Sleep disorder

This study compares three treatments for obstructive sleep apnea: positive airway pressure (CPAP), a dental device that moves the jaw forward, and a combination of two medications (atomoxetine and oxybutynin). About 2,400 adults with sleep apnea will be randomly assigned to one o…

This phase 3 study evaluates the safety of HS-10506, an experimental insomnia medication, in 600 Chinese adults aged 18 to 64 with insomnia disorder. Researchers track side effects, serious adverse events, and specific safety concerns over both short and long-term use. The goal i…

This study compares two common treatments for moderate obstructive sleep apnea: a custom mouth device that moves the jaw forward (MAD) and a machine that blows air through a mask (CPAP). Researchers want to see how well each treatment improves breathing during sleep and reduces d…

This Phase 2 trial tests IHL-42X, a combination of two drugs (dronabinol and acetazolamide), in people with obstructive sleep apnea. The study aims to see if the drug can reduce the number of breathing pauses during sleep and improve daytime symptoms. Participants will receive di…

This European trial tests a 24-week lifestyle program for 400 night-shift workers. The program, delivered via a mobile app and workshops, focuses on sleep, stress, diet, and exercise. The goal is to see if it helps workers sleep longer and improve their health.

This study compares two types of tonsil surgery for adults with obstructive sleep apnea and enlarged tonsils. One surgery removes the tonsils completely, while the other removes only part of them. The goal is to see if the less invasive approach works just as well at improving br…

This study looks at whether improving sleep habits can help teenagers with overweight or obesity better regulate blood sugar and energy. Researchers will enroll 60 teens aged 14-19 who get less than 7 hours of sleep on school nights. For two weeks, participants will follow a slee…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests whether a high-flow nasal cannula (HFNC) — a soft tube that delivers warm, humidified air through the nose — works as well as the standard CPAP mask for children with moderate-to-severe obstructive sleep apnea. About 258 children aged 2 to 18 will use one of the …

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This study tests whether combining a nerve-stimulating implant with two medications (atomoxetine and oxybutynin) can improve breathing during sleep more than either treatment alone. Twenty-four adults with obstructive sleep apnea who already have the implant will try each combina…

This study tests a new device called Elara APAP for people with obstructive sleep apnea. The device delivers air pressure to keep the airway open during sleep. About 55 adults who already use an APAP machine will have one night of sleep monitoring to see if the device reduces bre…

This study tests whether a traditional Chinese herbal formula (Tiaoshen Anti-cancer granules) combined with cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and possibly extend survival in 360 women with advanced ovarian cancer. Participants will receive either…

This study tests an injection called GZR18 in 140 obese adults with moderate-to-severe obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug improves breathing during sleep, reduces weight, and boosts quality of life compared to a place…

This study tests an injection called GZR18 in 140 obese adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. The goal is to see if the drug improves breathing during sleep and helps with weight loss over 52 weeks. Participants will rec…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study tests if a mouthpiece worn during sleep can help people with both heart failure and obstructive sleep apnea. The device keeps the airway open, which may reduce stress on the heart and improve quality of life. 328 participants will use either the real device or a sham o…

This study tests whether a program that includes remote monitoring, couple therapy, and peer support can help African American patients with sleep apnea use their CPAP machine more consistently. The goal is to improve sleep and quality of life for both the patient and their bed p…

This early trial tests a new wearable PAP mask system for people with obstructive sleep apnea. Fifteen participants will use the device for up to 7 nights to rate its comfort, seal, and usability. The goal is to improve the user experience, not to measure treatment effectiveness.

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study tests whether injecting botulinum toxin (like Botox) into a throat muscle can help people with moderate to severe obstructive sleep apnea. The goal is to reduce breathing pauses during sleep and improve oxygen levels and daytime sleepiness. The trial involves 20 adults…

This study tests a program called On Track for Wellness, which combines Fitbit activity trackers with health education and goal setting. The goal is to help 365 people recently diagnosed with psychosis improve their sleep and increase physical activity. Researchers want to see if…

This study tests whether a Garmin smartwatch that shows health data can help people with moderate to severe sleep apnea use their CPAP machine more regularly. 80 adults who are new to CPAP will be split into two groups: one can see their wearable data, the other cannot. The main …

This UK trial tests a device that uses mild electrical pulses to keep the airway open during sleep in people with obstructive sleep apnoea. It is for adults who cannot use standard CPAP therapy. The study will compare the device to usual CPAP care over three months to see if it i…

This study tests whether eating meals at times that match your body's internal clock can help people who have had weight-loss surgery keep the weight off and improve their health. About 246 adults who had sleeve gastrectomy at least six months ago will either follow standard diet…

This study tests whether a drug called dexmedetomidine, given through an IV to induce sleep, can help people with severe insomnia that hasn't improved with other treatments. 180 adults aged 18-65 will receive either the drug plus standard oral medication or standard medication al…

This study compares a new software, C. Santé, to the standard sleep test (polysomnography) to see if it can accurately measure sleep quality. The software uses sensors on a bed to track breathing and heart rate without disturbing sleep. If successful, it could allow people to mon…

Extremely preterm infants often have breathing issues that current monitors may miss. This study tests a wireless acoustic sensor placed on the baby's throat to more accurately detect pauses, shallow breaths, and irregular patterns. Researchers will compare the sensor to standard…

This study will develop and test artificial intelligence (AI) to automatically classify sleep stages from overnight sleep recordings (polysomnography). The goal is to see if the AI can match or beat expert manual scoring, with the aim of supporting diagnosis of chronic insomnia a…

This study will test several new wearable devices and a mobile app to see how well they diagnose obstructive sleep apnea (OSA) compared to the standard overnight sleep test. About 90 adults will wear devices like a finger sensor, wristband, ring, patches, and an eye mask while al…

This study will test whether a smart mattress with built-in sensors can accurately diagnose obstructive sleep apnea (OSA) compared to the standard hospital sleep test (polysomnography). Researchers plan to enroll 500 people and have them sleep on the mattress while also undergoin…

This study tests a smart mask that uses AI to detect sleep stages and breathing-related arousals in adults with sleep apnea. About 150 participants will wear the mask during an overnight sleep study, and its results will be compared to standard lab tests. If accurate, the mask co…

This study tests whether a digital program that combines cognitive behavioral therapy for insomnia with circadian rhythm coaching can prevent depressive symptoms from worsening in college students aged 18-24 who have trouble falling asleep and tend to be night owls. Participants …

This study tests whether adalimumab, an anti-inflammatory drug, can prevent brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD). RBD often precedes Parkinson's. Participants will receive adalimumab or a placebo every two weeks for two …

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…

This study tests a new approach to prevent delirium (sudden confusion) in intensive care patients. It uses an artificial intelligence system to help nurses make better care decisions and virtual reality to keep patients mentally active. The goal is to reduce the risk of long-term…

This study tests whether a digital insomnia treatment (dCBT-I) can prevent depression in perimenopausal women with sleep problems. 230 women will receive either dCBT-I or sleep hygiene education and be followed for 2 years. The goal is to see if improving sleep reduces depressive…

This study tests whether a 6-month program combining exercise, Mediterranean diet, sleep counseling, and cognitive training can help people with early Parkinson's or a sleep disorder (RBD) stick to healthy habits. Researchers will track how well 99 participants follow the program…

This study tests whether a daily capsule containing lotus seed and rice germ extract, called ZenRest™, can improve sleep quality in menopausal women aged 40 to 65 who have mild-to-moderate sleep problems. Participants take either the supplement or a placebo for six weeks, and sle…

This study tests a program to help adult patients sleep better in the intensive care unit (ICU) after surgery. The program includes sleep education, earplugs and eye masks, reducing noise and light at night, and grouping nursing tasks to avoid waking patients. Researchers will co…

This pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study tests a headset called HALO Clarity™ that sends mild electrical currents to the brain to help people with moderate-to-severe insomnia sleep better. 160 adults will use either the active device or a sham (fake) device at home for 4 weeks, then be followed for another 4 …

This study tests whether a handheld robot that guides meditation with touch and voice can improve sleep quality in older adults with mild memory concerns. 100 participants will either use the robot or a standard meditation app for daily sessions. The goal is to see if the robot h…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study tests whether neurofeedback—a type of brainwave training—can help adults with episodic migraine have fewer and less severe headaches. Participants will undergo 60 sessions over 12 weeks, learning to regulate their brain activity through real-time feedback. The goal is …

This study tests whether a dietary supplement called Radicle Energy VBM can help reduce fatigue and improve cognitive function, mental health, and sleep. Over 6 weeks, 550 adults will take either the active supplement or a placebo, without knowing which they received. The goal is…

This study tests whether listening to ASMR or white noise before bed can improve sleep quality for adults recovering from elective lower leg surgery. Participants are randomly assigned to listen to a 30-minute ASMR recording, white noise, or receive routine care. Sleep quality is…

This study tests a drug called samelisant in 240 people with narcolepsy (with or without cataplexy). The goal is to see if it reduces excessive daytime sleepiness and sudden muscle weakness episodes over 12 weeks. Participants will take the drug or a placebo and report their slee…

This study tests whether a digital bite-force sensor can objectively measure bruxism (teeth grinding) and track how well Botox injections work. Thirty-six adults with bruxism will receive either Botox or a placebo in their jaw muscles. Researchers will use the sensor and patient …

This study tests whether an online sleep improvement program can help people with ongoing concussion symptoms. 70 adults with insomnia after a concussion will use a digital platform for 8 weeks. The goal is to see if better sleep reduces symptoms and improves brain and heart func…

This study tests whether the sleep medication lemborexant can improve both sleep and motor symptoms in people with Parkinson's disease. Forty-four participants will take either lemborexant or a placebo nightly for 28 days. Researchers will measure changes in sleep quality and mov…

This study looks at whether taking magnesium glycinate or magnesium L-threonate at night can improve sleep, recovery, and athletic performance in UCLA varsity athletes. 150 participants will take either a magnesium supplement or a placebo for 4 weeks. Sleep and recovery data will…

This study tests whether a simple, low-cost sleep hygiene education program can improve insomnia as effectively as a standard cognitive behavioral therapy app. About 264 adults with insomnia will be randomly assigned to the education program, the app, or a control group. The goal…

This study tests whether a non-electric, hand-held temple massager—used daily for 4 weeks with a special lotion and optional lavender aromatherapy—can lower stress, improve emotional wellbeing, sleep quality, and overall quality of life in women aged 35 to 65. Participants use th…

This study tests whether learning progressive muscle relaxation and deep breathing exercises can improve sleep for cancer patients receiving chemotherapy. About 40 adults aged 40-60 with poor sleep will be split into two groups: one gets relaxation training plus usual care, the o…

This study tests whether feeding preterm infants breast milk at the same time of day it was expressed can improve their sleep in the NICU. Researchers will compare this circadian-synchronized feeding approach to routine feeding in 120 preterm infants born between 28 and 36 weeks.…

This study tests whether taking cannabidiol (CBD) every night for four weeks can improve sleep quality and reduce alcohol cravings and use. Fifty-eight adults with poor sleep and hazardous drinking will take either CBD or a placebo. Participants will wear activity monitors, compl…

This pilot study tests whether simple bedroom changes and sleep tips can improve sleep for older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to adjust the bedroom environment and provide s…

This study compares two exercise approaches—short 'exercise snacks' spread throughout the day versus traditional aerobic exercise—in adults with moderate to severe obstructive sleep apnea. Researchers will measure sleep quality, daytime sleepiness, and physical function over 8 we…

This study looks at whether improving sleep can help memory and thinking in older adults with mild memory problems and sleep issues. Fifty participants aged 60-85 will receive either talk therapy for insomnia or gentle sound stimulation during sleep. Researchers will track change…

This study tests a new smart home system that uses artificial intelligence to deliver cognitive behavioral therapy for insomnia to young adult cancer survivors. The system includes a smart speaker, smart lighting, and a special Wi-Fi router. Researchers will compare it to standar…

This study tests a sleep treatment called TranS-C, adapted for veterans with PTSD and sleep problems. The goal is to improve sleep, reduce nightmares, and help veterans function better in daily life. 182 veterans will receive either the sleep treatment or usual care to see if it …

This Phase 3 study tests whether expanded dosing regimens of Xywav can safely reduce excessive daytime sleepiness in adults with narcolepsy or idiopathic hypersomnia. About 108 participants will receive either Xywav or a placebo in a randomized withdrawal design. The main goal is…

This study tests whether a decision-making tool can help veterans with sleep apnea choose and stick with a treatment that works for them. About 128 veterans will be randomly assigned to receive either a brief education program or the same program plus a personalized tool. The goa…

This study will test a behavioral program to improve sleep and daily rhythms in autistic teenagers aged 13-17 who have sleep problems. The goal is to see if the program is practical and helps teens sleep better, which may also improve their mood and thinking. The study involves 1…

This study tests whether suvorexant, a medication already approved for insomnia, can help Veterans with PTSD and sleep problems better unlearn fear responses. About 40 Veterans will take either suvorexant or a placebo for 7 nights while researchers measure their skin responses to…

This study tests a small device called the Serene Sleep Palatal Implant, placed in the soft palate to reduce snoring and mild-to-moderate obstructive sleep apnea. About 26 adults will be split into two groups based on their condition. The main goal is to check safety, like whethe…

This study tests whether a daily supplement made from salmon protein (ProGo®) can help menopausal women manage their weight and improve quality of life. About 100 healthy, overweight women aged 40-65 will take either a low or high dose of ProGo® or a placebo for 18 weeks. Researc…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether a culturally tailored text-message program can help Spanish-speaking Hispanic adults with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. Fifty adults will receive automated texts that offer support, troubleshoo…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can reduce insomnia severity in physically active adults aged 30-59. Fifty participants will either receive 6 weeks of CBT-I or no treatment. The main goal is to see if CBT-I improves sleep quality and red…

This study tests whether smelling lavender essential oil can improve sleep in women aged 60 and older who are in the hospital and have trouble sleeping. Sixty-four participants will either receive lavender aromatherapy or a placebo, and their sleep quality will be measured using …

This study tests a nurse-led program for insomnia that also uses a health education chatbot. 80 adults with sleep problems will either get the program plus chatbot or just track their sleep. The goal is to see if the chatbot-assisted approach improves sleep, anxiety, depression, …

This study tests whether walking with a robot dog can improve sleep, reduce fatigue, and enhance quality of life in children aged 2-7 who are undergoing cancer treatment. Forty children will be randomly assigned to either robot-dog-assisted walks or usual care. The goal is to see…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…

This pilot study tests whether cold-water immersion, sauna use, or a combination of both can improve sleep quality in 45 military cadets. Participants will do 14 daily sessions of one of the therapies while wearing an Oura Ring to track sleep. The goal is to see if these temperat…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study tests whether a non-invasive magnetic brain stimulation treatment (rTMS) can improve sleep in people with chronic insomnia. About 70 adults aged 18 to 85 will receive six 25-minute sessions over two weeks. The goal is to see if insomnia severity and sleep patterns impr…

This study tests whether taking inulin (a prebiotic fiber) and spirulina (a nutrient-rich algae), alone or together, can improve sleep in adults aged 18 to 60 with chronic insomnia. Over 12 weeks, 180 participants will take one of four options: inulin, spirulina, both, or a place…

This study tests whether a newer 'splintless' jaw surgery is more accurate and safer than the standard method for treating obstructive sleep apnea. About 66 adults with moderate to severe sleep apnea who cannot use CPAP will be randomly assigned to one of the two surgeries. Resea…

This study tests a special gel (HA35) applied to the jaw at night to relieve pain and muscle tightness from temporomandibular joint disorder (TMD). About 30 adults with TMD will use the gel nightly for 8-12 hours. Researchers will check how well it reduces pain and tension after …

This study tests whether an artificial intelligence (AI)-guided sleep program is practical and well-liked by adults aged 60 and older who have both insomnia and mild memory concerns. Researchers will enroll 60 participants to check how many people join, stick with the program, an…

This phase 3 study tests whether the drug HS-10506 helps Chinese adults with insomnia fall asleep faster and wake up less during the night. About 732 participants will receive either the drug or a placebo for up to 84 days. The study measures sleep using both overnight lab tests …

This study tests a smartphone app called BELL-001 that plays sounds in sync with your breathing to help you relax and fall asleep. Forty adults with insomnia will use the app every night for 12 weeks. Researchers will track sleep quality, mood, and safety to see if this drug-free…

This study tests whether a non-invasive brain stimulation technique called temporal interference (TI) can reduce abnormal brain activity and improve sleep in adults with drug-resistant temporal lobe epilepsy. Twenty participants will stay in a sleep lab for six nights, receiving …

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

This study tests whether combining thread embedding acupuncture with ear acupressure can improve sleep in people with non-organic insomnia. Seventy adults aged 40 to 75 will receive either personalized or standard treatment over 8 weeks. Researchers will also check if changes in …

This study tests a sleep program for people hospitalized after a leg injury that needed surgery. The program includes sleep medicine, melatonin, and sleep tips. Researchers want to see if it helps patients sleep longer and better, and if it reduces the need for strong painkillers…

This study tests whether a short, telephone-delivered insomnia treatment (BBTI) can improve sleep and cognitive function in 214 older adults with HIV, compared to a mindfulness approach (BMT). Participants will complete four weekly phone sessions and attend in-person visits for s…

This study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…

This study tests a structured sleep hygiene education program for adults with insomnia. Ten Hong Kong Chinese participants will learn behavior-change techniques to improve their sleep. The goal is to see if this low-cost, non-drug approach is feasible and effective for reducing i…

This study looks at whether giving people with obstructive sleep apnea (OSA) access to their nightly oxygen levels can improve their experience with a mouthpiece device (MAD). About 120 adults with mild to severe OSA will either get standard care or also see their oximetry data t…

This study tests whether THC (with or without CBD) can improve sleep in people with solid organ cancer who have insomnia. About 69 participants will receive either THC, a THC/CBD mix, or a placebo as a liquid under the tongue. The goal is to see if these cannabis-based compounds …

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

This study will test a 4-step training program designed to help teenagers aged 13-18 reduce their social media addiction and improve their mental health. The program uses education, cognitive-behavioral techniques, and relapse prevention. Researchers will compare a group that rec…

This study tests whether taking steroids (dexamethasone) for a few days after sleep surgery helps reduce pain, allows patients to eat solid food sooner, and lowers the need for strong painkillers. About 120 adults with obstructive sleep apnea will receive either the steroid or a …

This study will test whether different massage techniques can reduce jaw pain and muscle stiffness in people with sleep bruxism (teeth grinding). Forty-two participants will receive either connective tissue massage, another massage method, or a standard mouthguard (occlusal splin…

This study compares a new device called KPAP to standard APAP for treating obstructive sleep apnea. The goal is to see if KPAP, which delivers lower pressure during breathing out, is more comfortable and used more each night. About 30 adults with sleep apnea will try both devices…

This study tests a brief sleep-focused workshop for people with PMDD who have trouble sleeping. The workshop teaches about sleep and simple strategies to improve it. Researchers want to see if it's practical and helpful, using sleep diaries and activity watches. 72 participants w…

This study tests whether a daily 200 mg dose of cannabidiol (CBD) for 12 weeks can reduce inflammation, ease pain, improve sleep, and boost quality of life in Brazilian Jiu-Jitsu athletes. One hundred healthy athletes aged 18-40 who train at least 3 times a week will be randomly …

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study tests whether daridorexant, a sleep medication, can help people who have both major depression and insomnia. Researchers want to see if it improves sleep quality and also eases depressive symptoms. About 134 adults will take either daridorexant or a placebo for three m…

This study looks at people who have both sleep apnea and chronic insomnia. All 120 participants will receive standard CPAP therapy for sleep apnea. Half will also get a digital program to treat their insomnia starting at the same time as CPAP. The other half will follow usual car…

This study looks at whether a type of talk therapy for insomnia (CBT-I) can also improve markers of metabolic syndrome, like blood sugar and insulin resistance. Twenty adults with insomnia and higher body weight will be randomly assigned to CBT-I or basic sleep tips for 5 weeks. …

This study tests if a gentle brain stimulation technique called tDCS can improve movement, balance, fatigue, sleep, and thinking in people with multiple sclerosis. Forty adults with MS will receive either real or sham stimulation over two weeks. Researchers will check if the trea…

This study tests whether giving a single dose of the steroid dexamethasone during nasal surgery can improve sleep quality on the first night after the operation. About 102 adults having nasal surgery under general anesthesia will be randomly assigned to receive either dexamethaso…

This study tests new parts for PAP machines (the devices that help people with sleep apnea breathe at night). Researchers want to see if the new masks, tubes, or machines are as comfortable and easy to use as current ones. About 30 adults who already use a PAP machine will try th…

This study tests whether a low-level laser applied to specific points on the ear can improve sleep in women with breast cancer who have insomnia. Seventy participants will receive either real or sham laser acupuncture twice a week for five weeks. Sleep quality, fatigue, and mood …

This study tests two simple, drug-free ways to improve sleep for adults in the intensive care unit: playing pink-brown noise to mask hospital sounds, or a quiet time protocol with earplugs and eye masks. Researchers will track sleep using a wrist-worn smartwatch in 18 patients. T…

This pilot study will test whether a 6-week program of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and blood sugar control in 30 adults aged 40+ with type 2 diabetes and chronic insomnia. Participants are randomly assigned to CBT-I or usual care, and outco…

This study looks at whether orofacial myofunctional therapy (OMT) – exercises for the mouth and tongue – can improve sleep apnea symptoms in adults with mild-to-moderate cases. It will compare OMT alone, CPAP alone, both together, and standard care in 168 participants over 12 wee…

This study tests whether a nasal spray called dexmedetomidine, taken at night, can help older adults (ages 65-90) sleep and reduce the risk of delirium after major abdominal surgery. 400 participants will be randomly assigned to receive either the drug or a placebo. The goal is t…

This study tests whether a medication called dexmedetomidine can help patients in the intensive care unit (ICU) sleep more restfully. Good sleep is important for recovery, but ICU conditions often disrupt it. About 50 adult ICU patients will either receive the medication or a pla…

This study compares how comfortable two different sleep apnea machines feel to people who have never used one before. Twenty-four adults with newly diagnosed obstructive sleep apnea will try each machine for 4 nights at home. The goal is to see which device people find more comfo…

This study tests a psychological program designed to improve sleep quality in female university students aged 18-25 who have insomnia. The goal is to see if better sleep helps their thinking skills and academic performance. About 35 participants will take part in the program and …

This study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults. About 90 college students with suicidal thoughts and sleep problems will be randomly assigned to one of three sleep interventions. Researchers will tr…

This study tests two different CPAP devices for people newly diagnosed with obstructive sleep apnea. One device uses a feature called KPAP, the other uses EPR. Researchers will compare how well each device controls breathing pauses during sleep and how patients feel about their s…

This study tests whether two relaxation techniques—Benson relaxation and progressive muscle relaxation—can help reduce pain and improve sleep quality in 160 patients who have had a lung lobectomy. Participants will practice these techniques after surgery, and their pain levels an…

This study looks at whether doing physical therapy in the daytime or evening helps people with a herniated disc in their lower back sleep better and feel less sleepy during the day. It includes 60 adults who also have a high risk for obstructive sleep apnea. Participants will be …

This study tests a wearable smart eye-mask that combines gentle heat and massage with voice-guided sleep therapy to help people who have both insomnia and sleep apnea. The 4-year project will first explore how the condition works, then develop the device, and finally test it in 1…

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests whether a mobile app or virtual reality program that teaches mindfulness and breathing exercises can lower stress, burnout, and improve sleep and thinking in nurses who work rotating shifts. 300 nurses will be split into four groups: one gets health education onl…

This study tests whether doing progressive relaxation exercises at times matched to each patient's natural circadian rhythm can help manage symptoms, improve sleep quality, increase comfort, and boost mental well-being in people receiving hemodialysis. Researchers will enroll 75 …

This study tests whether a smartphone app called SOLOMIYA is helpful and easy to use for people living under the stress of war in Ukraine. About 80 adults with mild to moderate depression or sleep problems will use the app for a few weeks. The app provides relaxation exercises, m…

This study tests an AI-driven home exercise program for adults aged 60 and older with chronic insomnia. The program uses a smart mirror for real-time exercise guidance and a wearable device to track sleep. Researchers will measure sleep quality, physical fitness, and body composi…

This small pilot study will test whether an 8-week group mindfulness program can reduce stress, anxiety, depression, and insomnia in parents caring for children with autism or ADHD. Thirty Chinese caregivers will attend weekly sessions and complete surveys before and after the pr…

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

This phase 2 trial tests whether a traditional Chinese herbal paste called Ning Shen Dan Xiang Gao Fang, made with donkey-hide gelatin, can improve sleep in adults with chronic insomnia. Sixty participants will take the paste or a placebo twice daily for 8 weeks. Researchers will…

This study tests a 4-month personalized digital program (PASS) to help people with obstructive sleep apnea start and continue using positive airway pressure (PAP) therapy. Sixty overweight, inactive adults newly diagnosed with sleep apnea will be randomly assigned to either the P…

This study tests whether teaching older adults (60+) about healthy sleep habits can reduce insomnia. Over 6 weeks, participants attend two face-to-face sessions and get regular phone follow-ups. The goal is to see if this behavioral approach improves sleep quality without medicat…

This pilot study tests whether a short, four-session cognitive behavioural therapy for insomnia (CBT-I) group, led by trained laypersons, can improve sleep quality in older adults in Hong Kong. Fifty participants aged 45 and older with mild depression and sleep problems will eith…

This study tests whether 12 weeks of daily breathing exercises using a special device can reduce sleep apnea severity and improve sleep quality in 10 adults with severe obesity (BMI over 40) and obstructive sleep apnea. Participants will do progressively harder breathing workouts…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study tests whether a drug called esketamine can improve sleep after surgery in postmenopausal women, who often have trouble sleeping. About 164 women having leg fracture surgery will receive esketamine or a placebo during the operation. Researchers will check their sleep qu…

This study tests whether taking a daily probiotic supplement for 8 weeks can reduce stress and anxiety in healthy university students during exam time. Two hundred students will receive either the probiotic or a placebo. Researchers will measure changes in stress, anxiety, sleep …

This study tests if tiny thumbtack needles placed on the skin can help women going through menopause sleep better. 198 women with chronic insomnia will either get real or fake needles for 4 weeks. The goal is to see if this simple, low-risk treatment improves sleep quality and re…

This study will test whether an 18-day spa therapy program can reduce insomnia severity. About 270 adults who are already scheduled for spa treatment will fill out questionnaires about their sleep, fatigue, pain, and mood before, right after, and two months after the program. The…

This study tests whether personalized lifestyle coaching can help emergency medicine residents stay alert and recover better during night shifts. Thirty residents will either receive one-on-one coaching or just a handout on sleep and nutrition. Researchers will track sleep, react…

This study tests whether a voice-based program called Talk Parenting, delivered through an Amazon Echo Dot, can help parents of children ages 3-5 improve challenging bedtime and morning routines. About 184 families will either use the program right away or wait 6 weeks. Researche…

This study tests a non-medication therapy called Imagery Rehearsal Therapy to see if it can reduce nightmares in adults with narcolepsy. About 80 participants will receive the therapy and complete three assessments, with half starting right away and half later. The goal is to imp…

This study tests a behavioral program called TranS-C to help autistic adults with sleep and circadian problems. The program teaches regular sleep routines, daytime habits, and helpful sleep beliefs. Researchers will enroll 24 autistic adults to see if the treatment improves overa…

This study will compare two sedative drugs, remimazolam and dexmedetomidine, in 60 adults with obstructive sleep apnea undergoing drug-induced sleep endoscopy. The goal is to see which drug provides more stable sedation, fewer side effects like low heart rate or low blood pressur…

This study looks at whether listening to music can help lower anxiety and improve sleep in people who have had a heart attack and are spending their first night in a special heart unit. About 64 adults will take part. They will listen to music and then use eye masks and earplugs …

This study looks at whether racism-related stress affects how well a digital cognitive behavioral therapy program (Sleepio) works for insomnia in Black adults. One hundred participants will use the app for 6-10 weeks while researchers track their sleep and stress levels. The goal…

This study tests whether two dietary supplements can help adults who are poor sleepers improve their sleep quality, thinking skills, and stress levels. Over 28 days, 68 participants will take either an active supplement or a placebo. Researchers will measure sleep efficiency, gut…

This study looks at whether laughter yoga can help menopausal women feel better. Researchers will split 80 women into two groups: one does laughter yoga for 8 sessions, the other does nothing new. They will check if the yoga group has fewer menopause symptoms, better sleep, and a…

This study compares standard fentanyl pain medicine to an opioid-free mix of acetaminophen, ibuprofen, ketamine, and dexamethasone in 64 children aged 5-10 with mild to moderate sleep apnea undergoing tonsil surgery. The goal is to see if the opioid-free option controls pain just…

This study tests a gentle, non-invasive brain stimulation technique called so-tDCS in 80 older adults who have mild memory and sleep complaints. Participants will receive either real or sham stimulation over 4 weeks. Researchers will track changes in memory, sleep quality, and br…

This study tests whether wearing blue-blocking glasses at night can help teenagers (ages 12-18) with insomnia or delayed sleep phase disorder who are already receiving psychiatric care. Forty participants will wear the glasses or use real darkness for one week. The goal is to see…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This study tests whether daily mindfulness exercises—like breathing and meditation—can reduce anxiety, depression, and poor sleep in women going through early menopause. Twenty women in Turkey will be split into two groups: one does mindfulness training for an hour, six days a we…

This Phase II trial tests a new drug called APSTZD for people with chronic insomnia. About 222 adults aged 18-64 will receive either APSTZD, an active comparator (Stilnox CR), or a placebo. The main goal is to see if APSTZD reduces time awake after falling asleep, measured by ove…

This study tests a new oral appliance called DPOA that gently and gradually moves the jaw forward during sleep to keep the airway open in people with mild to moderate obstructive sleep apnea. Forty adults aged 20 to 65 will be enrolled and monitored with sleep tests. The goal is …

This study tests whether teaching parents a consistent, calming bedtime routine can improve sleep in infants and toddlers diagnosed with behavioral insomnia. Thirty children aged 0-3 years will wear a watch-like device to track sleep quality, and parents will report on sleep patt…

This study tests whether combining relaxation exercises with listening to a specific Quran chapter (Surah Ar-Rahman) can reduce anxiety and improve sleep in people undergoing kidney dialysis. 76 adult Muslim patients will be split into two groups: one doing the relaxation and Qur…

This study tests whether an 8-week Mindfulness-Based Stress Reduction (MBSR) program can reduce hot flashes and improve sleep in menopausal women. 90 women aged 45-60 with hot flashes and poor sleep will be randomly assigned to either the MBSR program or no intervention. The prog…

This pilot study tests whether a smartphone app called SleepFix, combined with support from a psychologist, can help young people aged 16-24 with insomnia. The app uses sleep restriction therapy to reset sleep patterns. The trial will check if the approach is practical and accept…

This study tests a new software tool called Pressure Match that helps doctors set personalized minimum and maximum pressure levels on CPAP machines for people newly diagnosed with obstructive sleep apnea. The tool uses patient data like weight, gender, and severity of apnea to re…

This study tests whether taking a specific probiotic (Lactobacillus rhamnosus GG) with a special form of vitamin B2 for 12 weeks can improve memory and thinking in adults over 65 who have mild memory problems. Researchers will measure changes in cognitive tests and brain activity…

This study tests whether a sleep medication called lemborexant can help older adults in the intensive care unit (ICU) sleep better and reduce their risk of delirium, a state of sudden confusion. The trial will involve 100 patients aged 65 and older who are in the surgical ICU. Pa…

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be randomly assigned to either the exercise pro…

This study tests a safe, non-invasive therapy that uses gentle pressure on the arms to improve sleep and mood in people who have had a stroke and suffer from insomnia. The treatment, called remote ischemic adaptation, aims to help the brain recover by briefly restricting and rest…

This study tests a sleep therapy called SleepSMART for older veterans who have both insomnia and mild cognitive impairment (MCI). The therapy adapts standard insomnia treatment with extra memory and learning support. Researchers will compare SleepSMART to standard therapy in 150 …

This study tests a noninvasive device that stimulates a nerve in the leg to help people with restless legs syndrome who have developed complications from their usual medication. About 50 adults will use the device at home for 8 weeks. Researchers will measure changes in symptom s…

This study tests whether using a virtual reality headset for guided relaxation after night shifts can improve sleep quality in nurses and nursing assistants. Forty participants will either use the VR device for one month or receive standard care, then switch. Sleep quality, insom…

This study tests whether reducing blue light exposure in the evening—using amber-tinted glasses or smart lightbulbs—can help children ages 5 to 6 fall asleep faster. Sixty children with sleep difficulties will be randomly assigned to one of three light-reducing strategies for two…

This study tests whether short, controlled sessions of low-oxygen breathing (intermittent hypoxia) can improve sleep in people with primary insomnia. Thirty adults aged 18 to 60 who are not taking sleep medications will be randomly assigned to receive either the real low-oxygen t…

This study tests whether facial acupuncture and scraping can help people with insomnia sleep better. 82 participants aged 16-30 will receive treatments twice a week for four weeks. Researchers will measure sleep quality and other symptoms to see if this traditional Chinese medici…

This pilot study will test whether a special form of kava (AB-free kava) can improve mobility and physical function in adults over 70 who have mild sleep problems and are somewhat inactive. Forty participants will take either kava capsules or a placebo daily for a period, and res…

This study will test a robotic device called BackHug that delivers deep back massages to 30 adults with mild-to-moderate Parkinson's disease. The goal is to see if it improves walking, balance, back pain, and sleep quality. Participants will receive 40-minute sessions over a set …

This study tests whether EMDR group therapy can help adults who experienced the April 2025 Silivri earthquake in Turkey. Forty participants will be randomly assigned to either the therapy group or a waitlist. Researchers will measure changes in PTSD, depression, anxiety, sleep qu…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40 to 70 will choose whether to use the pillow or not. Their pain, sleep quality, and shoulder function will be checked …

This study looks at whether teaching people with rotator cuff syndrome the best sleeping positions can improve their sleep quality while they undergo physical therapy. Researchers will compare two groups: one getting standard physical therapy, and another getting physical therapy…

This study tests whether a small, home-use ear stimulation device can improve sleep and reduce stress in health sciences students who have trouble sleeping. Sixty students will either receive active stimulation or a placebo for three weeks. The goal is to see if this easy, non-in…

This study tests a special type of acupuncture—dense cranial electroacupuncture plus body acupuncture—in 148 teens aged 15-22 with mild to moderate anxiety or depression. Participants receive treatment twice a week for 8 weeks, and researchers measure changes in anxiety, depressi…

This study tests whether a warm foot bath on the night of abdominal surgery can reduce pain, improve sleep, and increase comfort. Around 96 adults will be randomly assigned to receive a foot bath or standard care. Researchers will measure pain levels and sleep quality using simpl…

This trial tests a non-transdermal biofield patch against a placebo patch in 40 adults who often feel anxious. Over 4 weeks, researchers will measure changes in anxiety, sleep quality, and energy levels. The goal is to see if the patch offers any real benefit beyond a placebo eff…

This study tests whether a special type of acupressure—timed to the body's natural daily rhythms—can improve sleep in nursing home residents aged 60 and older. Eighty participants will receive either real or fake acupressure twice a day for four weeks. Researchers will measure sl…

This study tests a nasal device (iNAP) that uses gentle suction to keep the airway open during sleep. It includes 65 adults aged 50-75 with mild cognitive impairment and moderate-to-severe sleep apnea. Half will use the device nightly for 24 weeks, while the other half receive sl…

This pilot study will test whether a smartphone app that teaches cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants will use the app for five weeks, and researchers will measure changes in insomnia severity, depress…

This study tests a digital, game-like exercise system called ApneaTheraPlay for people with obstructive sleep apnea. Participants will do a mix of breathing, aerobic, strengthening, and throat exercises three times a week for 12 weeks, either through the game or a structured prog…

This study looks at whether taking magnesium by mouth or soaking feet in a magnesium solution can help colorectal cancer patients who are on chemotherapy. The goal is to see if these simple treatments can reduce nerve damage (pain, tingling) and improve sleep quality. About 75 ad…

This study looks at whether 8 weeks of inspiratory muscle training can improve thinking, brain oxygen levels, and brain healing in 42 adults with moderate obstructive sleep apnea. Participants will do breathing exercises daily and be compared to those receiving a low-intensity ve…

This study tests whether daridorexant, a recently FDA-approved sleep medication, can improve sleep quality and daytime alertness in smokers who struggle with insomnia during quit attempts. About 44 adult smokers who smoke at least 10 cigarettes daily will take the drug or a place…

This study tests whether Emotional Freedom Techniques (EFT), a tapping-based therapy, can lower stress, anxiety, and improve sleep in nursing students. 105 students will be randomly assigned to either EFT or a placebo. The main goal is to see if stress levels drop after 8 weeks. …

This study tests a high-tech version of cognitive behavioral therapy for insomnia (CBT-I) in adults aged 65 and older. It uses smart devices, sensors, and artificial intelligence to personalize sleep coaching at home. Researchers will compare it to simpler digital sleep programs …

This study looks at whether a device called TENS, which sends mild electrical pulses through the skin, can help reduce pain and improve sleep after inguinal hernia surgery. About 80 adults having this surgery will either receive TENS or standard care. Researchers will measure pai…

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This study tests whether a special 40 Hz flickering light, used for 30 minutes each night for a week, can improve insomnia in people with Parkinson's disease. Thirty participants will be randomly assigned to receive either the 40 Hz light or a control light. The main goal is to s…

This study looks at whether adding stress management and sleep education to standard physiotherapy can help people with temporomandibular disorders (TMD). TMD causes jaw pain, teeth grinding, and sleep problems. Forty adults with TMD will receive either physiotherapy alone or phy…

This study tests a nurse-led program to reduce stress and improve sleep for patients in the intensive care unit (ICU). The program includes lowering noise, dimming lights at night, and grouping care tasks to avoid waking patients. About 68 awake adults will either receive this pr…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for sleep problems in people with Parkinson's disease. For 7 days, 48 participants will receive either active RIC (using a blood pressure cuff to briefly restrict arm blood flow) or a sham version…

This study tests whether teaching COPD patients how to use their inhalers correctly, via video calls with a nurse, can improve their sleep quality. Researchers will compare sleep scores between those who get the education and those who don't. Sixty adults who already use inhaled …

This study tests a drug-free approach for restless leg syndrome (RLS) in people with type 2 diabetes. 42 adults aged 50-65 will receive either vibration, near-infrared light, or both, plus stretching, for 4 weeks. Researchers will measure changes in pain, sleep quality, and RLS s…

This study tests whether Compound Ciwujia Granules, a traditional Chinese herbal medicine, can improve sleep in people with chronic insomnia. 1,200 adults aged 40-75 will take either the herb, a standard sleep drug (estazolam), or both for 4 weeks. Researchers will measure sleep …

This study tests whether a smartphone app can improve sleep for new parents struggling with insomnia. About 250 first-time parents with babies aged 4-12 months will use the Headspace Health Sleep Program for 18 days. The app combines sleep tracking, cognitive behavioral therapy, …

This early study tests a neck device that uses gentle suction to keep the airway open during sleep, which might help people with obstructive sleep apnea. Ten healthy volunteers will wear the device during one night of sleep and compare their breathing to a night without it. The g…

This study will test whether using an automatic baby swing helps newborns in the neonatal intensive care unit (NICU) sleep better, feel more comfortable, and have stable heart rate, breathing, and temperature. The study will include 40 healthy newborns born between 35 and 42 week…

This study tests a smartphone app called BELL-001 that plays personalized sounds in sync with your breathing to help you relax and fall asleep. 114 adults with insomnia will use the app or a sham version nightly for 4 weeks. Researchers will measure changes in sleep quality and d…

This study tests whether a relaxation method called autogenic training can help people on hemodialysis who suffer from restless leg syndrome, poor sleep, and fatigue. About 54 adults aged 45-55 will practice guided relaxation exercises for 8 weeks. Researchers will measure change…

This study looks at whether doing foot and ankle exercises at home can help people with diabetic nerve pain feel better. The exercises are done twice a day, three days a week, for eight weeks. Researchers will measure pain, sleep quality, and depression in 70 adults with diabetic…

This real-world study will test whether Ciwujia Capsules or Compound Ciwujia Granules can improve sleep quality and reduce insomnia severity in 40,000 adults aged 18-75. Participants will take the herbal supplement for 8 weeks, and researchers will measure changes in sleep scores…

This study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…

This study tests whether a mobile app called SleepQ can reduce insomnia symptoms in adults. The app provides a 12-week digital cognitive behavioral therapy program, including sleep scheduling and relaxation techniques. Eighty participants will be randomly assigned to use the app …

This study tests whether a nerve block (injecting numbing medicine near the cheekbone) can control pain after tonsillectomy in children aged 3-9, reducing the need for opioids. Sixty kids having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bloc…

This study tests a smartphone app called GoodShleep that gives personalized sleep and circadian tips in real time. It includes a wearable to track sleep and activity, plus mood check-ins. Researchers will first optimize the app with 77 adults in Hong Kong who have sleep or circad…

This study tests a smartphone app called GoodShleep+ that gives personalized, in-the-moment suggestions to help people with sleep and circadian problems. About 80 adults in Hong Kong will either use the app for 8 weeks or continue their usual care. The goal is to see if the app i…

This study tests whether a stellate ganglion block—a nerve block using the drug ropivacaine—given before surgery can improve sleep and recovery in 25 patients with prolonged disorders of consciousness after brain injury. Researchers will measure sleep time, brain oxygen levels, a…

This study looks at two ways to improve sleep after breast cancer surgery: a nerve block injection or a mild ear stimulation device. About 136 women will be randomly assigned to one of the two treatments. Their sleep will be tracked with a wrist monitor and questionnaires for the…

This study looks at whether eating special healthy cookies high in linoleic acid (a type of fat) for 8 weeks can improve sleep quality in overweight adults who have trouble sleeping. Researchers will measure sleep changes, blood fat levels, and how well people stick to eating the…

This study tests whether practicing tai chi for 8 weeks can improve sleep quality in adults aged 40 to 69 with mild to moderate chronic insomnia. Sixty participants will be randomly assigned to either a tai chi group or a walking group. The goal is to see if tai chi offers a safe…

This study tests whether a structured eye exercise program can improve sleep quality in older adults (65+) living in a nursing home. Participants will do eye exercises three times a week for four weeks, guided by a researcher. The goal is to see if these exercises lead to better …

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults who have been on dialysis for at least three months will be randomly assigned to use the app daily for four…

This study looks at whether a regular, low-intensity exercise program can improve sleep quality in people aged 65 and older. Eighteen participants will do safe movements like chair exercises, balance work, and stretching. Researchers will measure sleep changes using questionnaire…

This study tests whether a non-invasive device called TENS, placed on the neck, can improve sleep in postmenopausal women. Thirty-two women aged 50-65 with new sleep problems will receive the treatment. Researchers will measure changes in sleep quality and estradiol levels.

This study tests whether myofunctional therapy—simple exercises for the tongue, face, and breathing muscles—can improve sleep in children aged 6-12 with obstructive sleep apnea. Half of the 174 participants will do these exercises for 24 weeks with remote coaching, while the othe…

This study looks at whether doing moderate resistance exercises in the morning can improve sleep quality in young adults aged 18-35. Over 8 weeks, 64 participants with different sleep patterns (morning or evening types) will follow an online exercise program. Researchers will mea…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve sleep and reduce anxiety in adults over 60 who have chronic insomnia. Sixty participants will receive tACS sessions, and researchers …

This study tests whether a brief behavioral therapy for insomnia (BBTI) can improve sleep in 58 bereaved adults who have trouble sleeping. Participants will either receive BBTI or sleep hygiene education. The study also looks at whether better sleep eases symptoms of complicated …

This study tests whether a type of talking therapy called Cognitive Behavioral Therapy for Insomnia (CBTi) can improve sleep and reduce mental distress in young people aged 12-24 in Hong Kong who have moderate mental health concerns. Participants will attend six weekly group sess…

This study looks at whether placing children in a specific position when their breathing tube is removed after sleep apnea surgery can reduce the risk of dangerously low oxygen levels. About 262 children aged 2-10 will take part. The goal is to find a simple, no-cost way to make …

This study tests whether drinking a ketone supplement (Ketone-IQ) before sleep can improve sleep quality and reduce breathing pauses in people with moderate-to-severe obstructive sleep apnea. Thirty adults who already use CPAP will try the ketone drink for two nights and a placeb…

This study looks at whether Benson relaxation exercises can improve sleep quality in people with lung cancer who are staying in the hospital. About 60 patients will be randomly assigned to do the exercises or not. The goal is to see if this simple, drug-free technique helps them …

This study tests whether a dietary supplement can help people with poor sleep quality fall asleep faster and improve their overall sleep. About 70 adults aged 24-65 with mild sleep issues will take either the supplement or a placebo, and their sleep will be tracked with a wrist m…

This study looks at whether listening to music during dialysis sessions can help reduce fatigue, improve sleep quality, and boost mental well-being. Sixty adults on hemodialysis will receive 30 minutes of music therapy after the second hour of each session for four weeks. Researc…

This study tests a gentle exercise method called global postural reeducation in 30 housewives aged 25-40 who have had low back pain for over 3 months. The goal is to see if it can reduce pain, lower stress, and improve sleep quality. Unlike painkillers, this approach focuses on r…

This study tests whether inhaling agarwood essential oil while sleeping can reduce fatigue and improve sleep quality in hospital staff. About 78 participants will use either an agarwood sachet or a placebo (almond oil) near their bed for one week. Researchers will measure changes…

This study looks at whether teaching people with chronic neck pain better sleep habits, along with standard physiotherapy exercises, can improve their sleep quality and reduce disability. 120 adults aged 20-55 with poor sleep and neck pain lasting over 3 months will be split into…

This study will test whether taking a break from digital devices and social media can help reduce depression, anxiety, stress, and improve sleep quality in young adults. One hundred participants who use social media at least 8 hours a day will be randomly assigned to a digital de…

This study tests whether low-dose laser acupuncture (LLA) can safely improve sleep in 120 adults with major depressive disorder and insomnia. Participants will receive either real or sham laser acupuncture five times a week for six weeks, while continuing their usual depression m…

This study tests whether a 4-week program combining ergonomic training with exercise can reduce pain, improve sleep quality, and lower anxiety in nursing students. Sixty participants will be randomly assigned to either the program or standard curriculum. The goal is to see if the…

This study looks at how stress from being a refugee—like trauma, discrimination, and adjusting to a new culture—affects sleep in Bhutanese refugees living in Ohio. Researchers will hold focus groups and interviews with 70 adults to understand their sleep problems and coping strat…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills like attention and memory, and how those changes relate to quality of life. Adults newly diagnosed with OSA will take an overnight sleep test, followed by computer tasks and questionnaires. Their result…

This study looks at how diet, physical activity, and sleep relate to body composition in women in Kazakhstan. About 200 women aged 20 and older will have a DEXA scan to measure fat, muscle, and bone density, and fill out questionnaires. The goal is to build a clearer picture of w…

This study looks at whether university students who exercise regularly have better cognitive awareness, body awareness, and sleep quality compared to those who are sedentary. Researchers will survey 140 students aged 18-25, grouping them by their physical activity levels. No drug…

This study follows adults waiting for a liver transplant to see how their sleep quality changes from before surgery to six months after. Researchers use questionnaires to measure sleep, anxiety, and other factors. The goal is to understand what influences sleep problems in these …

This study looks at sleep health in people with HIV who are on different antiretroviral therapies. Some participants switch from a dolutegravir-based regimen to a doravirine-based one, while others stay on dolutegravir. Sleep is measured using questionnaires, wrist-worn activity …

This study develops and tests a digital sleep intervention called Nurturing Sleep for preschoolers (ages 3-5) living in foster care. Foster parents use a smartphone app to learn about sleep hygiene and receive tailored strategies based on their child's sleep challenges. The goal …

This study observes pain levels in teenagers aged 13-18 after outpatient tonsil and adenoid removal. Participants receive either acetaminophen with ibuprofen or acetaminophen with oral ketorolac, based on their surgeon's usual practice. They report pain and recovery via text surv…

This study looks at whether exercise can help protect the body from health problems caused by shift work, which disrupts natural sleep-wake cycles. Sixteen healthy but inactive adults will spend 5 days in a lab, simulating day shifts then night shifts, with some doing exercise. R…

This observational study will follow 200 women aged 45 to 60 to understand how muscle strength, bone density, body composition, physical activity, sleep, mood, and menopause symptoms relate to overall functional health. Participants will undergo simple strength tests, bone scans,…

This study follows 100 new nurses over time, using non-invasive sleep monitors and questionnaires to track sleep quality, stress, and burnout. Researchers will use AI to see if sleep data can predict which nurses are at risk of burnout or leaving their jobs. No treatments are giv…

This study looks at whether sleep patterns—like duration, quality, and heart rate during sleep—are linked to how well stomach cancer responds to immunotherapy before surgery. Researchers will monitor sleep non-invasively in 120 patients with locally advanced gastric or gastroesop…

This study follows 25 adolescent girls with anorexia nervosa over 12 months of psychiatric treatment. Researchers will measure sleep patterns, inflammation, hormones, and quality of life at the start and after one year. The goal is to see how these factors change with treatment a…

This study tests whether a video camera with artificial intelligence can track newborn brain health by analyzing their movements. About 200 babies in the NICU will be recorded continuously from admission to discharge. The AI's findings are kept from doctors for now, to see if the…

This study looks at how mental health, especially stress, affects gum disease in people who grind their teeth. About 110 adults aged 30-50 with both teeth grinding and gum disease will answer mental health questions and get a dental check-up. The goal is to see if poor mental hea…

This study looks at how stress levels, sleep quality, and teeth grinding (bruxism) together affect gum disease in adults aged 30-45. Researchers will compare two groups of people with gum disease: those who grind their teeth and those who do not. The goal is to understand how the…

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This study looks at whether psychological resilience — the ability to bounce back from stress — can reduce the harmful effects of stress on gums in people who grind their teeth (bruxers). Researchers will measure stress and resilience using questionnaires and check gum health in …

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study will use a painless ultrasound to examine tongue stiffness, thickness, and other features in 80 adolescents aged 12-18 with obesity and sleep-disordered breathing. Participants are already enrolled in a weight-loss program. The goal is to better understand how the tong…

This study will examine 600 men aged 35-59 in Uzbekistan to find out which physical, lifestyle, and emotional factors are linked to low testosterone. Participants will have blood tests, physical measurements, and complete questionnaires. The goal is to create a model that helps d…

This study looks at how internet addiction affects sleep quality and academic performance in medical students at Sohag University. Researchers will survey 499 students using standard tests for internet addiction, sleep quality, and grades. The goal is to understand the problem, n…

This study aims to find out how much dental interns in Egypt know about pediatric obstructive sleep apnea, a common but often missed sleep disorder in children. Researchers will survey 350 interns using a questionnaire to assess their knowledge, attitudes, and practices. The goal…

This study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…

This study will test a new wearable device that monitors your body's internal clock (circadian rhythm) by tracking signals like heart rate and movement. Researchers will compare the device's readings to standard saliva tests in 30 adults who are either healthy, have sleep apnea, …

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study will monitor 75 adults—natural short sleepers, normal sleepers, and people with idiopathic hypersomnia—over 32 continuous hours in a sleep lab. Using EEG and actigraphy, researchers will track brain wave patterns and blood sugar changes to understand how the body regul…

This study looks at how losing sleep and having a disrupted body clock (like shift workers) can make the body less responsive to insulin, a key step toward obesity and type 2 diabetes. Researchers will test 48 healthy adults aged 18-45 to see how the timing of the stress hormone …

This study will track sleep patterns in 20 people before and after reverse shoulder replacement surgery. Participants will wear a MotionWatch 8 sleep tracker for a week before surgery and again 6 months after. The goal is to see if better sleep is linked to better recovery and sh…

This study looks at how sleep apnea measurements change from night to night. Current tests rely on a single night, which can be inaccurate. Researchers will track 192 people over multiple nights to find more reliable markers for diagnosis and treatment.

This study aims to find out which daily habits and surroundings are linked to poor sleep in people with lupus. Researchers will survey 250 adults with lupus from different parts of Spain about their sleep, physical activity, screen time, and bedroom environment. The goal is to id…

This study looks at how abnormal proteins, like alpha-synuclein and tau, build up and affect brain function in people with Parkinson's disease. Researchers will use brain scans, blood tests, and skin biopsies to track these changes. The goal is to find better ways to diagnose and…

This study looks at whether children aged 6 to 12 with a specific teeth alignment issue (posterior crossbite) are more likely to have obstructive sleep apnea. Researchers will use a questionnaire to measure sleep apnea risk in 420 children. The goal is to understand if there is a…

This study looks at whether a quick, non-invasive breathing test called impulse oscillometry (IOS) can help doctors find the right pressure settings for sleep apnea machines. Currently, patients often need an overnight sleep study to determine the correct pressure. The study will…

This pilot study looks at how sleep, physical activity, and meal timing in early pregnancy relate to blood sugar patterns and the risk of gestational diabetes. Researchers will track 140 pregnant women using wearable devices and an AI food-logging app. The goal is to see if real-…

This study looks at why many people with obstructive sleep apnea still feel very sleepy during the day even after successful treatment with CPAP or other devices. Researchers will test 100 adults to see if the amount of oxygen drops during sleep before treatment predicts this lef…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study looks at whether giving preterm babies their mother's breast milk at the same time of day it was expressed (like night milk at night) helps them sleep better and develop a healthy day-night rhythm. About 200 preterm infants will be split into two groups: one gets milk …

This study will test whether reducing recreational screen use to 1 hour per day for 4 weeks can improve mental well-being, sleep, and social interaction in 240 young people aged 13 to 24. Participants will either cut their screen time or continue as usual, and researchers will tr…

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This pilot study tests a self-guided digital program called SOAR that shares science-backed sleep tips with people starting treatment for an eating disorder. The program includes videos on sleep hygiene and setting a regular sleep schedule. Researchers want to see if the program …

This study looks at how the size of the upper airway might influence teeth grinding (bruxism) during sleep in people with obstructive sleep apnea. Researchers will use safe, low-radiation 3D scans and sleep tests to measure airway volume and bruxism in 80 adults. The goal is to b…

This study will test three ways of giving oxygen to 280 adults during colonoscopy sedation: standard continuous flow, breath-synchronized pulses via the Sovant device, and CPAP. Researchers will track how often patients have breathing pauses or low oxygen levels. The goal is to f…

This study looks at whether taking melatonin earlier in the evening (3 hours before bed) or at a higher dose (4 mg) helps healthy adults fall asleep faster and sleep better. Fourteen participants will try different combinations of melatonin and placebo while their sleep is measur…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This study looks at how often people develop speech or swallowing problems after a jaw-advancement surgery for obstructive sleep apnea. Researchers will measure nasality, speech, and swallowing in 28 adults before and after surgery at five different times. The goal is to better u…

This study uses smartphone surveys to track the daily ups and downs of 300 parents in German-speaking Switzerland. Parents will answer quick questions about their mood, sleep, and activities five times a day for two weeks. The goal is to understand what makes parenting feel good …

This study tests whether a sleep education and hygiene program can improve sleep in young male soccer players aged 16-19. Fifty-two players from an academy will either receive sleep tips and access to their sleep data or continue as usual. Researchers will measure changes in slee…

This study looks at whether a simple arm exercise test, called the 6-Minute Pegboard and Ring Test, can reliably measure upper body function in adults with obstructive sleep apnea. Researchers will compare test results with sleep study data and questionnaires. The goal is to impr…

This study looks back at data from 80 veterans and first responders who completed a 12-week program that combined mental health support, physical therapy, nutrition advice, and occupational therapy. Researchers want to see if the program helped improve sleep, anxiety, depression,…

This study will give 180 healthy adults a daily probiotic supplement (Lactobacillus plantarum) for 1 or 6 months. Researchers will collect blood and stool samples and run online cognitive tests to see if the supplement changes gut bacteria, blood markers, or thinking skills. The …

This study looks at how physical activity levels are linked to posture, sleep quality, depression, and muscle or joint pain in health science professors and researchers at Istanbul Aydin University. About 73 academics aged 23 to 65 will fill out questionnaires. The goal is to und…

This study looks at whether being male or female changes how the body handles hunger and blood sugar when sleep and eating are out of sync, like during night shifts. Researchers will compare 36 healthy adults in a controlled lab setting. Results could lead to personalized shift s…

This study explores whether virtual reality (VR) construction tasks can detect changes in performance caused by lack of sleep. Researchers will enroll 12 participants and have them perform VR tasks after different sleep conditions. The goal is to see if VR can reliably measure sl…

This study explores whether stress in children and their parents is related to bruxism (teeth grinding) in kids aged 8-11. Researchers will compare 100 children with and without bruxism, using questionnaires to measure stress levels. The goal is to better understand the role of s…

This study will collect health data from 250 Taiwanese adults aged 40 and older to understand how aging affects the brain, sleep, and thinking skills. Participants will undergo brain scans and wear activity monitors, and answer sleep questionnaires. The goal is to build a compreh…

This study uses a large Korean health database to see if developing insomnia after a heart attack (treated with stents or bypass surgery) is linked to worse long-term outcomes like death, another heart attack, or stroke. Researchers will compare patients who take insomnia medicat…

This study looks at how the amount of deep sleep just before waking affects how alert people feel after a 2-hour nap taken at night. Researchers will monitor brain activity during sleep and test reaction times after waking. The goal is to understand sleep inertia and improve nap …

This study looks at how mental state, emotional eating, and sleep quality together influence the risk of metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) in people with schizophrenia or bipolar disorder. Researchers will measure these factors …

This study tests a 12-week after-school active play program for primary school children in Bangladesh. The program includes free play and guided activities to boost physical activity, reduce sitting time, improve sleep, and build movement skills like running and jumping. About 35…

This study will collect health data from 5,000 adults with sleep-related breathing disorders like obstructive sleep apnea. Researchers will track symptoms and test results over time to better understand these conditions and improve patient monitoring. No new treatments are being …

This study will follow 1200 people who have had a heart attack or unstable angina and also have sleep apnea. Researchers will collect blood, urine, and stool samples to understand how sleep apnea affects metabolism and heart risk. The goal is to build an AI-based tool to better p…

This study looks at how the time of day and the menstrual cycle (specifically low vs. high progesterone phases) affect strength and thinking in female athletes. Thirty women aged 18-30 who train regularly will be tested at 7am, 12pm, and 6pm during two different phases of their c…

This pilot study will test whether a drug called dexmedetomidine can reduce activity in a brain region (the locus coeruleus) that may be too active during sleep in people with insomnia. Fifteen adults with insomnia will receive either the drug or a placebo before bed in a crossov…

This study aims to understand how working night shifts in busy hospital settings like intensive care and emergency rooms affects what and when healthcare workers eat. Researchers will ask 245 adults who work night shifts in healthcare or other jobs to fill out an online questionn…

This study follows 160 adults in Hong Kong over time to see if disruptions in daily activity and sleep (rest-activity rhythms) can predict who develops major depressive disorder. Participants will wear activity monitors and complete questionnaires about mood and sleep. The goal i…

This study will give a single dose of morphine or a placebo to 26 adults (some healthy, some with obstructive sleep apnea) during a sleep study night. Researchers will measure how much their breathing changes. The goal is to understand why opioids can dangerously slow breathing d…

This study will follow 11,100 adults with sleep-disordered breathing for up to 5 years. Researchers will collect health data and samples to find better ways to predict risks and tailor treatments. No new drug or device is being tested; participants receive standard care like CPAP…

This study looks at how a device that stimulates a nerve in the tongue changes the way the upper airway collapses in people with obstructive sleep apnea. Researchers will measure airway collapsibility during a sleep endoscopy in 21 adults already using the therapy. The goal is to…

This study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…

This study looks at how low oxygen levels during sleep (from obstructive sleep apnea) are connected to problems in the tiny blood vessels of the heart. Researchers will follow 560 adults with suspected heart issues to see if sleep apnea patterns can predict future heart events li…

This study will track 100 adults receiving a single dental implant to see if the implant moves between placement and the final crown, about 3-4 months later. Researchers will use 3D scans taken right after surgery and before loading the crown to measure any shifts in position or …

This study looks at whether exercising at different times of day changes how we feel pain. Fifty-six healthy adults will do a 12-minute high-intensity workout in both the morning and evening. Researchers will measure pain thresholds before and after exercise to see if time of day…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study will use PET-MRI brain scans to compare the reward system in 44 Parkinson's patients, some of whom have a sleep disorder called RBD. The goal is to understand why some patients develop impulse control problems, like gambling or compulsive behaviors, as a side effect of…

This study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lun…

This study looks at 50 children aged 3-7 with type 1 obstructive sleep apnea who are scheduled for adenotonsillectomy. Researchers want to see if changes in how much children open their mouths during sleep are linked to improvements in their quality of life. Parents will answer q…

This study looks at whether low magnesium levels are linked to sleep problems in people with major depressive disorder. Researchers will measure magnesium in the blood of 90 adults and compare it to their sleep quality. The goal is to better understand this possible connection, n…

This study looks at whether giving different oxygen levels during rest breaks between short cycling exercises helps people with COPD feel less breathless and exercise more easily. Fifty adults with moderate COPD will do four short cycling sessions with rest in between. Researcher…

This study looks at whether the natural drop in blood pressure during sleep (called 'dipping') is linked to changes in the heart's electrical activity in people with high blood pressure. Researchers will monitor 140 adults using a 24-hour blood pressure device and compare those w…

This study looks at whether a short sleep education program can improve sleep habits and quality in health sciences students. About 100 students will attend four weekly 40-minute classes covering bedtime routines, caffeine limits, and stress management. Researchers will measure s…

This study will observe 55 adults with obstructive sleep apnea to see if the severity of their breathing pauses during sleep is linked to higher blood pressure in the lungs. Researchers will use echocardiography to measure lung artery pressure. The goal is to better understand th…

This study will check for stress, anxiety, depression, sleep problems, and bad breath in 110 adults with obesity who are getting ready for weight-loss surgery. Participants will fill out questionnaires and use a portable breath tester. The goal is to learn more about these issues…

This study will use an overnight sleep test (polysomnography) to measure breathing problems during sleep in 30 adults with systemic sclerosis (scleroderma). The goal is to find out how common sleep-disordered breathing is in this group. No treatment is given—this is purely an obs…

This study looks at whether treating obstructive sleep apnea with CPAP can change how certain immune cells (neutrophils) behave. Researchers will collect blood from 120 people — 80 with moderate-to-severe sleep apnea and 40 healthy controls — to measure immune cell activity and r…

This study will check how common it is for obese people with sleep apnea to still have low breathing at night even when using a CPAP machine. About 139 adults will wear a special skin sensor that measures oxygen and carbon dioxide levels overnight. The goal is to find out how man…