GOUT

This study looked at whether giving the gout medication pegloticase over a shorter time is safe and works well for people with uncontrolled gout who are also taking methotrexate. About 191 adults took part. The main goal was to check for infusion reactions, and a key measure was …

This study tested a new drug called LC350189 in 156 adults with gout and high uric acid. The goal was to see if it could safely lower uric acid levels over 12 weeks. Participants received one of three doses of the drug, a placebo, or an active comparator. The main measure was the…

This phase 3 study tested a new drug called epaminurad against the standard gout medication febuxostat in 612 adults with gout. The goal was to see which drug better lowers uric acid levels below 6 mg/dL over time. Participants took either epaminurad or febuxostat, and researcher…

This study tested a new medicine called AR882 in 818 adults with gout. The goal was to see if it could lower uric acid levels below a target of 6 mg/dL over 6 to 12 months. Participants took either a low dose, a high dose, or a placebo pill. The results will show if AR882 is safe…

This early-stage trial tested a new medicine called HEC93077 in 126 healthy Chinese volunteers and people with high uric acid (gout). The main goals were to check safety, how the drug moves through the body, and how it affects uric acid levels. Participants received either the dr…

This study tested a new medicine called tigulixostat in 354 adults with gout and high uric acid levels. The goal was to see if taking the drug for 6 months could safely lower uric acid below a target level. Participants received either one of three doses of tigulixostat or a plac…

This study tested a new drug called ABP-671 in 300 adults with gout. The goal was to see if it could safely lower uric acid levels in the blood. Participants received either ABP-671, a placebo (dummy pill), or the standard gout drug allopurinol. The main measure of success was th…

This study tested whether a gout medication called pegloticase can be given every 4 weeks instead of every 2 weeks, while still controlling uric acid levels. About 262 adults with hard-to-treat gout took part. The goal was to see if the longer interval works just as well when com…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, or lupus. Participants were followed for up to one year to see if the program helped reduce pain and improve physical function like walking and chair stands. T…

This study looked at 60 adults with gout who were starting medication to lower uric acid. Researchers compared two types of imaging—ultrasound and a special CT scan—to see how well they measure changes in urate crystal deposits over 6, 12, and 24 months. The goal was to understan…

This study tested a new skin patch that measures uric acid levels in people with gout. Six participants wore the patch for a week and after a meal to see if it was comfortable and accurate. The goal is to make monitoring gout easier without blood draws.

This study looked at 33 Polynesian adults with gout and their family members to find genetic factors that increase gout risk. Researchers compared the genes of gout patients with healthy relatives to identify variants linked to the disease. The goal is to better understand why go…

This study followed over 18,000 Taiwanese adults to see if a vegetarian diet is linked to lower rates of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers used health insurance records to trac…

This study looked at how often nursing home residents over 65 have joint complaints like pain or swelling. Researchers examined 100 residents, some with dementia and some without, to count tender or swollen joints. The goal was to better understand these issues in a group that is…

This study aimed to find out how common gout is in French Polynesia and what genetic factors might be involved. Over 1,000 adults from several islands took part. Researchers measured gout rates and analyzed DNA to look for genetic variants linked to the disease. The goal was to b…

This study looked at medical records from nearly 295,000 older adults with gout to see if two different medications—probenecid and allopurinol—affect the risk of developing dementia or Alzheimer's disease. The goal was to find out if one drug might be better at protecting the bra…

This study looked at 50,000 living kidney donors in Canada to see if they develop gout more often than similar people who did not donate a kidney. Researchers used health records to track gout diagnoses and related medications over many years. The goal is to help doctors and pote…

This study aims to find the genetic causes of a rare, inherited kidney disease called HTIN. Researchers will study 225 adults with the condition and their families to look for specific gene mutations. The goal is to better understand the disease, not to test a new treatment.