GOUT

This is an early-stage study to check the safety and find the right dose of a new injectable drug called peguricase, given alongside methotrexate, for people with gout. It is for adults whose gout and high uric acid levels are not controlled by standard oral medications. The main…

This study is testing whether starting a long-term gout medication called febuxostat immediately after a painful flare-up works as well as the current standard of waiting 6 weeks. It involves 128 adults in France who are having a gout attack. The goal is to see if early treatment…

This study aims to see if a new drug called Tigulixostat works as well or better than the standard drug Febuxostat at lowering uric acid levels in people with gout. About 600 Chinese adults with gout will take one of these drugs for 52 weeks while researchers track their uric aci…

This study is testing whether a new medication called PRX-115, given through an IV drip, can help control gout in people who haven't responded well to standard pills. About 150 adults with gout will receive either the actual drug or a placebo (inactive solution) over 24 weeks, wi…

This study is testing a new combination of medications (AR882 with a standard drug) for people with severe, uncontrolled gout. It's specifically for those whose gout did not improve or who had bad reactions to a previous strong treatment called uricase. The main goals are to see …

This study tests a follow-up program for people who visit the emergency room for painful gout attacks. Researchers will use patient navigators—trained community members—to help patients schedule doctor appointments and manage their gout better. The goal is to improve long-term ca…

This study aims to find out how long it takes for urate crystals, which cause painful gout flare-ups, to completely dissolve in the joints. Researchers will enroll 250 adults with newly diagnosed gout and use medication to aggressively lower their uric acid levels. They will trac…

This study aims to find the best long-term strategy for managing gout by comparing two common approaches. It will follow 650 adults with gout for two years to see which method better prevents painful flare-ups and improves quality of life. The trial focuses on practical care that…

This study is testing whether a new medication called dotinurad works better than the standard drug allopurinol at lowering uric acid levels in people with gout. It will involve about 500 adults who have had multiple gout flares and are already taking allopurinol. Researchers wil…

This study is testing two different doses of an injected medication called Cortrophin Gel to see how well and how quickly it can relieve the intense pain of a sudden gout attack. It is for adults who have just started a gout flare and cannot take common gout medicines like NSAIDs…

This study is testing whether an experimental pill called dapansutrile can safely reduce the severe pain and swelling of a sudden gout attack. About 300 adults currently experiencing a gout flare-up will take either the study drug or a placebo pill twice a day for one week. Resea…

This study aims to understand how crystal deposits from gout and CPPD diseases build up in joints and blood vessels over a very long time. Researchers will follow 450 patients for up to 10 years, using regular check-ups and scans to see how the deposits change and if they are lin…