Sleep disorder

This study tests whether a device can detect when a patient's breathing slows after surgery and then play a recorded voice telling them to breathe. The device uses standard monitors already used in hospitals. The study includes patients who have or may have sleep apnea and are st…

This study tests whether involving patients in managing CPAP machine alerts—using a connected watch and app—can improve how often they use the device. It includes 556 adults with sleep apnea who are at risk for heart problems and likely to struggle with CPAP adherence. The goal i…

This study tests whether an oral drug called PXS-4728A can reduce brain inflammation in 40 adults aged 50-80 with isolated REM sleep behavior disorder (iRBD), a condition often leading to Parkinson's disease. Participants receive either the drug or a placebo for 12 weeks, and bra…

This study tests a device that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot use a CPAP machine. The goal is to see if the device is safe and improves breathing and sleep quality.

This study tests a device that delivers mild electrical stimulation to muscles in the throat to strengthen them and keep the airway open during sleep. It includes 5 healthy volunteers and 12 people with mild to severe obstructive sleep apnea. The goal is to see if using the devic…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This study follows 110 adults with moderate to severe obstructive sleep apnea who have the Genio® device implanted. The device stimulates a nerve to keep the airway open during sleep. Researchers will track safety and effectiveness over 5 years, including changes in breathing pau…

This study looks at whether terazosin, a drug usually used for high blood pressure, can slow the progression of Parkinson's disease. Researchers are tracking changes in heart and brain scans of 15 people who are either in early stages or at high risk for Parkinson's. The goal is …

This phase 2 trial tests whether carvedilol, a drug usually used for heart conditions, can slow the loss of dopamine transporters in the brain and delay Parkinson's symptoms. It follows 15 people with REM sleep behavior disorder and other early Parkinson's risk factors over three…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study looks at whether using a CPAP machine to treat obstructive sleep apnea can help improve insulin resistance and hormone levels in women with Polycystic Ovary Syndrome (PCOS). Researchers will measure changes in fat production, testosterone, and insulin in 20 women aged …

This study looks at whether using a CPAP machine at night can reduce the chance of atrial fibrillation (an irregular heartbeat) returning in people who have both sleep apnea and a history of AF. Researchers will follow 91 adults for 12 months, tracking how often they use CPAP and…

This study tests whether the sleep medication trazodone can slow memory loss in people with mild cognitive impairment and obstructive sleep apnea. Researchers will measure changes in blood markers and thinking skills over one year. 134 participants are enrolled in this double-bli…

This study tests whether a personalized lifestyle plan focused on improving diet, exercise, and sleep according to the body's natural rhythms can lower blood sugar levels in older adults. Sixteen participants aged 50-80 with elevated blood sugar and a long daily eating window wil…

This study follows children with hypotonia (low muscle tone) who have obstructive sleep apnea. They use a flexible silicone nasal tube called ssNPA at night to keep the airway open. Researchers will check how well it works and if children can tolerate it over a year.

This study tests whether the drug idebenone can slow or prevent the progression of a sleep disorder called iRBD into Parkinson's disease or similar brain conditions. About 142 adults aged 40-75 with iRBD will receive either idebenone or a placebo for 5 years. Researchers will tra…

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot or will not use a CPAP machine. Researchers will measure blood pressure changes over 36 weeks in 122 p…

This phase 3 trial tests whether a once-daily pill called orforglipron can improve sleep apnea in 600 adults with moderate-to-severe sleep apnea who are also obese or overweight. Participants are split into two groups: those who cannot or will not use a CPAP machine, and those wh…

This study tests a device that stimulates a nerve in the neck to treat sleep apnea in 57 teens and young adults (ages 10-21) with Down syndrome. The goal is to see if better sleep leads to improvements in thinking, attention, and language skills over 12 months. Participants must …

This study tests a device called the Genio® System, which is implanted under the chin and stimulates a nerve to keep the airway open during sleep. It is for people with obstructive sleep apnea who have not been helped by CPAP machines and have a specific type of airway collapse. …

This study tests whether a millimeter-wave radar system can accurately diagnose type 1 narcolepsy by monitoring sleep without physical contact. Forty patients will use the radar alongside standard sleep tests (PSG/MSLT) to see if the radar matches the standard results. If it work…

This study checks how well a new home sleep test system called SleepView+ can diagnose moderate to severe obstructive sleep apnea in people ages 12 and older. About 200 participants will first use the device during an overnight lab sleep study to compare results, then try it at h…

This study is testing whether a wearable ring and a small body sensor can accurately diagnose sleep-disordered breathing, including sleep apnea. About 79 adults with suspected sleep apnea will wear the devices during an overnight sleep lab test. The goal is to see if the ring's r…

This study explores whether parents can use their smartphones to record short videos of their child sleeping to screen for obstructive sleep apnea (OSA). Children with Down syndrome are at higher risk for OSA, but standard sleep studies can be hard to access. Parents will rate th…

This study planned to test a new wearable wireless device that wraps around a child's abdomen to monitor central sleep apnea. It would have involved 15 children aged 1 month to 5 years already undergoing standard sleep studies. The device's accuracy and comfort would have been co…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study tests whether Withings bathroom scales can accurately measure pulse wave velocity (PWV), a key indicator of vascular stiffness. Researchers will compare readings from the scales with a standard medical device in 176 adults, including those with high blood pressure, sle…

This study checks if a special mouthpiece that measures oxygen levels during sleep is as accurate as the standard sleep lab test. Thirty adults with obstructive sleep apnea will wear the device overnight in a sleep lab. If it works well, it might offer a simpler way to track oxyg…

This study checks if a Withings smartwatch can accurately detect sleep apnea compared to a full hospital sleep test. About 220 adults who are already scheduled for a sleep test will wear the watch overnight. The goal is to see if the watch can help screen more people for sleep ap…

This study tests whether a non-contact device placed under the mattress can accurately detect sleep apnea. Researchers will compare the device's readings to standard sleep tests in 200 adults suspected of having sleep apnea. If proven reliable, this could offer a simple, low-cost…

This study tests a new 'intelligent duvet' called Easy Sleep Monitoring (ESM) that uses built-in sensors to detect movement and estimate sleep. Researchers will compare its accuracy to standard sleep lab tests (video-polysomnography) in 50 people, including those with sleep disor…

This study tests whether a short, modified exposure therapy given soon after rape can prevent post-traumatic stress disorder (PTSD) in women. About 166 women who have experienced sexual assault will be randomly assigned to either the brief therapy or standard care. The goal is to…

This study tests whether a digital sleep program (CBT-I) can prevent depression in pregnant people with insomnia. 456 participants will either use the CBT-I app or receive standard sleep hygiene education. Researchers will track who develops depression through one year after birt…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This study tests whether inhaling or massaging with lavender, marjoram, and vetiver oils can help people with bruxism (teeth grinding). Sixty-four adults aged 18-25 will use the oils twice daily for a period. Researchers will measure changes in jaw muscle elasticity and thickness…

This study tests whether a dietary supplement called Dong'e Brand Ejiao Yuanjiang can help improve sleep quality. Researchers will enroll 66 adults aged 25 to 55 and track their sleep over 60 days using questionnaires and wearable devices. The goal is to see if the supplement lea…

This Phase 3 study tests whether nightly doses of CBD (75mg or 150mg) can reduce insomnia severity in adults over 8 weeks. Participants take capsules or a placebo, and researchers measure changes in sleep quality using a standard questionnaire and sleep efficiency. The goal is to…

This study tests whether adding personalized feedback to an online sleep program helps university students with insomnia. About 70 students will be split into three groups: standard online therapy, enhanced therapy with feedback, or a waitlist. The goal is to see if the extra fee…

This study investigates whether menopausal hormone therapy (MHT) can improve sleep quality in women going through menopause. Researchers will compare sleep in women who receive MHT to those who do not, using questionnaires and sleep diaries. The goal is to see if MHT can help wit…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This study tests whether a constructive ICU diary can reduce stress, sleep problems, and fatigue in family caregivers of ICU patients on ventilators. About 142 caregivers will be invited to keep a diary during their loved one's ICU stay. Researchers will measure changes in sleep,…

This study tests whether drinking a ketone supplement (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use a CPAP machine. Participants will try two different doses and compare effects to a placebo. The goal is to find a si…

This study is testing whether a 6-month program of online exercise classes, guided meditation, and nutrition advice can improve thinking, sleep, and overall health in people with Parkinson's disease. 60 participants aged 40 to 85 will take part, with some starting the program rig…

This study tests whether a wearable headband that shines near-infrared light can improve depression and sleep in adults aged 60 and older with major depression. Participants will wear the device for up to 8 weeks, and researchers will track sleep, mood, and daily activity using a…

This pilot study tests a tailored sleep health program for family caregivers who live with and assist a loved one with chronic health conditions. The program combines cognitive behavioral therapy, mindfulness, and caregiving guidance to improve sleep regularity, timing, efficienc…

This study tests whether an 8-week forest therapy program—combining walking, resistance band exercises, and sensory activities like aromatherapy—can improve muscle strength and well-being in older women with sarcopenia. Thirty-six women aged 55 and older will participate in 16 se…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep quality. The goal is to find simple, at-home way…

This study tests a modified version of Cognitive Behavioral Therapy for Insomnia (CBTi) to see if it can improve sleep and thinking in adults with insomnia. About 37 participants will receive the therapy and be monitored for changes in sleep quality and cognitive function. The go…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who have lost weight and have little desire to eat. About 98 patients will receive either mirtazapine or a placebo for 29 days. Researchers will track ch…

This study compares two parent training programs for 3-5 year olds with sleep problems and early signs of ADHD. One program focuses on behavior, the other adds sleep strategies. Researchers want to see if the sleep-focused approach is more helpful and practical for families in pe…

This study aimed to see if taking branched-chain amino acids (BCAAs) could improve oxygen levels during sleep in people with sleep apnea. The researchers planned to include adults with confirmed sleep apnea but exclude those with severe cases. However, the study was withdrawn bef…

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This study compares listening to Holy Qur'an recitation versus calming music before bed in children aged 6 to 10 who are undergoing chemotherapy. Sleep problems are common in these children, and the goal is to find a safe, non-medication way to improve sleep quality. Ninety child…

This phase 2 trial tests whether combining cognitive behavioral therapy, a stimulant (methylphenidate), melatonin, and light therapy can improve sleep in cancer patients. About 68 patients currently on cancer treatment who have sleep problems will participate. The study measures …

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

This study compares two digital stress-reduction programs for first-year college students: a personalized mindfulness app (Equa) and a problem-solving program. About 200 students from four universities will use one of the programs and report on stress, sleep, mood, and grades. Th…

This study tests whether an 8-week aquatic high-intensity interval training (HIIT) program can improve balance, physical function, and muscle health in people with Parkinson's disease. Fifty-six participants with mild to moderate Parkinson's will do Tabata-style exercises in a po…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety, improve sleep, and lessen pain and itching in adults recovering from burn injuries. About 60 participants will either get standard physical therapy plus this nerve st…

This study aims to find the best way to deliver cognitive behavioral therapy for insomnia (CBT-I) to cancer survivors who have chronic sleep problems. Researchers are comparing individual vs. group sessions and whether adding booster sessions helps. The goal is to create an effec…

This study looks at whether a non-invasive device that stimulates the vagus nerve can improve anxiety, sleep, pain, and itching in teenagers aged 12-18 who have had burn injuries. About 60 participants will either get this stimulation plus standard physical therapy, or just stand…

This study tests whether listening to specific sound frequencies for just 9 minutes a week can improve mental health. 110 adults with mild anxiety, stress, or depression will either sit in a special sound chamber or use headphones. The goal is to see if this simple, drug-free app…

This Phase 2A study tests three drugs—sivopixant, acetazolamide, and SASS-001—in 60 adults with sleep apnea that has a central component (where the brain fails to signal breathing). The goal is to see if these drugs can reduce the number of breathing pauses during sleep. Particip…

This study tests two different mouthpieces (mandibular advancement devices) for people with obstructive sleep apnea who cannot use a CPAP machine. Twenty-eight participants will wear one of the two devices for a year, and researchers will track comfort, side effects like jaw pain…

This study tests whether a numbing injection near the glossopharyngeal nerve, combined with topical anesthesia, can help people recover faster after surgery for obstructive sleep apnea. The trial involves 80 adults with moderate to severe sleep apnea who are scheduled for palatop…

This study tests a mobile app called RN-SLEEP that teaches night-shift nurses cognitive-behavioral strategies to improve sleep and reduce fatigue. 76 nurses will use either the RN-SLEEP app or a control app for several weeks. Researchers will measure sleep duration, quality, and …

This early-phase study looks at whether Emotional Freedom Techniques (EFT) — a practice that combines tapping on acupressure points with counseling — can reduce anxiety, depression, pain, and insomnia in people with cholangiocarcinoma, a rare and aggressive bile duct cancer. Four…

This study tests whether virtual reality (VR) meditation can improve sleep and reduce anxiety in people with chronic pain and insomnia. About 30 adults with both conditions for at least 6 months will use VR meditation and track their sleep, pain, and mood. The goal is to see if t…

This study tests whether virtual yoga classes can help cancer survivors who have trouble sleeping. About 42 survivors will either take 8 virtual yoga sessions over 4 weeks or continue their usual care. Researchers will measure changes in insomnia and sleep quality to see if the o…

This study tests a wearable device called PeakSleep that uses mild electrical stimulation on the brain to help people with insomnia fall asleep faster and wake up less during the night. About 78 adults with insomnia will wear the device at home and track their sleep with a FitBit…

This study tests whether a digital version of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in 140 adults with chronic pain and insomnia. Participants will either receive the digital CBT-I program or digital sleep hygiene education. The goal …

This study tests a phone-based sleep therapy for people who have insomnia and drink alcohol in ways that could harm their health. The therapy adapts standard insomnia treatment to also address alcohol-related thoughts and behaviors. Researchers will first refine the approach with…

This pilot study from Mayo Clinic tests whether dry needling combined with therapeutic exercise can improve sleep in people with chronic neck pain and sleep problems. Researchers will enroll 28 adults aged 18–75 who have had neck pain for over 3 months and report poor sleep. The …

This study tests whether a special type of talk therapy for insomnia (CBT-I) that is customized for shift workers can improve sleep, mental health, and quality of life. About 84 healthcare workers who work rotating shifts including nights will either receive this tailored therapy…

This study compares a home-based, tailored sleep therapy (CBT-I) to a web-based version for 80 caregivers who have insomnia while caring for a child with autism. The goal is to see which approach is more acceptable and feasible for improving sleep and reducing caregiver burden. P…

This study looks at whether a combination of back adjustments (thoracic manipulation) and classic massage can help people with long-term mechanical back pain. About 60 adults aged 18 to 65 with at least 3 years of back pain will receive these treatments. Researchers will measure …

This study tests whether using a virtual reality (VR) relaxation program can reduce nausea and vomiting, improve sleep quality, and increase comfort in pregnant women. About 90 women in early pregnancy (6-14 weeks) will either use VR relaxation or receive standard care. The goal …

This study tests a combination of two medicines (atomoxetine and oxybutynin) given at bedtime for 6 months to children aged 6-17 with Down syndrome and obstructive sleep apnea. The goal is to see if the treatment improves sleep quality and thinking skills. About 36 children will …

This study tested whether taking 400 mg of magnesium citrate daily for 90 days could improve sleep quality and cognitive function in healthy Saudi adults who reported poor sleep. Researchers compared 41 participants who took the supplement to a control group that took nothing. Th…

This study aimed to see if an educational game called Yapouni could help children aged 3 to 16 use their CPAP or NIV breathing machines more consistently. The game was designed to motivate children by linking machine use to a hot air balloon's flight. However, the study was withd…

This study tests whether watching calming 360-degree videos through virtual reality goggles can improve sleep quality and comfort for older adults (60+) staying in the hospital. Sixty participants will be randomly assigned to either watch the videos for 20 minutes each night or r…

This study tests whether a 9-week online cognitive behavioral therapy program can improve sleep in people with multiple sclerosis (MS). About 550 participants in Norway will either receive the digital therapy or digital education about insomnia. The main goal is to see if the the…

This study tests whether a breathing training program can improve sleep in people whose insomnia is linked to anxiety or depression. Researchers will monitor sleep quality and heart activity in 188 adults. The goal is to find a simple, drug-free way to ease sleep problems and und…

This study tests whether an app that provides cognitive behavioral therapy for insomnia, enhanced with an AI chatbot, can help young people (ages 18-25) sleep better. Half of the 168 participants will use the app with the chatbot, and the other half will use the same app without …

This study compares two mind-body programs—Mahayana Buddhist Awareness Training and Qigong—to see which helps people aged 50-75 with insomnia sleep better. Participants will practice one of these methods and researchers will measure sleep quality, brain activity, and heart rate c…

This study looks at whether adding pelvic floor muscle exercises to deep breathing can help reduce pain during periods in women with primary dysmenorrhea. Forty women will be split into two groups: one doing both exercises, the other only deep breathing. Researchers will measure …

This study tests whether a four-week program called Brief Behavioral Treatment for Insomnia (BBTi) can help middle-aged and older adults with chronic insomnia sleep better and feel less stressed. The program includes sleep education, relaxation techniques, and personalized coachi…

This pilot study tests whether listening to specially designed audio patterns (Brain Dynamic Audio Stimulation) for 30 minutes daily can improve sleep in healthcare workers with insomnia. Fifteen participants will use the audio for two weeks, and researchers will measure changes …

This study tests whether teaching people with type 2 diabetes about good sleep habits and a simple relaxation exercise can help them sleep better, feel less anxious, and improve their blood sugar control. Fifty-two adults with poor sleep quality will be followed for six months. T…

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study aimed to see if using a special nasal mask that provides positive airway pressure (PAP) during colonoscopy sedation could reduce the frequency, length, and severity of low oxygen levels compared to standard oxygen through a nasal cannula. The study planned to enroll hi…

This study tests whether a mobile web-based app can reduce stress and improve sleep quality in nursing students. About 116 students will use the app for 12 weeks, and researchers will measure changes in stress levels and sleep quality. The goal is to find a simple, accessible too…

This study tests whether acupressure (applying pressure to specific points on the body) and back massage can reduce pain, fatigue, and improve sleep quality in women recovering from a cesarean section. About 111 new mothers will receive these non-drug treatments after surgery. Th…

This study tests whether combining two sedatives, remimazolam and propofol, works better than propofol alone or with midazolam during a procedure called drug-induced sleep endoscopy (DISE) for people with obstructive sleep apnea. The goal is to see if the combo leads to more succ…

This study tests whether a special cooling mat can reduce hot flashes and night sweats in people taking hormone therapy for breast or prostate cancer. About 40 participants will use the mat for 8 weeks and track their symptoms. The goal is to see if this simple, non-drug approach…

This study tests whether doing simple mouth, tongue, and throat exercises using a mobile app can improve snoring and sleep apnea better than following a paper guide. The 34 participants are adults with mild to severe obstructive sleep apnea who could not or would not use a CPAP m…

This study tests a device called Cereset that plays tones to mirror your brainwaves, aiming to reduce stress, anxiety, insomnia, and depression. About 40 nurses from one hospital unit will use the device. The goal is to see if it improves their well-being and job performance.

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study tests whether a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve sleep and daily functioning in veterans who have both psychosis and insomnia. About 152 veterans are taking part. The goal is to see if better sleep leads to bette…

This pilot study tested whether kava, a herbal supplement, could safely reduce anxiety and stress in 43 cancer survivors who had completed treatment. Participants took either kava or a placebo for 14 days, then switched after a washout period. The trial is currently suspended, an…

This phase II study tests whether a computerized cognitive training program can improve sleep and brain health in 240 older adults (65+) with insomnia. Participants will do brain exercises at home for about 36 minutes a day, five days a week, for 36 sessions. The study compares t…

This study tests whether an 8-week mobile app program, including education and counseling, can reduce urinary incontinence symptoms and improve quality of life and sleep in menopausal women. 82 women aged 40-65 are split into two groups: one uses the app with phone support, the o…

This study looked at whether sunlight exposure therapy could improve sleep problems in people with Alzheimer's disease. Sixty participants with mild Alzheimer's and sleep issues received a health education plan on sun exposure and were followed for 14 days. The goal was to see if…

This study tests two simple activities—pedaling a stationary bike and using a breathing device—during dialysis sessions to see if they reduce fatigue and improve sleep. 102 adults on hemodialysis will be split into three groups: one does leg exercises, one does breathing exercise…

This study tests a new digital app called Stellar Sleep, which provides cognitive behavioral therapy for insomnia (CBT-I) online. It aims to help people with insomnia improve their sleep by using a smartphone or computer, and it can automatically upload sleep data from wearable d…

This study tests a 6-week educational program called SLEEP, designed to teach older adults better sleep habits. Researchers will measure changes in sleep quality, duration, daytime sleepiness, and insomnia symptoms in 210 participants aged 40 and older. The goal is to see if this…

This study tests whether taking a prebiotic supplement for 56 days can improve sleep quality, gut health, thinking, immune function, and stress in healthy adults who report poor sleep. Sixty-eight volunteers will be randomly assigned to receive either a prebiotic blend or a place…

This study looks at whether actively caring for plants (like watering and pruning) can lower stress, improve mood, and boost academic motivation in college students. About 87 students will either care for plants on campus, at home, or not engage with plants at all. Over a 16-week…

This study tests whether ear acupuncture can help active-duty military members and their families sleep better. 180 people with sleep problems will receive either ear acupuncture or a sham treatment. The needles stay in for a few days or are removed after 45 minutes. Researchers …

This study looks at whether pranayama breathing exercises can help people with fibromyalgia feel less pain, anxiety, and sleep better. About 54 adults with fibromyalgia will practice these breathing techniques. The goal is to see if this gentle, low-cost approach can improve qual…

This study tests whether two different essential oil blends can reduce agitation (sundowning) and improve sleep in 35 people with dementia living in long-term care. Participants receive a stimulating morning blend and a relaxing afternoon blend, then a calming all-day blend, each…

This study tests whether showing people with sleep apnea how their CPAP machine use compares to other patients helps them use it more consistently. About 186 adults who have been on CPAP for at least three months will be split into two groups: one gets routine feedback on their o…

This study tests a new, non-invasive treatment using low-intensity ultrasound to stimulate a deep brain area (the hippocampus) in older adults with mild memory and sleep problems. The goal is to see if it safely improves sleep quality and thinking skills. Twenty participants aged…

This study tests whether a short, nurse-led group therapy based on sleep restriction can help people with insomnia. 104 adults with insomnia will either receive the sleep restriction program or standard sleep hygiene advice. The goal is to see if this simpler approach reduces ins…

This study tests a behavioral sleep and circadian intervention for 50 school-aged children (6–12 years) with autism who have sleep problems. Parents receive 5 Zoom sessions over 12 weeks to learn strategies to improve their child's sleep. The goal is to see if the program is feas…

This study tests whether an 8-week mindfulness program (breathing, body scans, mindful movement) can reduce digital game addiction, stress, and improve sleep in 80 adolescents aged 12-16. Participants are randomly assigned to either the mindfulness group or a control group that c…

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty participants will try three different stimulation patterns over several weeks. The goal is to find t…

This study tests whether a simplified behavioral relaxation program can improve sleep in pregnant women with insomnia. Twenty women in their second or third trimester will receive coaching calls and sleep hygiene tips. The goal is to see if this approach helps them fall asleep fa…

This study compares two non-drug therapies—mindfulness-based therapy and cognitive-behavioral therapy—for pregnant women who have both insomnia and depression. About 100 women in their second trimester will participate to see which approach better reduces sleep problems and depre…

This study is testing whether special drug-free patches can help relieve acute back, shoulder, or other muscle pain and improve sleep. The patches use a gentle vibration technology instead of medication. 150 adults aged 18-64 will wear either an active patch or a sham (fake) patc…

This study tests a special sound app designed to help pregnant women in their first or second trimester who have trouble sleeping. Thirty women will use the app for two weeks, and researchers will track their sleep quality using diaries and smartwatches. The goal is to see if the…

This study compares two common surgical tools (monopolar and bipolar electrocautery) used during tonsil removal to see which one causes less pain and bleeding after surgery. It involves 74 people aged 5 to 40 who need their tonsils out due to chronic tonsillitis or other issues. …

This study looks at whether adding 10 grams of fibre to your daily diet for two weeks can improve mental wellbeing, including anxiety, stress, sleep, and mood. Researchers will track changes in 40 healthy adults aged 18-40 using questionnaires. It's a small, early-stage trial to …

This study looks at whether acceptance and commitment therapy (ACT) can improve sleep for adults with sickle cell disease. Participants will have weekly video chats with a coach for 8 weeks and wear a wrist device to track sleep. The goal is to see if this approach is practical a…

This study looks at whether Tai Chi, a gentle moving meditation, can improve chronic insomnia in breast cancer survivors. About 90 women who have completed cancer treatment and have had trouble sleeping for at least 6 months will practice Tai Chi. Researchers will measure sleep q…

This study is testing whether magnesium L-threonate, a form of magnesium that can reach the brain, improves sleep, recovery, and athletic performance in 100 UCLA varsity athletes aged 18-35. Participants take either the supplement or a placebo nightly for 4 weeks while wearing a …

This study tests whether gentle electrical stimulation to the brain can improve sleep quality and help people with insomnia fall asleep faster. Researchers will compare a personalized stimulation approach to a fixed one and a sham (fake) stimulation. 1000 adults aged 18-75 with i…

This study looks at whether adding stabilization exercises to regular neck exercises helps office workers with neck pain feel better, improve their posture, and sleep more soundly. Thirty participants will do either neck exercises alone or neck exercises plus stabilization exerci…

This study tests whether a gentle hand massage along the vagus nerve can quickly improve blood pressure, heart rate, and oxygen levels in people with moderate to severe sleep apnea. One hundred adults will either receive the 16-minute massage or rest quietly. Researchers will mea…

This study looks at whether eating more protein—from either animal (casein) or plant (soy) sources—can improve sleep quality in adults aged 60 to 85 in Singapore. Fifty-four participants will follow a higher-protein diet and have their sleep measured using questionnaires and acti…

This study tests whether a program called the Model of Occupational Harmony (MOHar) can help people with sleep disorders sleep better and feel better. Forty adults with poor sleep will either get this program—which helps them redesign their daily routines with an occupational the…

This study looks at whether adding cognitive behavioral therapy for insomnia (CBT-I) to standard knee osteoarthritis care (education and exercise) helps reduce pain and improve function. About 128 adults aged 45+ with both knee osteoarthritis and insomnia will be followed for 6 m…

This study looks at whether weekly group drumming for 8 weeks can improve the health of people aged 60 and older living in the community. Researchers will measure changes in quality of life, depression, sleep, and blood pressure. 300 participants will take part, and the goal is t…

This study tests whether simple changes to electronic health records can help doctors prescribe fewer Z-drugs (like Ambien) for insomnia. About 444 primary care clinicians will be randomly assigned to receive either a default of only 10 pills for new orders, an alert suggesting a…

This study was designed to see if cognitive behavioral therapy for insomnia (CBT-I) could help teenagers with ADHD who also have trouble sleeping. It planned to enroll adolescents aged 11-18 with both ADHD and insomnia. However, the trial was withdrawn before any participants wer…

This study will survey directors of dental programs at Italian universities to find out if sleep medicine is part of the curriculum. The goal is to understand how much future dentists learn about sleep-disordered breathing like sleep apnea. About 70 program directors will answer …

This study examines how common obstructive sleep apnea (OSA) is in adult survivors of Hodgkin lymphoma who received chest radiation. Researchers will compare 220 survivors to matched controls using sleep tests, brain scans, and heart assessments. The goal is to understand links b…

This study looks at how continuous positive airway pressure (CPAP) therapy affects body signals like oxygen levels, heart rate, and breathing in adults with obstructive sleep apnea. Researchers will analyze data from 160 people who completed a previous trial, comparing signals be…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This study tests whether a single evening yoga session can improve sleep and heart health in adults aged 18–40, both those with insomnia and healthy sleepers. Participants will try a moderate-intensity vinyasa yoga session, a gentle yoga session, and a quiet rest period on separa…

This Mayo Clinic study will follow 100 adults with narcolepsy or idiopathic hypersomnia who are starting a new treatment. Researchers will measure changes in blood pressure over 24 hours and track eye movements during a simple mental test before and after at least 3 months on med…

This study looks at how changing sleep patterns affects eating behavior and self-control in 120 children who are overweight or at risk for obesity. Researchers will monitor sleep, brain activity, and real-world eating to understand the link between sleep and weight gain. The goal…

This study is testing whether a simple breath test, called fractional exhaled nitric oxide (FeNO), can help measure the severity of obstructive sleep apnea (OSA). Researchers will compare FeNO levels in 200 adults with different levels of sleep apnea to see if the test can predic…

This study was designed to see if drinking MoonBrew every evening for 30 days helps people sleep better and feel less stressed. It was open to US-based adults without allergies to mushrooms or adaptogens. The study was withdrawn before any participants enrolled, so no results are…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study explores whether a smartwatch app with personalized reminders can help people with insomnia better track their emotions, diet, exercise, and sleep. Sixty participants will wear a smartwatch and use an app for two weeks, with some receiving reminders timed to their dail…

This study tests whether showing parents an infographic about obstructive sleep apnea (OSA) symptoms helps more children get diagnosed. About 200 parents of children with OSA symptoms will either see the infographic or receive usual care. Researchers will compare how many childre…

This study looks at whether improving sleep through cognitive behavioral therapy (CBT-I) can reduce neuropsychiatric symptoms like anxiety, depression, and agitation in 150 older adults with mild cognitive impairment or early Alzheimer's. Participants are randomly assigned to CBT…

This study looks at how the body's internal clock (circadian rhythm) affects heart disease risk, especially in people with obesity. Researchers measured blood pressure and other heart markers in 17 lean and overweight adults over 5 days. The goal is to understand if obesity creat…

This study tests a program that offers housing and on-site employment to adults who are at risk of homelessness. Researchers want to see if this approach reduces emergency room visits and improves housing stability, employment, and quality of life. About 750 participants will be …

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study was designed to see if a new type of airway device can prevent dangerous drops in oxygen levels during anesthesia in patients who are at high risk, such as those with obesity or sleep apnea. Researchers planned to compare the new device with standard ones in adults und…

This study looks at why sleep apnea raises the risk of diabetes. Overweight adults with and without sleep apnea will have their blood sugar control measured. Some will receive CPAP, some will get extra oxygen at night, and others will get a sham treatment. The goal is to find out…

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at whether adding one structured 60-minute play session each week for 12 weeks helps preschool children aged 3-6 improve their movement, sleep, motor skills, fitness, thinking, and emotions. About 80 children from a school in Portugal are taking part, with some g…

This study looks at whether bruxism (teeth grinding) is linked to changes in muscle function and a higher risk of injuries, especially in the shoulder, among amateur athletes. Researchers will measure muscle tone, stiffness, and strength in 120 swimmers and handball players. The …

This study looks at how sleep apnea might cause prediabetes to turn into diabetes. Researchers will use CPAP machines and niacin infusions in 300 overweight, prediabetic adults with sleep apnea to measure changes in blood chemicals. The goal is to understand the biological steps …

This study looks at sleep health in 50 low-income pregnant women. Researchers will use a home sleep test and a wrist activity monitor to measure sleep. They want to see how sleep relates to heart health and social factors. The goal is to create better sleep screening and treatmen…

This small study tests whether the supplement N-acetylcysteine (NAC) can reduce oxidative stress and inflammation in people with obstructive sleep apnea who are already using standard PAP therapy. Researchers want to see if the effects differ between men and women. The study invo…

This pilot study aimed to see if personalized lifestyle coaching and a simple handout could help emergency medicine residents stay alert and perform better during night shifts. The study planned to compare coached residents to those receiving only a handout, measuring reaction ti…

This study compares two ways to predict heart and metabolic problems in people with mild-to-moderate obstructive sleep apnea: one based on inflammation in the body, and the other based on how severe the sleep apnea is. Researchers will measure things like waist size, blood pressu…

This study looks at whether spending time at the Belgian coast can improve physical and mental health in people over 60. Sixty retired adults will take a walk along the coast and another walk in the city on different days. They will wear sensors to measure heart rate and stress, …

This study planned to work with teens to improve a mobile app called Firefly, which uses cognitive behavioral therapy to help with insomnia. The goal was to make the app more engaging for teenagers. However, the study was withdrawn before any participants were enrolled, so no res…

This study follows 104 Singaporean children ages 7–12 and their parents to understand how parents' attitudes, rules, and own sleep habits affect children's sleep, mental health, social skills, and school performance. Researchers will track sleep using watches and surveys over tim…

This study tested whether a mobile app called 'Smart Nurse' could improve the nutrition, exercise, and sleep habits of high school students aged 14-18. For 12 weeks, 146 teens used the app daily to log meals, activity, and sleep, and received personalized health tips. Researchers…

This study looks at how well children sleep before knee surgery and whether that affects their pain and need for painkillers afterward. Researchers will ask kids about their sleep and track their pain and opioid use for two weeks after surgery. They will also use smart pill bottl…

This study looks at whether measuring body water with a harmless device can help detect obstructive sleep apnea (OSA) in pregnant women with severe obesity. OSA is common but often missed in this group, and can be dangerous for both mother and baby. Researchers will enroll 52 wom…

This study looks at how age-related sleep changes and sleep apnea might increase the risk of Alzheimer's disease. Researchers will use brain scans and overnight sleep tests in 158 healthy adults aged 55-75 to measure amyloid buildup and sleep patterns over two years. The goal is …

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study looks at whether treating obstructive sleep apnea (OSA) with a breathing device (CPAP) lowers blood pressure more in people who are very sleepy compared to those who are not. Researchers will analyze data from about 10,000 adults with OSA from previous studies. The goa…

This study aims to understand the genetic factors behind obstructive sleep apnea (OSA) and its related health issues. Researchers will enroll 5,000 adults who have been diagnosed with or are suspected of having sleep apnea. Participants will provide genetic samples and answer sle…

This study uses a 30-40 minute online survey to understand how being on call affects sleep in 1,000 medical trainees (students, residents, fellows). It looks at sleep quality, quantity, and disruption to body rhythms. The goal is to gather knowledge to improve sleep health for he…

This study looks at how jaw surgery changes not just your bite and appearance, but also your emotions, jaw muscles, and joint health. Researchers will follow 100 patients before and after surgery, using scans, muscle tests, and questionnaires to track these changes. The goal is t…

This study looks at how chronic insomnia affects brain function during memory and emotional tasks, and whether cognitive-behavioral therapy (CBT-I) can reverse those changes. About 120 adults (80 with insomnia and 40 healthy sleepers) will undergo brain scans before and after the…

This study aims to develop an algorithm that can detect insomnia and measure its severity using data from Withings smart devices (like the ScanWatch or Sleep Analyzer) and questionnaires. Researchers will enroll 17,000 adults who already own these devices. The goal is to create a…

This study looks at whether continuous heart rate variability (HRV) monitoring can predict how well patients with inflammatory bowel disease (IBD) respond to biologic therapies like infliximab or vedolizumab. Researchers will track HRV in 100 patients starting treatment and compa…

This study is investigating whether bruxism (teeth grinding or clenching) is associated with pelvic pain, erectile dysfunction, and anxiety in young men aged 18-30. Researchers will use questionnaires and physical exams to assess 100 participants. The goal is to better understand…

This study explores whether bruxism (teeth grinding or clenching) is related to pelvic floor dysfunction in young women aged 18-30. Researchers will use questionnaires and physical exams to assess jaw function, pelvic floor symptoms, and anxiety in 100 participants. The goal is t…

This study looks at whether taking a special morning and evening food supplement for 6 months can improve blood markers linked to aging in healthy adults aged 50 to 70. Sixty participants will be randomly assigned to take either the supplement or a placebo. Researchers will measu…

This study examines the links between sleep bruxism (teeth grinding during sleep) and sleep quality, heart health, thyroid function, and mood. Researchers will give some participants opipramol, a drug that may reduce grinding activity, and monitor them with sleep tests. The goal …

This study looks at whether carvedilol, a drug used for heart failure, can reverse early heart changes seen in people with a sleep disorder that puts them at high risk for Parkinson's disease. Fifteen participants with REM sleep behavior disorder or reduced sense of smell will ta…

This study looks at whether terazosin, a drug used for high blood pressure, can change heart nerve activity in people at high risk for Parkinson's disease. Researchers are studying 15 adults with REM sleep behavior disorder (a strong early sign of Parkinson's) to see if the drug …

This study looks at how working night shifts changes eating behaviors and appetite compared to day shifts. Researchers will measure food intake, hunger hormones, and fullness in 100 healthy adults who work either day or night shifts. The goal is to understand why night workers ar…

This study looks at whether sleep-disordered breathing, like obstructive sleep apnea, is linked to worsening spine curves in children with idiopathic scoliosis. Researchers will follow 405 children aged 6 to 15 with mild to moderate scoliosis. They will measure spine curves and s…

This study uses a small skin sample to measure levels of a protein linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 participants for 18 months to see if changes in the protein match disease progression. The goal is to develop a simple bio…

This study looks at whether remote video visits (tele-visits) work as well as in-person home visits for people using a CPAP machine to treat sleep apnea. About 320 adults who have been using CPAP for at least a year will take part. The main goal is to see if tele-visits help peop…

This study looks at whether doing brain-training exercises in the morning or the afternoon helps older adults (60+) recover thinking skills after a stay in the intensive care unit. Forty participants will either train in the morning, in the late afternoon/evening, or receive usua…

This study looks at whether dopamine levels and certain genes affect the risk and severity of sleep breathing disorders like sleep apnea. Researchers will monitor 100 adults overnight and take blood samples to measure dopamine and check for genetic variations. The goal is to bett…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study looks at how sleep and your internal body clock influence blood pressure at night. Researchers will monitor over 1,400 participants using a constant routine protocol—staying awake in a dim room for over 24 hours—to measure melatonin, body temperature, and blood pressur…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study looks at whether leaving a breathing tube in for 24-48 hours after gastric cancer surgery can lower complications in patients who also have severe obstructive sleep apnea. Researchers will compare two groups of 240 patients: one with standard tube removal and one with …

This study looks at whether eating a high-carb or high-protein dinner 3-4 hours before bed can help medical residents sleep better. 90 participants will be assigned to one of three meal types for two weeks. Sleep quality will be measured using questionnaires and smartwatches, and…

This study interviews 20 people aged 16-25 who have had bladder or urinary problems since childhood and are now moving from pediatric to adult care. Researchers want to learn about their experiences, challenges, and opinions to make this transition smoother for others. No treatme…

This study follows 1,500 people with long-term pain who are joining rehabilitation programs. Researchers want to understand how insomnia symptoms influence pain, function, and work ability. The goal is to use this knowledge to improve future treatments for chronic pain.

This study looks at how stimulating two specific tongue muscles (palatoglossus and genioglossus) affects airway size during a sleep endoscopy procedure. Researchers will measure changes in the airway with and without stimulation in 60 adults with obstructive sleep apnea who canno…

This study is surveying 2500 adults from Croatia, Greece, Italy, Slovenia, and Spain to explore how diet, exercise, sleep, stress, and social habits relate to physical and mental health. Participants complete an online questionnaire about their lifestyle and well-being. The goal …

This study was designed to see if stimulating both sides of a tongue nerve during sleep could improve airway collapse in people with obstructive sleep apnea who already have an Inspire device. It was withdrawn before enrolling anyone, so no results are available.

This study aimed to see if giving extra oxygen at night could improve blood sugar control in people living at high altitudes who have sleep-disordered breathing. It was designed for permanent residents of Puno, Peru, but was withdrawn before any participants were enrolled. No res…

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study looks at children aged 10-15 who need braces for prominent upper front teeth. Some will have upper premolars removed as part of treatment, others will not. Researchers will use sleep studies before and after treatment to see if the extractions increase the risk of obst…

This early study at Mayo Clinic tests whether using a device that massages the legs at night can help the brain clear waste products better in people with obstructive sleep apnea. The study involves 12 adults aged 50 and older who already use CPAP therapy. Researchers will measur…

This study looks at whether measuring how hard you bite can help predict and prevent problems with dental implants. Researchers will follow 85 adults with dental implants for up to 10 years, measuring their bite force each year and checking for complications. The goal is to creat…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study looks at whether long-term use of a breathing device called adaptive servo-ventilation (ASV) can improve how the heart uses energy and how nerves work in people with heart failure and sleep apnea. Researchers will use PET scans to measure heart metabolism and nerve fun…

This study will enroll 20 children with a narrow upper jaw to see if their jaw shape is linked to sleep apnea. Researchers will use a home sleep monitor to measure breathing pauses during sleep and compare that to dental X-rays and exams. The goal is to understand how jaw develop…

This study looks at 150 people with knee osteoarthritis to see how often night pain and nerve pain (neuropathic pain) occur together. Researchers will use questionnaires and physical exams to measure pain and sleep quality. The goal is to better understand these pain types and th…

This study tests a sleep-health program that uses habit-formation science to help young adults (ages 18-30) improve their sleep. Researchers want to see if adding text message reminders makes it easier for people to stick with healthy sleep routines. The goal is to find simple, e…

This study looks at how problems with the body's internal clock (circadian rhythm) may contribute to REM sleep behavior disorder (RBD), a condition where people physically act out their dreams. Researchers will measure melatonin levels and sleep patterns in 30 adults recently dia…

This observational study follows 10 adults with obstructive sleep apnea who are already receiving a cryotherapy treatment (the Cryosa Procedure). Researchers will use MRI and ultrasound before and after treatment to measure fat in the throat and nerve activity. The goal is to fin…

This study looks at how sleep problems like apnea, insomnia, and poor sleep quality are linked to heart disease and diabetes in rural southern areas. About 3,680 adults already in a larger health study will wear sleep trackers and answer questionnaires. The goal is to understand …

This study follows 1,545 adults over many years to understand how sleep-disordered breathing and other sleep problems develop and affect health. Participants were Wisconsin state employees aged 30-60 when the study began. Researchers use overnight sleep tests, questionnaires, and…

This study was designed to find out if treating obstructive sleep apnea with a CPAP machine could help improve insulin resistance and heart function in people with heart failure. It planned to enroll adults aged 18 to 75 with moderate to severe sleep apnea and reduced heart pumpi…

This study investigates how electrical stimulation of the thalamus—a brain region key for sleep—can trigger or disrupt sleep brainwaves. Researchers will work with 50 patients who already have electrodes implanted for medical reasons. The goal is to understand how current brain s…

This study looks at whether teaching people how to care for their mouth and teeth can improve oral health, sleep, and quality of life for those using a non-invasive ventilator at home. Thirty adults will be split into two groups: one gets standard printed leaflets, the other gets…

This study uses a wrist-worn activity watch to measure sleep quality in people with orthostatic intolerance (a condition where standing causes dizziness) compared to healthy volunteers. Researchers want to see if these patients have worse sleep, like taking longer to fall asleep.…

This study was designed to explore how the glossopharyngeal nerve varies in shape and size, and whether electrically stimulating it could open the airway during surgery. It planned to enroll adults with head and neck cancer or sleep apnea, but was withdrawn before any participant…

This study looks at sleep quality in 60 adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Researchers will measure how well participants sleep and see if poor sleep is linked to more severe lung disease, worse breathing tests, or more lung damage on CT sca…

This study aims to create a computer model that can predict how airway surgery will affect obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will measure airway resistance during a sleep MRI to gather data for the model. The goal is to help doctors choose …

This study checks whether sleep questionnaires can reliably detect obstructive sleep apnea (OSA) in children with Down syndrome, who are at higher risk for the condition. Researchers will compare questionnaire results with overnight sleep studies (the gold standard) in about 81 c…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk. About 800 participants at higher risk will receive either usual care or a personalized program with nutrition, exercise, and stress management advice. T…

This study looks at how the body's natural melatonin levels affect pain and sleep quality after root canal treatment. Forty-five adults will each get two root canals—one in the morning and one in the afternoon. Researchers will measure melatonin in saliva before each treatment an…

This study was designed to understand how obstructive sleep apnea (OSA) speeds up the natural drop in testosterone as men age. Researchers planned to use CPAP machines—one real, one placebo—to test hormone changes in men aged 30 to 70 with moderate to severe OSA. However, the stu…

This study looks at pain, sleep quality, eating habits, and physical activity in 50 adults with bipolar disorder who are currently stable (euthymic). Researchers will use questionnaires to measure these factors and better understand how they affect quality of life. The goal is to…