which drug better controls uric acid and suppor…

This study is testing two common ways to manage gout: one that aims to lower uric acid levels to a specific target, and another that treats flare symptoms as they happen. Researchers will track 650 adults with gout over two years to see which approach leads to fewer gout attacks …

This Danish trial tests whether nurse-led telehealth support helps people with gout stick to their urate-lowering medication and maintain healthy uric acid levels. 200 adults who have already reached target levels will be randomly assigned to either usual care or a support progra…

This study is testing a new blood-based test that aims to predict which medication will work best for each person with rheumatic diseases like rheumatoid arthritis or lupus. Researchers will take a blood sample and analyze immune cells to create a personalized treatment profile. …

This study is testing a smartphone app called 'MinUrinsyregikt' to help people with gout manage their condition. The app provides information, tracks gout flares, urate levels, and medication reminders. Fifty adults with gout will use the app for 3 months to see if it is practica…

This Phase 2 trial tests punarlimab, a new IV drug, against a standard steroid injection for quick relief of acute gouty arthritis pain. About 170 adults with frequent gout flares will receive a single dose and report their pain levels over 72 hours. The goal is to see if punarli…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests whether dapansutrile tablets can reduce joint pain from an acute gout flare better than a placebo. About 300 adults with confirmed gout will take the drug or a dummy pill for 7 days. The main goal is to see if pain drops significantly within 72 hours of the first…

This study tests whether a single injection of Purified Cortrophin Gel can safely reduce pain from an acute gout flare. About 150 adults with gout will receive either a 40-unit or 80-unit dose and report their pain levels over the next week. The goal is to find the best dose for …

This Phase 2 trial tests an experimental drug called ABP-745 against colchicine (a standard gout medicine) and a placebo in 380 adults with acute gout flares. The goal is to see if ABP-745 reduces pain and swelling better than current options. Participants will take tablets and r…

This study tests whether taking krill oil supplements for 12 weeks can improve muscle strength and function in adults with long-term conditions like diabetes, heart disease, or arthritis. Thirty participants will be randomly assigned to receive either krill oil or a placebo. Rese…

This study looks at children with suspected or confirmed genetic and metabolic disorders to find new disease-causing gene mutations. Researchers will analyze blood samples for DNA and metabolites, and in some cases take a small skin sample. The goal is to better understand these …

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study follows 450 adults with gout, CPPD (a crystal-related joint disease), or osteoarthritis to see how crystal deposits in joints and blood vessels change over time. Participants receive routine care and undergo ultrasound and lab tests every six months for up to 10 years.…

This study follows 250 adults with gout to see how long it takes for urate crystals in the joints to dissolve when uric acid levels are kept below 40 mg/L. Participants will have regular ultrasounds of their feet and knees to track crystal disappearance. The goal is to identify f…

This study uses MRI scans to look for brain differences in people with metabolic diseases compared to healthy volunteers. Researchers will track changes over time and link them to body fat and other health measures. About 126 adults will take part at Ulm University Hospital. No d…

This study looks at the genes of 2,750 people in French Polynesia to find out why gout, inflammation, and metabolic diseases like diabetes are common there. Participants must be of Polynesian ancestry and either have gout or be part of the general population. The goal is to disco…

The SMILE study is tracking 10,000 adults aged 18 and older to see how sarcopenia (age-related muscle loss) and metabolic diseases like diabetes influence overall health and lifespan. Researchers will collect data from medical records, tests, and surveys over time. This is an obs…

This study follows 100 children under 18 who are already on a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life. The die…