New gout pill aims to stop flare pain in 3 days

NCT ID NCT05658575

Recruiting now Symptom relief Sponsor: Olatec Therapeutics LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether dapansutrile tablets can reduce joint pain from an acute gout flare better than a placebo. About 300 adults with confirmed gout will take the drug or a dummy pill for 7 days. The main goal is to see if pain drops significantly within 72 hours of the first dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dapansutrile (also called OLT1177) tablets
What this could lead to: If it works, this could provide a new, non-steroid option to quickly ease severe gout flare pain.
What could go wrong: This is an early-to-mid stage trial with only 300 participants. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arthralgia arthritic joint disease Arthritis, Gouty gout Hyperuricemia Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE GOUT FLARE ARTHRITIS GOUT GOUT ATTACK GOUT FLARE GOUTY ARTHRITIS JOINT PAIN

Contacts and locations

Locations

Advanced Quality Medical Research
RECRUITING

Orland Park, Illinois, 60462, United States
Altoona Research
WITHDRAWN

Duncansville, Pennsylvania, 16635, United States
Amarillo Center of Clinical Research
RECRUITING

Amarillo, Texas, 79124, United States
American Institute of Research
WITHDRAWN

Los Angeles, California, 90017, United States
Arizona Arthritis & Rheumatology Associates (AARA), P.C. - Mesa
RECRUITING

Mesa, Arizona, 85210, United States
Arizona Arthritis & Rheumatology Associates - Glendale
RECRUITING

Glendale, Arizona, 85306, United States
Arthritis Center of North Georgia - Gainesville
RECRUITING

Gainesville, Georgia, 30501, United States
Arthritis Northwest
RECRUITING

Spokane, Washington, 99204, United States
CHU de Rouen - Hôpital Charles-Nicolle
RECRUITING

Rouen, France
Carmel Medical Center
RECRUITING

Haifa, 3436212, Israel
Centre Hospitalier Universitaire de Bordeaux - Hôpital Pellegrin
RECRUITING

Bordeaux, 33076, France
Clinical Research of West Florida
RECRUITING

Tampa, Florida, 33765, United States
Clinical Trial Site
WITHDRAWN

Bothell, Washington, 98021, United States
Emek Medical Center
RECRUITING

Afula, Israel
Great Lakes Clinical Trials
WITHDRAWN

Chicago, Illinois, 60640, United States
Hillcrest Medical Research
RECRUITING

DeLand, Florida, 32720, United States
Hospital Universitario Infanta Leonor
RECRUITING

Madrid, 28031, Spain
Hospital Universitario de La Princesa
RECRUITING

Madrid, 28006, Spain
Hospital Universitario san Juan de Alicante
WITHDRAWN

Alicante, 03010, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08025, Spain
Hôpital Lariboisière
RECRUITING

Paris, France
Hôpital Saint Philibert
RECRUITING

Lomme, 59462, France
IMA Clinical Research - Manhattan
WITHDRAWN

New York, New York, 10036, United States
Lower Country Rheumatology - Summerville
RECRUITING

Summerville, South Carolina, 29486, United States
Maastricht Universitair Medisch Centrum
RECRUITING

Maastricht, 6229 HX, Netherlands
Montana Medical Research
RECRUITING

Missoula, Montana, 59808, United States
NYU Langone
ACTIVE_NOT_RECRUITING

New York, New York, 10016, United States
Rabin Medical Center - Beilinson and Hasharon
RECRUITING

Petah Tikva, 49100, Israel
Reade Research BV
RECRUITING

Amsterdam, Netherlands
SIMEDHealth
RECRUITING

Gainesville, Florida, 32607,, United States
The Chaim Sheba Medical Center
RECRUITING

Ramat Gan, 5266202, Israel
The Research Group of Lexington
ACTIVE_NOT_RECRUITING

Lexington, Kentucky, 40503, United States
TriWest Research Associates
RECRUITING

San Diego, California, 92108, United States
University of Alabama at Birmingham
WITHDRAWN

Birmingham, Alabama, 35294, United States
University of Florida Health Jacksonville
RECRUITING

Jacksonville, Florida, 32256, United States
University of Michigan
WITHDRAWN

Ann Arbor, Michigan, 48109, United States
Utah Health - University of Utah Hospital
RECRUITING

Salt Lake City, Utah, 84108, United States
Valiance Clinical Research - Tarzana
RECRUITING

Tarzana, California, 91356, United States
VieCuri Medisch Centrum
RECRUITING

Venlo, Netherlands
Well Pharma Medical Research
RECRUITING

Miami, Florida, 33173, United States

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