OBSTRUCTIVE SLEEP APNEA (OSA)

This study tests whether removing the tonsils and adenoids can slow or stop the progression of scoliosis (curved spine) in children aged 6 to 15 who also have mild sleep-disordered breathing. Half of the 160 participants will have surgery within 4 weeks, while the other half will…

This study tests whether matching sleep apnea treatment to the specific cause in each person with Down syndrome works better than a one-size-fits-all approach. 200 children and adults will receive either a combination of two drugs (ato-oxy) or oxygen therapy based on their indivi…

This study is testing a device called Inspire, which is implanted in the body to treat obstructive sleep apnea. It is being studied in people with more severe sleep apnea (higher AHI) and higher body weight (higher BMI) who cannot use CPAP machines. The study will follow 70 parti…

This pilot study tests a device implanted in the neck that stimulates nerves to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot use a CPAP machine. The study will check if the device is safe and improves sleep quality…

This study tests whether telehealth care, including a human sleep navigator, works as well as private sector care for obstructive sleep apnea in 160 military members aged 18-64. Participants will receive education, support, and troubleshooting via telehealth. The goal is to see i…

This registry follows 1,000 people with obstructive sleep apnea who have received the Inspire implant, a device that stimulates nerves to keep the airway open during sleep. Researchers will track how well the device works over time and how consistently patients use it, using rout…

This study looks at whether a simple questionnaire given during a dental checkup can identify children at risk for sleep-disordered breathing (like sleep apnea). Sixty children aged 8-13 will fill out the questionnaire and then wear a home sleep monitor for one night to measure t…

This study is testing whether simple measurements like facial scans, videos of blinking and swallowing, and heart rate changes can help doctors diagnose obstructive sleep apnea (OSA). Researchers will collect this data from 800 adults who do not already have an OSA diagnosis. The…

This study tests whether a combination of noninvasive sensors—listening to breathing sounds, measuring oxygen levels, and tracking body movement—can accurately estimate the severity of obstructive sleep apnea. Researchers will enroll 150 adults suspected of having sleep apnea and…

This study is testing whether a portable sleep monitor can accurately detect obstructive sleep apnea in children with autism spectrum disorder. Twenty children aged 6 to 18 will wear the portable device at the same time as their standard in-hospital sleep test. Researchers will c…

This study is testing whether short video clips recorded by parents on their smartphones can help screen for moderate-to-severe obstructive sleep apnea (OSA) in children. OSA affects 1-4% of kids and can lead to serious health issues if untreated, but getting a sleep study is oft…

This study tests two simple ways to prevent bite changes in people using a mouthpiece for sleep apnea or snoring. Some participants will use a special aligner each morning to gently guide their jaw back into place, while others will do daily jaw exercises. The goal is to see whic…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This study tests whether remote monitoring of CPAP machines helps people with severe sleep apnea use their therapy more regularly. About 200 adults who are new to CPAP will either get standard care or have their device tracked remotely via an app. The goal is to see if digital su…

This pilot study tests a digital program that uses facial recognition and guided exercises to strengthen throat muscles in people with mild-to-moderate obstructive sleep apnea. Sixty adults who cannot or will not use a CPAP machine will either receive the 3-month app-based therap…

This study tests whether simple exercises (like drinking water and breathing in a certain way) can improve sleep quality in 60 U.S. service members with obstructive sleep apnea. Some participants have also had a traumatic brain injury. The goal is to see if these exercises reduce…

This study tests whether a dental mouthpiece (MAD) works as well as a CPAP machine to improve thinking and memory in people with sleep apnea who also have mild memory problems. About 260 adults aged 45 and older will be randomly assigned to use either device for one year. Researc…

This observational study looks at whether removing excess fluid from the body (diuresis) can reduce sleep apnea severity in adults hospitalized with heart failure. Fifty participants will wear a sleep monitor before and after fluid removal, and researchers will track changes in n…

This study tests how different frequencies of electrical stimulation affect tongue muscles in 28 adults at high risk for sleep apnea. During a single visit, participants receive five different stimulation frequencies in random order. Researchers measure changes in tongue muscle t…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers use ultrasound to measure tongue fat, stiffness, and shape, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be scanned …

This study looks at a new system for classifying obstructive sleep apnea (OSA) based on how sleepy patients feel and their heart health. Researchers will follow 1,800 adults newly diagnosed with OSA to see if this classification helps predict long-term improvements. The goal is t…