New hope for gout sufferers: drug dotinurad targets high uric acid

NCT ID NCT07535034

Recruiting now Disease control Sponsor: Crystalys Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests a new drug called dotinurad in 90 adults with gout who cannot take common medications like allopurinol or have not responded to other treatments. The goal is to see if dotinurad can safely lower uric acid levels over 24 weeks. Participants are randomly assigned to receive either the drug or a placebo, and neither they nor their doctors will know which they receive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dotinurad (a drug taken orally to lower uric acid levels)
What this could lead to: If successful, dotinurad could offer a new treatment option for people with gout who cannot tolerate standard medications or for whom other treatments have failed.
What could go wrong: This is an early Phase 2 trial with only 90 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

gout

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GOUT

Contacts and locations

Locations

Amicis Research Center
RECRUITING

Granada Hills, California, 91344, United States
Anchor Medical Research
RECRUITING

Miami, Florida, 33176, United States
Clinical Research Institute of Michigan
RECRUITING

Saint Clair Shores, Michigan, 48081, United States
Clinical Research of Central Florida
RECRUITING

Lakeland, Florida, 33805, United States
Cohen Medical Center
RECRUITING

Thousand Oaks, California, 91360, United States
D&H Pompano Research Center, LLC
RECRUITING

Margate, Florida, 33063, United States
DM Clinical Research
RECRUITING

Tomball, Texas, 77375, United States
Denver Arthritis Clinic - Lowry
RECRUITING

Denver, Colorado, 80230, United States
Digestive Health Research of North Texas
RECRUITING

Wichita Falls, Texas, 76301, United States
Discovery Clinical Trials, LLC
RECRUITING

San Antonio, Texas, 78229, United States
Drug Trials America
RECRUITING

Hartsdale, New York, 10530, United States
Ellipsis Research Group
RECRUITING

Brooklyn, New York, 11215, United States
Epic Medical Research
RECRUITING

DeSoto, Texas, 75115, United States
Health Awareness, Inc.
RECRUITING

Jupiter, Florida, 33458, United States
Herco Medical and Research Center, Inc
RECRUITING

Flagami, Florida, 33126, United States
Hometown Urgent Care and Research
RECRUITING

Dayton, Ohio, 45424, United States
Las Vegas Clinical Trials
RECRUITING

Las Vegas, Nevada, 89030, United States
MD Medical Research
RECRUITING

Oxon Hill, Maryland, 20745, United States
New Generation of Medical Research
RECRUITING

Hialeah, Florida, 33016, United States
Omega Research Group
RECRUITING

DeBary, Florida, 32713, United States
Panax Clinical Research
RECRUITING

Miami, Florida, 33014, United States
Pioneer Research Solutions
RECRUITING

Houston, Texas, 77479, United States
Premier Health Research
RECRUITING

Sparta, New Jersey, 07871, United States
R&H Clinical Research - Westborough Drive
RECRUITING

Katy, Texas, 77449, United States
Revival Research Institute
RECRUITING

Sterling Heights, Michigan, 48313, United States
Shelby Clinical Research
RECRUITING

Shelby, North Carolina, 28150, United States
Solace Clinical Research
RECRUITING

Tustin, California, 92780, United States
Southwest Rheumatology Research
RECRUITING

Mesquite, Texas, 75150, United States
Zenos Clinical Research
RECRUITING

Dallas, Texas, 75230, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.