A dual sleep disorder: can one pill boost CPAP success?

NCT ID NCT07743931

Not yet recruiting Disease control Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study looks at people with COMISA, a condition where obstructive sleep apnea and insomnia occur together. Many people with this combination struggle to use CPAP, a standard treatment for sleep apnea, consistently. The study will compare those who take daridorexant, a sleep aid, alongside CPAP to those who use CPAP alone, to see if the medication improves CPAP adherence and overall outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: daridorexant (a sleep medication) combined with CPAP (a breathing device for sleep apnea)
What this could lead to: If adding daridorexant helps people use CPAP more consistently, it could improve sleep and overall health for those with both sleep apnea and insomnia.
What could go wrong: This is an observational study, so it can't prove cause and effect. Results may be influenced by other factors, and daridorexant may not improve CPAP adherence for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COMISA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

insomnia obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMISA INSOMNIA OBSTRUCTIVE SLEEP APNEA (OSA)

Contacts and locations

Locations

Centre Médical Les Jasmins

Metz, 57070, France
Hôpital Européen Marseille

Marseille, 13003, France
Hôpital de la Pitié Salpêtrière - AP-HP

Paris, 75013, France
Polyclinique Saint-Laurent - Hospitalité Saint-Thomas de Villeneuve

Rennes, 35700, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.