Could a daily supplement ease joint pain, fatigue, and sleep troubles in middle age?

NCT ID NCT07729930

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether a combination of dietary supplements, including creatine monohydrate, can improve common health complaints in healthy women aged 35 to 65. Over 8 weeks, participants take either the supplements or a placebo, and researchers measure changes in joint pain, fatigue, sleep quality, body composition, strength, and inflammation. The goal is to see if a simple supplement routine can help manage the physical and mental changes that often come with middle age.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
creatine monohydrate (a dietary supplement)
What this could lead to
If it works, this could point to a simple supplement routine that helps middle-aged women manage common age-related complaints like joint pain, fatigue, and sleep troubles.
What could go wrong
This is a small, early-stage trial with only 38 participants, so results may not apply broadly. Supplements can also cause digestive upset or other side effects.

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Conditions

The condition(s) this trial relates to.

Arthralgia Fatigue sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Loughborough University

    RECRUITING

    Loughborough, LE11 3TU, United Kingdom

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