Sleep disorder

This study investigates whether two medications—acetazolamide and eszopiclone—can improve sleep apnea outcomes when taken after soft palate surgery. The trial includes adults with moderate to severe obstructive sleep apnea who cannot use CPAP or oral appliances. Researchers will …

This study investigates whether oxygen and the drug acetazolamide can help stabilize breathing during sleep in people who take prescription opioids and have sleep apnea. Researchers will measure breathing patterns and sleep quality in 150 veterans. The goal is to find new ways to…

This study tests whether HBS-301 (pitolisant) can reduce excessive daytime sleepiness and cataplexy (sudden muscle weakness) in adults with narcolepsy. Participants receive either the drug or a placebo for several weeks, followed by an open-label phase where everyone gets the dru…

This study looks at the long-term safety and tolerability of the drug TAK-360 in people with narcolepsy (type 1 or 2) or idiopathic hypersomnia — conditions that cause severe daytime sleepiness. Participants who completed a previous TAK-360 study can join and will continue taking…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Partic…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a CPAP machine. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Par…

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This phase 3 trial tests a weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The study looks at whether the drug can improve sleep apnea symptoms and help with weight loss. Participants are …

This study is testing a device called the Genio® System for people with moderate to severe obstructive sleep apnea who cannot use CPAP machines. The device is implanted and stimulates the tongue to keep the airway open during sleep. Researchers will track how well it reduces brea…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study tests a new medicine, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and already use a CPAP machine. The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss over 52 weeks. About 250…

This phase 3 trial tests whether maridebart cafraglutide, a drug that may help with weight loss, can reduce sleep apnea episodes in 250 adults who are overweight or obese and not using a breathing machine. Participants receive either the drug or a placebo for 52 weeks. The main g…

This early-stage study tests a new drug called VX-433 in 118 people with narcolepsy type 1. The main goal is to check if it is safe and how the body processes it. Researchers will also see how VX-433 interacts with other drugs like midazolam and bupropion. This is a first step to…

This study tests whether a non-invasive ventilator (NIV) or a CPAP machine is better at preventing severe COPD flare-ups and death in people who also have sleep apnea. About 386 adults who recently survived a life-threatening breathing crisis will use one of the two machines at h…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests whether a behavioral sleep intervention combined with the drug varenicline can help heavy smokers quit. Researchers will measure sleep quality, smoking habits, and brain activity in 114 participants. The goal is to see if improving sleep reduces negative emotions…

This study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the …

This study tests a culturally tailored sleep program for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The program includes three telehealth sessions teaching sleep skills and support strategies. Researchers want to see if it improves CPAP use and…

This study tests a non-surgical laser treatment for people with obstructive sleep apnea who still have breathing problems even after using a dental mouthpiece. The laser aims to stiffen the soft palate and tongue to keep the airway open during sleep. Researchers will enroll 528 a…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This study compares two anti-rejection drugs in older kidney transplant recipients: a once-daily extended-release version (Envarsus XR) versus the standard twice-daily immediate-release version (Prograf). Researchers will measure changes in thinking, memory, and other cognitive s…

This study tests whether using a bright blue light device for 15-30 minutes each morning can slow the progression of idiopathic scoliosis in children aged 10-15 who are night owls. The trial will enroll 120 participants and follow them for 6 months, measuring spine curve changes …

This study tests whether removing the tonsils and adenoids can slow or stop the progression of scoliosis (curved spine) in children aged 6 to 15 who also have mild sleep-disordered breathing. Half of the 160 participants will have surgery within 4 weeks, while the other half will…

This study tests whether TAK-861 can control symptoms of narcolepsy type 1, a condition causing sudden sleep attacks and muscle weakness. About 88 adults will take TAK-861 for several months, then some will switch to a placebo to see if symptoms return. The goal is to see if the …

This study tests whether acetazolamide, a cheap and well-tolerated diuretic, can help people with obstructive sleep apnea who cannot use a CPAP mask. Sixty adults with moderate to severe sleep apnea will receive either the drug or a placebo for 4 weeks each. Researchers will meas…

This study looks at whether a structured program to find and treat obstructive sleep apnea can reduce the amount of time people with atrial fibrillation have an irregular heartbeat. About 209 adults with AF will use a home sleep test device and a Fitbit smartwatch to track their …

This study tests a new device that uses freezing (cryotherapy) to treat obstructive sleep apnea in adults who cannot use standard treatments like CPAP machines. About 25 people with moderate to severe sleep apnea will receive the procedure. The main goal is to check safety and se…

This phase 3 trial tests an injectable drug called XW003 (Ecnoglutide) in 140 obese adults with obstructive sleep apnea who do not use CPAP machines. The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants receive either the d…

This study tests whether short behavioral therapy sessions can improve sleep and reduce alcohol and cannabis use in young adults aged 18-29 who struggle with insomnia and heavy drinking or marijuana use. Researchers will enroll 800 participants in Washington State and compare tho…

This study compares two alternative treatments for moderate-to-severe obstructive sleep apnea in people who cannot use a CPAP machine: a custom mouthpiece (mandibular advancement device) and a surgically implanted nerve stimulator (hypoglossal nerve stimulation). Researchers will…

This study is a long-term follow-up for people with narcolepsy or idiopathic hypersomnia who previously took the experimental drug ORX750. Researchers want to see if the drug remains safe and effective over time. About 90 participants will take ORX750 orally and be monitored for …

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants will receive either the drug or a p…

This study tests whether a special therapy program with a mobile app helps pregnant people stay on their buprenorphine medication for opioid use disorder, compared to just logging their doses. About 37 pregnant women will be randomly assigned to either the app-based therapy or da…

This study tests whether matching sleep apnea treatment to the specific cause in each person with Down syndrome works better than a one-size-fits-all approach. 200 children and adults will receive either a combination of two drugs (ato-oxy) or oxygen therapy based on their indivi…

This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study is testing a device called Inspire, which is implanted in the body to treat obstructive sleep apnea. It is being studied in people with more severe sleep apnea (higher AHI) and higher body weight (higher BMI) who cannot use CPAP machines. The study will follow 70 parti…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This study tests whether a custom mouthpiece called EVO can safely treat severe obstructive sleep apnea. About 49 adults with severe sleep apnea will use the device, which moves the jaw forward to keep the airway open. The goal is to see if it reduces breathing pauses by at least…

This study tests a custom mouthpiece (mandibular advancement device) for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP and have not improved with a nerve stimulation implant. Researchers will measure if the device reduces breathing pauses during …

This study tests a flexible silicone tube that people insert into one nostril before sleep to keep their airway open. It's for adults with moderate to severe obstructive sleep apnea who cannot tolerate CPAP machines. Twenty participants will use the device for 30 days to see if i…

This study is checking the long-term safety of a drug called TAK-861 in 500 people with type 1 narcolepsy who have already taken it in earlier trials. Participants will continue taking TAK-861 tablets, and researchers will monitor for side effects. The goal is to see if the drug …

This study looks at whether lifestyle changes (diet and exercise) plus CPAP therapy can reduce eye pressure in people with glaucoma, sleep apnea, and obesity. Forty participants will be split into two groups: one gets CPAP alone, the other gets CPAP plus lifestyle changes. The ma…

This study tests a jaw surgery called maxillomandibular advancement for people with moderate to severe obstructive sleep apnea who cannot use standard treatments like CPAP machines. The surgery moves the jaw forward to open the airway, and researchers will track breathing, sleepi…

This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either …

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

This phase II trial is testing whether mirtazapine, an antidepressant, can improve mood, sleep, and motor symptoms in people with Rett syndrome. The study will enroll 54 females aged 5 to 40 with a confirmed MECP2 mutation. Participants will receive increasing doses of mirtazapin…

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people at high risk. Participants with REM sleep behavior disorder or early Parkinson's will wear a headband and headphones for 18 months. Researchers will track ch…

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsil and adenoid removal for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery …

This study tests a custom mouthpiece called OrthoApnea NOA for obstructive sleep apnea, a condition where breathing stops and starts during sleep. Researchers want to see if it can reduce breathing pauses by at least half, to fewer than 5 per hour. They will compare new patients …

This study aims to see if a French version of the OSA-18 questionnaire can accurately identify obstructive sleep apnea in children. Parents of children aged 4 to 17 who are already scheduled for a sleep test (polysomnography) will fill out the questionnaire. The results will be c…

This study is testing a wearable sensor that measures oxygen levels in the brain and limbs of children with and without obstructive sleep apnea (OSA). The sensor, called near-infrared spectroscopy (NIRS), is compared to standard sleep study techniques. Researchers hope it could l…

This study is testing whether simple wearable devices can accurately screen for sleep disorders in children with cerebral palsy. About 140 children aged 6 to 15 will wear the devices at home and then undergo a standard hospital sleep test. The goal is to see if the wearable metho…

This study tests whether a smartphone app called Apneal can help screen for obstructive sleep apnea in people with head and neck cancer. Sleep apnea is common but often missed in these patients, and current diagnosis requires expensive equipment. Participants use the app at home …

This study tests whether a small, single-use home monitor called Sunrise can help doctors decide how to adjust CPAP therapy for people with obstructive sleep apnea who are not getting enough benefit. About 105 adults will use the Sunrise device at home and also undergo a standard…

This study looks at whether a simple questionnaire given during a dental checkup can identify children at risk for sleep-disordered breathing (like sleep apnea). Sixty children aged 8-13 will fill out the questionnaire and then wear a home sleep monitor for one night to measure t…

This study is testing whether simple measurements like facial scans, videos of blinking and swallowing, and heart rate changes can help doctors diagnose obstructive sleep apnea (OSA). Researchers will collect this data from 800 adults who do not already have an OSA diagnosis. The…

This study looks at whether a home sleep apnea test is as accurate as the standard overnight sleep lab test for children ages 5 to 12. Researchers will compare results from both tests and see how they affect treatment choices. The goal is to find a more comfortable and convenient…

This study tests whether a combination of noninvasive sensors—listening to breathing sounds, measuring oxygen levels, and tracking body movement—can accurately estimate the severity of obstructive sleep apnea. Researchers will enroll 150 adults suspected of having sleep apnea and…

This study looks at whether a protein linked to Parkinson's disease can be found in colon tissue samples taken during a routine colonoscopy. Researchers will compare samples from people with Parkinson's, those with REM sleep behavior disorder, and healthy individuals. The goal is…

This study tests whether taking the sleep medication suvorexant (Belsomra) nightly for two years can slow the buildup of amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will enroll 200 healthy adults aged 65 and older with no signs of dementia. The go…

This study tests two simple ways to prevent bite changes in people using a mouthpiece for sleep apnea or snoring. Some participants will use a special aligner each morning to gently guide their jaw back into place, while others will do daily jaw exercises. The goal is to see whic…

This study tests whether a mindfulness-based sleep program for pregnant women with insomnia can prevent depression during and after pregnancy. Researchers will enroll 500 women and compare the program to standard care. The goal is to improve sleep and reduce the risk of perinatal…

This study tests a digital sleep platform that offers different levels of help based on how severe a person's insomnia symptoms are. Over 1,000 adults in Hong Kong with mild sleep issues will take part. The goal is to see if this stepped-care approach can prevent full-blown insom…

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent depression, anxiety, and daytime sleepiness. About 3000 students in Swedish high schools will take part, and their results will be comp…

This study tests whether an online sleep improvement program for pregnant women can reduce stress and prevent postpartum depression and anxiety. Researchers will enroll 114 women early in pregnancy and track their sleep, stress hormones, and mood for months after birth. The progr…

This study tests a new tablet called ALKS 2680 to see if it can reduce daytime sleepiness in adults with narcolepsy type 2. About 176 participants will receive either the study drug or a placebo for 12 weeks. The main goal is to measure how well they can stay awake using a standa…

This study looks at how sensory sensitivity affects sleep and emotions in autistic children ages 6-10. Researchers will test a simple bedtime routine called Power Down, where caregivers give their child a gentle massage to help them relax before sleep. The goal is to see if this …

This study tests an experimental drug called HBS-301 to see if it can reduce symptoms of idiopathic hypersomnia, a condition causing severe daytime sleepiness, trouble waking up, and fatigue. About 248 adults with moderate to very severe symptoms will receive either the drug or a…

This phase 3 trial tests whether a daily tablet called ALKS 2680 can reduce daytime sleepiness and cataplexy (sudden muscle weakness) in 150 adults with narcolepsy type 1. Participants will take the drug or a placebo for 12 weeks, and researchers will measure changes in sleep tes…

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This study tests whether a gentle movement program called Body Awareness Therapy (BAT) can help young adults (ages 20-30) who feel very stressed. Over 8 weeks, one group does BAT twice a week while another group does nothing new. Researchers will measure changes in balance, sleep…

This study tests an experimental drug called cleminorexton in 222 adults with narcolepsy type 1 or 2. The drug mimics a natural brain protein that helps keep people awake. The goal is to see if it safely reduces daytime sleepiness and improves daily functioning. Participants must…

This study tests whether using the soundBrilliance app—which combines enhanced music, natural visuals, and spoken guidance—can help people aged 13 and older manage anxiety, depression, and stress. Over 12 weeks, participants use the app at least 4 days per week and report their m…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This study tests whether osteopathic manipulative treatment (OMT) — a hands-on therapy using gentle techniques on the head, neck, and ribs — can improve sleep quality in people with Parkinson's disease. Participants are split into two groups: one receives OMT, the other a light t…

This study tests a new drug, TAK-360, for adults with narcolepsy type 1, a condition causing severe daytime sleepiness and sudden muscle weakness (cataplexy). About 92 participants will receive either TAK-360 or a placebo to see if the drug is safe and well-tolerated. Participant…

This study tests a 4-week telehealth program called I-SLEPT for Veterans leaving a rehabilitation facility. The program combines sleep education and tips for staying active in meaningful activities. Researchers want to see if it is acceptable and feasible for Veterans, and whethe…

This pilot study is testing a device that sends a mild electrical current to the brain (tACS) to see if it can reduce anxiety and improve sleep in people with generalized anxiety disorder and chronic insomnia. Thirty adults will receive 20 sessions over four weeks. The goal is to…

This study tests a new drug called ALKS 2680 to see if it can safely reduce daytime sleepiness in people with idiopathic hypersomnia, a condition causing excessive sleepiness without clear cause. About 126 participants will receive either the drug or a placebo daily for 8 weeks. …

This study tests whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep faster. Thirty adults with insomnia will be split into three groups: one uses the app with guided meditation, one uses the app without guidance, and one receiv…

This study tests whether a silicone mouth tape worn during sleep can reduce snoring and improve sleep quality in people with mild sleep apnea or simple snoring. About 100 adults with a bed partner will use the tape for a period, and both the snorer and partner will report on snor…

This study tests a stepped care model for delivering cognitive behavioral therapy for insomnia (CBT-I) to 1100 adults across 18 districts in Hong Kong. Participants first receive online self-help CBT-I, and those who need more support get therapist-guided sessions. The goal is to…

This study tests whether daridorexant, a sleep medication, can improve sleep in people with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. Sixty-two participants will receive either the drug or a placebo for one month, and their sleep wi…

This study tests whether acetazolamide, a drug used for other types of sleep apnea, can help people on methadone or buprenorphine who develop central sleep apnea. Forty participants will take either the drug or a placebo for 7 days, then have an overnight sleep study. Researchers…

This study tests whether short, calming virtual reality (VR) sessions can safely reduce anxiety, agitation, and delirium in adult intensive care unit (ICU) patients. Thirty participants will watch nature-based VR content using a headset. The main goal is to see if this approach i…

This study tests a behavioral sleep program called Care2Sleep for people with Alzheimer's disease and their caregivers. The program includes sleep hygiene, activity, and light exposure. Researchers will compare it to a sleep education group to see if it improves sleep, health, an…

This study tests a new drug called TAK-360 for people with narcolepsy type 2, a condition that causes severe daytime sleepiness. The drug acts like a natural brain chemical (orexin) that helps keep people awake. About 88 adults will receive either TAK-360 or a placebo to see if t…

This study tests whether a parent-led online program can improve sleep in autistic children aged 3 to 7 years. About 130 children will be randomly assigned to one of two behavioral sleep programs for 10 weeks. The goal is to see if the structured program reduces insomnia symptoms…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study tests whether a non-invasive earbud that gently stimulates a nerve in the ear can help adult survivors of childhood leukemia who have trouble sleeping. Forty participants will be randomly assigned to receive either active or sham stimulation nightly for 2 to 8 weeks. T…

This study tests whether trazodone, a sleep medication, can improve sleep and memory in people with early Alzheimer's and sleep problems. About 100 participants will receive either trazodone or a placebo for 4 weeks. Researchers will measure changes in sleep quality and memory pe…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study tests a digital program called NiteCAPP Jr, which delivers cognitive behavioral therapy for insomnia (CBT-I) to children aged 6-12. The program aims to improve sleep by teaching healthy sleep habits through interactive online sessions. Researchers will measure how well…

This phase 3 trial tests whether a daily tablet called ALKS 2680 can reduce severe daytime sleepiness and sudden muscle weakness (cataplexy) in adults with narcolepsy type 1. About 150 participants will receive either the drug or a placebo for 12 weeks. The study measures improve…

This study tests a web-based version of cognitive behavioral therapy for insomnia (CBT-I) in 60 family caregivers of people with dementia. Caregivers will complete four online sessions focused on sleep habits, relaxation, and changing unhelpful thoughts. The goal is to improve sl…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce fatigue in people with multiple sclerosis. About 70 adults with MS and insomnia will receive CBT-I or an active control. The goal is to see if this talk therapy approach can ea…

This study tests whether adding lower-body strength training to static stretching helps pregnant women with restless legs syndrome (RLS) feel better. Thirty pregnant women with RLS will be split into two groups: one does only stretching, the other does stretching plus strength ex…

This study tests two hands-on treatments—nerve stretches and muscle pressure release—to see which better reduces menstrual cramps, improves sleep quality, and lowers stress in women with Polycystic Ovary Syndrome (PCOS). 38 women aged 18-35 with PCOS and painful periods will be r…

This study compares two non-drug approaches to improve sleep in adults with poor sleep quality. One group uses aromatherapy and pink noise, while another practices muscle relaxation and breathing exercises. All participants also receive sleep hygiene education. The goal is to see…

This study tests whether hemp-derived CBD (with or without THC) can help older adults (60+) who use cannabis for pain, anxiety, depression, or sleep problems. Over 8 weeks, 385 participants will take either CBD+THC, CBD alone, or a placebo. The goal is to see if CBD can reduce sy…

This early-stage trial is testing a new drug called Lu AH69593 to see if it is safe and how the body handles it. The study includes healthy volunteers and people with narcolepsy. Researchers will monitor side effects and measure drug levels in the blood, including how food affect…

This study compares three common insomnia treatments—two medications (trazodone and daridorexant) and an online behavioral therapy program—in 1,000 women aged 40-62 who are in or near menopause. Participants will take one treatment for 12 months, wear a Fitbit, and complete sleep…

This study compares two easy relaxation methods—Laura Mitchell's technique and Benson's relaxation response—in 38 adults aged 40–60 with moderate to severe COPD. Participants will practice one of the techniques for 15–20 minutes daily over 6 weeks. The goal is to see which method…

This study looks at whether adding pork protein to the diet can help middle-aged women with overweight or obesity who are taking GLP-1 medications (like Ozempic or Wegovy) maintain muscle and improve well-being. Over 12 weeks, 75 women will continue their medication and eat prote…

This study tests whether giving pregnant women personalized heat alerts, cooling tips, and indoor air cleaners can reduce their exposure to heat and air pollution, and improve sleep quality. About 102 healthy pregnant women in Italy and Cyprus will be split into groups: some get …

This study tests whether the drug Lemborexant helps people with delayed sleep phase syndrome fall asleep faster at their desired bedtime. Fifteen adults will take either the drug or a placebo nightly for up to 2 years, tracking sleep with logs and a wrist monitor. The goal is to …

This study tests whether a 15-minute virtual reality meditation session each night can help adults aged 25 to 50 with insomnia fall asleep faster and sleep more soundly. Thirty participants will either use the VR relaxation or be placed on a waiting list. Researchers will track s…

This study tests a sleep-focused program (TranS-C) plus bright light therapy in 90 teens aged 12-18 with moderate to severe depression and sleep problems. Half get the full program with a sleep therapist and light glasses; the other half just track their sleep. The goal is to see…

This study tests whether adding foot reflexology to standard physical therapy can reduce pain and improve sleep in women with fibromyalgia. Sixty women aged 18–65 will receive either standard therapy alone or standard therapy plus foot reflexology twice a week for six weeks. Rese…

This study is testing a version of Cognitive Behavioral Therapy for Insomnia (CBT-I) that has been adapted specifically for teenagers. The treatment includes healthy sleep habits, a consistent sleep schedule, and relaxation techniques. Researchers will compare teens who receive t…

This study compares the effectiveness, safety, and long-term benefits of commonly used insomnia medications, including prescription drugs like zolpidem and trazodone, and over-the-counter options like melatonin and diphenhydramine. Researchers will enroll 1,200 adults with chroni…

This study tests whether a daily dose of tasimelteon helps children aged 2 to 17 with insomnia fall asleep faster and sleep better. About 420 participants will receive either the drug or a placebo. The goal is to improve sleep and daytime functioning without serious side effects.

This study tests whether female health sciences students can improve their sleep patterns and reduce social jet lag by doing acupressure on themselves every day for 12 weeks. Half the participants will use real acupressure points, while the other half will use sham (fake) points,…

This pilot study tests whether a device called Cereset Research can help caregivers of people with dementia who feel stressed, anxious, or have trouble sleeping. The device plays tones that echo the brain's own rhythms, aiming to improve heart rate variability and reduce stress. …

This study tests whether a sleep medication called eszopiclone can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. About 250 adults with a new sleep apnea diagnosis will receive either eszopiclone or a placebo f…

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests whether a simple breathing exercise called the 4-7-8 technique can help people sleep better, feel less pain, and recover faster after bladder surgery. About 68 adults having this surgery will be randomly assigned to either learn the breathing exercise or receive …

This study compares an intelligent digital cognitive behavioral therapy (CBT) program against traditional sleep medications for treating insomnia. Researchers will enroll 200 adults with insomnia to see which approach improves sleep, anxiety, and depression more, and which is mor…

This study tests whether a structured exercise program can improve heart rate variability (a measure of heart health), reduce menopausal symptoms, and enhance sleep and quality of life in postmenopausal women aged 45 to 65. Forty women will either join a supervised 12-week exerci…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This study tests two school-based sleep programs in 1,320 teens aged 12-18 with sleep problems. One program is a standard sleep health education, the other is a more intensive cognitive behavioral sleep intervention. Researchers will compare which program improves sleep quality m…

This small pilot study tests whether a special rocking bed (Somnomat Casa) can improve sleep quality in people with Parkinson's disease. Fifteen participants will use the bed at home for two months, and researchers will measure how acceptable and helpful the treatment is. The goa…

This study tests whether a type of talk therapy for insomnia, delivered via telemedicine, can improve sleep and reduce cannabis use in adults who have trouble sleeping and use cannabis regularly. 200 participants will be randomly assigned to either cognitive behavioral therapy fo…

This study tests whether a breathing therapy device (adaptive servo ventilation) can reduce insomnia severity in adults with moderate to severe chronic insomnia. About 25 participants will use the device and report changes in sleep quality and how long it takes to fall asleep ove…

This study tests whether a daily snack rich in plant chemicals and fibre can ease perimenopause symptoms like hot flushes, mood changes, and sleep problems. Twenty women aged 40-55 who are not on hormone therapy will eat either the special snack or a placebo for several weeks, th…

This study compares two behavioral approaches to see which works better for improving mood, sleep, and reducing suicide risk in adults aged 55 and older with depression. Participants will complete interviews, questionnaires, and wear a sleep tracker for 8 weeks. The goal is to fi…

This study looks at whether a culturally tailored Latin dance program can help Hispanic cancer survivors sleep better. Researchers will enroll 40 adults who have finished their main cancer treatment but still have trouble sleeping. Participants will either take dance classes or c…

This study tests a combination of sleep-promoting and circadian-aligning treatments (a "sleep chronobundle") in 160 critically ill ICU patients. The goal is to see if realigning the body's internal clock can improve sleep quality and metabolism. Participants will receive the bund…

This study tests whether bright light therapy can help reduce excessive daytime sleepiness in people with Prader-Willi syndrome. About 50 participants will receive either bright light or a dim placebo light. The goal is to see if the therapy improves alertness, mood, and behavior…

This study tests whether E2086, an oral tablet, can reduce excessive daytime sleepiness in adults with narcolepsy. About 64 participants will receive either the drug or a placebo for 4 weeks. Researchers will measure how long people can stay awake using a standard test, and also …

This study tests whether suvorexant, a sleep medication, can help people with opioid use disorder fall asleep and stay asleep. About 300 participants will receive either suvorexant or a placebo. The goal is to see if the drug improves total sleep time and is safe to use.

This study tests whether a smartphone app that helps improve sleep, along with a wearable activity tracker, can support brain health in older adults (65+) after hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surge…

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This study tests whether a low-dose melatonin pill (0.5 mg) combined with a behavioral sleep program can shift the body's internal clock earlier and improve mood in people with bipolar disorder who are night owls. Fifty participants will either get melatonin plus sleep therapy or…

This study tests whether a sleep-focused therapy can improve depression in teenagers whose body clocks are out of sync with their wake-up time. Researchers will enroll 200 adolescents with depression and delayed sleep phase. The therapy aims to realign their internal circadian rh…

This study looks at how a low-sodium version of the drug oxybate affects total sleep time in adults with idiopathic hypersomnia, a condition causing excessive sleepiness. About 30 participants will use sleep trackers and special earbuds to measure sleep. The goal is to see if the…

This study tests a comfort program for children aged 5-10 in the pediatric intensive care unit (PICU). The program includes listening to their mother's voice, dimming lights, and using a weighted blanket, along with regular nursing care. Researchers want to see if this helps chil…

This study tests whether a type of light therapy called photobiomodulation can help people with obstructive sleep apnea tolerate their CPAP machine better. About 30 adults who currently use CPAP but have trouble with it will receive the light treatment. The goal is to see if it l…

This study looks at how to best offer cognitive behavioral therapy for chronic insomnia to older veterans at 20 VA clinics. About 20 veterans will take part to see if the therapy helps them sleep better and feel better. The goal is to find the best way to bring this effective tre…

This study looks at whether children with medical complexity (ages 5-17) can safely start using a nighttime breathing machine at home instead of in a hospital sleep lab. The machine helps them breathe better at night, improving quality of life. Researchers will compare home start…

This study aims to help socioeconomically disadvantaged adults who struggle with insomnia. Researchers will compare two types of behavioral therapy delivered remotely (by phone or video) to see if a shorter treatment works as well as the standard longer one. 350 adults from prima…

This study tests if Lemborexant, a sleep medication, can improve sleep in adults whose depression is already treated but who still have insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep with diaries and a wearable device. The…

This phase 2 trial tests whether taking CBD before bed can improve sleep quality after a late evening high-intensity workout. Twenty healthy adults will each complete a rest session and two exercise sessions, receiving either CBD or a placebo. Sleep is measured overnight using br…

This study looks at whether a custom mouthguard (occlusal splint) can reduce pain and improve muscle function in people with teeth grinding (bruxism) and related jaw and neck muscle pain. About 40 adults will be split into two groups: one gets the mouthguard right away, the other…

This study tests a device called Cereset Research to see if it can improve how the body handles stress, anxiety, and insomnia. About 200 adults with these symptoms will use the device while researchers measure heart rate and blood pressure changes. The goal is to find a non-drug …

This study looks at whether endoscopic sinus surgery can improve sleep in people with chronic sinusitis and nasal polyps. Researchers will measure sleep quality before and after surgery in 30 participants. The goal is to see if removing polyps and opening blocked sinuses helps wi…

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to 12 months of exercise, cognitive behavioural therapy for insomnia (CBT-I), or both. The goal is…

This study tests whether a special online therapy for insomnia, adapted for people with ulcerative colitis (UC), is helpful and practical. About 20 adults with active UC and insomnia will take part. They will complete online questionnaires, keep a daily sleep diary, and attend 5 …

This study tests whether a drug called pimavanserin can improve sleep in veterans with post-traumatic stress disorder (PTSD) who also have insomnia. About 60 veterans will receive either the drug or a placebo for 8 weeks. The goal is to see if it reduces insomnia severity and imp…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study tests whether a nasal spray of oxytocin, a natural hormone, can lower the air pressure needed from a CPAP machine in people with obstructive sleep apnea. Forty adults who already use CPAP will take the spray or a placebo before bed for 14 days. Researchers will measure…

This study tests whether taking melatonin can improve sleep quality and duration for medical residents working night float shifts. Fifty residents will be randomly assigned to receive either melatonin or a placebo, and their sleep will be measured with a portable brain-wave monit…

This study tests whether extra support—like a health pamphlet, a video, and motivational counseling—helps people with obstructive sleep apnea use their mandibular advancement appliance (a mouth guard) more consistently. Fifty-six adults (age 40+) with sleep apnea will be randomly…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This study looks at whether a custom mouthpiece that gently moves the lower jaw forward during sleep can improve sleep quality, heart rate patterns, and blood oxygen levels. About 24 healthy adults aged 40-65 will wear both the active device and a placebo device to compare effect…

This study looks at whether extending the nightly fasting period (not eating for a longer stretch each night) can improve sleep, thinking, and quality of life in breast cancer survivors. Researchers will compare this approach to health education alone. The study involves 60 femal…

This study is testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and daily function in 15 people with mild traumatic brain injury (mTBI) who have trouble sleeping. Participants will learn techniques like sleep scheduling and changing unhelpful tho…

This study tests a group therapy program called Sleep School for people with chronic insomnia. 250 participants will either attend Sleep School once a week for six weeks or receive standard short counseling from a nurse. The goal is to see if Sleep School reduces insomnia symptom…

This study tests whether a device that sends mild electrical currents to the brain (hi-tACS) can improve sleep in people with neuroimmune diseases like multiple sclerosis who also have insomnia. Eighty participants will receive 20 sessions of the stimulation or a sham treatment. …

This study tests a web-based program called NiteCAPP designed to improve sleep in people caring for a loved one with dementia, especially those living in rural areas. One hundred caregiver-patient pairs will use the program for 4 weekly sessions plus follow-up boosters. Researche…

This study tests whether dupilumab (Dupixent) can improve sleep and reduce itching in 40 children aged 6-17 with moderate to severe eczema. Participants receive dupilumab for 12 weeks, and researchers measure sleep quality and itch using questionnaires and overnight sleep tests. …

This study tests an internet-based sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers will check if the course is easy to use and helpful for people in Saskatchewan. About 56 adul…

This study tests whether giving 3-5 year olds a daily prebiotic fiber powder for several weeks can improve their mood, sleep, emotional control, and thinking. Parents of 106 children with low fiber intake will report on their child's behavior and emotions. The study is double-bli…

This pilot study tests whether adding a digital insomnia treatment (CBT-I) to standard suicide-focused therapy (DBT) helps reduce suicidal thoughts and self-harm in teens aged 12-18 who are at high risk for suicide. Forty-four participants will be randomly assigned to receive eit…

This study looks at whether wearing a night guard can reduce jaw muscle thickness and pain in children aged 10-12 who grind their teeth. Researchers will use ultrasound to measure muscle changes and track symptoms like headaches and jaw fatigue over 3 and 6 months. The goal is to…

This study tests a new drug called ORX750 (cleminorexton) in 248 adults with narcolepsy type 1, type 2, or idiopathic hypersomnia—conditions that cause severe daytime sleepiness. The drug mimics a natural brain protein that helps keep people awake. The main goals are to check saf…

This study is testing whether a weighted blanket can help veterans with chronic pain and sleep problems. 160 veterans will use either a light (3-pound) or heavy (15-pound) blanket at home for 6 weeks. Researchers will track changes in pain, sleep quality, and medication use to se…

This study tests whether doing specific mouth and tongue exercises can help people with obstructive sleep apnea who cannot use a CPAP machine. Forty-five adults will be randomly assigned to real exercises, sham exercises, or unsupervised exercises for 10 weeks. The main goal is t…

This study looks at whether aerobic exercise can help college students with insomnia as much as a digital therapy program. Fifty students will be split into two groups: one does exercise, the other uses a sleep app. Researchers will track sleep quality, mood, and stress to see wh…

This study tests whether adding sauna blanket sessions to an online insomnia therapy program helps people sleep better. Forty adults with insomnia will all receive digital cognitive behavioral therapy, and half will also use a sauna blanket for 15 minutes several times a week. Th…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study looks at whether taking ETAS® daily for 12 weeks can improve memory, mood, and brain activity in healthy adults aged 60 to 80 who have mild memory complaints. Participants will be randomly assigned to receive either ETAS® or a placebo, and will undergo memory tests, br…

This study tests two treatments for insomnia in veterans who also have PTSD. One is a brief behavioral therapy focused on sleep habits, and the other is a relaxation technique. Researchers want to see which one improves sleep and daily life more, and if benefits last over time. A…

This study tests whether adding Five Shu point acupuncture to standard acupuncture can improve sleep in people with insomnia linked to a Heart-Spleen deficiency pattern. 46 adults will receive either standard acupuncture or standard plus Five Shu points over 20 sessions in 28 day…

This study compares two behavioral programs for people with chronic pain, chronic insomnia, and long-term opioid use. One program uses cognitive behavioral therapy for insomnia (CBT-I), the other is standard treatment. The goal is to see if improving sleep can also reduce opioid …

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This study tests whether a magnesium supplement called Magnesium-L-Threonate (MgT) can improve sleep quality and reduce pain in people recovering from total knee or hip replacement. Researchers will enroll 64 adults having surgery at the University of Miami Hospital. Participants…

This study looks at whether a 16-week program combining mindfulness meditation and Nordic walking pole exercise can improve physical function, mood, and sleep in adults aged 55 and older. About 1,500 participants will take part in the program and be assessed at several points. Th…

This study tests whether natural supplements like lavender oil, PEA, and OEA can help adults with moderate stress and sleep problems. About 240 participants will take a daily capsule for 8 weeks, comparing the supplements to a placebo. The goal is to see if these natural options …

This pilot study at Stanford University is testing whether giving rTMS (a non-invasive brain stimulation) in the morning or evening works better for treating insomnia. Ten adults with insomnia will receive ten sessions over two weeks. Researchers will track sleep quality and brai…

This study tests whether a proven sleep therapy (CBT-I) can improve how the brain regulates emotions, helping treat depression and anxiety. Researchers will use brain scans to see changes in emotion networks. 120 adults with insomnia and depression will participate. The goal is t…

This study tests an internet-based therapy program called the Sleep Course, designed to help public safety personnel (like police, firefighters, and paramedics) who have trouble sleeping. The program teaches skills to manage sleep difficulties and includes optional support from a…

This pilot study tests whether a non-invasive headset that delivers mild electrical stimulation to nerves behind the ear can safely improve sleep in adults who are blind or severely sight impaired. Sixty participants will use the device for 30 minutes a day, five times a week for…

This study tests whether a sleep health program can help U.S. Marines sleep better and feel mentally healthier. About 860 Marines will be randomly assigned to one of five groups to receive different versions of the program. Researchers will use surveys and wearable sleep trackers…

This study tests whether a non-medication sleep program (CBT-I) can improve sleep, PTSD symptoms, and heart health in older adults with PTSD who still have sleep problems after PTSD therapy. About 167 veterans aged 50 and older will receive PTSD therapy first, then the sleep prog…

This study compares two behavioral sleep training methods for infants with insomnia: 'bedtime checking' (only at bedtime) and 'standard checking' (also during night-wakings). The goal is to see which approach improves infant and parent sleep faster while being more acceptable to …

This study tests whether a mobile health program (mPATH) can help low-income older adults who have trouble sleeping and are not very active. Participants will use the program to increase physical activity, and researchers will measure changes in memory and sleep quality. The goal…

This study compares two approaches for older adults with knee osteoarthritis and insomnia: personalized exercise coaching alone versus exercise plus a digital insomnia treatment. Researchers want to see if adding sleep therapy leads to greater pain relief. The trial involves 288 …

This study is testing whether taking a daily saffron extract supplement (30 mg) for six weeks can improve sleep quality in middle-aged adults who have mild-to-moderate sleep problems. Researchers will measure sleep using a wrist-worn device and track other factors like mood and s…

This study looks at whether using a CPAP machine in a personalized way can reduce the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will alternate two weeks on and two week…

This study tests whether a nose spray containing two drugs, dexmedetomidine and esketamine, can reduce pain after tonsil and adenoid surgery in children aged 3 to 7. About 160 kids will receive either the drug combo or a placebo spray right after anesthesia. Researchers will trac…

This study is testing whether a wearable device that plays personalized low-frequency sounds (like pink noise) can help people with insomnia sleep better. Forty adults with sleep problems will use the device for 12 weeks, and their sleep will be measured with overnight brain-wave…

This study tests whether person-centered behavioral programs can improve sleep in first-time mothers with insomnia. 135 women will either receive a sleep management program, an aerobic exercise program, or usual care. The main goal is to see if these approaches reduce insomnia se…

This study tests whether a mobile app called EnergyPoints can help cancer survivors reduce fatigue and improve sleep by guiding them through self-acupressure. About 180 adults who have or had cancer and feel at least moderately tired will use the app daily for six weeks while wea…

This study tests a brief group therapy called Acceptance and Commitment Therapy for insomnia (ACT-i) in 76 adults aged 18-59 with chronic insomnia and mild depression or anxiety. Participants are randomly assigned to either ACT-i or a general support group. The goal is to see if …

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study looks at whether the speed of a manual therapy called the Graston Technique affects muscle tightness, pain, and oxygen levels in people with bruxism (teeth grinding or jaw clenching). Researchers will apply the technique at two different speeds (60 vs 120 strokes per m…

This study tests a type of hypnotherapy called E2R for people with chronic insomnia. It compares E2R to usual care (like sleep medications) to see if it reduces insomnia severity. About 136 adults with chronic insomnia will take part, and the goal is to find a safer, non-drug opt…

This study tests whether eating a whole food plant-based diet for 8 weeks can reduce daytime sleepiness and improve sleep apnea severity. Researchers will measure changes using a sleepiness questionnaire and a home sleep test. The study involves 40 adults with sleep apnea who are…

This study tests whether a low dose of clonidine, a drug usually used for high blood pressure, can improve sleep and reduce PTSD symptoms in veterans. About 32 veterans with PTSD will take a flexible dose of clonidine nightly for 6 weeks. Researchers will track changes in sleep q…

This study tests whether a brief behavioral treatment for insomnia (BBTi) — guided by a nurse or through a mobile app — can improve sleep, mood, and thinking in people recovering from traumatic brain injury (TBI). About 93 participants with chronic TBI and insomnia will be assign…

This study tests whether taking melatonin before bed can help adults with obstructive sleep apnea and insomnia sleep through the night and restore a healthy nighttime blood pressure dip. Fifty participants will take 3 mg of melatonin daily for 30 days. Researchers will measure ch…

This pilot study tests whether a standardized sleep bundle—including a sleep mask, ear plugs, a noise machine, and stepwise medications (melatonin, then trazodone if needed)—can improve sleep for adults recovering from cardiac surgery. Twenty participants will be randomly assigne…

This study looks at whether complex decongestive physiotherapy (CDP) can improve sleep quality and quality of life in women with stage 2 breast cancer-related lymphedema. CDP includes massage, skin care, compression bandages, and exercises. The study will follow 31 women for 4 we…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study tests the MedCline Sleep System, a device placed on the bed to keep people sleeping on their side. It aims to reduce breathing pauses and snoring in adults with mild obstructive sleep apnea. Researchers will measure changes in apnea and oxygen levels during sleep. The …

This study looks at how tai chi and yoga affect flexibility, anxiety, and sleep in healthy women aged 18 to 45. Participants will do either tai chi or yoga for 8 weeks, twice a week. Researchers will measure changes using simple tests and questionnaires to see which activity offe…

This study tests whether a daily probiotic supplement called Limosilactobacillus reuteri LM1063 can improve sleep in healthy adults who have poor sleep quality. Over 8 weeks, 80 participants will take either the probiotic or a placebo, and researchers will measure sleep using bot…

This Phase 2 trial tests TAK-360, a drug that mimics the brain chemical orexin, in 96 adults with idiopathic hypersomnia (IH). IH causes severe daytime sleepiness and trouble waking up, even after long sleep. Participants will receive either TAK-360 or a placebo to see if the dru…

This study tests whether a headband that uses sound waves (acoustic resonance therapy) can improve sleep quality in people with moderate to severe chronic insomnia. It compares the headband to a standard behavioral therapy (CBT-I) over 6 weeks. About 60 adults will participate to…

This study tests a special type of talk therapy called Multi-Modal Cognitive Processing Therapy (MMCPT) for people with posttraumatic stress disorder (PTSD). Sixty adults with PTSD will either receive 12 weekly therapy sessions or standard care. Researchers will track changes in …

This study looks at whether doing yoga during pregnancy can lower stress, improve sleep, and enhance sexual quality of life. Researchers will compare 35 pregnant women who practice yoga with 35 who do not. All participants are in their third trimester and must be able to read Tur…

This study looks at whether a supplement called MyVitalC (ESS60 in extra virgin olive oil) can improve sleep and reduce headaches. About 100 adults will track their sleep and headaches for 4 weeks without the supplement, then take it daily for 6 weeks and report any changes. The …

This study tests an online program (eCBTi+) that teaches older adults with insomnia and memory concerns how to improve sleep, manage anxiety and low mood, and potentially protect brain health. About 275 people aged 60 and older will use the program or a control version for severa…

This study tests whether limiting social media use to a set amount each day can reduce loneliness, fear of missing out (FoMO), and improve sleep quality in university students. Seventy students aged 18-25 who use social media at least 2 hours daily will be randomly assigned to ei…

This study tests whether older adults (ages 65-74) can improve their balance, reduce fear of falling, and sleep better by doing combined physical and mental exercises at home via video calls with a physiotherapist. Participants will perform 4 weeks of dual-task exercises—like wal…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This study tests whether a digital sleep therapy program (Sleepio) can improve quality of life and movement in 142 adults with fibromyalgia who also have trouble sleeping. Participants will use the program at home for 10 weeks and wear devices to track sleep and activity. Researc…

This study tests whether remote monitoring of CPAP machines helps people with severe sleep apnea use their therapy more regularly. About 200 adults who are new to CPAP will either get standard care or have their device tracked remotely via an app. The goal is to see if digital su…

This study tests a behavioral (non-drug) treatment to reduce nightmares in adults with REM sleep behavior disorder (RBD). Participants attend 7 video sessions, with a family member joining 2 of them. The goal is to see if the therapy lowers nightmare frequency and severity.

This study tests a virtual, 4-session sleep program based on cognitive behavioral therapy for insomnia (CBT-I) in 198 cancer survivors. Participants are randomly assigned to the program or usual care. The goal is to see if the program reduces insomnia severity, improves sleep qua…

This pilot study tests a digital program that uses facial recognition and guided exercises to strengthen throat muscles in people with mild-to-moderate obstructive sleep apnea. Sixty adults who cannot or will not use a CPAP machine will either receive the 3-month app-based therap…

This study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…

This study looks at whether art therapy, delivered through virtual reality glasses or in person, can help reduce anxiety and improve sleep and well-being in people with colorectal cancer. 78 patients receiving chemotherapy will be randomly assigned to one of three groups: virtual…

This study tests a sleep improvement program designed specifically for older Korean immigrants who have trouble sleeping. The program adapts standard sleep therapy to fit Korean culture and language. Researchers will measure sleep quality and gather feedback from 32 participants …

This study tests whether a virtual cognitive behavioral therapy program can help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home. The goal is to see if the program is easy to use and helpful for improving…

This study is testing the long-term safety and how well ALKS 2680 works over time in people with narcolepsy type 1, type 2, or idiopathic hypersomnia. Participants take a once-daily tablet at different doses. The goal is to see if the drug remains safe and effective for staying a…

This study tests a brief behavioral sleep program for depressed teens aged 12-18 who sleep less than 7 hours or have irregular sleep. The program uses two sessions and smartphone tools to help teens set sleep goals. Researchers will compare it to a simple sleep education session …

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can ease chronic symptoms like pain, itch, anxiety, and sleep problems in adult burn survivors. About 34 participants will try both VR-enhanced…

This study tests whether eating pistachios daily and receiving coaching on healthy habits can improve sleep quality in midlife women aged 45-65 who have poor sleep. Participants will eat either pistachios or potato chips for a month and attend a one-hour coaching session. Researc…

This study tests a 6-week videoconference program that teaches sleep-improving skills to older adults with memory loss or dementia and their care partners. About 80 participants will join either individually or together. The goal is to see if the program is practical, acceptable,…

This study tests whether pressing small seeds on specific ear points can help people with functional dyspepsia (chronic stomach discomfort) who also have insomnia. Researchers will track symptom relief and sleep quality in 176 adults over 8 weeks, and explore how the treatment af…

This early-phase study tests whether a combination of two drugs—atomoxetine and DAW2022—can reduce the severity of obstructive sleep apnea (OSA) in 18 adults with moderate-to-severe OSA. The goal is to find a better-tolerated alternative to current treatments by measuring breathi…

This study tests a mobile app called SHIFT that uses data from an Apple Watch to give personalized light exposure advice, helping night shift workers sleep better. Researchers will enroll 300 night shift workers who have poor sleep. The goal is to see if the app improves sleep, h…

This study tests two techniques to help people with insomnia: mental imagery (turning negative thoughts into positive ones) and using a scent during sleep to strengthen that positive feeling. 120 adults aged 18-45 with insomnia will be split into four groups to compare these meth…

This study tests whether a 12-week supervised exercise program done during dialysis can improve muscle mass, strength, sleep, and quality of life in adults over 40 with chronic kidney disease. Participants are randomly assigned to either exercise during the first 90 minutes of di…

This study compares 3D-printed night guards to standard acrylic ones for people who grind their teeth (bruxism). Forty-four adults will wear the splints during sleep for 3 months. Researchers will measure how much the splints wear down and ask participants about their satisfactio…

This study tests whether adding a quick stitching step (lateral pharyngoplasty) to standard tonsillectomy helps children recover better. About 160 kids aged 3-17 will be randomly assigned to get tonsillectomy with or without the extra stitch. Parents will track pain, eating, and …

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women with early-stage breast cancer who are overweight and have insomnia will either get a sleep therapy (CBT-I) or sleep education before starting a weight loss program. Researchers …

This study tests whether personalized exercise and a gentle nerve stimulation device can reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise plus standar…

This study tests a smartphone app called iCANSleep, which provides a type of talk therapy (CBT-I) to help cancer survivors with insomnia. Researchers will enroll 146 Canadian cancer survivors who have trouble sleeping and compare those using the app to a waitlist group. The goal …

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help older African Americans sleep better and think more clearly. Twenty participants will receive 8 weekly sleep training sessions via Zoom or a single education session. Researchers will measure slee…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study tests whether simple exercises (like drinking water and breathing in a certain way) can improve sleep quality in 60 U.S. service members with obstructive sleep apnea. Some participants have also had a traumatic brain injury. The goal is to see if these exercises reduce…

This study tests whether a respiratory rehabilitation program (exercise and education sessions over 8 weeks) can improve sleep quality in people with stable COPD. 90 adults aged 50 and older will be randomly assigned to either the rehab program or usual care. Sleep will be measur…

This study tests whether a nurse-supported mobile app that teaches healthy sleep habits can reduce insomnia in people caring for a family member or friend with cancer. About 208 caregivers will either use the app for 6 weeks with weekly nurse check-ins or receive basic sleep tips…

This study tests a 6-week mindfulness-based program designed to improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 women and track changes in sleep quality, stress levels, and how acceptable and feasible the program is. The goal is to see if…

This study looks at whether adding yoga to usual care can reduce insomnia severity in adults aged 18-65 with chronic insomnia. 72 participants will be split into three groups: yoga plus standard care, stretching plus standard care, or standard care alone. The main goal is to see …

This study tests a guided online version of cognitive behavioral therapy for insomnia in 80 people who have had a moderate or severe traumatic brain injury at least a year ago and currently have insomnia. Participants will either receive the online therapy (6 modules over 6-9 wee…

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This study tests two wearable devices in 20 people with Alzheimer's and their caregivers in rural Taiwan. One device tracks sleep and activity, while the other uses light therapy to improve sleep and mood. The goal is to see if these tools are easy to use and can help reduce beha…

This study tests whether a smartphone-based mindfulness program is practical and liked by teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use a guided meditation app for about 8 weeks. The goal is to see if people…

This pilot study tests a wellness program for adults with cystic fibrosis (CF) to see if it helps with fatigue, sleep, and physical activity. The program includes 8 coaching sessions on topics like balancing activity and rest, improving sleep, and managing stress. Researchers wil…

This study tests whether a special 3D exercise program (the Schroth method) can improve back muscle endurance, sleep, and quality of life in 60 adolescents aged 12-18 with hyperkyphosis (excessive rounding of the upper back). Participants will do the exercises for at least 3 mont…

This study is testing whether a daily supplement called AGZ can help adults aged 25-59 who have trouble sleeping feel more relaxed in the evening, sleep better, and have more energy in the morning. About 300 people will take AGZ or a placebo for 30 days and answer questionnaires …

This study tests whether a non-invasive electrical stimulation device can help people with obstructive sleep apnoea breathe easier during sleep. Fifteen adults with moderate to severe sleep apnoea will wear sticky electrodes under their chin while sleeping. The goal is to see if …

This study tests whether a smartphone app, with or without personal coaching by phone, can improve sleep in children aged 6–12 with autism and insomnia. Parents use the app to learn behavioral sleep strategies. The trial will enroll 195 families and also measure effects on childr…

This study tests whether a daily nutritional supplement can improve sleep quality in adults aged 35-65 who have mild sleep problems. About 140 participants will take either the supplement or a placebo for several weeks, and sleep will be tracked using a special ring and questionn…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can reduce impulsivity and risk-taking in young people aged 12-24 who have trouble sleeping. Researchers will measure changes in impulsive behavior and sleep quality. The goal is to see if improving sleep …

This study tests a program called TAILOR, which uses sleep-focused therapy to help teens with insomnia who are also having suicidal thoughts. The goal is to see if improving sleep can lower their risk of suicidal behavior. The study will enroll 235 teens aged 11-18 and track chan…

This study investigates a technique called drug-induced sleep endoscopy (DISE) to examine the upper airway in adults with obstructive sleep apnea (OSA) who are considering surgery. Participants receive a mild sedative (propofol) to induce sleep, then a thin camera is passed throu…

This study looks at whether special mouth and throat exercises can improve sleep apnea by strengthening the muscles that keep the airway open. Thirty adults with sleep apnea will use myofunctional therapy devices for three months. Researchers will measure muscle pressure in the t…

This study investigates whether the match between a person's chronotype (morning or evening preference) and the time of day influences how they perceive time. Healthy adults who are clear morning or evening types complete perception and cognition tasks both early in the morning a…

This study investigates whether people with sleep disorders before noncardiac surgery take longer to wake up from anesthesia and have a lower quality recovery. Researchers will monitor brain activity during and after surgery in 80 adults, comparing those with poor sleep to those …

This study will test new methods to measure how sleep apnea affects the heart. Researchers will follow 270 adults with moderate to severe sleep apnea who use CPAP, mouth devices, or nerve stimulation. The goal is to see if these new metrics can better predict heart problems than …

This study looks at whether stimulating two nerves in the neck (the ansa cervicalis and hypoglossal nerve) can help people with obstructive sleep apnea. Researchers will measure how the airway changes during sleep in 100 adults. The goal is to understand if combining these stimul…

This early-stage study at Stanford tests whether giving magnetic brain stimulation during sleep is safe and practical for people with major depression. Fifteen adults who have not gotten better with at least one antidepressant will receive both real and fake stimulation in separa…

This study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This study aims to understand what causes delayed sleep wake phase disorder (DSWPD), a condition where people's sleep times are shifted later. Researchers will compare 66 participants with DSWPD to healthy controls by measuring body temperature, melatonin, and thinking ability du…

This study will track jaw muscle activity in 42 adults with chronic jaw pain and teeth grinding (bruxism) who use a custom mouth splint at night. Participants will wear a portable device for 24 hours to measure muscle activity before starting the splint, two weeks later, and afte…

This pilot study at Tulane University is testing whether obstructive sleep apnea (OSA) can cause scarring (fibrosis) in the heart's upper chambers, even in people without atrial fibrillation. Researchers will use a special MRI with contrast dye to measure scarring in 60 adults wi…

This study looks at how often sleep apnea occurs in people with peripheral artery disease (blocked leg arteries). Researchers will monitor 295 adults with leg artery disease using a sleep test. The goal is to better understand the connection between these two conditions, which ma…

This study tracks pregnant women with narcolepsy who take pitolisant (Wakix) or other narcolepsy medications, as well as pregnant women without narcolepsy who take pitolisant. Researchers compare pregnancy outcomes, including birth defects, to see if the drug poses risks. The goa…

This trial tests whether mailing a sleep apnea home-testing device to people with atrial fibrillation can improve their quality of life. About 936 participants will either receive the device and possible treatment, or no test at all. Researchers will track symptoms, activity, and…

This study looks at how the brain changes over time in people with REM sleep behavior disorder, a condition that often leads to Parkinson's disease or similar disorders. Researchers will use brain scans and thinking tests to track these changes in about 86 adults. The goal is to …

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Twenty participants who already have a DBS implant will spend two nights in a sleep lab—one night with the device on and one night with it off. Researchers will measure sleep qu…

This study looks at how things like air quality, noise, and light in hospital wards affect patients' sleep. Researchers will measure these factors and track the sleep of 120 adult patients who stay at least two nights. The goal is to understand the hospital environment better and…

This study looks at how the pupils of people with Delayed Sleep-Wake Phase Disorder react to light. Researchers want to see if there are differences in light sensitivity and whether a single dose of citalopram (a serotonin-boosting drug) can increase melatonin suppression during …

This pilot study will give 70 children aged 6-13 either a daily almond butter snack or a chocolate spread snack for 8 weeks. Researchers will measure changes in gut and mouth bacteria, blood markers, and digestion. The goal is to see if almonds can improve gut health and reduce f…

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study aims to understand how working night shifts impacts blood sugar, fat levels, and heart health in hospital staff. Researchers will compare workers who do night shifts with those who don't, using continuous glucose monitors and other measurements. The goal is to gather k…

This study compares 240 people with paraphilic disorders, compulsive sexual behavior, or sexsomnia to healthy controls. Researchers will assess violence history, psychiatric traits, and genetic factors through interviews, questionnaires, and blood samples. The clinical group will…

This study looks at how the timing of aerobic exercise—morning versus late afternoon—affects deep sleep and body temperature. Researchers will compare endurance athletes with inactive people to see who is more affected. The goal is to understand how exercise timing can improve sl…

This study looks at whether taking a nap during a night shift can improve blood pressure and alertness in healthcare and public safety workers. Researchers will compare naps lasting 0, 15, 30, 45, or 60 minutes taken at 2:00 AM. The goal is to find the nap length that best balanc…

This observational study looks at how sleep quality influences cognitive flexibility, physical activity, body awareness, and reaction time in people with multiple sclerosis. Researchers will compare those with good and poor sleep using questionnaires, computer tests, and a wearab…

This study looks at how eating affects sleepiness and nighttime sleep in people with type 1 narcolepsy, idiopathic hypersomnia, and healthy volunteers. Over 4 days, participants will log their meals, wear a glucose monitor, and track sleep with a headband and watch. The goal is t…

This study looks at how narcolepsy (types 1 and 2) and idiopathic hypersomnia affect social cognition—skills like recognizing emotions and making decisions. Researchers will give 75 adults several questionnaires to measure attention, impulse control, empathy, and emotion recognit…

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic disorder, to track how the condition changes over time. Participants will undergo brain scans, EEGs, and genetic testing, and complete developmental assessments. The goal is to create better tool…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart. Researchers will compare people with one or both conditions and test two breathing treatments—a special mask that helps breathing at night and extra oxygen—to see which may impro…

This study aims to understand how the light from tablet screens and the type of content children watch before bed affect their sleep, thinking skills, and emotions. Researchers will have 220 children aged 8 to 11 spend one hour before bed either using a bright tablet, a dim table…

This study looks at whether a quality-of-life questionnaire (OSA-18) can help parents of children with mild obstructive sleep apnea make treatment decisions. About 130 parents of children aged 3-12 with mild sleep apnea will take the survey. The goal is to see if the survey reduc…

This study looks at older veterans who have both sleep apnea and COPD, a combination called 'overlap syndrome.' Researchers want to see if having both conditions worsens thinking and memory more than having just one. They will also test whether using a breathing machine (CPAP) pl…

This study looks at whether treating obstructive sleep apnea (OSA) with a CPAP machine can improve asthma control in people with difficult-to-treat asthma. Eighty adults will be randomly assigned to receive CPAP, no OSA treatment, or serve as a reference group without OSA. The go…

This study looks at how sleep helps clean the brain. Researchers will use special MRI scans to see the brain's waste-clearing system in 16 healthy young adults. They will also test a headband that tracks brain waves and uses mild electrical pulses to improve sleep and brain funct…

This study looks at immune cells in the gut to understand how they might be linked to multiple sclerosis, Parkinson's disease, and REM sleep behavior disorder. Researchers will collect colon tissue samples from 100 adults during colonoscopy. The goal is to map these cells and the…

This observational study looks at whether removing excess fluid from the body (diuresis) can reduce sleep apnea severity in adults hospitalized with heart failure. Fifty participants will wear a sleep monitor before and after fluid removal, and researchers will track changes in n…

This study looks at whether being awake during the late-night hours (2:00-4:00 AM) can worsen mood, increase hopelessness, and impair decision-making in people who have had suicidal thoughts in the past six months. Researchers will monitor 90 adults in a lab and at home under dif…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

This study aims to understand why many patients have poor sleep after scheduled surgery. Researchers will give questionnaires to 1,000 adults undergoing general anesthesia to measure sleep quality and daytime drowsiness. The goal is to identify factors that disrupt sleep, such as…

This study looks at whether giving light therapy to critically ill children (ages 4-17) in the pediatric ICU is practical and well-tolerated. Each morning, a light box is placed at the bedside, and light levels are measured. Children, families, and staff fill out surveys about th…

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple heart monitoring method. Researchers will track 100 adults with high blood pressure who are at risk for OSA, using heart monitors and slee…

This study looks at whether giving tube feedings during the day instead of at night can improve sleep and body rhythms in patients recovering from heart surgery in the ICU. Researchers will monitor sleep patterns and body temperature in 30 adults. The goal is to learn if simple c…

This study aims to find out how many people in Spain have been diagnosed with narcolepsy type 1 or type 2, and how many new cases are diagnosed each year. Researchers will review medical records from hospitals across Spain to count patients and understand patterns. No treatment o…

This study follows 320 people with small-to-moderate thoracic aortic aneurysms for up to 5 years. Researchers will track major complications like rupture or need for surgery, and look for factors such as high blood pressure or sleep problems that might speed up aneurysm growth. T…

This study looks at two different sedative drugs used during a sleep endoscopy procedure in children with obstructive sleep apnea. The goal is to see if one drug causes more airway collapse than the other, and whether the collapse patterns can predict if sleep apnea will continue…

This study explores whether practicing breathing exercises while awake and then replaying them during sleep can change how people breathe at night and boost their thinking skills. Researchers will recruit 18 adults with untreated obstructive sleep apnea. Participants will train a…

This pilot study tests whether a drug called aprepitant (currently used for nausea) can lower a hormone called aldosterone in people with severe sleep apnea and high blood pressure. The study will enroll 24 adults and measure aldosterone levels before and after taking the drug or…

This study looks at 100 dental students to see if teeth grinding (bruxism), anxiety, and gum health are linked. Participants fill out anxiety questionnaires and get a gum exam. No treatment is given—just observation. The goal is to understand how stress might affect oral health i…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study will explore whether sleep apnea makes multiple sclerosis worse. Researchers will collect sleep studies, MRIs, and lab results from 800 adults with MS to see if there is a link. The goal is to better understand how sleep problems might affect the brain and overall heal…

This study looks at how pregnant women sleep, focusing on the positions they spend the most time in and how often they snore. About 500 women who are at least 28 weeks pregnant will use a sleep monitor at home. The goal is to learn more about sleep patterns during pregnancy and s…

This study looks at how sleep problems and stress can trigger migraines in adults. Participants wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give tailored advice to reduce migraine at…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers think special light-sensitive cells in the eye might be involved. They will measure pupil responses, brain waves during sleep, and daily sleep patterns in 200 adults…

This study looks at how sleep and body clock disruptions impact the brain's reward and impulse control systems in teenagers. Researchers will monitor sleep, brain activity, and decision-making in 100 healthy high school students. The goal is to understand why poor sleep may incre…

This study explores whether simple tongue motor tests can predict where and how severely a child's airway is blocked during sleep. Researchers will assess tongue strength, mobility, and frenulum tightness in 48 children aged 6-17 who are scheduled for surgery to treat obstructive…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study looks at pain in people with idiopathic REM sleep behavior disorder (iRBD), a condition that strongly increases the risk of developing Parkinson's disease. Researchers will compare pain levels and patterns between 24 participants with iRBD and a control group with narc…

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and assess physical function with walking tests. The goal is to find factors that can…

This study is testing new ResMed mask systems in 500 adults who already use CPAP for obstructive sleep apnea. Researchers will track how often the mask is used, how well it seals, and how comfortable it feels. The goal is to confirm the masks work well in everyday life.

This study follows 102 men with metastatic hormone-sensitive prostate cancer who are taking standard drugs (abiraterone, apalutamide, enzalutamide, or darolutamide) plus hormone therapy. Researchers will check thinking skills, fatigue, mood, and sleep at the start, 3 months, and …

This study looks at how sleep quality relates to cognitive functions like attention, memory, and problem-solving in 75 healthy adults aged 18-35. Participants will wear a sleep tracker for five nights and complete thinking tests. The goal is to better understand the link between …

This study looks at how daily light patterns relate to migraine headaches and sleep quality in adults. Over 8 weeks, 20 participants will track their migraines, light exposure, and sleep using diaries and devices. The goal is to understand these connections, not to test a new tre…

This study follows 640 participants—including people with Parkinsonism, those with REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers will use brain scans, movement tests, voice analysis, and other tools to track how the disease progresses and improve di…

This study looks at whether having obstructive sleep apnea (OSA) might help protect the body from damage during surgery to fix a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress o…

This study is following 1,000 people in Korea who have symptoms of sleep apnea, like loud snoring or feeling very tired during the day. The goal is to learn more about the condition and how well patients stick with breathing machine therapy. Participants will have sleep tests and…

This Stanford study watches 20 young women for 28 days to see how sleep, body rhythms, and the menstrual cycle work together. Researchers track movement, heart rate, and other body signals. The goal is to learn how these cycles might affect injury risk, not to test a treatment.

This study looks at how Cognitive Behavioral Therapy for Insomnia (CBT-I) affects the body's stress system, including the hormone cortisol. Researchers will track 115 adults with chronic insomnia, measuring sleep and stress markers before, during, and after therapy. The goal is t…

This study looks at how sleep changes affect the bacteria in your gut. Researchers will ask people who sleep too little to sleep more, and people who sleep enough to sleep less, for 14 days. They want to see if these sleep changes alter the types and amounts of gut bacteria. The …

This study aims to find biological markers in spinal fluid and blood that could signal the start of prion disease before symptoms appear. Researchers will follow 150 people who carry a genetic mutation for prion disease, along with family members and healthy volunteers. Participa…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep in people with normal-pressure hydrocephalus. Researchers want to see if these pressure changes affect how well a surgically placed shunt (a tube that drains fluid from the brain) works. The …

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study is translating a sleep screening questionnaire into Turkish and testing how well it works for children with complex chronic conditions. Researchers will enroll 330 children and teens, tracking their sleep at home and during stays in the pediatric intensive care unit. T…

This study looks at whether simple equations can accurately predict the right CPAP pressure for Thai people with obstructive sleep apnea, compared to the standard overnight lab test. About 150 participants will have a sleep study to check which equation works best. The goal is to…

This study looks at how getting only 4 hours of sleep for three nights, or having insomnia, changes the way people process and control their emotions. Researchers will use brain scans and behavioral tests to compare these groups with people who sleep normally. The goal is to bett…

This study follows 650 people with early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers use brain scans, heart tests, and fluid samples to track changes over time. The goal is to better understand how these conditions de…

This study is testing a small, wireless wearable device that tracks breathing in children. It aims to see if the device works well for kids who have trouble with standard sleep or breathing tests, including premature infants, children with sleep apnea, and those with epilepsy at …

This study tests a new computer program that reads brain activity to tell if someone is conscious or not. Thirty healthy adults will have their brains scanned while awake and asleep. The goal is to see if a simpler, portable version of the test can accurately detect consciousness…

This study watches 150 adults with heart valve problems who are getting a procedure (TAVI or M-TEER) to see if it helps their sleep-disordered breathing. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves mig…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth sores in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal i…

This study looks at how sleeping at high altitude (2,877 meters) affects the sleep quality of 32 employees at Pic du Midi. Researchers will compare nights spent at home versus nights spent at the summit using sleep recordings. The goal is to understand sleep changes in people who…

This study looks at how sleep and body clocks affect the brains of teenagers and their risk for using substances like alcohol or drugs. Researchers will monitor the sleep patterns and brain activity of 200 healthy teens aged 13-18. The goal is to understand how changes in sleep a…

This study looks at whether limiting food intake to an 8-hour window each day can improve sleep, physical activity, and reduce sitting time in college-aged women. Thirty-six female students at the University of Georgia will either follow this eating pattern or receive basic nutri…

This study looks at whether eating smooth peanut butter every day for 8 weeks can improve gut and metabolic health in children aged 6 to 13. Researchers will compare kids who eat peanut butter to those who eat a nut-free chocolate spread. The goal is to see changes in gut bacteri…

This study looks at 135 preschool children aged 3 to 6 to see if being raised by relatives, caregivers, or in daycare affects their development, sensory processing, and sleep. Researchers will use standard tests to measure these areas and compare results across different caregivi…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study compares how people with chronic insomnia and healthy controls recognize facial emotions. Using eye-tracking, researchers will look for subtle differences in attention and emotional processing. The goal is to better understand social challenges linked to insomnia and i…

This study looks at how cannabis use and stopping it affect sleep, daily body rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal i…

This study is testing whether giving expecting parents sleep information and advice can help their babies sleep longer and have fewer sleep problems. About 391 families will be followed for 24 months, with some receiving regular sleep tips and others none. The goal is to see if s…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study looks at 30 six-month-old infants with Down syndrome to see if their sucking patterns are linked to the severity of obstructive sleep apnea (OSA). Researchers will measure sucking bursts and compare them to sleep study results. The goal is to find a simple way to scree…

This study looks at 1,200 children and young adults (ages 1-20) with suspected sleep-disordered breathing to see if their sleep test results match up with problems in thinking, mood, and behavior. Participants will complete sleep studies, questionnaires, and thinking tests. The g…

This study looks at how a brain chemical called norepinephrine affects sleep and thinking in older adults with insomnia, who are at higher risk for Alzheimer's. Researchers will measure this chemical in the blood and use a light therapy to try to improve sleep and mental sharpnes…

This study looks at whether children with a narrow upper jaw (transverse orthodontic deficiency) are more likely to have obstructive sleep apnea. Researchers will compare sleep test results from 102 children aged 6 to 16, some with and some without this jaw issue. The goal is to …

This study looks at young women with anorexia nervosa to see if changes in a gene related to appetite and wakefulness (the orexin gene) are linked to how severe their eating disorder is, whether they have depression, and how well they sleep. Researchers will compare these women t…

This study is creating a national biobank of blood samples and health data from 230 people with Parkinson's disease or a related sleep disorder (REM sleep behavior disorder). Researchers will analyze the complete DNA of each participant to find rare genetic changes that may cause…

This observational study surveys 150 people with isolated REM sleep behavior disorder (iRBD) and their caregivers. iRBD causes people to act out dreams during sleep and is linked to future brain diseases. The study asks about their emotional well-being, access to information, and…

This study checks tongue strength in 78 children with suspected obstructive sleep apnea. Researchers use a device to measure tongue pressure during pushing and swallowing. They compare results to healthy kids to see if weak tongue muscles are linked to sleep problems.

This study explores how severe sleep deprivation in the first 48 hours after childbirth impacts a mother's motivation to breastfeed and her breastfeeding success. Researchers will track 167 new mothers, including those who had C-sections, using surveys and feeding assessments. Th…

This study looks at what happens to blood pressure when healthy adults sleep only 4 hours a night. Researchers will compare normal-weight and obese participants to see if lack of sleep affects their blood pressure differently. The goal is to better understand the link between sle…

This study looks at proteins and metabolites in the body fluids of 60 people with narcolepsy, a rare sleep disorder. The goal is to find biological markers that could explain what causes the condition and help doctors diagnose it more accurately. Participants provide samples for …

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study looks at whether obstructive sleep apnea (OSA) changes how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea using glucose tests. No treatment is given; the goal is to better understand how OSA might affect energ…

This study tests whether it is possible to measure and improve sleep and body clock rhythms in children aged 3 to 6 who are in the pediatric intensive care unit (PICU). Researchers will use a watch-like device and saliva tests to track sleep, and try two simple approaches: bright…

This study looks at adults having dental procedures under general anesthesia to see if undiagnosed sleep apnea raises the risk of breathing problems after surgery. Researchers will use two common screening tools (STOP-BANG and ASA criteria) to identify high-risk patients and refe…

This study is testing whether artificial intelligence can predict hospital readmissions in surgical patients by analyzing data from smartwatches and smart rings. About 300 adults undergoing elective surgery will wear these devices before and after their operation, tracking heart …

This study looks at how reliable the Maintenance of Wakefulness Test (MWT) is for people who feel very sleepy during the day. Researchers will test 100 participants twice to see if the results are consistent. If the test proves reliable, it could help doctors decide who is safe t…

This study looks at whether orthodontic treatments like Twin Block and Hyrax appliances can improve breathing in children aged 8-14 with small jaws and narrow upper airways. Researchers will use 3D scans to measure changes in airway shape and airflow. The goal is to understand if…

This study aims to improve how sleep is measured for nightshift workers, whose inverted schedules make standard sleep trackers inaccurate. Researchers will use an Apple Watch along with machine learning to better detect daytime sleep. About 100 nightshift workers will participate…

This study tests a new program called Bedtime Stories that sends tailored sleep health messages to caregivers of school-aged children (ages 5-11) from low-income and historically marginalized communities. The goal is to see if the program is easy to use and helps improve children…

This study looks at how quickly losing weight through dehydration (using a sauna) affects combat athletes' sleep quality, thinking skills, and leg strength. Twelve athletes with prior weight-cutting experience will be monitored before and after losing 3% of their body weight. The…

This study looks at why central sleep apnea happens and how to treat it better. Researchers will test a combination of a drug (acetazolamide), extra oxygen, and a breathing machine (PAP therapy) in 200 veterans with this condition. The goal is to understand the body's breathing c…

This study looks at whether breathing through the nose or mouth changes how the airway collapses in people with sleep apnea. About 50 adults will have a sleep endoscopy while lightly sedated. The goal is to see if the breathing route during the test matches natural sleep and affe…

This study tests how different frequencies of electrical stimulation affect tongue muscles in 28 adults at high risk for sleep apnea. During a single visit, participants receive five different stimulation frequencies in random order. Researchers measure changes in tongue muscle t…

This study looks at how carpal tunnel syndrome (CTS) severity relates to sleep quality. Researchers will compare 120 CTS patients with healthy controls using ultrasound and sleep questionnaires. The goal is to better understand the connection between nerve compression and poor sl…

This study looks at how sleep and physical activity change for blood cancer patients and their caregivers after a stem cell transplant. Researchers will use a Fitbit to monitor activity, sleep, and heart rate, and ask participants to complete questionnaires about their quality of…

This study looks at how sleep, physical activity, and daily rhythms relate to ADHD symptoms and brain function in 200 children. Kids wear a wristband for two weeks and complete cognitive tests and MRI scans. The goal is to better understand why ADHD affects people differently and…

This study looks at how sleep issues contribute to tiredness and thinking problems in people with multiple sclerosis (MS). About 382 MS patients and a control group without MS will have overnight sleep tests, thinking assessments, and questionnaires. The goal is to better underst…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep disorder called REM sleep behavior disorder (iRBD). Researchers will compare sleep quality among these groups and healthy volunteers using overnight sleep tests. The goal is to better und…

This study aims to see if a short, easy questionnaire can help detect sleep disorders in people visiting a heart doctor. Researchers will ask 1500 adults about their sleep and check if certain sleep problems are linked to heart disease. The goal is to make it simpler for doctors …

This study tests whether installing cooling equipment in low-income homes in Bangladesh can reduce heat stress and improve health. About 1,500 participants will have sensors placed inside and outside their homes and wear monitors to track heart rate, sleep, and other health measu…

This study looks at whether the number of steps breast cancer patients take each day, tracked by a smartwatch, is linked to how well their treatment works. About 82 women with non-metastatic HER2-negative breast cancer will wear a Huawei Fit 2 smartwatch during chemotherapy befor…

This study looks at how cognitive behavioral therapy for insomnia (CBT-I) changes a specific brain receptor (mGluR5) in people with major depression. 42 adults with depression and insomnia will receive online CBT-I and undergo PET brain scans before and after treatment. The goal …

This study looks at whether working unusual hours or having idle time at work makes people more likely to gamble in risky ways. Researchers will interview 25 adults who currently have or have had gambling problems and who have worked in the past year. The goal is to understand ho…

This study will follow 1,000 adults in Spain who are suspected of having obstructive sleep apnea (OSA) and daytime sleepiness. Participants will undergo standard sleep tests, blood pressure monitoring, and fill out questionnaires about their quality of life and sleepiness. Resear…

This study looks at whether sleep quality is linked to gum disease (periodontitis). Researchers will measure sleep quality, fatigue, and certain substances in saliva from 48 healthy adults with or without gum disease. The goal is to better understand how oral health and sleep are…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study looks at how sleep apnea changes fat tissue in adults. Researchers will take small fat samples from the belly and thigh to check for signs of cell damage. They hope to understand why sleep apnea raises the risk of heart disease. The study is currently recruiting 120 pa…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have a 'non-dipping' pattern where blood pressure stays high at night. The goal is to uncover mec…

This study looks at whether taking atorvastatin (a statin) for 4 weeks can lower inflammation in the blood vessels of adults with obstructive sleep apnea who are already using CPAP therapy. Researchers will measure specific markers of inflammation and blood clotting. The goal is …

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track how insomnia develops over the first year, using questionnaires to measure sleep quality and severity. The goal is to understand what factors—like treatment type or em…

This study aims to see if it's practical to measure sleep in adults who play video games regularly but don't have gaming disorder. Forty participants (gamers and non-gamers) will keep sleep and gaming diaries, wear a wrist monitor, and provide urine samples for melatonin testing.…

This study looks at people with interstitial lung disease (ILD) and obstructive sleep apnea (OSA) to learn more about these conditions. Researchers will collect medical data, lung samples, and sleep test results from 70 participants. The goal is to find better ways to diagnose an…

This study tests a program called REPOSE, where a patient navigator helps families overcome barriers to getting specialist care for children with sleep-disordered breathing. The navigator provides support, resources, and coordinates care between doctors and parents. The goal is t…