GOUT

This study tests a new medicine called PRX-115, given through a vein, to see if it can lower uric acid levels in adults with gout who haven't improved with standard pills. About 150 participants will receive either PRX-115 (with or without methotrexate) or a placebo over 24 weeks…

This study tests a new drug called dotinurad in 90 adults with gout who cannot take common medications like allopurinol or have not responded to other treatments. The goal is to see if dotinurad can safely lower uric acid levels over 24 weeks. Participants are randomly assigned t…

This study looks at whether giving gout medication (febuxostat) right after an attack is better than waiting 6 weeks, which is the current standard. About 128 people with gout will be split into two groups to compare how many days they have gout symptoms. The goal is to see if ea…

This study tests a new medicine called dotinurad against the standard drug allopurinol for lowering uric acid in adults with gout. About 500 people who have had at least two gout flares in the past year will take either dotinurad or allopurinol for 24 weeks. The main goal is to s…

This study looks at whether people with well-controlled gout (for at least 5 years) can safely reduce or stop their daily febuxostat. Fifty-nine adults will be split into three groups: one that lowers the dose, one that stops for 6 months then restarts a lower dose, and one that …

This early-stage study is testing whether a new investigational drug called ABP-671 can be safely taken together with the standard gout medication allopurinol. Twenty adults with gout who are already on a stable dose of allopurinol will take the drugs alone and together over thre…

This study compares two ways of managing gout: a supported self-management approach where patients monitor their own urate levels with a finger-prick test and adjust medication via a smartphone app, versus usual care where a doctor manages treatment. The goal is to see if the sel…

This Phase 3 trial tests whether a new drug, tigulixostat, is better than the standard gout medication febuxostat at lowering uric acid levels in Chinese adults with gout. About 600 participants will take one of the two drugs for 24 weeks, then switch to tigulixostat for another …

This study tests a new program to help people with gout get the follow-up care they need after an emergency room visit for a flare-up. The goal is to improve both short-term treatment and long-term management of gout. The study will enroll 200 adults and also aims to increase par…

This early-stage study tests a new injectable drug called peguricase, given together with methotrexate, in 36 adults with gout that standard treatments cannot control. The main goals are to check safety, how the drug moves through the body, and whether it helps lower uric acid. P…

This study is testing two common ways to manage gout: one that aims to lower uric acid levels to a specific target, and another that treats flare symptoms as they happen. Researchers will track 650 adults with gout over two years to see which approach leads to fewer gout attacks …

This study is testing a smartphone app called 'MinUrinsyregikt' to help people with gout manage their condition. The app provides information, tracks gout flares, urate levels, and medication reminders. Fifty adults with gout will use the app for 3 months to see if it is practica…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests whether dapansutrile tablets can reduce joint pain from an acute gout flare better than a placebo. About 300 adults with confirmed gout will take the drug or a dummy pill for 7 days. The main goal is to see if pain drops significantly within 72 hours of the first…

This study tests whether a single injection of Purified Cortrophin Gel can safely reduce pain from an acute gout flare. About 150 adults with gout will receive either a 40-unit or 80-unit dose and report their pain levels over the next week. The goal is to find the best dose for …

This study tests whether taking krill oil supplements for 12 weeks can improve muscle strength and function in adults with long-term conditions like diabetes, heart disease, or arthritis. Thirty participants will be randomly assigned to receive either krill oil or a placebo. Rese…

This study follows 450 adults with gout, CPPD (a crystal-related joint disease), or osteoarthritis to see how crystal deposits in joints and blood vessels change over time. Participants receive routine care and undergo ultrasound and lab tests every six months for up to 10 years.…

This study follows 250 adults with gout to see how long it takes for urate crystals in the joints to dissolve when uric acid levels are kept below 40 mg/L. Participants will have regular ultrasounds of their feet and knees to track crystal disappearance. The goal is to identify f…