GOUT

This study compares two ways of starting the gout medication febuxostat: right after an attack versus waiting 6 weeks. Gout is a painful joint condition caused by high uric acid. The goal is to see if early treatment reduces the number of gout flare days. About 128 adults with a …

This study looks at whether people with gout who have kept their uric acid levels low for at least 5 years can safely take a lower dose or even stop their medication without symptoms coming back. About 59 adults will be split into three groups: one that reduces their febuxostat d…

This study tests a new drug, tigulixostat, against the standard gout medication febuxostat in 600 Chinese adults with gout. The main goal is to see if tigulixostat can lower uric acid levels more effectively at 24 weeks. Researchers will also monitor gout attacks, kidney function…

This study tests a new medicine called dotinurad to see if it lowers uric acid better than the standard drug allopurinol in adults with gout. About 500 people with frequent gout flares will take either dotinurad or allopurinol for 24 weeks. The main goal is to see how many reach …

This early-stage trial tests a new drug called peguricase, given with methotrexate, in 36 adults with gout that standard treatments can't control. The goal is to check safety, how the body processes the drug, and initial signs of effectiveness. Participants must be 18-70 years ol…

This study tracks 250 adults with gout to see how quickly urate crystals in joints dissolve when uric acid levels are kept very low (below 40 mg/L). Participants will get regular ultrasound scans of their feet and knees until crystals are gone. The goal is to find out what factor…

This study tests two common gout treatment strategies in 650 adults: one that aims to lower urate levels to a target, and another that treats symptoms as they occur. The goal is to see which approach better reduces gout flares and improves overall health over two years. Participa…

This study tests a new drug called AR882 combined with a standard gout medication (XOI) in 25 adults with uncontrolled gout who had severe reactions or failed uricase therapy. The goal is to lower uric acid levels below 6 mg/dL and shrink painful uric acid crystal deposits (tophi…

This study tests a new medicine called PRX-115, given through a vein, to see if it can safely lower uric acid levels in adults with gout who haven't been helped by standard pills. About 150 people will receive either PRX-115 (with or without methotrexate) or a placebo over 24 wee…

This study tests a new way for people with gout to manage their condition. Participants will either use a smartphone app to check their own urate levels and adjust medication, or receive standard care. The goal is to see if this self-monitoring approach reduces painful gout flare…

This study tests a program to help people with gout get the follow-up care they need after an emergency room visit for a flare-up. The goal is to improve both short-term treatment and long-term management of gout. The study will enroll 200 adults who had a confirmed gout flare in…

This study tests whether a tablet called dapansutrile can safely reduce joint pain during an acute gout flare. About 300 adults with gout will receive either the study drug or a placebo. The main goal is to measure pain relief 72 hours after the first dose.

This study looks at how three different levels of physical activity (45, 90, or 150 minutes per week) affect arthritis symptoms like pain and physical function. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. …

This study tests two different doses of a gel called Purified Cortrophin Gel to see how well it eases pain from sudden gout attacks. About 150 adults with gout will get one injection and be followed for a week. The goal is to find out if the gel can quickly reduce joint pain and …

This study looks at how a new drug, ABP-671, interacts with the standard gout medication allopurinol. About 20 adults with gout who are already taking allopurinol will receive ABP-671 as well. Researchers will measure drug levels in the blood to see if there are any interactions,…

This study is testing whether a smartphone app called 'MinUrinsyregikt' can help people with gout manage their condition. Fifty adults with gout will use the app for three months to track their uric acid levels. The goal is to see if the app is easy to use and if a larger study i…

This study follows 450 adults with gout, calcium pyrophosphate deposition disease (CPPD), or osteoarthritis over up to 10 years. Researchers use regular ultrasounds and blood tests to see how crystal deposits in joints change over time and whether they are linked to heart problem…