OBSTRUCTIVE SLEEP APNEA (OSA)

This study looks at whether removing the tonsils and adenoids (a surgery called adenotonsillectomy) can slow down or prevent the worsening of spine curves in children aged 6 to 15 who have mild sleep-disordered breathing and scoliosis. The researchers will measure spine curvature…

This study looks at how safe and effective Inspire therapy is for people with severe obstructive sleep apnea who have a higher AHI (65-100) or a higher BMI (32-40). About 70 adults who cannot use CPAP machines will get the Inspire implant and be followed for years. Researchers wi…

This study looks at whether telehealth care for obstructive sleep apnea (OSA) works as well as private sector care for military members. Researchers will compare how well patients use their breathing machines, their symptoms, and costs. The goal is to improve health and readiness…

This study tests a small device implanted in the chest that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot use a CPAP mask. About 30 participants will be followed for safety and slee…

This study is testing two common methods to prevent unwanted bite changes in people who use a special mouthpiece at night for sleep apnea or snoring. Participants will be randomly assigned to either use a morning alignment mouthguard or perform daily jaw exercises for three month…

This study tests a new way to estimate obstructive sleep apnea severity using a chest sensor, finger clip, and motion tracker instead of a full overnight sleep lab. Researchers will build an AI model that combines sound, oxygen, and movement data to predict breathing pauses durin…

This study explores whether short smartphone videos recorded by parents at home can accurately screen for moderate-to-severe obstructive sleep apnea (OSA) in children. OSA causes breathing to stop during sleep and can lead to serious health issues if untreated. The study will enr…

This study checks if a portable sleep monitor can accurately detect obstructive sleep apnea in children with autism spectrum disorder. About 20 children aged 6 to 18 will use the monitor at home and also have a standard lab sleep test. The goal is to see if the portable device is…

This study tests whether using a smartphone app and remote monitoring can help people with severe sleep apnea use their CPAP machine more regularly. Researchers will follow 200 adults in Brazil who are new to CPAP therapy. Half will get standard care, and half will have their CPA…

This pilot study tests a digital program that uses facial recognition to guide mouth and throat exercises for people with mild-to-moderate obstructive sleep apnea. The goal is to strengthen airway muscles, reduce snoring, and improve sleep quality. Sixty adults who cannot use sta…

This study tests whether simple breathing and drinking exercises can improve sleep quality in 60 U.S. service members with obstructive sleep apnea (OSA), some of whom also have a history of traumatic brain injury (TBI). Participants will do either high- or low-resistance exercise…

This study tests whether a dental mouthpiece or a CPAP machine better improves memory and thinking in people with sleep apnea and mild cognitive issues. About 260 adults aged 45 and older will be randomly assigned to one of the two treatments for one year. The goal is to see whic…

This study tests a personalized approach to treat obstructive sleep apnea (OSA) in people with Down syndrome. Researchers will compare giving everyone the same drug combination (atomoxetine and oxybutynin) versus assigning either that drug or oxygen therapy based on each person's…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers use ultrasound to measure tongue fat, size, and stiffness, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be scanned a…

This study looks at how different speeds of mild electrical pulses to the tongue and chin muscles affect muscle size, strength, and comfort in 28 adults at high risk for sleep apnea. Participants receive five different stimulation frequencies in one visit, and researchers measure…

This study aims to improve how doctors classify obstructive sleep apnea by combining sleepiness levels with cardiovascular risk scores. Researchers will follow 1,800 adults aged 40 and older who are newly diagnosed with sleep apnea. The goal is to see if this new classification b…

This study follows 1,000 people who have the Inspire System implanted for obstructive sleep apnea. Researchers will collect data from routine clinic visits to see how well the device works over time and how consistently patients use it. No extra tests or treatments are required b…